{"id":"https://openalex.org/W7207649092","doi":"https://doi.org/10.1158/2643-3230.33424173","title":"Supplementary Figure S4 from LY3410738, a Covalent Inhibitor of Mutant IDH1/2, Is Effective in Acute Myeloid Leukemia Preclinical Models","display_name":"Supplementary Figure S4 from LY3410738, a Covalent Inhibitor of Mutant IDH1/2, Is Effective in Acute Myeloid Leukemia Preclinical Models","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207649092","doi":"https://doi.org/10.1158/2643-3230.33424173"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.33424173","doi":"https://doi.org/10.1158/2643-3230.33424173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.33424173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2643-3230.33424173","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062649281","display_name":"Nathan A. Brooks","orcid":"https://orcid.org/0009-0007-6028-2096","observed_orcids":["https://orcid.org/0009-0007-6028-2096","https://orcid.org/0000-0002-5111-6914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathan A. Brooks","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-6028-2096","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003340533","display_name":"Anna Skwarska","orcid":"https://orcid.org/0000-0002-0979-026X","observed_orcids":["https://orcid.org/0000-0002-0979-026X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Skwarska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0979-026X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064334845","display_name":"Vivian Salama","orcid":"https://orcid.org/0000-0002-4870-4635","observed_orcids":["https://orcid.org/0000-0002-4870-4635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivian Salama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4870-4635","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043503183","display_name":"Mark H. Bender","orcid":"https://orcid.org/0009-0006-7918-4229","observed_orcids":["https://orcid.org/0009-0006-7918-4229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark H. Bender","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7918-4229","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011118925","display_name":"Lisa M. Kays","orcid":"https://orcid.org/0009-0007-9343-7314","observed_orcids":["https://orcid.org/0009-0007-9343-7314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Kays","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9343-7314","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143465174","display_name":"Robin I. DeWalt","orcid":"https://orcid.org/0009-0000-2996-0054","observed_orcids":["https://orcid.org/0009-0000-2996-0054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin I. DeWalt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2996-0054","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143484029","display_name":"Bryan Perria","orcid":"https://orcid.org/0009-0000-0546-526X","observed_orcids":["https://orcid.org/0009-0000-0546-526X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan Perria","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-0546-526X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062877915","display_name":"Deepti Thete","orcid":"https://orcid.org/0009-0006-7915-4070","observed_orcids":["https://orcid.org/0009-0006-7915-4070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepti Thete","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7915-4070","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041068728","display_name":"Jason R. Manro","orcid":"https://orcid.org/0009-0006-4046-1989","observed_orcids":["https://orcid.org/0009-0006-4046-1989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason R. Manro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-4046-1989","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143471491","display_name":"Rachel N. Cavitt","orcid":"https://orcid.org/0009-0007-3939-8019","observed_orcids":["https://orcid.org/0009-0007-3939-8019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Cavitt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-3939-8019","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086288582","display_name":"Rebecca Leon","orcid":"https://orcid.org/0009-0005-8038-6568","observed_orcids":["https://orcid.org/0009-0005-8038-6568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Leon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-8038-6568","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143493683","display_name":"Sandra Gomez","orcid":"https://orcid.org/0000-0003-1804-6405","observed_orcids":["https://orcid.org/0000-0003-1804-6405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Gomez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1804-6405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076650628","display_name":"Raquel Torres","orcid":"https://orcid.org/0009-0005-6145-0691","observed_orcids":["https://orcid.org/0009-0005-6145-0691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raquel Torres","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6145-0691","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032901924","display_name":"John M. Strelow","orcid":"https://orcid.org/0000-0002-9310-7629","observed_orcids":["https://orcid.org/0000-0002-9310-7629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Strelow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9310-7629","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143519945","display_name":"Paul Milligan","orcid":"https://orcid.org/0009-0003-2083-0618","observed_orcids":["https://orcid.org/0009-0003-2083-0618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Milligan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-2083-0618","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040050683","display_name":"Kate Newell","orcid":"https://orcid.org/0009-0000-9296-5405","observed_orcids":["https://orcid.org/0009-0000-9296-5405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Newell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-9296-5405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143474442","display_name":"Kenneth D. Roth","orcid":"https://orcid.org/0000-0002-3650-9808","observed_orcids":["https://orcid.org/0000-0002-3650-9808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth D. Roth","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3650-9808","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053533004","display_name":"Jean\u2010Emmanuel Sarry","orcid":"https://orcid.org/0000-0002-6704-2032","observed_orcids":["https://orcid.org/0000-0002-6704-2032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Emmanuel Sarry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6704-2032","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059745705","display_name":"Steven M. Chan","orcid":"https://orcid.org/0000-0002-4354-0731","observed_orcids":["https://orcid.org/0000-0002-4354-0731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven M. Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4354-0731","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143467982","display_name":"Danalyn Manglicmot. Lagutan","orcid":"https://orcid.org/0009-0008-7351-0016","observed_orcids":["https://orcid.org/0009-0008-7351-0016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danalyn Manglicmot Lagutan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-7351-0016","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125141778","display_name":"Richard Romero","orcid":"https://orcid.org/0009-0004-9954-2965","observed_orcids":["https://orcid.org/0009-0004-9954-2965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Romero","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-9954-2965","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143490999","display_name":"Stephen Antonysamy","orcid":"https://orcid.org/0000-0003-1596-2790","observed_orcids":["https://orcid.org/0000-0003-1596-2790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Antonysamy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1596-2790","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101851570","display_name":"Robert L. Johnson","orcid":"https://orcid.org/0000-0002-0478-6069","observed_orcids":["https://orcid.org/0000-0002-0478-6069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0478-6069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110959","display_name":"Xueqian Gong","orcid":"https://orcid.org/0009-0005-5647-4090","observed_orcids":["https://orcid.org/0009-0005-5647-4090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueqian Gong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5647-4090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002630184","display_name":"Renato A. Bauer","orcid":"https://orcid.org/0000-0001-5352-6389","observed_orcids":["https://orcid.org/0000-0001-5352-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renato A. Bauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5352-6389","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114004117","display_name":"Timothy P. Burkholder","orcid":"https://orcid.org/0009-0003-1677-7674","observed_orcids":["https://orcid.org/0009-0003-1677-7674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy P. Burkholder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-1677-7674","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426190","display_name":"Patric J. Hahn","orcid":"https://orcid.org/0009-0005-0592-1022","observed_orcids":["https://orcid.org/0009-0005-0592-1022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patric J. Hahn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0592-1022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018685169","display_name":"Zoran Rankovi\u0107","orcid":"https://orcid.org/0000-0001-6866-4290","observed_orcids":["https://orcid.org/0000-0001-6866-4290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoran Rankovic","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6866-4290","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069030672","display_name":"Serge L. Boulet","orcid":"https://orcid.org/0009-0000-7399-8383","observed_orcids":["https://orcid.org/0009-0000-7399-8383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serge L. Boulet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7399-8383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010786159","display_name":"Courtney Denton Dinardo","orcid":"https://orcid.org/0000-0001-9003-0390","observed_orcids":["https://orcid.org/0000-0001-9003-0390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney D. DiNardo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9003-0390","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022647201","display_name":"Marina Y Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Konopleva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9347-2212","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108694174","display_name":"Raymond Gilmour","orcid":"https://orcid.org/0009-0000-6753-0071","observed_orcids":["https://orcid.org/0009-0000-6753-0071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Gilmour","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6753-0071","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.781000018119812},{"id":"https://openalex.org/keywords/covalent-inhibitors","display_name":"covalent inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/2-hydroxyglutarate","display_name":"2-hydroxyglutarate","score":0.968999981880188},{"id":"https://openalex.org/keywords/h3k9me2","display_name":"H3K9me2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dose-dependent-inhibition","display_name":"dose-dependent inhibition","score":0.7879999876022339},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7049999833106995},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6452000141143799},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6029000282287598},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5321000218391418},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5174999833106995},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2838999927043915},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.27090001106262207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26930001378059387},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2689000070095062}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2643-3230.33424173","doi":"https://doi.org/10.1158/2643-3230.33424173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.33424173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.33424173","doi":"https://doi.org/10.1158/2643-3230.33424173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.33424173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7207533942","https://openalex.org/W7170170993","https://openalex.org/W3080386471","https://openalex.org/W3088661094","https://openalex.org/W2955608015","https://openalex.org/W4365514035","https://openalex.org/W3040213136","https://openalex.org/W2592825589","https://openalex.org/W3126866891","https://openalex.org/W3133654640"],"abstract_inverted_index":{"In":[0],"vitro":[1],"dose-dependent":[2],"inhibition":[3],"of":[4],"2-HG":[5],"production":[6],"and":[7],"H3K9me2":[8],"hypermethylation":[9]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-04T00:00:00"}