{"id":"https://openalex.org/W7207549014","doi":"https://doi.org/10.1039/d6ay01554a","title":"AI-assisted sustainable pharmaceutical bioanalysis: critical review of LC-MS, matrix effects, and white analytical chemistry","display_name":"AI-assisted sustainable pharmaceutical bioanalysis: critical review of LC-MS, matrix effects, and white analytical chemistry","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7207549014","doi":"https://doi.org/10.1039/d6ay01554a","pmid":"https://pubmed.ncbi.nlm.nih.gov/42708214"},"language":"en","primary_location":{"id":"doi:10.1039/d6ay01554a","doi":"https://doi.org/10.1039/d6ay01554a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d6ay01554a","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012139614","display_name":"Hemn A.H. Barzani","orcid":"https://orcid.org/0000-0002-1875-7760","observed_orcids":["https://orcid.org/0000-0002-1875-7760"]},"institutions":[{"id":"https://openalex.org/I4210125537","display_name":"Lebanese French University","ror":"https://ror.org/030t96b35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210125537"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Hemn A. H. Barzani","raw_affiliation_strings":["Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Erbil, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Erbil, Iraq","institution_ids":["https://openalex.org/I4210125537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016344071","display_name":"Rebaz Anwar Omer","orcid":"https://orcid.org/0000-0002-3774-6071","observed_orcids":["https://orcid.org/0000-0002-3774-6071"]},"institutions":[{"id":"https://openalex.org/I4896460","display_name":"Koya University","ror":"https://ror.org/017pq0w72","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4896460"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Rebaz Anwar Omer","raw_affiliation_strings":["Department of Chemistry, Faculty of Sciences and Health, Koya University, Koya 44023, Kurdistan Region \u2013 F. R., Iraq"],"raw_orcid":"https://orcid.org/0000-0002-3774-6071","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Sciences and Health, Koya University, Koya 44023, Kurdistan Region \u2013 F. R., Iraq","institution_ids":["https://openalex.org/I4896460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149953032","display_name":"Ibrahim  Ibrahim Khalamala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253865","display_name":"Erbil Polytechnic University","ror":"https://ror.org/015m6h915","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405253865"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Khalamala Ibrahim Salih Barzani","raw_affiliation_strings":["Department of Nursing, Mergasor Technical Institute, Erbil Polytechnic University, 44001, Erbil, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Mergasor Technical Institute, Erbil Polytechnic University, 44001, Erbil, Iraq","institution_ids":["https://openalex.org/I4405253865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017330605","display_name":"Hazha Omar Othman","orcid":"https://orcid.org/0000-0002-3011-926X","observed_orcids":["https://orcid.org/0000-0002-3011-926X"]},"institutions":[{"id":"https://openalex.org/I46208956","display_name":"Salahaddin University-Erbil","ror":"https://ror.org/02124dd11","country_code":"IQ","type":"education","lineage":["https://openalex.org/I46208956"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Hazha Omar Othman","raw_affiliation_strings":["Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq"],"raw_orcid":"https://orcid.org/0000-0002-3011-926X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq","institution_ids":["https://openalex.org/I46208956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114242319","display_name":"Ali Sedeeq Noaman","orcid":"https://orcid.org/0000-0002-8154-9550","observed_orcids":["https://orcid.org/0000-0002-8154-9550"]},"institutions":[{"id":"https://openalex.org/I4394709131","display_name":"Akre University for Applied Sciences","ror":"https://ror.org/04ekebw10","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4394709131"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ali Sedeeq Noaman","raw_affiliation_strings":["Department of Biology, College of Education, Akre University for Applied Sciences, Akre, Duhok, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Education, Akre University for Applied Sciences, Akre, Duhok, Iraq","institution_ids":["https://openalex.org/I4394709131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026904182","display_name":"Kovan Dilawer Issa","orcid":"https://orcid.org/0000-0003-2860-0246","observed_orcids":["https://orcid.org/0000-0003-2860-0246"]},"institutions":[{"id":"https://openalex.org/I908820301","display_name":"Tishk International University","ror":"https://ror.org/03pbhyy22","country_code":"IQ","type":"education","lineage":["https://openalex.org/I908820301"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Kovan Dilawer Issa","raw_affiliation_strings":["Anesthesia Department, Tishk International University, Erbil, Kurdistan Region, Iraq"],"raw_orcid":"https://orcid.org/0000-0003-2860-0246","affiliations":[{"raw_affiliation_string":"Anesthesia Department, Tishk International University, Erbil, Kurdistan Region, Iraq","institution_ids":["https://openalex.org/I908820301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149444917","display_name":"Hamadameen  A.H. Sulaiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125537","display_name":"Lebanese French University","ror":"https://ror.org/030t96b35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210125537"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Seerwan