{"id":"https://openalex.org/W7207376865","doi":null,"title":"Neonatal Environment Influences Behavioural and Physiological Reactivity to Stressors, and Mammary Gland Development in BALB/c Mice: Implications for Breast Cancer Risk","display_name":"Neonatal Environment Influences Behavioural and Physiological Reactivity to Stressors, and Mammary Gland Development in BALB/c Mice: Implications for Breast Cancer Risk","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W7207376865"},"language":"en","primary_location":{"id":"pmh:oai:trentu.scholaris.ca:20.500.14987/2058","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14987/2058","pdf_url":"https://trentu.scholaris.ca/bitstreams/573562fd-8905-42b1-aa88-5e05296e21c8/download","source":{"id":"https://openalex.org/S7407064435","display_name":"Digital Collections (Trent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I662221","host_organization_name":"Trent University","host_organization_lineage":["https://openalex.org/I662221"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trentu.scholaris.ca/bitstreams/573562fd-8905-42b1-aa88-5e05296e21c8/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5149203615","display_name":"Kyle Kenniphaas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kenniphaas, Kyle","raw_affiliation_strings":["Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5149203615"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-life-stress","display_name":"early life stress","score":0.9679999947547913},{"id":"https://openalex.org/keywords/maternal-separation","display_name":"maternal separation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.7559999823570251},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stressor-reactivity","display_name":"stressor reactivity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9599999785423279},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carm1","display_name":"CARM1","score":0.7269999980926514},{"id":"https://openalex.org/keywords/coping-behaviour","display_name":"coping behaviour","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mother-infant-interaction","display_name":"mother-infant interaction","score":0.7300000190734863},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7885000109672546},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.7483999729156494},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7093999981880188},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7045999765396118},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6743999719619751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6741999983787537},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.635200023651123},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5148000121116638},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4878999888896942},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.460099995136261},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.41679999232292175},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3961000144481659},{"id":"https://openalex.org/C73282008","wikidata":"https://www.wikidata.org/wiki/Q1759895","display_name":"Coping (psychology)","level":2,"score":0.3910999894142151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38580000400543213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3474999964237213},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C3020294031","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breast feeding","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C123202247","wikidata":"https://www.wikidata.org/wiki/Q2322778","display_name":"Maternal deprivation","level":2,"score":0.27410000562667847}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:trentu.scholaris.ca:20.500.14987/2058","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14987/2058","pdf_url":"https://trentu.scholaris.ca/bitstreams/573562fd-8905-42b1-aa88-5e05296e21c8/download","source":{"id":"https://openalex.org/S7407064435","display_name":"Digital Collections (Trent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I662221","host_organization_name":"Trent University","host_organization_lineage":["https://openalex.org/I662221"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:trentu.scholaris.ca:20.500.14987/2058","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14987/2058","pdf_url":"https://trentu.scholaris.ca/bitstreams/573562fd-8905-42b1-aa88-5e05296e21c8/download","source":{"id":"https://openalex.org/S7407064435","display_name":"Digital Collections (Trent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I662221","host_organization_name":"Trent University","host_organization_lineage":["https://openalex.org/I662221"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7207376865.pdf","grobid_xml":"https://content.openalex.org/works/W7207376865.