{"id":"https://openalex.org/W7207637579","doi":"https://doi.org/10.64898/2026.09.01.747915","title":"The filopodial scaffold polyphosphate dictates cell adhesion- versus -invasion decisions","display_name":"The filopodial scaffold polyphosphate dictates cell adhesion- versus -invasion decisions","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207637579","doi":"https://doi.org/10.64898/2026.09.01.747915","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684594"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.01.747915","doi":"https://doi.org/10.64898/2026.09.01.747915","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.747915","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.09.01.747915.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.09.01.747915.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102549780","display_name":"Akash Rai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akash Rai","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101238426","display_name":"Aanchal Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aanchal Jain","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118137043","display_name":"Hannah Zunker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Zunker","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042939444","display_name":"Bonje N. Obua","orcid":"https://orcid.org/0000-0002-9814-3645","observed_orcids":["https://orcid.org/0000-0002-9814-3645"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonje N. Obua","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100500065","display_name":"Harshita Ramchandani","orcid":"https://orcid.org/0009-0007-9517-3658","observed_orcids":["https://orcid.org/0009-0007-9517-3658"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harshita Ramchandani","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049299641","display_name":"Jian Guan","orcid":"https://orcid.org/0000-0002-4671-7432","observed_orcids":["https://orcid.org/0000-0002-4671-7432"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Guan","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061268764","display_name":"Akter Mousumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mousumi Akter","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015366500","display_name":"Yongkang Xi","orcid":"https://orcid.org/0009-0001-0290-4850","observed_orcids":["https://orcid.org/0009-0001-0290-4850"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongkang Xi","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149504017","display_name":"Amanda Erwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Erwin","raw_affiliation_strings":["Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052091521","display_name":"Pavithra Mahadevan","orcid":"https://orcid.org/0000-0002-5459-5551","observed_orcids":["https://orcid.org/0000-0002-5459-5551"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavithra Mahadevan","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001344320","display_name":"Bryndon J. Oleson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryndon J. Oleson","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149893586","display_name":"Adrian BJ Bardwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian B.J. Bardwell","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149784191","display_name":"Jaclyn Shoudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaclyn Shoudis","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149554858","display_name":"Jiage Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiage Song","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149783309","display_name":"Megha Suresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megha Suresh","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040600416","display_name":"Shyamal Mosalaganti","orcid":"https://orcid.org/0000-0002-5934-687X","observed_orcids":["https://orcid.org/0000-0002-5934-687X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamal Mosalaganti","raw_affiliation_strings":["Department of Biological Chemistry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","Department of Biophysics, University of Michigan, Ann Arbor, MI, USA","Department of Cell and Developmental Biology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":"https://orcid.org/0000-0002-5934-687X","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Biophysics, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058661506","display_name":"Allen P. Liu","orcid":"https://orcid.org/0000-0002-0309-7018","observed_orcids":["https://orcid.org/0000-0002-0309-7018"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen P. Liu","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":"https://orcid.org/0000-0002-0309-7018","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149524251","display_name":"Junior West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junior West","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046177432","display_name":"Ursula