{"id":"https://openalex.org/W7207613767","doi":"https://doi.org/10.1128/mbio.01991-26","title":"Ablation of a maternal Cryptosporidium mRNA-binding protein results in sterile sporozoites","display_name":"Ablation of a maternal Cryptosporidium mRNA-binding protein results in sterile sporozoites","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7207613767","doi":"https://doi.org/10.1128/mbio.01991-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684627"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.01991-26","doi":"https://doi.org/10.1128/mbio.01991-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01991-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.01991-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070860964","display_name":"Abigail M. Daniels","orcid":"https://orcid.org/0000-0002-6542-1960","observed_orcids":["https://orcid.org/0000-0002-6542-1960"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail M. Daniels","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-6542-1960","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079265883","display_name":"Sebastian Shaw","orcid":"https://orcid.org/0000-0001-7163-5650","observed_orcids":["https://orcid.org/0000-0001-7163-5650"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Shaw","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0001-7163-5650","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046427249","display_name":"Christopher N\u00f6tzel","orcid":"https://orcid.org/0000-0001-6065-889X","observed_orcids":["https://orcid.org/0000-0001-6065-889X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher N\u00f6tzel","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045499577","display_name":"Rui Xiao","orcid":"https://orcid.org/0000-0003-4178-3497","observed_orcids":["https://orcid.org/0000-0003-4178-3497"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Xiao","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045183447","display_name":"Keenan M. O\u2019Dea","orcid":"https://orcid.org/0000-0001-9278-0697","observed_orcids":["https://orcid.org/0000-0001-9278-0697"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keenan O\u2019Dea","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090415813","display_name":"Daniel P. Beiting","orcid":"https://orcid.org/0000-0002-2865-4589","observed_orcids":["https://orcid.org/0000-0002-2865-4589"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel P. Beiting","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-2865-4589","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015049795","display_name":"Boris Striepen","orcid":"https://orcid.org/0000-0002-7426-432X","observed_orcids":["https://orcid.org/0000-0002-7426-432X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Striepen","raw_affiliation_strings":["Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-7426-432X","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":5.4288,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96089517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"e0199126","last_page":"e0199126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptosporidium","display_name":"Cryptosporidium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/female-gametogenesis","display_name":"female gametogenesis","score":0.671999990940094},{"id":"https://openalex.org/keywords/sex-determination","display_name":"sex determination","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sporozoite-infectivity","display_name":"sporozoite infectivity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/p-bodies","display_name":"P-bodies","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.3700000047683716},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.800000011920929},{"id":"https://openalex.org/keywords/apicomplexa","display_name":"Apicomplexa","score":0.6159999966621399},{"id":"https://openalex.org/keywords/oocyst-formation","display_name":"oocyst formation","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8920999765396118},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5845999717712402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5554999709129333},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47769999504089355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47369998693466187},{"id":"https://openalex.org/C2776803348","wikidata":"https://www.wikidata.org/wiki/Q211050","display_name":"Gamete","level":3,"score":0.44929999113082886},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.42890000343322754},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.40450000762939453},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.35350000858306885},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3407999873161316},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.3310000002384186},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C99389464","wikidata":"https://www.wikidata.org/wiki/Q3319949","display_name":"Gametocyte","level":4,"score":0.2987000048160553},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29739999771118164},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.29499998688697815},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C2778877831","wikidata":"https://www.wikidata.org/wiki/Q133078","display_name":"Cryptosporidium","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2865000069141388},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2752000093460083},{"id":"https://openalex.org/C63405245","wikidata":"https://www.wikidata.org/wiki/Q9076644","display_name":"Sexual