Hamadameen Sulaiman","raw_affiliation_strings":["Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Erbil, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Erbil, Iraq","institution_ids":["https://openalex.org/I4210125537"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"38","first_page":"8458","last_page":"8498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.10159999877214432,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.8420000076293945},{"id":"https://openalex.org/keywords/liquid-chromatography-mass-spectrometry","display_name":"liquid chromatography-mass spectrometry","score":0.9179999828338623},{"id":"https://openalex.org/keywords/matrix-effects","display_name":"matrix effects","score":0.9760000109672546},{"id":"https://openalex.org/keywords/white-analytical-chemistry","display_name":"white analytical chemistry","score":0.8080000281333923},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.6990000009536743},{"id":"https://openalex.org/keywords/explainable-ai","display_name":"explainable AI","score":0.8690000176429749},{"id":"https://openalex.org/keywords/digital-twin","display_name":"digital twin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/automated-analysis","display_name":"automated analysis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6779999732971191},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.9314000010490417},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5716000199317932},{"id":"https://openalex.org/C2988629283","wikidata":"https://www.wikidata.org/wiki/Q44337","display_name":"Complex matrix","level":2,"score":0.5058000087738037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4788999855518341},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.43320000171661377},{"id":"https://openalex.org/C178144697","wikidata":"https://www.wikidata.org/wiki/Q2111609","display_name":"Process analytical technology","level":3,"score":0.41679999232292175},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.41370001435279846},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.41130000352859497},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.39070001244544983},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.3630000054836273},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3499000072479248},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C2778870860","wikidata":"https://www.wikidata.org/wiki/Q4751155","display_name":"Analytical procedures","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3037000000476837},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2778605646","wikidata":"https://www.wikidata.org/wiki/Q223729","display_name":"White paper","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.25380000472068787}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d6ay01554a","doi":"https://doi.org/10.1039/d6ay01554a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d6ay01554a","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},{"id":"pmid:42708214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42708214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical methods : advancing methods and applications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W1816647015","https://openalex.org/W1996842820","https://openalex.org/W2177837771","https://openalex.org/W2548851082","https://openalex.org/W2781931056","https://openalex.org/W2900186284","https://openalex.org/W2904053549","https://openalex.org/W2911618184","https://openalex.org/W2966440116","https://openalex.org/W2980985102","https://openalex.org/W2991326743","https://openalex.org/W2994463190","https://openalex.org/W2995969061","https://openalex.org/W3034396232","https://openalex.org/W3035028232","https://openalex.org/W3043543689","https://openalex.org/W3087245954","https://openalex.org/W3087432859","https://openalex.org/W3088363010","https://openalex.org/W3093294162","https://openalex.org/W3098020756","https://openalex.org/W3121847180","https://openalex.org/W3131877153","https://openalex.org/W3132104108","https://openalex.org/W3137024757","https://openalex.org/W3159662538","https://openalex.org/W3183469616","https://openalex.org/W3194376819","https://openalex.org/W3196283908","https://openalex.org/W3205463382","https://openalex.org/W3207225325","https://openalex.org/W4200149698","https://openalex.org/W4211208685","https://openalex.org/W4213368100","https://openalex.org/W4220871466","https://openalex.org/W4225639685","https://openalex.org/W4231420236","https://openalex.org/W4292074794","https://openalex.org/W4302306904","https://openalex.org/W4304757231","https://openalex.org/W4308600794","https://openalex.org/W4312226049","https://openalex.org/W4316259235","https://openalex.org/W4321599838","https://openalex.org/W4364378718","https://openalex.org/W4382202503","https://openalex.org/W4384130901","https://openalex.org/W4385442020","https://openalex.org/W4385851778","https://openalex.org/W4385999973","https://openalex.org/W4386045955","https://openalex.org/W4386236099","https://openalex.org/W4386407085","https://openalex.org/W4386580119","https://openalex.org/W4387767199","https://openalex.org/W4387931179","https://openalex.org/W4390202158","https://openalex.org/W4390640352","https://openalex.org/W4391993349","https://openalex.org/W4391998118","https://openalex.org/W4392754835","https://openalex.org/W4393002228","https://openalex.org/W4393010954","https://openalex.org/W4393202280","https://openalex.org/W4393993287","https://openalex.org/W4396221592","https://openalex.org/W4396509