{"id":"https://openalex.org/W7207614282","doi":"https://doi.org/10.1016/j.tice.2026.103921","title":"Association of AKT expression with melanocyte restoration in vitiligo: A comparative study of platelet-rich plasma and Fr CO2 laser","display_name":"Association of AKT expression with melanocyte restoration in vitiligo: A comparative study of platelet-rich plasma and Fr CO2 laser","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207614282","doi":"https://doi.org/10.1016/j.tice.2026.103921","pmid":"https://pubmed.ncbi.nlm.nih.gov/42710232"},"language":"en","primary_location":{"id":"doi:10.1016/j.tice.2026.103921","doi":"https://doi.org/10.1016/j.tice.2026.103921","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tice.2026.103921","pdf_url":null,"source":{"id":"https://openalex.org/S165572755","display_name":"Tissue and Cell","issn_l":"0040-8166","issn":["0040-8166","1532-3072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue and Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075223169","display_name":"Marwa Hassan Bakr","orcid":"https://orcid.org/0000-0001-8833-7916","observed_orcids":["https://orcid.org/0000-0001-8833-7916"]},"institutions":[{"id":"https://openalex.org/I4405268423","display_name":"Badr University in Assiut","ror":"https://ror.org/00wtg0r80","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405268423"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marwa H. Bakr","raw_affiliation_strings":["Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Basic Medical Science Department, Badr University in Assiut (BUA), Assiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Basic Medical Science Department, Badr University in Assiut (BUA), Assiut, Egypt","institution_ids":["https://openalex.org/I4405268423","https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047881757","display_name":"Dalia A. Elgamal","orcid":"https://orcid.org/0000-0002-4398-7293","observed_orcids":["https://orcid.org/0000-0002-4398-7293"]},"institutions":[{"id":"https://openalex.org/I4405268423","display_name":"Badr University in Assiut","ror":"https://ror.org/00wtg0r80","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405268423"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Dalia A. Elgamal","raw_affiliation_strings":["Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Basic Medical Science Department, Badr University in Assiut (BUA), Assiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Basic Medical Science Department, Badr University in Assiut (BUA), Assiut, Egypt","institution_ids":["https://openalex.org/I4405268423","https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051056823","display_name":"Fatma Y. Meligy","orcid":"https://orcid.org/0000-0002-6372-8731","observed_orcids":["https://orcid.org/0000-0002-6372-8731"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Fatma Y. Meligy","raw_affiliation_strings":["Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan","institution_ids":["https://openalex.org/I36622005","https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038541338","display_name":"Reham ElGibaly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reham I. EL Gibaly","raw_affiliation_strings":["Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050236450","display_name":"Eman M. K. Youssef","orcid":"https://orcid.org/0000-0002-2420-4708","observed_orcids":["https://orcid.org/0000-0002-2420-4708"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eman M. Kamal Youssef","raw_affiliation_strings":["Dermatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073827914","display_name":"Fares E.M. Ali","orcid":"https://orcid.org/0000-0001-8341-7458","observed_orcids":["https://orcid.org/0000-0001-8341-7458"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I4405272027","display_name":"Aqaba University of Technology","ror":"https://ror.org/03ernr789","country_code":"JO","type":"education","lineage":["https://openalex.org/I4405272027"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Fares E.M. Ali","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt; Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan. Electronic address: Faresali@azhar.edu.eg"],"raw_orcid":"https://orcid.org/0000-0001-8341-7458","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt; Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan. Electronic address: Faresali@azhar.edu.eg","institution_ids":["https://openalex.org/I184834183","https://openalex.org/I4405272027"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"Pt 2","first_page":"103921","last_page":"103921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/melanin","display_name":"melanin","score":0.5099999904632568},{"id":"https://openalex.org/keywords/melan-a","display_name":"Melan-A","score":0.9409999847412109},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9710000157356262},{"id":"https://openalex.org/keywords/melanocyte-apoptosis","display_name":"melanocyte apoptosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/depigmentation","display_name":"depigmentation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pigmentary-disorders","display_name":"skin pigmentation