{"id":"https://openalex.org/W7207572154","doi":"https://doi.org/10.1007/s12672-026-05809-0","title":"In-silico identification of SNPs associated with breast cancer for disclosing pathogenetic processes and therapeutic candidates","display_name":"In-silico identification of SNPs associated with breast cancer for disclosing pathogenetic processes and therapeutic candidates","publication_year":2026,"publication_date":"2026-09-03","ids":{"openalex":"https://openalex.org/W7207572154","doi":"https://doi.org/10.1007/s12672-026-05809-0"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-026-05809-0","doi":"https://doi.org/10.1007/s12672-026-05809-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05809-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s12672-026-05809-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126282893","display_name":"Mohammad Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mohammad Ali","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035197124","display_name":"Md. Asif Ahsan","orcid":"https://orcid.org/0000-0002-0043-6184","observed_orcids":["https://orcid.org/0000-0002-0043-6184"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Asif Ahsan","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Md. Shariful Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Shariful Islam","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039793458","display_name":"Md. Fahim Faysal","orcid":"https://orcid.org/0009-0009-9082-2350","observed_orcids":["https://orcid.org/0009-0009-9082-2350"]},"institutions":[{"id":"https://openalex.org/I17477748","display_name":"Rajshahi University of Engineering and Technology","ror":"https://ror.org/049ysg747","country_code":"BD","type":"education","lineage":["https://openalex.org/I17477748"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Fahim Faysal","raw_affiliation_strings":["Deptartment. of Computer Science and Engineering, Rajshahi University of Engineering and Technology, Rajshahi, 6204, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptartment. of Computer Science and Engineering, Rajshahi University of Engineering and Technology, Rajshahi, 6204, Bangladesh","institution_ids":["https://openalex.org/I17477748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136099311","display_name":"Hussain Muhammad Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Hussain Muhammad Ryan","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149684204","display_name":"Umma Tanjina Azam Sipa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24057909","display_name":"Bangladesh Agricultural University","ror":"https://ror.org/03k5zb271","country_code":"BD","type":"education","lineage":["https://openalex.org/I24057909"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Umma Tanjina Azam Sipa","raw_affiliation_strings":["Department of Agrometeorology, Bangladesh Agricultural University, Mymensingh, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agrometeorology, Bangladesh Agricultural University, Mymensingh, Bangladesh","institution_ids":["https://openalex.org/I24057909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198381","display_name":"Md. Sanoar Hossain","orcid":"https://orcid.org/0009-0001-8751-0286","observed_orcids":["https://orcid.org/0009-0001-8751-0286"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Sanoar Hossain","raw_affiliation_strings":["Institute of Bangladesh Studies (IBS), University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bangladesh Studies (IBS), University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027967717","display_name":"Md. Hadiul Kabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Hadiul Kabir","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149913487","display_name":"Md Mehedi Hasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Mehedi Hasan","raw_affiliation_strings":["Department of Pathobiological Sciences School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiological Sciences School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130320395","display_name":"Nibas Kumar Pal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Nibas Kumar Pal","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028741163","display_name":"Md. Nurul Haque Mollah","orcid":"https://orcid.org/0000-0002-3883-3396","observed_orcids":["https://orcid.org/0000-0002-3883-3396"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Md. Nurul Haque Mollah","raw_affiliation_strings":["Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028741163"],"corresponding_institution_ids":["https://openalex.org/I902853133"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5630067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.2190999984741211,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6949999928474426},{"id":"https://openalex.org/keywords/key-genes","display_name":"key genes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cadd-score","display_name":"CADD score","score":0.7400000095367432},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chek2","display_name":"CHEK2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mdm4","display_name":"MDM4","score":0.996999979019165},{"id":"https://openalex.org/keywords/esr1","display_name":"ESR1","score":0.996999979019165},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":1.0},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.46700000762939453},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.652999997138977},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/masitinib","display_name":"masitinib","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7781999707221985},{"id":"https://openalex.org/C2776071976","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"CHEK2","level":5,"score":0.7239000201225281},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6391000151634216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932000279426575},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5580000281333923},