434","https://openalex.org/W4397007819","https://openalex.org/W4398210924","https://openalex.org/W4399009666","https://openalex.org/W4399148093","https://openalex.org/W4400193174","https://openalex.org/W4400448047","https://openalex.org/W4401045010","https://openalex.org/W4401275323","https://openalex.org/W4401321139","https://openalex.org/W4401510958","https://openalex.org/W4401535000","https://openalex.org/W4402469515","https://openalex.org/W4403052529","https://openalex.org/W4403651078","https://openalex.org/W4404413193","https://openalex.org/W4405151315","https://openalex.org/W4405639893","https://openalex.org/W4408017019","https://openalex.org/W4408318986","https://openalex.org/W4408319097","https://openalex.org/W4408829001","https://openalex.org/W4408845653","https://openalex.org/W4408894254","https://openalex.org/W4409119769","https://openalex.org/W4409647959","https://openalex.org/W4410099192","https://openalex.org/W4410113665","https://openalex.org/W4410323950","https://openalex.org/W4410751447","https://openalex.org/W4411242624","https://openalex.org/W4412017076","https://openalex.org/W4412025070","https://openalex.org/W4412678211","https://openalex.org/W4412702432","https://openalex.org/W4412980080","https://openalex.org/W4413257319","https://openalex.org/W4413257856","https://openalex.org/W4413446729","https://openalex.org/W4414436681","https://openalex.org/W4414768277","https://openalex.org/W4415203689","https://openalex.org/W4415321284","https://openalex.org/W4415664899","https://openalex.org/W4415679841","https://openalex.org/W4416095542","https://openalex.org/W4416459597","https://openalex.org/W4416764465","https://openalex.org/W4417114481","https://openalex.org/W7117725920","https://openalex.org/W7122774792","https://openalex.org/W7123345292","https://openalex.org/W7123936058","https://openalex.org/W7127118525","https://openalex.org/W7128773366","https://openalex.org/W7130645022","https://openalex.org/W7133215741","https://openalex.org/W7133326240","https://openalex.org/W7135017855","https://openalex.org/W7137090920","https://openalex.org/W7139007775","https://openalex.org/W7139919390","https://openalex.org/W7140170517","https://openalex.org/W7160715806","https://openalex.org/W7162685939","https://openalex.org/W7163989964","https://openalex.org/W7166477804","https://openalex.org/W7172160728"],"related_works":["https://openalex.org/W7167808629","https://openalex.org/W7164830178","https://openalex.org/W7221132994","https://openalex.org/W7160119905","https://openalex.org/W3047894385","https://openalex.org/W7158169673","https://openalex.org/W7214109138","https://openalex.org/W7202172824","https://openalex.org/W7203569220","https://openalex.org/W7162552343"],"abstract_inverted_index":{"Pharmaceutical":[0],"bioanalysis":[1,67,181],"has":[2],"undergone":[3],"remarkable":[4],"technological":[5],"advancement":[6],"with":[7,135],"the":[8,62,77,125,172],"widespread":[9],"adoption":[10],"of":[11,23,65,80,127],"liquid":[12],"chromatography-mass":[13],"spectrometry":[14],"(LC-MS)":[15],"platforms,":[16,155],"enabling":[17],"highly":[18],"sensitive":[19],"and":[20,29,46,54,76,84,95,118,130,141,161,177,186],"selective":[21],"quantification":[22],"pharmaceuticals,":[24],"metabolites,":[25],"biomarkers,":[26],"peptides,":[27],"proteins,":[28],"oligonucleotides.":[30],"Despite":[31],"these":[32],"developments,":[33],"persistent":[34],"challenges,":[35],"including":[36],"matrix":[37,42],"effects,":[38],"analytical":[39,52,74,89,114,149],"instability,":[40],"biological":[41],"complexity,":[43],"data":[44],"overload,":[45],"sustainability":[47],"concerns,":[48],"continue":[49],"to":[50,170,174],"compromise":[51],"reliability":[53],"translational":[55],"applicability.":[56],"This":[57],"critical":[58],"review":[59,122],"comprehensively":[60],"evaluates":[61],"current":[63,128],"state":[64],"pharmaceutical":[66,180],"by":[68],"examining":[69],"emerging":[70],"LC-MS":[71,154],"technologies,":[72],"sustainable":[73,179],"strategies,":[75],"growing":[78],"role":[79],"artificial":[81],"intelligence":[82],"(AI)":[83],"machine":[85],"learning":[86],"(ML)":[87],"in":[88],"optimization,":[90],"spectral":[91],"interpretation,":[92],"biomarker":[93],"discovery,":[94],"autonomous":[96],"decision-making.":[97],"Particular":[98],"emphasis":[99],"is":[100],"placed":[101],"on":[102],"White":[103],"Analytical":[104],"Chemistry":[105],"(WAC)":[106],"as":[107],"a":[108],"multidimensional":[109],"framework":[110],"that":[111,151,182],"simultaneously":[112],"considers":[113],"performance,":[115],"environmental":[116],"sustainability,":[117],"practical":[119],"feasibility.":[120],"The":[121],"critically":[123],"assesses":[124],"limitations":[126],"AI-assisted":[129],"sustainability-driven":[131],"approaches,":[132],"highlighting":[133],"issues":[134],"algorithmic":[136],"transparency,":[137],"regulatory":[138],"acceptance,":[139],"standardization,":[140],"insufficient":[142],"real-world":[143],"validation.":[144],"Furthermore,":[145],"it":[146],"explores":[147],"intelligent":[148],"ecosystems":[150],"integrate":[152],"advanced":[153],"explainable":[156],"AI,":[157],"digital":[158],"twins,":[159],"automation,":[160],"cloud-based":[162],"infrastructure.":[163],"Finally,":[164],"realistic":[165],"future":[166],"priorities":[167],"are":[168],"proposed":[169],"facilitate":[171],"transition":[173],"autonomous,":[175],"reliable,":[176],"environmentally":[178],"supports":[183],"precision":[184],"medicine":[185],"next-generation":[187],"drug":[188],"development.":[189]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-04T00:00:00"}