differentiation","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.26019999384880066},{"id":"https://openalex.org/C2781154746","wikidata":"https://www.wikidata.org/wiki/Q1431408","display_name":"Neospora caninum","level":4,"score":0.2547000050544739},{"id":"https://openalex.org/C99498324","wikidata":"https://www.wikidata.org/wiki/Q7075151","display_name":"Obligate parasite","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C178809742","wikidata":"https://www.wikidata.org/wiki/Q3455913","display_name":"Post-transcriptional regulation","level":4,"score":0.2533999979496002},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.2522999942302704}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1128/mbio.01991-26","doi":"https://doi.org/10.1128/mbio.01991-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01991-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"doi:10.64898/2026.09.01.748511","doi":"https://doi.org/10.64898/2026.09.01.748511","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.01.748511","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/03/2026.09.01.748511.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684627","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684627/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684627/pdf/nihpp-2026.09.01.748511v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42922627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42954483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42954483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/mbio.01991-26","doi":"https://doi.org/10.1128/mbio.01991-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01991-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000866814","display_name":"Genetic Analysis of Cryptosporidium","funder_award_id":"R37AI112427","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000920571","display_name":"Sexual Development of Cryptosporidium","funder_award_id":"R01AI127798","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207613767.pdf","grobid_xml":"https://content.openalex.org/works/W7207613767.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1561188778","https://openalex.org/W1668595180","https://openalex.org/W1709815505","https://openalex.org/W1735309556","https://openalex.org/W1897612191","https://openalex.org/W1970853805","https://openalex.org/W2000608709","https://openalex.org/W2021868082","https://openalex.org/W2024080079","https://openalex.org/W2036897871","https://openalex.org/W2053758959","https://openalex.org/W2061276931","https://openalex.org/W2075162016","https://openalex.org/W2077004296","https://openalex.org/W2079758746","https://openalex.org/W2088366327","https://openalex.org/W2094381221","https://openalex.org/W2096031010","https://openalex.org/W2103777723","https://openalex.org/W2105694586","https://openalex.org/W2107617405","https://openalex.org/W2113982265","https://openalex.org/W2114053580","https://openalex.org/W2114570899","https://openalex.org/W2117101240","https://openalex.org/W2132819627","https://openalex.org/W2133787542","https://openalex.org/W2139993911","https://openalex.org/W2144454685","https://openalex.org/W2153330083","https://openalex.org/W2169456326","https://openalex.org/W2592811885","https://openalex.org/W2746422290","https://openalex.org/W2759621766","https://openalex.org/W2790348370","https://openalex.org/W2807735066","https://openalex.org/W2811147411","https://openalex.org/W2888567975","https://openalex.org/W2902929870","https://openalex.org/W2941712145","https://openalex.org/W2947025010","https://openalex.org/W2951791227","https://openalex.org/W2971610683","https://openalex.org/W2973731173","https://openalex.org/W3008516049","https://openalex.org/W3120655475","https://openalex.org/W3203769463","https://openalex.org/W4210282571","https://openalex.org/W4210535141","https://openalex.org/W4224225772","https://openalex.org/W4281776863","https://openalex.org/W4310963917","https://openalex.org/W4311748029","https://openalex.org/W4315927889","https://openalex.org/W4320709516","https://openalex.org/W4353060771","https://openalex.org/W4366481724","https://openalex.org/W4367396112","https://openalex.org/W4378175144","https://openalex.org/W4378212544","https://openalex.org/W4379114727","https://openalex.org/W4385575775","https://openalex.org/W4390046968","https://openalex.org/W4390237565","https://openalex.org/W4391091562","https://openalex.org/W4391808031","https://openalex.org/W4392949796","https://openalex.org/W4395661700","https://openalex.org/W4396605126","https://openalex.org/W4399121803","https://openalex.org/W4399728292","https://openalex.org/W4400584509","https://openalex.org/W4409468965","https://openalex.org/W4411