{"id":"https://openalex.org/W7207579913","doi":"https://doi.org/10.5281/zenodo.22283832","title":"PANCREATIC AND HEPATIC PROTECTIVE EFFECTS OF SENNA TORA (L.) ROXB. SEED EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS: A COMPARATIVE HISTOPATHOLOGICAL AND RELATIVE ORGAN WEIGHT STUDY","display_name":"PANCREATIC AND HEPATIC PROTECTIVE EFFECTS OF SENNA TORA (L.) ROXB. SEED EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS: A COMPARATIVE HISTOPATHOLOGICAL AND RELATIVE ORGAN WEIGHT STUDY","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207579913","doi":"https://doi.org/10.5281/zenodo.22283832"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22283832","doi":"https://doi.org/10.5281/zenodo.22283832","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22283832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22283832","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116823213","display_name":"Raphael Umeh Ogba","orcid":"https://orcid.org/0009-0007-9163-2984","observed_orcids":["https://orcid.org/0009-0007-9163-2984"]},"institutions":[{"id":"https://openalex.org/I4402554054","display_name":"Federal Polytechnic, Idah","ror":"https://ror.org/05tppve82","country_code":"NG","type":"education","lineage":["https://openalex.org/I4402554054"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ogba, Raphael Umeh","raw_affiliation_strings":["Department of Chemistry/Biochemistry, Federal Polytechnic Idah, Kogi State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry/Biochemistry, Federal Polytechnic Idah, Kogi State","institution_ids":["https://openalex.org/I4402554054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066864129","display_name":"F.D. Tarfa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201292520","display_name":"Bingham University","ror":"https://ror.org/04dbvvk55","country_code":"NG","type":"education","lineage":["https://openalex.org/I201292520"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Dr. Tarfa, F. D","raw_affiliation_strings":["Department of Biochemistry, Bingham University, Karu, Nasarawa State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bingham University, Karu, Nasarawa State","institution_ids":["https://openalex.org/I201292520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008002172","display_name":"Okere O. S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201292520","display_name":"Bingham University","ror":"https://ror.org/04dbvvk55","country_code":"NG","type":"education","lineage":["https://openalex.org/I201292520"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Dr Okere, O. S","raw_affiliation_strings":["Department of Biochemistry, Bingham University, Karu, Nasarawa State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Bingham University, Karu, Nasarawa State","institution_ids":["https://openalex.org/I201292520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senna-tora","display_name":"Senna tora","score":0.9990000128746033},{"id":"https://openalex.org/keywords/seed-extract","display_name":"seed extract","score":0.9120000004768372},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pancreatic-protection","display_name":"pancreatic protection","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/relative-organ-weight","display_name":"relative organ weight","score":0.6079999804496765},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7570000290870667},{"id":"https://openalex.org/keywords/islet-degeneration","display_name":"islet degeneration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.5950000286102295},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.49300000071525574},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7757999897003174},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7590000033378601},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6301000118255615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6269000172615051},{"id":"https://openalex.org/C2776242352","wikidata":"https://www.wikidata.org/wiki/Q2739004","display_name":"Cassia tora","level":3,"score":0.5782999992370605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5253000259399414},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.310699999332428},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C2779456107","wikidata":"https://www.wikidata.org/wiki/Q311117","display_name":"Senna","level":2,"score":0.2646999955177307}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22283832","doi":"https://doi.org/10.5281/zenodo.22283832","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22283832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.22283833","doi":"https://doi.org/10.5281/zenodo.22283833","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22283833","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22283832","doi":"https://doi.org/10.5281/zenodo.22283832","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22283832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2467118942","https://openalex.org/W2766189401","https://openalex.org/W2183226847","https://openalex.org/W3117216686","https://openalex.org/W3189173295","https://openalex.org/W4283274419","https://openalex.org/W4289533765","https://openalex.org/W3196481450","https://openalex.org/W4282834377","https://openalex.org/W6950204302"],"abstract_inverted_index":{"This":[0],"study":[1],"evaluated":[2],"the":[3,129],"organ-safety":[4],"profile":[5,141],"and":[6,39,45,78,100],"hepato-pancreatic":[7,122],"protective":[8],"effects":[9],"of":[10],"Senna":[11],"tora":[12,104,119],"ethanol":[13],"seed":[14],"extract":[15],"in":[16],"streptozotocin-induced":[17],"diabetic":[18,68],"rats.":[19],"Male":[20],"Wistar":[21],"rats":[22,69],"were":[23,48],"allocated":[24],"to":[25],"experimental":[26],"groups":[27],"receiving":[28],"200,":[29],"400,":[30],"or":[31,63],"600":[32,82],"mg/kg":[33,83,112,126],"S.":[34,103,118],"tora,":[35],"with":[36,110,136],"normal,":[37],"diabetic,":[38],"metformin-treated":[40],"controls.":[41],"Relative":[42],"organ":[43],"weights":[44],"histopathological":[46],"alterations":[47],"assessed":[49],"following":[50],"treatment.":[51],"Liver":[52],"relative":[53,73],"weight":[54],"remained":[55],"comparable":[56],"across":[57],"groups,":[58],"indicating":[59],"no":[60],"gross":[61],"hepatomegaly":[62],"hepatic":[64,91],"atrophy.":[65],"In":[66],"contrast,":[67],"exhibited":[70,120],"increased":[71],"kidney":[72],"weight,":[74],"which":[75],"was":[76],"further":[77],"significantly":[79],"elevated":[80],"at":[81],"(p":[84],"<":[85],"0.05).":[86],"Histologically,":[87],"diabetes":[88],"produced":[89],"marked":[90],"sinusoidal":[92],"dilation,":[93],"hepatocellular":[94],"necrosis,":[95,99],"pyknosis,":[96],"pancreatic":[97],"acinar":[98],"islet":[101],"degeneration.":[102],"treatment":[105],"progressively":[106],"ameliorated":[107],"these":[108],"lesions,":[109],"400\u2013600":[111],"demonstrating":[113],"substantial":[114],"architectural":[115],"preservation.":[116],"Overall,":[117],"pronounced":[121],"protection,":[123],"while":[124],"400":[125],"emerged":[127],"as":[128],"most":[130],"favourable":[131],"dose,":[132],"balancing":[133],"therapeutic":[134],"efficacy":[135],"a":[137],"superior":[138],"renal":[139],"safety":[140]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-09-04T00:00:00"}