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.541100025177002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5171999931335449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5069000124931335},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.46939998865127563},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.454800009727478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45019999146461487},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3779999911785126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3427000045776367},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.31850001215934753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.3149999976158142},{"id":"https://openalex.org/C154456304","wikidata":"https://www.wikidata.org/wiki/Q18027046","display_name":"FOXA1","level":4,"score":0.3093000054359436},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.29429998993873596},{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.29109999537467957},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.2759999930858612},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.2727000117301941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2694999873638153},{"id":"https://openalex.org/C2778144015","wikidata":"https://www.wikidata.org/wiki/Q18046302","display_name":"PALB2","level":5,"score":0.2581999897956848},{"id":"https://openalex.org/C43821964","wikidata":"https://www.wikidata.org/wiki/Q18025461","display_name":"GATA2","level":4,"score":0.25380000472068787},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.25189998745918274},{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12672-026-05809-0","doi":"https://doi.org/10.1007/s12672-026-05809-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05809-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s12672-026-05809-0","doi":"https://doi.org/10.1007/s12672-026-05809-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05809-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416821713","https://openalex.org/W2789997334","https://openalex.org/W2082402899","https://openalex.org/W3084037491","https://openalex.org/W4406146799","https://openalex.org/W1992074987","https://openalex.org/W2921576484","https://openalex.org/W4387742163","https://openalex.org/W2035097151","https://openalex.org/W2963876460"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,289],"(BC)":[2],"is":[3,36,293],"a":[4,27,278],"leading":[5],"cause":[6],"of":[7,15,60,68,79,133,167,225,230],"premature":[8],"death":[9],"in":[10,172,177,184,191,199,286],"women.":[11],"However,":[12],"researcher\u2019s":[13],"understanding":[14],"BC":[16,57,100],"development,":[17],"progression":[18],"and":[19,75,117,137,146,181,196,209,211,215,222,234,245,269,275],"its":[20],"treatment":[21],"strategies":[22],"has":[23],"not":[24],"yet":[25],"reached":[26],"satisfactory":[28],"level.":[29],"To":[30],"address":[31],"these":[32,297],"issues,":[33],"first,":[34,84],"it":[35],"necessary":[37],"to":[38,51,110,295],"accurately":[39],"identify":[40,52],"the":[41,77,111,131,220,253,287],"key":[42],"molecular":[43,241],"signatures":[44],"associated":[45,55,98,155,251],"with":[46,56,99,156,232,252,283],"BC.":[47,157,254],"This":[48],"study":[49],"aimed":[50],"genetic":[53,81,89],"variants":[54,90],"through":[58],"meta-analysis":[59,67],"multiple":[61,69],"genome-wide":[62],"association":[63],"studies":[64],"(GWAS),":[65],"as":[66,93,169,219,277],"GWAS":[70,147],"datasets":[71],"increases":[72],"statistical":[73],"power":[74],"improves":[76],"reliability":[78],"identified":[80,87,150,160,218,259],"associations.":[82],"At":[83],"we":[85,149],"have":[86,159],"728":[88],"also":[91],"known":[92],"single":[94],"nucleotide":[95],"polymorphisms":[96],"(SNPs)":[97],"using":[101,114],"METAL":[102],"software":[103],"tool.":[104],"These":[105,121],"SNPs":[106,164],"were":[107,123,217],"then":[108],"mapped":[109],"corresponding":[112],"genes":[113,122,136],"FUMA":[115],"web-tools,":[116],"found":[118],"68":[119],"genes.":[120],"analyzed":[124],"via":[125],"independent":[126],"PPI":[127],"networks.":[128],"By":[129],"taking":[130],"intersection":[132],"top":[134],"hub":[135],"filtering":[138],"for":[139,165],"combined":[140],"annotation":[141],"dependent":[142],"depletion":[143],"(CADD)":[144],"scores":[145],"significance,":[148],"5":[151],"Key":[152],"Genes":[153],"(KGs)":[154],"We":[158],"top-ranked":[161,261],"functionally":[162],"significant":[163],"each":[166],"KGs":[168,231],"rs11571833":[170],"T/C":[171,176],"BRCA2":[173],",":[174,179,186,193,207],"rs186430430":[175],"CHEK2":[178],"rs4252685A/C":[180],"rs4252686":[182],"A/G":[183,198],"MDM4":[185],"rs6940919":[187],"T/G,":[188],"rs35240111":[189],"C/G":[190],"ESR1":[192],"rs4751844":[194],"T/G":[195],"rs17542768":[197],"FGFR2":[200],".":[201],"Top-ranked":[202],"three":[203,264],"transcription":[204],"factors":[205],"FOXC1":[206],"GATA2":[208],"E2F1":[210],"two":[212],"miRNAs":[213],"hsa-miR-34a-5p":[214],"hsa-let-7i-5p":[216],"transcriptional":[221],"post-transcriptional":[223],"regulators":[224],"KGs.":[226],"Functional":[227],"enrichment":[228],"analysis":[229],"GO-terms":[233],"KEGG-pathways":[235],"revealed":[236],"some":[237],"crucial":[238],"biological":[239],"processes,":[240],"functions,":[242],"cellular":[243],"components":[244],"signaling":[246],"pathways":[247],"that":[248],"might":[249],"be":[250],"Finally,":[255],"KG-guided":[256],"drug":[257,273],"prioritization":[258],"five":[260],"compounds,":[262],"including":[263],"FDA-approved":[265],"drugs":[266],"(Imatinib,":[267],"Nilotinib,":[268],"Lynparza),":[270],"one":[271],"investigational":[272],"(Masitinib),":[274],"NVP-BHG712":[276],"computationally":[279],"prioritized":[280],"repurposing":[281],"candidate":[282],"limited":[284],"evidence":[285],"breast":[288],"literature.":[290],"Experimental":[291],"validation":[292],"required":[294],"confirm":[296],"computational":[298],"predictions.":[299]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-09-04T00:00:00"}