{"id":"https://openalex.org/W7207693298","doi":"https://doi.org/10.64898/2026.09.01.745409","title":"Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitability","display_name":"Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitability","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7207693298","doi":"https://doi.org/10.64898/2026.09.01.745409"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.745409","doi":"https://doi.org/10.64898/2026.09.01.745409","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.745409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.01.745409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013906415","display_name":"Cayetana Arnaiz","orcid":"https://orcid.org/0000-0001-5069-1469","observed_orcids":["https://orcid.org/0000-0001-5069-1469"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Cayetana Arnaiz","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0001-5069-1469","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149542978","display_name":"Gonzalo Escalante","orcid":"https://orcid.org/0009-0006-5277-048X","observed_orcids":["https://orcid.org/0009-0006-5277-048X"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Gonzalo Escalante","raw_affiliation_strings":["Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0009-0006-5277-048X","affiliations":[{"raw_affiliation_string":"Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149816628","display_name":"Lautaro Rodriguez Donghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Lautaro Rodriguez Donghi","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078774136","display_name":"Mariana In\u00e9s Holubiec","orcid":"https://orcid.org/0000-0002-7532-8890","observed_orcids":["https://orcid.org/0000-0002-7532-8890"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Mariana I Holubiec","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-7532-8890","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044282471","display_name":"Olivia Pedroncini","orcid":"https://orcid.org/0009-0009-0613-4126","observed_orcids":["https://orcid.org/0009-0009-0613-4126"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Olivia Pedroncini","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0009-0009-0613-4126","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136499654","display_name":"Indiana P\u00e1ez Paz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Indiana P\u00e1ez Paz","raw_affiliation_strings":["Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120011814","display_name":"Clara Gaguine","orcid":"https://orcid.org/0009-0003-5498-2708","observed_orcids":["https://orcid.org/0009-0003-5498-2708"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Clara Gaguine","raw_affiliation_strings":["Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina","Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0009-0003-5498-2708","affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008179180","display_name":"Julieta Bianchelli","orcid":"https://orcid.org/0000-0003-4560-1099","observed_orcids":["https://orcid.org/0000-0003-4560-1099"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Julieta Bianchelli","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0003-4560-1099","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063841440","display_name":"Jordi Navarro","orcid":"https://orcid.org/0000-0002-7187-0367","observed_orcids":["https://orcid.org/0000-0002-7187-0367","https://orcid.org/0000-0003-3164-7563"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Jordi Navarro","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0003-3164-7563","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062387732","display_name":"Micaela D. Garc\u00eda","orcid":"https://orcid.org/0000-0002-0650-3771","observed_orcids":["https://orcid.org/0000-0002-0650-3771"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Micaela D Garcia","raw_affiliation_strings":["Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-0650-3771","affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076312583","display_name":"Luc\u00eda F. Lopez","orcid":"https://orcid.org/0000-0002-2596-2113","observed_orcids":["https://orcid.org/0000-0002-2596-2113"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Luc\u00eda F Lopez","raw_affiliation_strings":["Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030280316","display_name":"Alan M. Szalai","orcid":"https://orcid.org/0000-0002-3795-3230","observed_orcids":["https://orcid.org/0000-0002-3795-3230"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alan M Szalai","raw_affiliation_strings":["Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-3795-3230","affiliations":[{"raw_affiliation_string":"Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034448567","display_name":"Antonia Mar\u00edn\u2010Burgin","orcid":"https://orcid.org/0000-0003-0684-9796","observed_orcids":["https://orcid.org/0000-0003-0684-9796"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":false,"raw_author_name":"Antonia Marin-Burgin","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0003-0684-9796","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002719525","display_name":"Fernando Daniel Stefani","orcid":"https://orcid.org/0000-0002-3277-7215","observed_orcids":["https://orcid.org/0000-0002-3277-7215"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Fernando D Stefani","raw_affiliation_strings":["Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina","Universidad de Buenos Aires, Departamento de F\u00edsica, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-3277-7215","affiliations":[{"raw_affiliation_string":"Centro de Investigaciones en Bionanociencias (CIBION), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Departamento de F\u00edsica, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079670341","display_name":"Mar\u00eda