{"id":"https://openalex.org/W7207614523","doi":"https://doi.org/10.64898/2026.08.31.748241","title":"Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation","display_name":"Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207614523","doi":"https://doi.org/10.64898/2026.08.31.748241"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.31.748241","doi":"https://doi.org/10.64898/2026.08.31.748241","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748241","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.08.31.748241.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.08.31.748241.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104218610","display_name":"Lucas Rinc\u00f3n de la Rosa","orcid":"https://orcid.org/0009-0001-4863-2088","observed_orcids":["https://orcid.org/0009-0001-4863-2088"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucas Rinc\u00f3n de la Rosa","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France"],"raw_orcid":"https://orcid.org/0009-0001-4863-2088","affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087475465","display_name":"Noemie Barillot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"No\u00e9mie Barillot","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089831786","display_name":"Isaias Hern\u00e1ndez-Verd\u00edn","orcid":"https://orcid.org/0000-0001-6295-2507","observed_orcids":["https://orcid.org/0000-0001-6295-2507"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isaias Hern\u00e1ndez-Verdin","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005001615","display_name":"Roser Velasco","orcid":"https://orcid.org/0000-0003-3194-9406","observed_orcids":["https://orcid.org/0000-0003-3194-9406"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roser Velasco","raw_affiliation_strings":["Neuro-Oncology Unit, Department of Neurology, Hospital Universitari de Bellvitge\u2013Institut Catal\u00e0 d\u2019Oncologia, IDIBELL, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-Oncology Unit, Department of Neurology, Hospital Universitari de Bellvitge\u2013Institut Catal\u00e0 d\u2019Oncologia, IDIBELL, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075420722","display_name":"Bertrand Mathon","orcid":"https://orcid.org/0000-0002-9182-5846","observed_orcids":["https://orcid.org/0000-0002-9182-5846"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bertrand Mathon","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","Department of Neurosurgery, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"Department of Neurosurgery, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006815303","display_name":"Sandrine Eimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210112727","display_name":"H\u00f4pital Pellegrin","ror":"https://ror.org/02x581406","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Eimer","raw_affiliation_strings":["Department of Pathology, CHU de Bordeaux, H\u00f4pital Pellegrin, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, CHU de Bordeaux, H\u00f4pital Pellegrin, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110827620","display_name":"Jean Rodolphe Vignes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210112727","display_name":"H\u00f4pital Pellegrin","ror":"https://ror.org/02x581406","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Rodolphe Vignes","raw_affiliation_strings":["Department of Neurosurgery, CHU de Bordeaux, H\u00f4pital Pellegrin, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, CHU de Bordeaux, H\u00f4pital Pellegrin, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210112727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005202884","display_name":"Audrey Rousseau","orcid":"https://orcid.org/0000-0002-2496-9903","observed_orcids":["https://orcid.org/0000-0002-2496-9903"]},"institutions":[{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Rousseau","raw_affiliation_strings":["Department of Pathology, CHU d\u2019Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, CHU d\u2019Angers, Angers, France","institution_ids":["https://openalex.org/I4210112910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003275683","display_name":"J\u00e9r\u00f4me Paillassa","orcid":"https://orcid.org/0000-0001-5280-018X","observed_orcids":["https://orcid.org/0000-0001-5280-018X"]},"institutions":[{"id":"https://openalex.org/I4210112910","display_name":"Centre Hospitalier Universitaire d'Angers","ror":"https://ror.org/0250ngj72","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210112910"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Paillassa","raw_affiliation_strings":["Department of Hematology, CHU d\u2019Angers, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, CHU d\u2019Angers, Angers, France","institution_ids":["https://openalex.org/I4210112910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003368354","display_name":"Guido Ahle","orcid":"https://orcid.org/0000-0002-0877-2289","observed_orcids":["https://orcid.org/0000-0002-0877-2289"]},"institutions":[{"id":"https://openalex.org/I4210092661","display_name":"Hopitaux Civils de Colmar","ror":"https://ror.org/00jtq6z81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092661"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guido Ahle","raw_affiliation_strings":["Department of Neurology, H\u00f4pitaux Civils de Colmar, Colmar, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, H\u00f4pitaux Civils de Colmar, Colmar, France","institution_ids":["https://openalex.org/I4210092661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047364619","display_name":"Felix Lerintiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092661","display_name":"Hopitaux