{"id":"https://openalex.org/W7207193059","doi":null,"title":"Caracterizacion filogenetica, molecular y funcional de los receptores de prostaglandinas de peces teleosteos","display_name":"Caracterizacion filogenetica, molecular y funcional de los receptores de prostaglandinas de peces teleosteos","publication_year":2021,"publication_date":"2021-05-31","ids":{"openalex":"https://openalex.org/W7207193059"},"language":"es","primary_location":{"id":"pmh:oai:hispana.mcu.es:61728538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/112103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/112103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082189039","display_name":"Fatma Hermi","orcid":"https://orcid.org/0000-0003-4275-8533","observed_orcids":["https://orcid.org/0000-0003-4275-8533"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hermi, Fatma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082189039"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2-receptor","display_name":"prostaglandin E2 receptor","score":0.796999990940094},{"id":"https://openalex.org/keywords/teleosts","display_name":"teleosts","score":0.6480000019073486},{"id":"https://openalex.org/keywords/gilthead-seabream","display_name":"Sparus aurata","score":0.843999981880188},{"id":"https://openalex.org/keywords/fish-immune-response","display_name":"fish immune response","score":0.609000027179718},{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ptger3","display_name":"PTGER3","score":0.996999979019165},{"id":"https://openalex.org/keywords/ep4-receptor","display_name":"EP4 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/peritoneal-exudate","display_name":"peritoneal exudate","score":0.6449999809265137},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5285000205039978},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.47189998626708984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4641000032424927},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33719998598098755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28619998693466187},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.22200000286102295},{"id":"https://openalex.org/C2992581678","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Digestive tract","level":2,"score":0.20659999549388885},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.20589999854564667},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.1873999983072281},{"id":"https://openalex.org/C2776842983","wikidata":"https://www.wikidata.org/wiki/Q581319","display_name":"Production system (computer science)","level":3,"score":0.18700000643730164}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:hispana.mcu.es:61728538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/112103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:hispana.mcu.es:61728538","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/112103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7033655901","https://openalex.org/W3045564040","https://openalex.org/W7002377606","https://openalex.org/W3013506043","https://openalex.org/W2059148862","https://openalex.org/W2404323857","https://openalex.org/W2990939913","https://openalex.org/W2529069349","https://openalex.org/W7056839292","https://openalex.org/W3132972362"],"abstract_inverted_index":{"El":[0,75,127,320,347],"sistema":[1],"inmunol\u00f3gico":[2],"de":[3,15,35,54,72,77,87,100,109,116,139,141,151,172,174,182,197,199,210,219,225,227,239,268,284,290,313,317,323,333,338,345,349,377,383,385,406,409,411,423,431,443,450,452,466,490,494,499,505,517,521,532],"los":[4,16,73,142,164,168,193,214,235,240,258,281,314,381,407,421,448,453,491,533],"peces":[5],"tele\u00f3steos":[6,495],"se":[7,21,160,242,354,360,471],"ha":[8,62],"estudiado":[9],"durante":[10],"d\u00e9cadas,":[11],"pero":[12],"a":[13,29,145,464,503],"pesar":[14],"importantes":[17],"avances":[18],"realizados,":[19],"a\u00fan":[20],"desconoce":[22],"mucho,":[23],"especialmente":[24],"en":[25,58,82,96,125,162,178,186,204,234,257,264,273,287,301,357,474,528],"lo":[26],"que":[27,132,159,256,305,352,374,387,397,427,455,484,500],"respecta":[28],"la":[30,59,69,97,101,149,187,237,247,261,265,285,288,375,467,525],"presencia":[31],"y":[32,40,42,91,93,112,114,119,123,176,181,184,202,216,231,270,303,342,359,366,496,524],"el":[33,83,104,137,179,205,295,336,343,429,436,440,508,515,519],"papel":[34,86,520],"las":