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1737076464","https://openalex.org/W1966656140","https://openalex.org/W1971439306","https://openalex.org/W1972500493","https://openalex.org/W1978275630","https://openalex.org/W1983773860","https://openalex.org/W1987559321","https://openalex.org/W1987900652","https://openalex.org/W1987959876","https://openalex.org/W1988287623","https://openalex.org/W1988394540","https://openalex.org/W1991315454","https://openalex.org/W1998166694","https://openalex.org/W2011914193","https://openalex.org/W2012372126","https://openalex.org/W2017467542","https://openalex.org/W2025258310","https://openalex.org/W2025845020","https://openalex.org/W2026702399","https://openalex.org/W2028299419","https://openalex.org/W2030086348","https://openalex.org/W2034189826","https://openalex.org/W2040856103","https://openalex.org/W2042622775","https://openalex.org/W2043123430","https://openalex.org/W2055751544","https://openalex.org/W2057537378","https://openalex.org/W2062267315","https://openalex.org/W2062989629","https://openalex.org/W2063328658","https://openalex.org/W2064206814","https://openalex.org/W2067614354","https://openalex.org/W2071000148","https://openalex.org/W2073151077","https://openalex.org/W2079464767","https://openalex.org/W2081108290","https://openalex.org/W2082431946","https://openalex.org/W2083896472","https://openalex.org/W2084003501","https://openalex.org/W2085595419","https://openalex.org/W2089248525","https://openalex.org/W2092300733","https://openalex.org/W2098723642","https://openalex.org/W2099384073","https://openalex.org/W2100763819","https://openalex.org/W2101153293","https://openalex.org/W2102889645","https://openalex.org/W2104655568","https://openalex.org/W2104680520","https://openalex.org/W2106793970","https://openalex.org/W2108117544","https://openalex.org/W2114965225","https://openalex.org/W2115194311","https://openalex.org/W2120260765","https://openalex.org/W2124218468","https://openalex.org/W2125471242","https://openalex.org/W2128366895","https://openalex.org/W2131832357","https://openalex.org/W2136025689","https://openalex.org/W2146024217","https://openalex.org/W2146771808","https://openalex.org/W2155181385","https://openalex.org/W2157641272","https://openalex.org/W2166812695","https://openalex.org/W2167205401","https://openalex.org/W2167210028","https://openalex.org/W2980657582"],"related_works":["https://openalex.org/W2319080733","https://openalex.org/W2166812695","https://openalex.org/W2949200828","https://openalex.org/W4234983970","https://openalex.org/W49343034","https://openalex.org/W3184218925","https://openalex.org/W2000907886","https://openalex.org/W2125813431","https://openalex.org/W4296527452","https://openalex.org/W2069588969"],"abstract_inverted_index":{"Using":[0],"rodent":[1],"models,":[2],"it":[3],"is":[4],"possible":[5],"to":[6,54,108,139],"study":[7],"the":[8,18,31,44,75,94,112,120,200,206],"behavioural":[9,187],"and":[10,17,25,63,128,151,188],"physiological":[11,189],"outcomes":[12],"of":[13,33,36,46,59,66,86,114,119,161,175,202],"early":[14,182,211],"life":[15,183,212],"stress":[16],"influences":[19],"on":[20,199],"normal":[21],"mammary":[22,159,176,214],"gland":[23,160,215],"development":[24],"carcinogenic":[26],"risk.":[27],"Results":[28],"demonstrate":[29],"that":[30,82,181],"experience":[32,113],"three":[34,84],"weeks":[35,85],"prolonged":[37],"maternal":[38],"separation":[39,88],"(LMS;":[40],"4":[41],"hrs/day)":[42],"increased":[43,95],"susceptibility":[45],"adult,":[47],"but":[48],"not":[49],"pubertal,":[50],"female":[51,100,162],"BALB/c":[52],"mice":[53,164],"engage":[55],"in":[56,74,123,135,158,192,205],"higher":[57],"levels":[58,65,106,131],"depressive-related":[60],"immobility":[61,96],"behaviour":[62],"lower":[64,103],"active":[67],"floating":[68],"(a":[69],"suggested":[70],"adaptive":[71],"coping":[72],"behaviour)":[73],"acute":[76],"forced":[77],"swim":[78],"test,":[79],"than":[80],"offspring":[81,101],"experienced":[83],"brief":[87],"(BMS;":[89],"15":[90],"min/day)":[91],"events.":[92],"Despite":[93],"behaviour,":[97],"adult":[98,136],"LMS":[99,163],"demonstrated":[102],"basal":[104],"corticosterone":[105,130],"relative":[107],"BMS":[109],"females.":[110],"However,":[111],"chronic":[115],"early-life":[116],"stress,":[117,213],"regardless":[118],"length,":[121],"results":[122],"greater":[124],"changes":[125,144],"between":[126],"non-stressed":[127],"stressed":[129],"(i.e.":[132],"stressor":[133,221],"reactivity)":[134],"females":[137],"compared":[138],"their":[140,172],"male":[141],"counterparts.":[142],"These":[143,178],"were":[145],"associated":[146],"with":[147],"decreased":[148],"glucocorticoid":[149],"receptor":[150],"coactivator-associated":[152],"arginine":[153],"methyltransferase":[154],"1":[155],"protein":[156],"expression":[157],"at":[165],"young":[166],"adulthood,":[167,193],"highlighting":[168],"potential":[169],"mechanisms":[170],"underlying":[171],"heightened":[173],"risk":[174],"tumourigenesis.":[177],"data":[179],"suggest":[180],"environments":[184],"can":[185],"induce":[186],"alterations":[190],"observed":[191],"which":[194],"may":[195],"have":[196],"an":[197],"influence":[198],"likelihood":[201],"malignancies":[203],"developing":[204],"breast.":[207],"Author":[208],"Keywords:":[209],"coping,":[210],"development,":[216],"mother-infant":[217],"interactions,":[218],"steroid":[219],"receptors,":[220],"reactivity":[222]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-03T00:00:00"}