{"id":"https://openalex.org/W7207536252","doi":"https://doi.org/10.1186/s12905-026-05017-6","title":"Adverse childhood experiences and age at menopause: a cross-sectional analysis in the UK Biobank and US Health and Retirement Study","display_name":"Adverse childhood experiences and age at menopause: a cross-sectional analysis in the UK Biobank and US Health and Retirement Study","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7207536252","doi":"https://doi.org/10.1186/s12905-026-05017-6"},"language":"en","primary_location":{"id":"doi:10.1186/s12905-026-05017-6","doi":"https://doi.org/10.1186/s12905-026-05017-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05017-6","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12905-026-05017-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123734507","display_name":"Weiqian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiqian Zhang","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149521732","display_name":"Yiling Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiling Tan","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013171074","display_name":"Rui Qu","orcid":"https://orcid.org/0000-0002-2716-6401","observed_orcids":["https://orcid.org/0000-0002-2716-6401"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Qu","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109707285","display_name":"Jia Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Liang","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100782390","display_name":"Yu Guan","orcid":"https://orcid.org/0000-0002-5297-7273","observed_orcids":["https://orcid.org/0000-0002-5297-7273"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Guan","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092311112","display_name":"Tailang Yin","orcid":"https://orcid.org/0000-0003-2032-0901","observed_orcids":["https://orcid.org/0000-0003-2032-0901"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tailang Yin","raw_affiliation_strings":["Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762790","display_name":"Dongdong Tang","orcid":"https://orcid.org/0000-0002-9966-3642","observed_orcids":["https://orcid.org/0000-0002-9966-3642"]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongdong Tang","raw_affiliation_strings":["Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People\u2019s Republic of China, Hefei, 230032, China","NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, 230032, China","Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People\u2019s Republic of China, Hefei, 230032, China","institution_ids":["https://openalex.org/I1327237609","https://openalex.org/I197869895"]},{"raw_affiliation_string":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, 230032, China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China","institution_ids":["https://openalex.org/I4210136596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149535287","display_name":"Yan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5092311112","https://openalex.org/A5100762790","https://openalex.org/A5149535287"],"corresponding_institution_ids":["https://openalex.org/I1327237609","https://openalex.org/I197869895","https://openalex.org/I4210136596","https://openalex.org/I4210140357"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66450253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-childhood-experiences","display_name":"adverse childhood experiences","score":1.0},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.9950000047683716},{"id":"https://openalex.org/keywords/early-menopause","display_name":"early menopause","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cumulative-ace-score","display_name":"cumulative ACE score","score":0.6209999918937683},{"id":"https://openalex.org/keywords/child-abuse","display_name":"child abuse","score":0.8450000286102295},{"id":"https://openalex.org/keywords/parental-death","display_name":"parental death","score":0.9909999966621399},{"id":"https://openalex.org/keywords/area-deprivation","display_name":"area deprivation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/socioeconomic-deprivation","display_name":"socioeconomic deprivation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/reproductive-aging","display_name":"reproductive aging","score":0.765999972820282},{"id":"https://openalex.org/keywords/ace-screening","display_name":"ACE screening","score":0.8349999785423279},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7422999739646912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.741599977016449},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.636900007724762},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5486999750137329},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.5317999720573425},{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.5091999769210815},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.47780001163482666},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4453999996185303},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.4422999918460846},{"id":"https://openalex.org/C2780176501","wikidata":"https://www.wikidata.org/wiki/Q5690755","display_name":"Health