Civils de Colmar","ror":"https://ror.org/00jtq6z81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092661"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Felix Lerintiu","raw_affiliation_strings":["Department of Pathology, H\u00f4pitaux Civils de Colmar, Colmar, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H\u00f4pitaux Civils de Colmar, Colmar, France","institution_ids":["https://openalex.org/I4210092661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075378844","display_name":"Emmanuelle Uro\u2010Coste","orcid":"https://orcid.org/0000-0001-7300-5724","observed_orcids":["https://orcid.org/0000-0001-7300-5724"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Uro-Coste","raw_affiliation_strings":["Department of Pathology, IUCT-Oncopole, CHU de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IUCT-Oncopole, CHU de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009487344","display_name":"Lucie Ob\u00e9ric","orcid":"https://orcid.org/0000-0002-0039-1983","observed_orcids":["https://orcid.org/0000-0002-0039-1983"]},"institutions":[{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucie Oberic","raw_affiliation_strings":["Department of Hematology, IUCT-Oncopole, CHU de Toulouse, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, IUCT-Oncopole, CHU de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I3019448017","https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059620448","display_name":"\u00c9meline Tabouret","orcid":"https://orcid.org/0000-0002-4031-2178","observed_orcids":["https://orcid.org/0000-0002-4031-2178"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210097886","display_name":"Institut de Neurophysiopathologie","ror":"https://ror.org/00w2q5j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210097886"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emeline Tabouret","raw_affiliation_strings":["Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, GlioME Team, Equipe Labellis\u00e9e Ligue Contre le Cancer, plateforme PETRA, CHU Timone, Service de Neurooncologie, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, GlioME Team, Equipe Labellis\u00e9e Ligue Contre le Cancer, plateforme PETRA, CHU Timone, Service de Neurooncologie, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210097886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032170932","display_name":"Romain Appay","orcid":"https://orcid.org/0000-0003-4545-6063","observed_orcids":["https://orcid.org/0000-0003-4545-6063"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210097886","display_name":"Institut de Neurophysiopathologie","ror":"https://ror.org/00w2q5j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210097886"]},{"id":"https://openalex.org/I4210162909","display_name":"H\u00f4pital de la Timone","ror":"https://ror.org/05jrr4320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210162909"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Appay","raw_affiliation_strings":["Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, GlioME Team, Equipe Labellis\u00e9e Ligue Contre le Cancer, plateforme PETRA, CHU Timone, Service d\u2019Anatomie et Cytologie Pathologiques, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, GlioME Team, Equipe Labellis\u00e9e Ligue Contre le Cancer, plateforme PETRA, CHU Timone, Service d\u2019Anatomie et Cytologie Pathologiques, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210097886","https://openalex.org/I4210162909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068248388","display_name":"Guillaume Gauchotte","orcid":"https://orcid.org/0000-0001-5585-9195","observed_orcids":["https://orcid.org/0000-0001-5585-9195"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Gauchotte","raw_affiliation_strings":["Department of Biopathology, CHRU de Nancy, Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopathology, CHRU de Nancy, Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028622664","display_name":"Luc Taillandier","orcid":"https://orcid.org/0000-0002-9422-793X","observed_orcids":["https://orcid.org/0000-0002-9422-793X"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Luc Taillandier","raw_affiliation_strings":["Department of Neuro-Oncology, CHRU de Nancy, Universit\u00e9 de Lorraine, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, CHRU de Nancy, Universit\u00e9 de Lorraine, Nancy, France","institution_ids":["https://openalex.org/I4210100260","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106184775","display_name":"Jean\u2010Pierre Marolleau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Marolleau","raw_affiliation_strings":["Department of Hematology, CHU Amiens-Picardie, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, CHU Amiens-Picardie, Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000224482","display_name":"Clovis Adam","orcid":"https://orcid.org/0000-0003-1083-8379","observed_orcids":["https://orcid.org/0000-0003-1083-8379"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Clovis Adam","raw_affiliation_strings":["Department of Neuropathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376972","display_name":"R\u00e9nata Ursu","orcid":"https://orcid.org/0000-0003-0123-8937","observed_orcids":["https://orcid.org/0000-0003-0123-8937","https://orcid.org/0000-0002-1099-9597"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Renata Ursu","raw_affiliation_strings":["Department of Neurology, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013902226","display_name":"Stefania Cuzzubbo","orcid":"https://orcid.org/0000-0003-0288-4607","observed_orcids":["https://orcid.org/0000-0003-0288-4607"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stefania