Elena Avale","orcid":"https://orcid.org/0000-0002-0251-0093","observed_orcids":["https://orcid.org/0000-0002-0251-0093"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria E. Avale","raw_affiliation_strings":["Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-0251-0093","affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI-CONICET), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073752557","display_name":"Tom\u00e1s Luis Falzone","orcid":"https://orcid.org/0000-0002-7984-1149","observed_orcids":["https://orcid.org/0000-0002-7984-1149"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210148385","display_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","ror":"https://ror.org/04c5b8z55","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210148385","https://openalex.org/I4387155568"]}],"countries":["AR","DE"],"is_corresponding":true,"raw_author_name":"Tomas L Falzone","raw_affiliation_strings":["Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-7984-1149","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires IBioBA (MPSP-CONICET), Partner Institute of the Max Planck Society, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210148385"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia IBCN (UBA-CONICET), Catedra de Biolog\u00eda Molecular y Gen\u00e9tica, Facultad de Medicina, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073752557"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210148385"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axon-initial-segment","display_name":"axon initial segment","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tau-isoforms","display_name":"tau isoforms","score":0.9909999966621399},{"id":"https://openalex.org/keywords/exon-10","display_name":"exon 10","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ankyrin-g","display_name":"ankyrin-G","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.9070000052452087},{"id":"https://openalex.org/keywords/axonal-trafficking","display_name":"axonal trafficking","score":0.7210000157356262},{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sodium-current","display_name":"sodium current","score":0.8769999742507935},{"id":"https://openalex.org/keywords/action-potential-generation","display_name":"action potential generation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hipsc-derived-neurons","display_name":"hiPSC-derived neurons","score":0.777999997138977},{"id":"https://openalex.org/keywords/axonal-microtubules","display_name":"axonal microtubules","score":0.7350000143051147},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7641000151634216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5861999988555908},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5526000261306763},{"id":"https://openalex.org/C182800266","wikidata":"https://www.wikidata.org/wiki/Q414971","display_name":"Ankyrin","level":3,"score":0.5400999784469604},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5139999985694885},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4975000023841858},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48159998655319214},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4814999997615814},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.43320000171661377},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.43309998512268066},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42809998989105225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40540000796318054},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.352400004863739},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C2777589315","wikidata":"https://www.wikidata.org/wiki/Q18048105","display_name":"NAV1","level":4,"score":0.3296999931335449},{"id":"https://openalex.org/C135979968","wikidata":"https://www.wikidata.org/wiki/Q609809","display_name":"Protein isoform","level":5,"score":0.3228999972343445},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.30070000886917114},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C135903288","wikidata":"https://www.wikidata.org/wiki/Q559423","display_name":"Growth cone","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.01.745409","doi":"https://doi.org/10.64898/2026.09.01.745409","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.745409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.745409","doi":"https://doi.org/10.64898/2026.09.01.745409","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.745409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6086999773979187}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1550995133","https://openalex.org/W1892403772","https://openalex.org/W1901737651","https://openalex.org/W1919573401","https://openalex.org/W1926421284","https://openalex.org/W1969076369","https://openalex.org/W1971775491","https://openalex.org/W1981662243","https://openalex.org/W1983765259","https://openalex.org/W1989092549","https://openalex.org/W1989809732","https://openalex.org/W2002812952","https://openalex.org/W2004368634","https://openalex.org/W2028082846","https://openalex.org/W2037981058","https://openalex.org/W2040949523","https://openalex.org/W2044098590","https://openalex.org/W2044974101","https://openalex.org/W2060458492","https://openalex.org/W2065925973","https://openalex.org/W2066032422","https://openalex.org/W2074676503","https://openalex.org/W2089180938","https://openalex.org/W2106158921","https://openalex.org/W2115420955","https://openalex.org/W2124317694","https://openalex.org/W2126264983","https://openalex.org/W2138070279","https://openalex.org/W2141490098","https://openalex.org/W2182809622","https://openalex.org/W2338064835","https://openalex.org/W2428108891","https://openalex.org/W2466670739","https://openalex.org/W2485106826","https