disorders","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.9056000113487244},{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.8611000180244446},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6252999901771545},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.566100001335144},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.5031999945640564},{"id":"https://openalex.org/C2779179668","wikidata":"https://www.wikidata.org/wiki/Q7193408","display_name":"Pigmentation disorder","level":2,"score":0.5},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.44769999384880066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43630000948905945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4205999970436096},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.399399995803833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38420000672340393},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3562000095844269},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3305000066757202},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2583000063896179}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tice.2026.103921","doi":"https://doi.org/10.1016/j.tice.2026.103921","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tice.2026.103921","pdf_url":null,"source":{"id":"https://openalex.org/S165572755","display_name":"Tissue and Cell","issn_l":"0040-8166","issn":["0040-8166","1532-3072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue and Cell","raw_type":"journal-article"},{"id":"pmid:42710232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42710232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue & cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3153323851","display_name":null,"funder_award_id":"2020-03-25-005-R1","funder_id":"https://openalex.org/F4320335500","funder_display_name":"Faculty of Medicine, Assiut University"}],"funders":[{"id":"https://openalex.org/F4320335500","display_name":"Faculty of Medicine, Assiut University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1595321812","https://openalex.org/W1957891768","https://openalex.org/W1965356288","https://openalex.org/W1971260998","https://openalex.org/W1981653618","https://openalex.org/W2014489753","https://openalex.org/W2044794199","https://openalex.org/W2055539585","https://openalex.org/W2056144049","https://openalex.org/W2072166430","https://openalex.org/W2099876644","https://openalex.org/W2101108802","https://openalex.org/W2114845873","https://openalex.org/W2128635872","https://openalex.org/W2138813960","https://openalex.org/W2144715802","https://openalex.org/W2150287504","https://openalex.org/W2197770437","https://openalex.org/W2274774578","https://openalex.org/W2314207375","https://openalex.org/W2358657972","https://openalex.org/W2557719001","https://openalex.org/W2595380205","https://openalex.org/W2595511842","https://openalex.org/W2624757319","https://openalex.org/W2726032666","https://openalex.org/W2739018431","https://openalex.org/W2752584391","https://openalex.org/W2768009648","https://openalex.org/W2780125076","https://openalex.org/W2795244196","https://openalex.org/W2802080267","https://openalex.org/W2802478812","https://openalex.org/W2802735023","https://openalex.org/W2887837540","https://openalex.org/W2890809709","https://openalex.org/W2891020045","https://openalex.org/W2900239671","https://openalex.org/W2907655186","https://openalex.org/W2920383346","https://openalex.org/W2922411960","https://openalex.org/W2924501347","https://openalex.org/W2936277186","https://openalex.org/W2946236810","https://openalex.org/W2970749438","https://openalex.org/W2974463060","https://openalex.org/W2975083463","https://openalex.org/W2980907934","https://openalex.org/W2991077477","https://openalex.org/W2997874389","https://openalex.org/W3036226772","https://openalex.org/W3037643916","https://openalex.org/W3045167528","https://openalex.org/W3080325690","https://openalex.org/W3108926435","https://openalex.org/W3118305246","https://openalex.org/W3163095124","https://openalex.org/W4206310937","https://openalex.org/W4206921605","https://openalex.org/W4214876443","https://openalex.org/W4281484949","https://openalex.org/W4294628971","https://openalex.org/W4303954669","https://openalex.org/W4307793315","https://openalex.org/W4379534930","https://openalex.org/W4384283284","https://openalex.org/W4385804141","https://openalex.org/W4387807536","https://openalex.org/W4388942850","https://openalex.org/W4389992379","https://openalex.org/W4390744994","https://openalex.org/W4392195982","https://openalex.org/W4393062352","https://openalex.org/W4394568226","https://openalex.org/W4401231807","https://openalex.org/W4404133956","https://openalex.org/W4410503658","https://openalex.org/W4411698312","https://openalex.org/W4414013959","https://openalex.org/W4415968193"],"related_works":["https://openalex.org/W4313646853","https://openalex.org/W2900239671","https://openalex.org/W7133131009","https://openalex.org/W4388942850","https://openalex.org/W7167421587","https://openalex.org/W3198358804","https://openalex.org/W3204193476","https://openalex.org/W3160899797","https://openalex.org/W3167447492","https://openalex.org/W7169833089"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-04T00:00:00"}