Cuzzubbo","raw_affiliation_strings":["Department of Neurology, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101933752","display_name":"Anna Schmitt","orcid":"https://orcid.org/0000-0002-6303-3294","observed_orcids":["https://orcid.org/0000-0002-6303-3294"]},"institutions":[{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anna Schmitt","raw_affiliation_strings":["Department of Hematology, Institut Bergoni\u00e9, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073727976","display_name":"Lucia Nichelli","orcid":"https://orcid.org/0009-0006-0934-5365","observed_orcids":["https://orcid.org/0009-0006-0934-5365"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucia Nichelli","raw_affiliation_strings":["Department of Neuroradiology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036702473","display_name":"Albert Pons\u2010Escoda","orcid":"https://orcid.org/0000-0003-4167-8291","observed_orcids":["https://orcid.org/0000-0003-4167-8291"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4405266402","display_name":"Institut de Diagn\u00f2stic per la Imatge","ror":"https://ror.org/02pmnab85","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405266402"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Albert Pons-Escoda","raw_affiliation_strings":["Department of Radiology, Institut de Diagn\u00f2stic per la Imatge (IDI), Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Institut de Diagn\u00f2stic per la Imatge (IDI), Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225","https://openalex.org/I4405266402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041168553","display_name":"Fr\u00e9d\u00e9ric Charlotte","orcid":"https://orcid.org/0000-0003-2803-6606","observed_orcids":["https://orcid.org/0000-0003-2803-6606"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Charlotte","raw_affiliation_strings":["Department of Pathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012486639","display_name":"Fr\u00e9d\u00e9ric Davi","orcid":"https://orcid.org/0000-0002-3764-063X","observed_orcids":["https://orcid.org/0000-0002-3764-063X"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Davi","raw_affiliation_strings":["Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051576311","display_name":"Magali Le Garff\u2010Tavernier","orcid":"https://orcid.org/0000-0002-3131-3240","observed_orcids":["https://orcid.org/0000-0002-3131-3240"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Le Garff-Tavernier","raw_affiliation_strings":["Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014153145","display_name":"Sylvain Choquet","orcid":"https://orcid.org/0000-0002-7791-0470","observed_orcids":["https://orcid.org/0000-0002-7791-0470"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Choquet","raw_affiliation_strings":["Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030570042","display_name":"Carole Soussain","orcid":"https://orcid.org/0000-0002-2479-0348","observed_orcids":["https://orcid.org/0000-0002-2479-0348"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Soussain","raw_affiliation_strings":["Department of Hematology, Institut Curie, Saint-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institut Curie, Saint-Cloud, France","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108370380","display_name":"Noem\u00ed Vidal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noem\u00ed Vidal","raw_affiliation_strings":["Department of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048566051","display_name":"Eva M. Gonz\u00e1lez-Barca","orcid":"https://orcid.org/0000-0002-1323-1508","observed_orcids":["https://orcid.org/0000-0002-1323-1508"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Gonz\u00e1lez-Barca","raw_affiliation_strings":["Department of Hematology, Institut Catal\u00e0 d\u2019Oncologia (ICO), IDIBELL, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institut Catal\u00e0 d\u2019Oncologia (ICO), IDIBELL, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136150502","display_name":"Fina Climent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fina Climent","raw_affiliation_strings":["Department of Hemopathology, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemopathology, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086666145","display_name":"Patricia L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia L\u00f3pez","raw_affiliation_strings":["Department of Clinical Hematology, Institut Catal\u00e0 d\u2019Oncologia (ICO), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Hematology, Institut Catal\u00e0 d\u2019Oncologia (ICO), Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064617409","display_name":"Fanny Drieux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152093","display_name":"Centre Henri Becquerel","ror":"https://ror.org/00whhby07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387152093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fanny Drieux","raw_affiliation_strings":["Department of Pathology, Centre Henri Becquerel, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Centre Henri Becquerel, Rouen, France","institution_ids":["https://openalex.org/I4387152093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083520942","display_name":"Elena\u2010Liana Veresezan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152093","display_name":"Centre Henri Becquerel","ror":"https://ror.org/00whhby07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387152093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elena-Liana Veresezan","raw_affiliation_strings":["Department of Pathology, Centre Henri