[36,88,291,310,389,487,529],"prostaglandinas,":[37],"como":[38],"PGE2":[39,90,283],"PGA2,":[41],"sus":[43,94,331],"receptores.":[44],"La":[45,189],"dorada":[46,286,302,324,468],"(Sparus":[47],"aurata":[48],"L.),":[49],"un":[50,107],"pez":[51],"tele\u00f3steo":[52],"marino":[53],"gran":[55],"valor":[56],"comercial":[57],"acuicultura":[60],"mediterr\u00e1nea,":[61],"sido":[63],"ampliamente":[64],"utilizado":[65],"para":[66,280,510],"comprender":[67,518],"mejor":[68],"respuesta":[70,98],"inmune":[71,99],"peces.":[74,534],"objetivo":[76],"esta":[78,318,522],"tesis":[79],"es":[80],"avanzar":[81],"conocimiento":[84],"del":[85,425],"prostaglandinas":[89],"PGA2":[92,306,364,378,417,438,461,485],"receptores":[95,135,143,241,282],"dorada.":[102,126],"En":[103,294,477],"primer":[105],"cap\u00edtulo,":[106],"ort\u00f3logo":[108],"PTGER1,":[110],"PTGER3":[111],"PTGER4,":[113],"dos":[115],"PTGER2":[117],"(Ptger2a":[118],"Ptger2b)":[120],"fueron":[121],"identificados":[122],"caracterizados":[124],"an\u00e1lisis":[128,348],"in":[129,156,308,512],"silico":[130],"mostr\u00f3":[131,351],"todos":[133,163,330],"estos":[134,275,412],"pose\u00edan":[136],"dominio":[138,337],"organizaci\u00f3n":[140],"acoplados":[144],"prote\u00edna":[146],"G,":[147],"con":[148,249,253,329,363,368,400,514],"excepci\u00f3n":[150],"Ptger2b.":[152],"Los":[153],"correspondientes":[154],"estudios":[155,511],"vivo":[157,513],"revelaron":[158],"expresaban":[161],"tejidos":[165],"examinados,":[166],"observ\u00e1ndose":[167],"niveles":[169,194,382,408,422,449],"m\u00e1s":[170,195],"altos":[171,196],"ARNm":[173,198,424],"ptger1":[175],"ptger3":[177,201,230],"bazo":[180],"ptger2a":[183,269],"ptger4":[185,203],"sangre.":[188],"infecci\u00f3n":[190],"bacteriana":[191],"indujo":[192,447],"ptger2a,":[200,229],"exudado":[206],"peritoneal":[207],"(el":[208],"sitio":[209,344],"inyecci\u00f3n":[211],"bacteriana).":[212],"Adem\u00e1s,":[213,233],"granulocitos":[215,259,444],"macr\u00f3fagos":[217,358],"acid\u00f3filos":[218,260,445],"ri\u00f1\u00f3n":[220],"cef\u00e1lico":[221],"mostraron":[222],"diferentes":[223,278],"perfiles":[224],"expresi\u00f3n":[226,238,350],"ptger1,":[228],"ptger4.":[232,271],"macr\u00f3fagos,":[236],"vio":[243],"d\u00e9bilmente":[244,380],"afectada":[245],"por":[246,481],"estimulaci\u00f3n":[248,262],"ADN":[250,341,369],"bacteriano":[251],"o":[252],"PGE2,":[254],"mientras":[255,396],"result\u00f3":[263],"regulaci\u00f3n":[266,289],"positiva":[267],"Tomados":[272],"conjunto,":[274],"resultados":[276],"sugieren":[277],"roles":[279],"respuestas":[292,530],"inmunes.":[293],"segundo":[296],"cap\u00edtulo":[297],"hemos":[298,479],"identificado":[299],"Nr4a3":[300,322,469],"demostrado":[304,480],"regula":[307,486],"vitro":[309],"principales":[311,488],"funciones":[312,489],"fagocitos":[315,492],"profesionales":[316,493],"especie.":[319],"receptor":[321,527],"revel\u00f3":[325],"motivos":[326],"altamente":[327],"conservados":[328],"ort\u00f3logos":[332],"vertebrados,":[334],"particularmente":[335],"uni\u00f3n":[339],"al":[340],"sumoilaci\u00f3n.":[346],"nr4a3":[353],"expresaba":[355],"constitutivamente":[356],"regulaba":[361],"positivamente":[362],"solo":[365],"combinado":[367],"bacteriano.":[370],"Es":[371],"importante":[372],"destacar":[373],"adici\u00f3n":[376],"disminuy\u00f3":[379],"transcripci\u00f3n":[384,451],"genes":[386,454],"codifican":[388,456],"citocinas":[390],"interleucina-1b":[391],"(Il1b),":[392],"Il6":[393],"e":[394,446,458],"Il10,":[395],"su":[398],"combinaci\u00f3n":[399],"VaDNA":[401],"promovi\u00f3":[402],"una":[403],"inducci\u00f3n":[404],"sin\u00e9rgica":[405],"mRNA":[410],"tres":[413],"genes.":[414],"Sin":[415],"embargo,":[416],"no":[418],"pudo":[419,462],"regular":[420],"gen":[426],"codifica":[428],"marcador":[430],"polarizaci\u00f3n":[432],"M2":[433],"Mrc1.":[434],"Por":[435],"contrario,":[437],"inhibi\u00f3":[439],"estallido":[441],"respiratorio":[442],"Il1b":[457],"Il10.":[459],"Finalmente,":[460],"se\u00f1alizar":[463,502],"trav\u00e9s":[465,504],"cuando":[470],"expres\u00f3":[472],"ect\u00f3picamente":[473],"c\u00e9lulas":[475],"HEK293.":[476],"conclusi\u00f3n,":[478],"primera":[482],"vez":[483],"aportado":[497],"evidencias":[498],"puede":[501],"Nr4a3,":[506],"allanando":[507],"camino":[509],"fin":[516],"prostaglandina":[523],"Nr4a3.":[526],"inmunitarias":[531]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-03T00:00:00"}
