{"id":"https://openalex.org/W7206201728","doi":"https://doi.org/10.1016/j.omtn.2026.103083","title":"An mRNA-lipid nanoparticle vaccine targeting the Plasmodium vivax E140 antigen","display_name":"An mRNA-lipid nanoparticle vaccine targeting the Plasmodium vivax E140 antigen","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7206201728","doi":"https://doi.org/10.1016/j.omtn.2026.103083","pmid":"https://pubmed.ncbi.nlm.nih.gov/42774878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13594723"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2026.103083","doi":"https://doi.org/10.1016/j.omtn.2026.103083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103083","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtn.2026.103083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089018748","display_name":"Rodolfo Ferreira Marques","orcid":"https://orcid.org/0000-0003-4402-9131","observed_orcids":["https://orcid.org/0000-0003-4402-9131"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Rodolfo Ferreira Marques","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010843768","display_name":"Guilherme Antonio de Souza Silva","orcid":"https://orcid.org/0000-0003-4364-6648","observed_orcids":["https://orcid.org/0000-0003-4364-6648"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Antonio de Souza-Silva","raw_affiliation_strings":["Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149164838","display_name":"Vitor Antunes da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Antunes da Silva","raw_affiliation_strings":["Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114260446","display_name":"Andr\u00e1s S\u00e1rk\u00f6zy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e1s S\u00e1rk\u00f6zy","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083906705","display_name":"M\u00e1t\u00e9 Vadovics","orcid":"https://orcid.org/0000-0001-9028-987X","observed_orcids":["https://orcid.org/0000-0001-9028-987X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M\u00e1t\u00e9 Vadovics","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083166651","display_name":"Hiromi Muramatsu","orcid":"https://orcid.org/0000-0003-1544-1493","observed_orcids":["https://orcid.org/0000-0003-1544-1493"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiromi Muramatsu","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101834082","display_name":"Edit \u00c1brah\u00e1m","orcid":"https://orcid.org/0000-0002-1268-760X","observed_orcids":["https://orcid.org/0000-0002-1268-760X"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210155639","display_name":"Institute of Genetics","ror":"https://ror.org/04tjemt46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Edit \u00c1brah\u00e1m","raw_affiliation_strings":["National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I4387152226"]},{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I4387152226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033556237","display_name":"Carolina Bioni Garcia Teles","orcid":"https://orcid.org/0000-0002-4529-2137","observed_orcids":["https://orcid.org/0000-0002-4529-2137"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina Bioni Garcia","raw_affiliation_strings":["Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rond\u00f4nia 76812-245, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oswaldo Cruz Foundation, Leishmaniasis and Malaria Bioassay Platform, Porto Velho, Rond\u00f4nia 76812-245, Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071304375","display_name":"Silvia Beatriz Boscardin","orcid":"https://orcid.org/0000-0002-7845-7110","observed_orcids":["https://orcid.org/0000-0002-7845-7110"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvia Beatriz Boscardin","raw_affiliation_strings":["Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118745480","display_name":"Rachel H. J. Jun","orcid":"https://orcid.org/0009-0008-9733-4715","observed_orcids":["https://orcid.org/0009-0008-9733-4715"]},"institutions":[{"id":"https://openalex.org/I4210149081","display_name":"Acuitas Therapeutics (Canada)","ror":"https://ror.org/04eaec870","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210149081"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rachel H.J. Jun","raw_affiliation_strings":["Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I4210149081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056150539","display_name":"Anna Caroline Campos Aguiar","orcid":"https://orcid.org/0000-0003-0139-8279","observed_orcids":["https://orcid.org/0000-0003-0139-8279"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anna Caroline Campos Aguiar","raw_affiliation_strings":["Department of Microbiology, Immunology, and Parasitology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Parasitology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042073653","display_name":"Zolt\u00e1n Lipinszki","orcid":"https://orcid.org/0000-0002-2067-0832","observed_orcids":["https://orcid.org/0000-0002-2067-0832"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210155639","display_name":"Institute of Genetics","ror":"https://ror.org/04tjemt46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zoltan Lipinszki","raw_affiliation_strings":["ATGandCo Biotechnology Ltd, 6782 M\u00f3rahalom, Hungary","National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ATGandCo Biotechnology Ltd, 6782 M\u00f3rahalom, Hungary","institution_ids":[]},{"raw_affiliation_string":"National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I4387152226"]},{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, 6726 Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I4387152226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067992777","display_name":"Norbert Pardi","orcid":"https://orcid.org/0000-0003-1008-6242","observed_orcids":["https://orcid.org/0000-0003-1008-6242"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Norbert Pardi","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034619264","display_name":"Daniel Y. Bargieri","orcid":"https://orcid.org/0000-0003-2564-3742","observed_orcids":["https://orcid.org/0000-0003-2564-3742"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daniel Youssef Bargieri","raw_affiliation_strings":["Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2564-3742","affiliations":[{"raw_affiliation_string":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5034619264","https://openalex.org/A5067992777"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I79576946"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65412249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"103083","last_page":"103083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9110000133514404},{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.996999979019165},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.6700000166893005},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.7020000219345093},{"id":"https://openalex.org/keywords/plasmodium-reichenowi","display_name":"Plasmodium