Jakob","orcid":"https://orcid.org/0000-0002-4020-4572","observed_orcids":["https://orcid.org/0000-0002-4020-4572"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ursula Jakob","raw_affiliation_strings":["Department of Biological Chemistry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046177432"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-polyphosphate","display_name":"inorganic polyphosphate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/filopodia","display_name":"filopodia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/irsp53","display_name":"IRSp53","score":0.9700000286102295},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.8360000252723694},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8050000071525574},{"id":"https://openalex.org/keywords/breast-cancer-organoids","display_name":"breast cancer organoids","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lipid-nanoparticle-delivery","display_name":"lipid nanoparticle delivery","score":0.800000011920929},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.722000002861023},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.718999981880188},{"id":"https://openalex.org/C2778038992","wikidata":"https://www.wikidata.org/wiki/Q420783","display_name":"Polyphosphate","level":3,"score":0.6460000276565552},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.57669997215271},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46239998936653137},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.44279998540878296},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4203999936580658},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.41819998621940613},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.38449999690055847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38199999928474426},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.37380000948905945},{"id":"https://openalex.org/C90301020","wikidata":"https://www.wikidata.org/wiki/Q14859810","display_name":"Filopodia","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3521000146865845},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C109185818","wikidata":"https://www.wikidata.org/wiki/Q3092607","display_name":"Lamellipodium","level":4,"score":0.31949999928474426},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.3091999888420105},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.3034999966621399},{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.2996000051498413},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C147905033","wikidata":"https://www.wikidata.org/wiki/Q1378887","display_name":"Primary cell","level":3,"score":0.2736999988555908},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.26759999990463257},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.26579999923706055},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.01.747915","doi":"https://doi.org/10.64898/2026.09.01.747915","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.747915","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.09.01.747915.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42922661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684594","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684594/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.01.747915","doi":"https://doi.org/10.64898/2026.09.01.747915","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.747915","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/02/2026.09.01.747915.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1584931589","display_name":"Compute Cluster for in vitro and in situ Analysis of Molecular Machines","funder_award_id":"1s10od030275-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G170378711","display_name":"In-situ architecture of membrane contact sites mediating organelle fission","funder_award_id":"1dp2gm150019-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320315388","display_name":"Emerald Foundation","ror":"https://ror.org/031tb8x29"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207637579.pdf","grobid_xml":"https://content.openalex.org/works/W7207637579.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W894880941","https://openalex.org/W1545398558","https://openalex.org/W1730677387","https://openalex.org/W1927046000","https://openalex.org/W1966175891","https://openalex.org/W1972689332","https://openalex.org/W1979324769","https://openalex.org/W1980824787","https://openalex.org/W1981979006","https://openalex.org/W1994936546","https://openalex.org/W2005047484","https://openalex.org/W2010745787","https://openalex.org/W2012652910","https://openalex.org/W2013511860","https://openalex.org/W2021133598","https://openalex.org/W2024342524","https://openalex.org/W2027216206","https://openalex.org/W2034162523","https://openalex.org/W2038634187","https://openalex.org/W2043706386","https://openalex.org/W2058416613","https://openalex.org/W2064232485","https://openalex.org/W2066091799","https://openalex.org/W2068379194","https://openalex.org/W2070899038","https://openalex.org/W2077832653","