Becquerel, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Centre Henri Becquerel, Rouen, France","institution_ids":["https://openalex.org/I4387152093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037255370","display_name":"Michael Heming","orcid":"https://orcid.org/0000-0002-9568-2790","observed_orcids":["https://orcid.org/0000-0002-9568-2790"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Heming","raw_affiliation_strings":["Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076180609","display_name":"Gerd Meyer zu H\u00f6rste","orcid":"https://orcid.org/0000-0002-4341-4719","observed_orcids":["https://orcid.org/0000-0002-4341-4719"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Meyer zu H\u00f6rste","raw_affiliation_strings":["Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047619883","display_name":"Oliver Martin Grauer","orcid":"https://orcid.org/0000-0003-4279-4497","observed_orcids":["https://orcid.org/0000-0003-4279-4497"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Grauer","raw_affiliation_strings":["Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082700087","display_name":"Fabrice Jardin","orcid":"https://orcid.org/0000-0002-6804-7943","observed_orcids":["https://orcid.org/0000-0002-6804-7943"]},"institutions":[{"id":"https://openalex.org/I4387152093","display_name":"Centre Henri Becquerel","ror":"https://ror.org/00whhby07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387152093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Jardin","raw_affiliation_strings":["Department of Hematology, Centre Henri Becquerel, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Centre Henri Becquerel, Rouen, France","institution_ids":["https://openalex.org/I4387152093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075595989","display_name":"Karima Mokhtari","orcid":"https://orcid.org/0000-0002-4777-7584","observed_orcids":["https://orcid.org/0000-0002-4777-7584"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karima Mokhtari","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","Department of Neuropathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"Department of Neuropathology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084107178","display_name":"Caroline Houillier","orcid":"https://orcid.org/0000-0003-2931-7522","observed_orcids":["https://orcid.org/0000-0003-2931-7522"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Houillier","raw_affiliation_strings":["Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011185863","display_name":"Kh\u00ea Hoang\u2010Xuan","orcid":"https://orcid.org/0000-0003-4072-1999","observed_orcids":["https://orcid.org/0000-0003-4072-1999"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kh\u00ea Hoang-Xuan","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056463022","display_name":"Agust\u00ed Alentorn","orcid":"https://orcid.org/0000-0002-7220-2686","observed_orcids":["https://orcid.org/0000-0002-7220-2686","https://orcid.org/0000-0002-0379-7639"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Agust\u00ed Alentorn","raw_affiliation_strings":["Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Tumor Heterogeneity, Immunity and Therapy (BRIGHT), Paris Brain Institute (ICM), Sorbonne Universit\u00e9, INSERM U1127, CNRS UMR7225, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"Department of Neurology, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":28,"corresponding_author_ids":["https://openalex.org/A5056463022"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705","https://openalex.org/I4210152724"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"primary central nervous system lymphoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/h-e-staining","display_name":"H&E staining","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8240000009536743},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6489999890327454},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7139999866485596},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.6570000052452087},{"id":"https://openalex.org/keywords/prototype-learning","display_name":"prototype learning","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mskcc-risk-score","display_name":"MSKCC risk score","score":0.5889999866485596},{"id":"https://openalex.org/keywords/immunocompetent-patient","display_name":"immunocompetent patient","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7821999788284302},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.736299991607666},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6805999875068665},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5997999906539917},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5662000179290771},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5212000012397766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5044999718666077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47530001401901245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4036000072956085},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.39239999651908875},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3862999975681305},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C180478619","wikidata":"https://www.wikidata.org/wiki/Q7574066","display_name":"Spatial heterogeneity","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.25459998846054077},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.31.748241","doi":"https://doi.org/10.64898/2026.08.31.748241","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748241","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.08.31.748241.