{"id":"https://openalex.org/W7207540139","doi":"https://doi.org/10.15083/00078336","title":"Exploring novel molecularly-targeted therapies which modulate anti-apoptotic proteins in endometrial and ovarian cancers","display_name":"Exploring novel molecularly-targeted therapies which modulate anti-apoptotic proteins in endometrial and ovarian cancers","publication_year":2018,"publication_date":"2018-03-22","ids":{"openalex":"https://openalex.org/W7207540139","doi":"https://doi.org/10.15083/00078336"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:00926:0004118487","doi":"https://doi.org/10.15083/00078336","is_oa":true,"landing_page_url":"https://repository.dl.itc.u-tokyo.ac.jp/records/53219","pdf_url":"https://repository.dl.itc.u-tokyo.ac.jp/record/53219/files/A35038_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.dl.itc.u-tokyo.ac.jp/record/53219/files/A35038_abstract.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075082538","display_name":"Agapiti H Chuwa","orcid":"https://orcid.org/0000-0001-7325-1167","observed_orcids":["https://orcid.org/0000-0001-7325-1167"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chuwa, Agapiti Hipoliti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075082538"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.9779999852180481},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.7070000171661377},{"id":"https://openalex.org/keywords/intrinsic-and-extrinsic-apoptotic-pathways","display_name":"intrinsic and extrinsic apoptotic pathways","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.8115000128746033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6347000002861023},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.588100016117096},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.5515999794006348},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48330000042915344},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4521999955177307},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.38909998536109924},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.3239000141620636},{"id":"https://openalex.org/C2908651487","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinomas","level":5,"score":0.32249999046325684},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.262800008058548}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:00926:0004118487","doi":"https://doi.org/10.15083/00078336","is_oa":true,"landing_page_url":"https://repository.dl.itc.u-tokyo.ac.jp/records/53219","pdf_url":"https://repository.dl.itc.u-tokyo.ac.jp/record/53219/files/A35038_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00926:0004118487","doi":"https://doi.org/10.15083/00078336","is_oa":true,"landing_page_url":"https://repository.dl.itc.u-tokyo.ac.jp/records/53219","pdf_url":"https://repository.dl.itc.u-tokyo.ac.jp/record/53219/files/A35038_abstract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207540139.pdf","grobid_xml":"https://content.openalex.org/works/W7207540139.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W184485106","https://openalex.org/W329007366","https://openalex.org/W2059659556","https://openalex.org/W2363643518","https://openalex.org/W4211110825","https://openalex.org/W7095779614","https://openalex.org/W25447251","https://openalex.org/W2780519817","https://openalex.org/W7204565314","https://openalex.org/W2401440149"],"abstract_inverted_index":{"Apoptosis,":[0],"or":[1,70],"programmed":[2],"cell":[3,12,23],"death,":[4],"is":[5,15,67,93],"a":[6,11,94],"genetically-controlled":[7],"process":[8],"in":[9,56,88],"which":[10,21,72],"undergoes":[13],"self-destruction.It":[14],"characterized":[16],"by":[17,39],"definite":[18],"morphological":[19],"features":[20],"include":[22],"shrinkage,":[24],"blebbing":[25],"of":[26,30,59,77,96],"the":[27,31,57,75],"membrane,":[28],"condensation":[29],"nucleus":[32],"and":[33,42,48,82],"DNA":[34,81],"fragmentation.Apoptosis":[35],"can":[36],"be":[37],"triggered":[38],"both":[40,46],"intrinsic":[41],"extrinsic":[43],"stimuli":[44],"under":[45],"physiological":[47],"pathological":[49],"conditions.Several":[50],"anti-and":[51],"pro-apoptotic":[52],"proteins":[53],"are":[54],"involved":[55],"control":[58],"this":[60],"vital":[61],"process.In":[62],"most":[63,97],"cancers,":[64],"however,":[65],"apoptosis":[66,92],"either":[68],"aberrant":[69],"lacking":[71],"leads":[73],"to":[74],"accumulation":[76],"cells":[78],"with":[79],"faulty":[80],"altered":[83],"cellular":[84,90],"processes,":[85],"consequently,":[86],"resulting":[87],"relentless":[89],"proliferation.Circumventing":[91],"hallmark":[95],"malignant":[98],"tumors.":[99]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-04T00:00:00"}