{"id":"https://openalex.org/W72075910","doi":null,"title":"Differences in the development of tolerance to various benzodiazepines.","display_name":"Differences in the development of tolerance to various benzodiazepines.","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W72075910","mag":"72075910","pmid":"https://pubmed.ncbi.nlm.nih.gov/2894019"},"language":"en","primary_location":{"id":"pmid:2894019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2894019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology and pharmacy","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042722940","display_name":"El\u017cbieta Nowakowska","orcid":"https://orcid.org/0000-0001-5515-9551","observed_orcids":["https://orcid.org/0000-0001-5515-9551"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"E Nowakowska","raw_affiliation_strings":["Department of Pharmacology, Medical Academy, Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medical Academy, Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053400638","display_name":"Alfons Chodera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Chodera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065347976","display_name":"D Cenajek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Cenajek-Musia\u0142","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037344168","display_name":"Krystyna Szczawinska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Szczawi\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00264862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"3","first_page":"245","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.14890000224113464,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9649999737739563},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nitrazepam","display_name":"nitrazepam","score":0.9350000023841858},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":1.0},{"id":"https://openalex.org/keywords/oxazepam","display_name":"oxazepam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chlordiazepoxide","display_name":"chlordiazepoxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/temazepam","display_name":"temazepam","score":1.0},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.6740000247955322},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-drug-administration","display_name":"chronic drug administration","score":0.5260000228881836},{"id":"https://openalex.org/keywords/stimulating-effect","display_name":"stimulating effect","score":0.5}],"concepts":[{"id":"https://openalex.org/C2776615572","wikidata":"https://www.wikidata.org/wiki/Q412299","display_name":"Oxazepam","level":4,"score":0.8680378794670105},{"id":"https://openalex.org/C2778325228","wikidata":"https://www.wikidata.org/wiki/Q178566","display_name":"Chlordiazepoxide","level":3,"score":0.8663743734359741},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.8636268377304077},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.8171339631080627},{"id":"https://openalex.org/C2781006864","wikidata":"https://www.wikidata.org/wiki/Q414796","display_name":"Temazepam","level":4,"score":0.7684271335601807},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.7276591658592224},{"id":"https://openalex.org/C2777207853","wikidata":"https://www.wikidata.org/wiki/Q410078","display_name":"Nitrazepam","level":3,"score":0.6720093488693237},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6625485420227051},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.6334429979324341},{"id":"https://openalex.org/C2777907850","wikidata":"https://www.wikidata.org/wiki/Q412164","display_name":"Clobazam","level":3,"score":0.5173661112785339},{"id":"https://openalex.org/C2779985140","wikidata":"https://www.wikidata.org/wiki/Q1425425","display_name":"Drug tolerance","level":2,"score":0.5137609243392944},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.3604472875595093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3510674834251404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34810522198677063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15895408391952515},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.11679166555404663},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06546580791473389},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05839100480079651}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2894019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2894019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of pharmacology and pharmacy","raw_type":"Journal Article"},{"id":"mag:72075910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2894019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024535965","https://openalex.org/W2416799498","https://openalex.org/W2026234808","https://openalex.org/W2060550948","https://openalex.org/W2077848384","https://openalex.org/W2042127335","https://openalex.org/W2050349038","https://openalex.org/W2283481958","https://openalex.org/W1965630813","https://openalex.org/W1518951878"],"abstract_inverted_index":{"Anticonvulsant,":[0],"sedative":[1],"and":[2,25,37,86,96,104],"anxiolytic":[3,38,82,100],"effects":[4,39,58,101],"of":[5,30,50,59,64,74,102],"the":[6,12,81,87,99,117],"following":[7],"benzodiazepines,":[8],"administered":[9],"chronically":[10],"by":[11],"intraperitoneal":[13],"route,":[14],"were":[15],"assessed:":[16],"nitrazepam":[17],"(NTZ),":[18],"diazepam":[19],"(DZ),":[20],"oxazepam":[21],"(OXZ),":[22],"chlordiazepoxide":[23],"(CDX)":[24],"temazepam":[26],"(TMZ).":[27],"The":[28,61,93],"action":[29,83,89,95],"NTZ":[31],"in":[32,116],"tests":[33],"for":[34],"sedative,":[35],"anticonvulsant":[36,88,118],"rapidly":[40],"changed":[41],"upon":[42],"a":[43],"repeated":[44],"daily":[45],"treatment,":[46,76],"which":[47],"suggests":[48],"development":[49],"tolerance,":[51],"while":[52],"no":[53,78],"tolerance":[54,79,97],"developed":[55,106],"to":[56,80,98],"such":[57],"OXZ.":[60],"stimulating":[62,94],"effect":[63],"DZ":[65],"was":[66,84,90,109],"found":[67],"not":[68],"earlier":[69],"than":[70],"after":[71],"5":[72],"weeks":[73],"chronic":[75],"but":[77,108],"observed,":[85],"even":[91],"potentiated.":[92],"CDX":[103],"TMZ":[105],"rapidly,":[107],"accompanied":[110],"with":[111],"an":[112],"only":[113],"slight":[114],"decrease":[115],"effect.":[119]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