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.31.748241","doi":"https://doi.org/10.64898/2026.08.31.748241","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748241","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.08.31.748241.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2077148382","display_name":null,"funder_award_id":"2025-PEPR SN-002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4038765881","display_name":"Clonal and spatial architecture of primary central nervous system lymphoma","funder_award_id":"ANR-23-CE17-0027","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5463663817","display_name":null,"funder_award_id":"OSIRIS25","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G5727723201","display_name":null,"funder_award_id":"SLT042/25/000013","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G7080048889","display_name":null,"funder_award_id":"ANR-23","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322263","display_name":"Conseil R\u00e9gional, \u00cele-de-France","ror":"https://ror.org/04ry1rt27"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320323866","display_name":"Canc\u00e9rop\u00f4le Ile de France","ror":"https://ror.org/00d5rxh07"},{"id":"https://openalex.org/F4320328517","display_name":"Xarxa de Bancs de Tumors de Catalunya","ror":"https://ror.org/03bbghz75"},{"id":"https://openalex.org/F4320337336","display_name":"Advanced Remanufacturing and Technology Centre","ror":"https://ror.org/04hmssf27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207614523.pdf","grobid_xml":"https://content.openalex.org/works/W7207614523.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1792532087","https://openalex.org/W1987012261","https://openalex.org/W1995875735","https://openalex.org/W2016966976","https://openalex.org/W2032101051","https://openalex.org/W2052611179","https://openalex.org/W2083283521","https://openalex.org/W2087189381","https://openalex.org/W2096910745","https://openalex.org/W2112316706","https://openalex.org/W2122825543","https://openalex.org/W2133059825","https://openalex.org/W2135838006","https://openalex.org/W2150461375","https://openalex.org/W2157076315","https://openalex.org/W2157338776","https://openalex.org/W2162871445","https://openalex.org/W2182664595","https://openalex.org/W2314481096","https://openalex.org/W2586629973","https://openalex.org/W2609243345","https://openalex.org/W2737082469","https://openalex.org/W2760946358","https://openalex.org/W2795184885","https://openalex.org/W2797542577","https://openalex.org/W2924359886","https://openalex.org/W2956228567","https://openalex.org/W3018295606","https://openalex.org/W3036901136","https://openalex.org/W3041047318","https://openalex.org/W3086629307","https://openalex.org/W3147894994","https://openalex.org/W4205817967","https://openalex.org/W4283381496","https://openalex.org/W4291123529","https://openalex.org/W4297201049","https://openalex.org/W4309437150","https://openalex.org/W4367393951","https://openalex.org/W4381851836","https://openalex.org/W4383896402","https://openalex.org/W4385285835","https://openalex.org/W4387948998","https://openalex.org/W4392947521","https://openalex.org/W4398201291","https://openalex.org/W4399884072","https://openalex.org/W4402220065","https://openalex.org/W4415385060","https://openalex.org/W7162416558"],"related_works":["https://openalex.org/W1607102713","https://openalex.org/W4220799551","https://openalex.org/W2751344447","https://openalex.org/W7214182766","https://openalex.org/W4417035573","https://openalex.org/W2380221375","https://openalex.org/W4360991148","https://openalex.org/W4295248711","https://openalex.org/W2773506942","https://openalex.org/W4414651408"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Clinical":[2],"scores":[3],"incompletely":[4],"capture":[5],"outcomes":[6],"in":[7,18,125],"primary":[8],"central":[9],"nervous":[10],"system":[11],"lymphoma":[12],"(PCNSL).":[13],"We":[14],"quantified":[15],"morphologic":[16],"heterogeneity":[17,124],"pretreatment":[19],"hematoxylin":[20],"and":[21,27,35,53,65,80,91,107],"eosin":[22],"(H&E)":[23],"whole":[24],"slides.":[25],"Patients":[26],"methods":[28],"Three":[29],"independent":[30],"cohorts":[31],"of":[32,76],"immunocompetent,":[33],"HIV-":[34],"EBV-negative":[36],"patients":[37],"treated":[38],"recently":[39],"were":[40,84],"analyzed:":[41],"LOC":[42],"2023":[43],"(122":[44],"slides),":[45],"phase":[46],"III":[47],"BLOCAGE-01":[48],"(245":[49],"slides;":[50],"NCT02313389":[51],"),":[52],"external":[54],"Barcelona":[55],"(BCN;":[56],"41":[57],"slides).":[58],"UNI":[59],"embeddings,":[60],"prototype":[61],"learning,":[62],"spatial":[63,123],"metrics,":[64],"elastic-net":[66],"Cox":[67],"regression":[68],"defined":[69],"ITH-C.":[70],"Results":[71],"Models":[72],"achieved":[73],"bootstrap-corrected":[74],"concordance":[75],"0.797\u20130.834.":[77],"Age-,":[78],"sex-,":[79],"KPS-adjusted":[81],"ITH-C":[82,96,114,127],"HRs":[83],"1.29":[85],"(95%":[86],"CI":[87],"1.01\u20131.64),":[88],"1.27":[89],"(1.07\u20131.51),":[90],"2.13":[92],"(1.35\u20133.37),":[93],"respectively.":[94],"Adding":[95],"increased":[97],"MSKCC":[98],"C-index":[99],"from":[100],"0.671":[101],"to":[102,105,109,115],"0.717,":[103],"0.560":[104],"0.593,":[106],"0.588":[108],"0.706.":[110],"Spatial":[111],"transcriptomics":[112],"linked":[113],"immune":[116],"programs.":[117],"Conclusions":[118],"Routine":[119],"H&E":[120],"encodes":[121],"prognostic":[122],"PCNSL.":[126],"complements":[128],"clinical":[129],"scores,":[130],"supporting":[131],"prospective":[132],"risk":[133],"stratification.":[134]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-04T00:00:00"}
