{"id":"https://openalex.org/W7207681997","doi":"https://doi.org/10.20944/preprints202609.0155.v1","title":"Integrative Meta-GWAS of European and Multi-Ancestry Parkinson\u2019s Disease Studies Refines Genetic Risk Architecture and Prioritizes Unresolved Candidate Loci","display_name":"Integrative Meta-GWAS of European and Multi-Ancestry Parkinson\u2019s Disease Studies Refines Genetic Risk Architecture and Prioritizes Unresolved Candidate Loci","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7207681997","doi":"https://doi.org/10.20944/preprints202609.0155.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202609.0155.v1","doi":"https://doi.org/10.20944/preprints202609.0155.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.0155.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202609.0155.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5149441197","display_name":"Faisal Khalique","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faisal Khalique","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001607248","display_name":"Farah Nadia Sheikh","orcid":"https://orcid.org/0000-0003-2610-0125","observed_orcids":["https://orcid.org/0000-0003-2610-0125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farah Nadia Sheikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033834086","display_name":"Hamid Mustafa","orcid":"https://orcid.org/0000-0003-1279-420X","observed_orcids":["https://orcid.org/0000-0003-1279-420X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hamid Mustafa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033834086"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/european-ancestry","display_name":"European ancestry","score":0.4830000102519989},{"id":"https://openalex.org/keywords/snca","display_name":"SNCA","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":1.0},{"id":"https://openalex.org/keywords/genomic-inflation","display_name":"genomic inflation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.7942000031471252},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7121000289916992},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.6664000153541565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6115999817848206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5848000049591064},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5496000051498413},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5253999829292297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4496000111103058},{"id":"https://openalex.org/C97425143","wikidata":"https://www.wikidata.org/wiki/Q164786","display_name":"1000 Genomes Project","level":5,"score":0.44179999828338623},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.3937000036239624},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.38580000400543213},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35910001397132874},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.3499999940395355},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.3441999852657318},{"id":"https://openalex.org/C134443026","wikidata":"https://www.wikidata.org/wiki/Q4809584","display_name":"Association mapping","level":5,"score":0.3312000036239624},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.3215999901294708},{"id":"https://openalex.org/C32792767","wikidata":"https://www.wikidata.org/wiki/Q1370484","display_name":"Summary statistics","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.3100000023841858},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C24756922","wikidata":"https://www.wikidata.org/wiki/Q1757694","display_name":"Data quality","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202609.0155.v1","doi":"https://doi.org/10.20944/preprints202609.0155.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.0155.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202609.0155.v1","doi":"https://doi.org/10.20944/preprints202609.0155.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.0155.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6948142470","https://openalex.org/W4408672672","https://openalex.org/W7161643489","https://openalex.org/W4319761874","https://openalex.org/W4412866987","https://openalex.org/W3017227862","https://openalex.org/W2566450482","https://openalex.org/W3105175400","https://openalex.org/W2148641246","https://openalex.org/W2111957326"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3],"a":[4,115],"highly":[5],"polygenic":[6],"neurodegenerative":[7],"disorder":[8],"whose":[9],"genome-wide":[10],"association":[11,176],"study":[12],"(GWAS)":[13],"discoveries":[14],"have":[15],"largely":[16],"arisen":[17],"from":[18],"European-ancestry":[19],"cohorts.":[20],"We":[21],"integrated":[22],"the":[23,40,158],"Nalls":[24,41],"et":[25,32],"al.":[26,33],"European":[27],"PD":[28,81,175,188],"GWAS":[29],"with":[30],"Kim":[31],"multi-ancestry":[34],"summary":[35],"statistics":[36],"(GCST90275127),":[37],"which":[38],"exclude":[39],"dataset.":[42],"Both":[43],"resources":[44],"were":[45],"aligned":[46],"to":[47,79,141,145],"GRCh37,":[48],"quality":[49,60],"controlled,":[50],"allele":[51],"harmonized,":[52],"and":[53,67,94,130,148,178],"combined":[54,159],"by":[55],"fixed-effect":[56],"inverse-variance":[57],"weighting.":[58],"After":[59],"control,":[61],"6,477,357":[62],"harmonized":[63],"variants":[64],"entered":[65],"meta-analysis,":[66],"7,085":[68],"reached":[69],"P":[70,89,100,109],"<":[71,110],"5":[72,111],"\u00d7":[73,92,103,112],"10\u207b\u2078.":[74],"The":[75],"strongest":[76],"signals":[77],"mapped":[78,140],"established":[80,174],"regions,":[82,143],"including":[83],"SNCA":[84],"(rs356220;":[85],"OR":[86,97],"=":[87,90,98,101,162],"1.270,":[88],"6.17":[91],"10\u207b\u2078\u2076)":[93],"GBA":[95],"(rs2230288;":[96],"1.989,":[99],"4.94":[102],"10\u207b\u2075\u2078).":[104],"Stringent":[105],"locus":[106],"analysis":[107],"at":[108],"10\u207b\u2079":[113],"using":[114],"1000":[116],"Genomes":[117],"all-ancestry":[118],"linkage":[119],"disequilibrium":[120],"reference":[121],"identified":[122],"357":[123],"independent":[124,183],"significant":[125],"variants,":[126,129],"128":[127],"lead":[128],"73":[131],"genomic":[132],"risk":[133],"loci":[134,139,181],"among":[135,164],"reference-covered":[136],"variants.":[137],"Forty-two":[138],"pre-Kim":[142],"three":[144],"Kim-published":[146],"loci,":[147],"28":[149],"remained":[150],"unresolved":[151,180],"candidates.":[152],"Genomic":[153],"inflation":[154],"was":[155],"elevated":[156],"in":[157],"statistic":[160],"(\u03bbGC":[161],"1.875":[163],"common":[165],"non-MHC":[166],"variants),":[167],"requiring":[168],"ancestry-aware":[169],"calibration.":[170],"These":[171],"results":[172],"refine":[173],"architecture":[177],"prioritize":[179],"for":[182],"validation":[184],"without":[185],"establishing":[186],"novel":[187],"loci.":[189]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-04T00:00:00"}