and Retirement Study","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.38089999556541443},{"id":"https://openalex.org/C2908744105","wikidata":"https://www.wikidata.org/wiki/Q105821669","display_name":"Adverse Childhood Experiences","level":3,"score":0.3472000062465668},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C117568660","wikidata":"https://www.wikidata.org/wiki/Q1650843","display_name":"Multinomial logistic regression","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2250968","wikidata":"https://www.wikidata.org/wiki/Q1512929","display_name":"Health equity","level":3,"score":0.2806999981403351},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C87227347","wikidata":"https://www.wikidata.org/wiki/Q7100713","display_name":"Ordered logit","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s12905-026-05017-6","doi":"https://doi.org/10.1186/s12905-026-05017-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05017-6","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10691011/v1","doi":"https://doi.org/10.21203/rs.3.rs-10691011/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10691011/v1","pdf_url":"https://www.researchsquare.com/article/rs-10691011/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1186/s12905-026-05017-6","doi":"https://doi.org/10.1186/s12905-026-05017-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12905-026-05017-6","pdf_url":null,"source":{"id":"https://openalex.org/S94788606","display_name":"BMC Women s Health","issn_l":"1472-6874","issn":["1472-6874"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Women's Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Reduced inequalities","score":0.7390999794006348,"id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223242156","https://openalex.org/W4386244301","https://openalex.org/W7170711748","https://openalex.org/W7160119384","https://openalex.org/W3092928397","https://openalex.org/W7164024324","https://openalex.org/W4205900399","https://openalex.org/W7118073742","https://openalex.org/W7166640184","https://openalex.org/W2985139013"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Adverse":[2],"childhood":[3,204],"experiences":[4],"(ACE)":[5],"represent":[6],"a":[7,150],"pervasive":[8],"global":[9],"health":[10],"burden,":[11],"yet":[12],"evidence":[13],"regarding":[14],"their":[15],"association":[16,36,158],"with":[17,85,118,143,177,189],"age":[18,40,86],"at":[19,41,87,219],"menopause":[20,42,88,92,120,191],"remains":[21],"inconsistent":[22],"and":[23,39,58,63,76,90,97,108,142,206,226],"largely":[24],"derived":[25,70],"from":[26,54,60],"single-cohort":[27],"studies.":[28],"This":[29,48],"cross-national":[30],"study":[31],"aimed":[32],"to":[33,131,140],"investigate":[34],"the":[35,55,61,81,157,165,182,199],"between":[37],"ACE":[38,67,84,113,185,210],"across":[43,106,174,192],"two":[44,193],"large-scale":[45],"cohorts.":[46,195],"Methods":[47],"cross-sectional":[49],"analysis":[50],"included":[51],"34,872":[52],"women":[53,218],"UK":[56],"Biobank":[57],"5,163":[59],"Health":[62],"Retirement":[64],"Study.":[65],"Cumulative":[66],"scores":[68,114],"were":[69,115],"using":[71],"validated":[72],"instruments.":[73],"Multivariable":[74],"linear":[75],"logistic":[77],"regression":[78],"models":[79],"assessed":[80],"associations":[82,171],"of":[83,146,203],"(continuous)":[89],"early":[91,147],"(<":[93],"40,":[94],"<":[95,98],"45,":[96],"48":[99],"years).":[100],"Subgroup":[101],"analyses":[102],"examined":[103],"effect":[104],"modification":[105],"socioeconomic":[107],"behavioral":[109],"strata.":[110],"Results":[111],"Higher":[112],"significantly":[116],"associated":[117,188],"earlier":[119,190],"in":[121,159,168,212],"both":[122],"cohorts":[123],"(UKB:":[124],"\u03b2":[125,134],"=":[126,135],"-0.074,":[127],"95%":[128,137],"CI:":[129,138],"-0.116":[130],"-0.032;":[132],"HRS:":[133],"-0.254,":[136],"-0.372":[139],"-0.136)":[141],"increased":[144],"odds":[145],"menopause,":[148],"demonstrating":[149],"significant":[151],"dose-response":[152],"relationship.":[153],"Direct":[154],"maltreatment":[155],"drove":[156],"UKB,":[160],"whereas":[161],"parental":[162],"death":[163],"was":[164],"predominant":[166],"driver":[167],"HRS.":[169],"The":[170],"remained":[172],"consistent":[173],"most":[175],"subgroups,":[176],"area-level":[178],"deprivation":[179],"potentially":[180],"intensifying":[181],"effects.":[183],"Conclusion":[184],"is":[186],"consistently":[187],"national":[194],"These":[196],"findings":[197],"underscore":[198],"enduring":[200],"reproductive":[201,224],"consequences":[202],"adversity":[205],"suggest":[207],"that":[208],"routine":[209],"screening\u2014particularly":[211],"socioeconomically":[213],"deprived":[214],"areas\u2014may":[215],"help":[216],"identify":[217],"heightened":[220],"risk":[221],"for":[222],"accelerated":[223],"aging":[225],"facilitate":[227],"targeted":[228],"preventive":[229],"interventions.":[230]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-04T00:00:00"}