454740","https://openalex.org/W4411624696","https://openalex.org/W4414380019","https://openalex.org/W4414422702","https://openalex.org/W4415234375","https://openalex.org/W4415481933","https://openalex.org/W4415486589","https://openalex.org/W4415567853","https://openalex.org/W7140925221","https://openalex.org/W7147128154","https://openalex.org/W7147321287","https://openalex.org/W7160524607","https://openalex.org/W7161172319"],"related_works":["https://openalex.org/W4399121803","https://openalex.org/W2971610683","https://openalex.org/W4310009590","https://openalex.org/W6886189421","https://openalex.org/W7222358910","https://openalex.org/W2946068408","https://openalex.org/W4399149701","https://openalex.org/W4411624696","https://openalex.org/W7124164405","https://openalex.org/W2792395016"],"abstract_inverted_index":{"ABSTRACT":[0],"Infection":[1,289],"with":[2],"Cryptosporidium":[3,69,247,326],"is":[4,60,122,160,248,264,286],"a":[5,113,200,205,266,270,282,376],"leading":[6],"cause":[7],"of":[8,36,81,85,109,116,138,180,186,233,236,252,254,268,293,305,316,322,334,348,355,368,387],"diarrheal":[9,256],"disease":[10,257],"and":[11,20,27,41,44,54,132,150,164,210,261,269,281,311,319,324,351,372],"early":[12,124,151],"childhood":[13],"mortality.":[14],"This":[15],"apicomplexan":[16],"parasite":[17,246,317,388],"undergoes":[18],"asexual":[19],"sexual":[21,349],"replication":[22,350],"within":[23],"the":[24,68,82,106,126,134,139,158,178,195,231,262,294,306,308,314,320,331,345,356,365,369,384],"same":[25],"host,":[26],"recent":[28],"studies":[29],"have":[30],"shown":[31],"an":[32,75,123,296,302,335],"intrinsic":[33],"developmental":[34],"program":[35],"obligate":[37],"transition":[38],"to":[39,73,101,144,177,218,228,363],"male":[40,52,325],"female":[42,57,86,110,130,152,196,323,339],"gametes":[43],"sex.":[45],"While":[46,120],"factors":[47],"were":[48],"identified":[49],"that":[50,182,361],"control":[51],"fate":[53,118],"development,":[55,111],"how":[56],"gene":[58,98,141,159],"expression":[59],"orchestrated":[61],"remains":[62],"largely":[63,287],"unknown.":[64],"Here,":[65,328],"we":[66,329],"use":[67],"Single":[70],"Cell":[71,171],"Atlas":[72],"discover":[74],"RNA-binding":[76,336],"protein":[77,127,207,337,357],"(F-RBP)":[78],"as":[79],"one":[80],"earliest":[83],"markers":[84],"identity":[87],"in":[88,154,162,168,194,214,230,258,338,359,390],"C.":[89],"parvum":[90],".":[91,156],"Reporter":[92],"parasites":[93],"engineered":[94],"based":[95],"on":[96,291],"this":[97,175],"allowed":[99],"us":[100],"calibrate":[102],"transcriptional":[103,117],"pseudotime":[104],"against":[105],"real":[107],"time":[108],"revealing":[112],"significant":[114],"window":[115],"ambiguity.":[119],"F-RBP":[121,140,189],"transcript,":[125],"persists":[128],"throughout":[129],"development":[131,153],"into":[133],"zygote.":[135],"Conditional":[136],"ablation":[137,374],"showed":[142],"it":[143],"be":[145,229],"dispensable":[146],"for":[147,199,241,250,273],"sex":[148,318,389],"determination":[149],"vitro":[155],"However,":[157],"essential":[161,226,385],"vivo,":[163],"its":[165],"loss":[166,176],"results":[167,358],"rapid":[169],"cure.":[170],"biological":[172],"experiments":[173],"link":[174],"production":[179],"oocysts":[181],"release":[183],"sporozoites":[184,312],"incapable":[185],"host-cell":[187],"invasion.":[188],"binds":[190],"transcripts":[191,343],"highly":[192],"expressed":[193],"gamete,":[197],"enriched":[198],"sequence":[201],"motif":[202],"recognized":[203],"by":[204],"Y-box":[206],"family":[208],"member,":[209],"forms":[211],"mRNA-protein":[212],"complexes":[213],"late":[215],"females":[216],"akin":[217],"processing":[219],"or":[220],"P":[221],"bodies.":[222],"We":[223],"propose":[224],"F-RBP\u2019s":[225],"role":[227,333,386],"regulation":[232],"long-term":[234],"homeostasis":[235],"maternally":[237],"inherited":[238],"RNA":[239],"required":[240],"sporozoite":[242],"infectivity.":[243],"IMPORTANCE":[244],"The":[245],"responsible":[249],"millions":[251],"cases":[253],"severe":[255],"young":[259],"children,":[260],"infection":[263],"both":[265],"consequence":[267],"risk":[271],"factor":[272],"chronic":[274],"malnutrition.":[275],"There":[276],"are":[277,313],"no":[278],"vaccines":[279],"available,":[280],"single":[283],"approved":[284],"treatment":[285],"ineffective.":[288],"relies":[290],"ingestion":[292],"oocyst,":[295],"environmentally":[297],"stable":[298],"spore,":[299],"which":[300],"contains":[301],"invasive":[303],"form":[304],"parasite,":[307],"sporozoite.":[309],"Oocysts":[310],"products":[315],"fusion":[321],"parasites.":[327],"report":[330],"critical":[332],"mRNA":[340],"homeostasis.":[341],"Maternal":[342],"orchestrate":[344],"complex":[346],"process":[347],"oocyst":[352],"formation.":[353],"Loss":[354],"spores":[360],"fail":[362],"initiate":[364],"next":[366],"round":[367],"life":[370],"cycle,":[371],"conditional":[373],"using":[375],"small-molecule":[377],"trigger":[378],"quickly":[379],"cures":[380],"infected":[381],"animals,":[382],"demonstrating":[383],"continued":[391],"infection.":[392]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-04T00:00:00"}