https://openalex.org/W2079282988","https://openalex.org/W2079553299","https://openalex.org/W2081076131","https://openalex.org/W2083884362","https://openalex.org/W2092040620","https://openalex.org/W2092564629","https://openalex.org/W2099133435","https://openalex.org/W2101361069","https://openalex.org/W2102872728","https://openalex.org/W2106369370","https://openalex.org/W2113351822","https://openalex.org/W2130480967","https://openalex.org/W2131271579","https://openalex.org/W2139784023","https://openalex.org/W2141055911","https://openalex.org/W2146894615","https://openalex.org/W2155443888","https://openalex.org/W2158850412","https://openalex.org/W2162080408","https://openalex.org/W2162768868","https://openalex.org/W2168292083","https://openalex.org/W2171570184","https://openalex.org/W2179438025","https://openalex.org/W2197124664","https://openalex.org/W2255991663","https://openalex.org/W2270516315","https://openalex.org/W2289016582","https://openalex.org/W2330509585","https://openalex.org/W2514403004","https://openalex.org/W2588557901","https://openalex.org/W2592811885","https://openalex.org/W2741792214","https://openalex.org/W2794873645","https://openalex.org/W2796153844","https://openalex.org/W2886250618","https://openalex.org/W2887692451","https://openalex.org/W2901009838","https://openalex.org/W2974372823","https://openalex.org/W2993731102","https://openalex.org/W2998931275","https://openalex.org/W2999726411","https://openalex.org/W3015472379","https://openalex.org/W3072675332","https://openalex.org/W3080375744","https://openalex.org/W3092106021","https://openalex.org/W3097019221","https://openalex.org/W3109445816","https://openalex.org/W3153286474","https://openalex.org/W3185965919","https://openalex.org/W3193295590","https://openalex.org/W3200890421","https://openalex.org/W3213170917","https://openalex.org/W3214166536","https://openalex.org/W4200210198","https://openalex.org/W4210598175","https://openalex.org/W4213374213","https://openalex.org/W4225252549","https://openalex.org/W4240924657","https://openalex.org/W4285076447","https://openalex.org/W4289176117","https://openalex.org/W4306194610","https://openalex.org/W4307432261","https://openalex.org/W4385077548","https://openalex.org/W4389786426","https://openalex.org/W4392203548","https://openalex.org/W4393021240","https://openalex.org/W4400321779","https://openalex.org/W4400415653","https://openalex.org/W4402844859","https://openalex.org/W4402992102","https://openalex.org/W4404843591","https://openalex.org/W4406936968","https://openalex.org/W4409382569","https://openalex.org/W4409411684","https://openalex.org/W7126111491","https://openalex.org/W7128390209","https://openalex.org/W7156045361"],"related_works":["https://openalex.org/W4411258023","https://openalex.org/W894880941","https://openalex.org/W2006292913","https://openalex.org/W2160487938","https://openalex.org/W2605145899","https://openalex.org/W2950485114","https://openalex.org/W2897545316","https://openalex.org/W1204907234","https://openalex.org/W2017818235","https://openalex.org/W2012745859"],"abstract_inverted_index":{"Inorganic":[0],"polyphosphate":[1],"(polyP)":[2],"is":[3,38],"an":[4],"ancient":[5],"polymer":[6],"conserved":[7],"across":[8],"all":[9],"life,":[10],"serving":[11],"cell":[12,56,70,80],"type-":[13],"and":[14,60,68,78,94,106,113,133],"location-specific":[15],"functions":[16],"in":[17,34],"every":[18],"major":[19],"compartment.":[20],"Yet":[21],"its":[22],"role":[23],"at":[24],"the":[25],"plasma":[26],"membrane,":[27],"where":[28],"it":[29],"accumulates":[30],"to":[31,119],"peak":[32],"levels":[33,117],"many":[35],"primary":[36],"cells,":[37],"largely":[39],"unknown.":[40],"Here":[41],"we":[42,83],"identify":[43],"polyP":[44,64,74,86,116,125,140],"as":[45,88,141],"a":[46,89,97,142],"stabilizing":[47],"component":[48],"of":[49],"filopodia,":[50],"actin-based":[51],"membrane":[52,98],"protrusions":[53],"that":[54,85,103],"govern":[55],"adhesion,":[57,71],"contact":[58],"inhibition,":[59],"chemotaxis.":[61],"Elevating":[62],"cellular":[63],"increases":[65],"filopodial":[66,76,91],"stability":[67],"enhances":[69],"whereas":[72],"reducing":[73],"accelerates":[75],"disassembly":[77],"promotes":[79],"migration.":[81],"Mechanistically,":[82],"find":[84],"acts":[87],"structural":[90],"scaffold,":[92],"recruiting":[93],"organizing":[95],"IRSp53,":[96],"curvature-inducing":[99],"protein.":[100],"We":[101],"show":[102],"metastatic":[104],"fibroblasts":[105],"breast":[107],"cancer":[108],"organoids":[109],"carry":[110],"markedly":[111],"reduced":[112],"intracellularly":[114],"reorganized":[115],"relative":[118],"their":[120,130],"non-transformed":[121],"counterparts.":[122],"Restoring":[123],"endogenous":[124],"via":[126],"lipid-nanoparticle":[127],"delivery":[128],"suppresses":[129],"invasive":[131],"phenotypes":[132],"reverses":[134],"pro-metastatic":[135],"gene":[136],"expression":[137],"signatures,":[138],"implicating":[139],"primordial":[143],"tumor":[144],"suppressor.":[145]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-04T00:00:00"}