://openalex.org/W2508219669","https://openalex.org/W2550515186","https://openalex.org/W2554784405","https://openalex.org/W2573566626","https://openalex.org/W2619800602","https://openalex.org/W2623709241","https://openalex.org/W2787301736","https://openalex.org/W2800724568","https://openalex.org/W2801680558","https://openalex.org/W2803819386","https://openalex.org/W2886220390","https://openalex.org/W2914613198","https://openalex.org/W2939097644","https://openalex.org/W2950571742","https://openalex.org/W2954476098","https://openalex.org/W2954910683","https://openalex.org/W2956696709","https://openalex.org/W2971448217","https://openalex.org/W2971541306","https://openalex.org/W2973501556","https://openalex.org/W4223629343","https://openalex.org/W4281653848","https://openalex.org/W4283645535","https://openalex.org/W4284968170","https://openalex.org/W4285092137","https://openalex.org/W4301585140","https://openalex.org/W4376871558","https://openalex.org/W4382793935","https://openalex.org/W4386766404","https://openalex.org/W4391514340","https://openalex.org/W4393384008","https://openalex.org/W4394683841","https://openalex.org/W4400686257","https://openalex.org/W4402625648","https://openalex.org/W4407391650","https://openalex.org/W4416584897"],"related_works":["https://openalex.org/W2619800602","https://openalex.org/W2766526677","https://openalex.org/W2550515186","https://openalex.org/W7203848986","https://openalex.org/W4414489232","https://openalex.org/W2573566626","https://openalex.org/W2250108446","https://openalex.org/W2044161925","https://openalex.org/W4390195327","https://openalex.org/W4205237593"],"abstract_inverted_index":{"Abstract":[0],"The":[1,21,255],"axon":[2,256],"initial":[3,257],"segment":[4,258],"(AIS)":[5,259],"is":[6,25,231,289,312],"a":[7,26,207,232,261,290,325,343,370],"specialized":[8],"neuronal":[9,217,251,318,327,361],"compartment":[10],"integrating":[11,268],"action":[12,188,269],"potential":[13,189,270,371],"initiation":[14,271],"with":[15,79,153,272],"selective":[16,273],"control":[17,274],"of":[18,29,52,101,111,157,171,210,228,235,275,279,286,293,346],"axonal":[19,148,276],"trafficking.":[20,277],"microtubule-associated":[22],"protein":[23],"tau":[24,37,53,90,107,114,138,146,161,172,203,226,246,280,287,309,339,357],"central":[27,262],"regulator":[28,209,345],"cytoskeletal":[30,214],"organization":[31,215],"and":[32,43,63,70,83,93,99,118,177,191,219,320,332,365],"transport,":[33],"yet":[34,297],"how":[35,244,355],"distinct":[36],"isoforms":[38,247],"contribute":[39,249],"to":[40,216,250],"AIS":[41,59,102,119,123,130,175,211,316,347,368],"development":[42],"function":[44,266],"remains":[45],"unclear.":[46],"Here,":[47,304],"we":[48,305],"examined":[49],"the":[50,97,158,197,223,367],"role":[51,263],"isoform":[54,94,139,168,204,310,340],"relative":[55],"abundance":[56],"in":[57,137,150,163,264,283,363],"regulating":[58],"establishment,":[60],"maturation,":[61,212,317],"excitability,":[62,319],"transport":[64,194,220,321,334],"selectivity":[65],"using":[66],"murine":[67,105],"primary":[68,236],"neurons":[69,77,126,165],"human":[71,326],"induced":[72],"pluripotent":[73],"stem":[74],"cell":[75],"(hiPSC)-derived":[76],"combined":[78],"super-resolution":[80,329],"imaging,":[81,330],"electrophysiology,":[82,331],"live":[84,333],"trafficking":[85],"assays.":[86],"We":[87],"found":[88],"that":[89,144,167,307],"expression":[91,311],"levels":[92],"content":[95],"modulate":[96],"timing":[98],"robustness":[100],"maturation.":[103],"In":[104],"neurons,":[106],"deficiency":[108],"or":[109],"predominance":[110],"3-repeat":[112],"(3R)":[113],"delays":[115],"Ankyrin-G":[116,178],"accumulation":[117],"stabilization":[120],"without":[121],"preventing":[122],"formation.":[124],"hiPSC-derived":[125,164],"display":[127],"an":[128],"intrinsic":[129],"developmental":[131,208],"program":[132],"accompanied":[133],"by":[134,267],"progressive":[135],"changes":[136],"content.":[140],"Super-resolution":[141],"DNA-PAINT":[142],"reveals":[143],"endogenous":[145,159],"decorates":[147],"microtubules":[149],"discrete":[151],"nanoclusters":[152],"compartment-specific":[154],"distributions.":[155],"Modulation":[156],"3R/4R":[160],"balance":[162,205,341],"shows":[166],"composition,":[169],"independently":[170],"levels,":[173],"regulates":[174],"positioning":[176],"organization.":[179],"Functionally,":[180],"shifts":[181],"towards":[182],"3R-tau":[183],"reduce":[184],"sodium":[185],"currents,":[186],"impairs":[187],"firing,":[190],"alters":[192],"lysosomal":[193],"dynamics":[195],"within":[196],"AIS.":[198],"Together,":[199],"these":[200],"findings":[201,350],"identify":[202],"as":[206,342,369],"linking":[213],"excitability":[218],"gating.":[221],"Because":[222],"aberrant":[224],"alternative":[225],"splicing":[227],"exon":[229],"10":[230],"defining":[233,291],"feature":[234,292],"tauopathies,":[237],"our":[238,336],"results":[239],"provide":[240,351],"mechanistic":[241,352],"insight":[242,353],"into":[243,354],"imbalanced":[245],"may":[248,359],"dysfunction.":[252],"Significant":[253],"Statement":[254],"plays":[260],"brain":[265],"Disruption":[278],"splicing,":[281],"resulting":[282],"altered":[284],"ratios":[285],"isoforms,":[288],"several":[294],"neurodegenerative":[295],"diseases,":[296],"its":[298],"functional":[299],"consequences":[300],"remain":[301],"poorly":[302],"understood.":[303],"show":[306],"balanced":[308],"required":[313],"for":[314],"proper":[315],"selectivity.":[322],"By":[323],"combining":[324],"model,":[328],"analysis,":[335],"work":[337],"identifies":[338],"key":[344],"development.":[348],"These":[349],"early":[356],"dysregulation":[358],"initiate":[360],"dysfunction":[362],"tauopathies":[364],"highlight":[366],"therapeutic":[372],"target.":[373]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-04T00:00:00"}