reichenowi","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7620999813079834},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5361999869346619},{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.4343999922275543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41530001163482666},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.41130000352859497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38989999890327454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35510000586509705},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.25929999351501465},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.omtn.2026.103083","doi":"https://doi.org/10.1016/j.omtn.2026.103083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103083","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13594723","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13594723/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13594723/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:42774878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42774878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2026.103083","doi":"https://doi.org/10.1016/j.omtn.2026.103083","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103083","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1150011823","display_name":null,"funder_award_id":"2022\u20102.1.1\u2010NL\u20102022\u201000008","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G128416949","display_name":null,"funder_award_id":"LP2017-7/2017","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G1456663148","display_name":null,"funder_award_id":"2021-1.1.4-GYORS\\u00CDT\\u00D3S\\u00C1V-2022-00008","funder_id":"https://openalex.org/F4320322193","funder_display_name":"Nemzeti Kutat\u00e1si \u00e9s Technol\u00f3giai Hivatal"},{"id":"https://openalex.org/G2137982084","display_name":"The UCI Vaccines for Pandemic Preparedness Center (VPPC)","funder_award_id":"U19AI181968","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3059208328","display_name":null,"funder_award_id":"2022-2.1.1-NL","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G3887993478","display_name":null,"funder_award_id":"2022-2.1.1-NL-2022-00005","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G4002205913","display_name":null,"funder_award_id":"739593","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G4675393368","display_name":null,"funder_award_id":"LP2017","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G5057311583","display_name":null,"funder_award_id":"2022-2.1.1-NL-2022-00008","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G5074127172","display_name":null,"funder_award_id":"2022\u20102.1.1\u2010NL\u20102022\u201000005","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G523680477","display_name":null,"funder_award_id":"2022-2.1.1-NL-2022-00008","funder_id":"https://openalex.org/F4320322193","funder_display_name":"Nemzeti Kutat\u00e1si \u00e9s Technol\u00f3giai Hivatal"},{"id":"https://openalex.org/G7445687531","display_name":null,"funder_award_id":"2022/00204-4","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8020708829","display_name":"Design and Development of a Pan-betacoronavirus Vaccine","funder_award_id":"P01AI158571","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8192111520","display_name":"Discovery of vaccine targets and compounds against Malaria transmission","funder_award_id":"21/06769-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8760335370","display_name":null,"funder_award_id":"739593","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G9000905804","display_name":"Lipid nanoparticle adjuvants for mRNA vaccines: composition-function relation and mechanism of action","funder_award_id":"R01AI153064","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320322193","display_name":"Nemzeti Kutat\u00e1si \u00e9s Technol\u00f3giai Hivatal","ror":"https://ror.org/03g2am276"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1976570057","https://openalex.org/W1994127090","https://openalex.org/W2002932555","https://openalex.org/W2003929892","https://openalex.org/W2004268547","https://openalex.org/W2046091098","https://openalex.org/W2068961074","https://openalex.org/W2071920067","https://openalex.org/W2101191292","https://openalex.org/W2101766603","https://openalex.org/W2115150674","https://openalex.org/W2146184301","https://openalex.org/W2160358721","https://openalex.org/W2414563893","https://openalex.org/W2538382920","https://openalex.org/W2612334930","https://openalex.org/W2750513907","https://openalex.org/W2765989691","https://openalex.org/W2784798198","https://openalex.org/W2799781675","https://openalex.org/W2802362769","https://openalex.org/W2802953285","https://openalex.org/W2806945765","https://openalex.org/W2807656595","https://openalex.org/W2898154893","https://openalex.org/W2915388137","https://openalex.org/W2934476057","https://openalex.org/W2969974048","https://openalex.org/W2975114208","https://openalex.org/W3008323327","https://openalex.org/W3025286601","https://openalex.org/W3122178751","https://openalex.org/W3135750809","https://openalex.org/W3177181935","https://openalex.org/W3198564411","https://openalex.org/W3205353257","https://openalex.org/W4200269625","https://openalex.org/W4212843503","https://openalex.org/W4284971906","https://openalex.org/W4291019342","https://openalex.org/W4307475654","https://openalex.org/W4316877854","https://openalex.org/W4385496703","https://openalex.org/W4385701556","https://openalex.org/W4389741250","https://openalex.org/W4390610724","https://openalex.org/W4399182554","https://openalex.org/W4402635999","https://openalex.org/W4402926577","https://openalex.org/W4403113763","https://openalex.org/W4406480552","https://openalex.org/W4406562514","https://openalex.org/W4409460088","https://openalex.org/W4412736158"],"related_works":["https://openalex.org/W1980458440","https://openalex.org/W7098989910","https://openalex.org/W4406480552","https://openalex.org/W2784755497","https://openalex.org/W4413883103","https://openalex.org/W4412736158","https://openalex.org/W4389741250","https://openalex.org/W4309764942","https://openalex.org/W7198728068","https://openalex.org/W4365148453"],"abstract_inverted_index":{"Plasmodium":[0,40],"vivax":[1,55,103],"(Pv)":[2],"remains":[3],"the":[4,23],"primary":[5,98],"cause":[6],"of":[7,28,97],"malaria":[8],"outside":[9],"Africa,":[10],"yet":[11],"no":[12],"licensed":[13],"vaccine":[14],"is":[15],"available":[16],"against":[17,48,126],"this":[18],"pathogen.":[19],"Here,":[20],"we":[21],"evaluate":[22],"immunogenicity":[24],"and":[25,53,68,81],"protective":[26],"efficacy":[27],"novel":[29],"vaccines":[30,47,125],"targeting":[31],"E140,":[32],"a":[33,119],"recently":[34],"identified":[35],"multi-stage":[36],"antigen":[37,121],"conserved":[38],"across":[39],"species.":[41],"Lipid":[42],"nanoparticle":[43],"(LNP)-formulated":[44],"nucleoside-modified":[45],"mRNA":[46],"P.":[49,54,102,127],"berghei":[50],"E140":[51,56,116],"(PbE140)":[52],"(PvE140)":[57],"induced":[58],"robust":[59],"antigen-specific":[60],"IgG":[61],"antibody":[62],"responses,":[63],"germinal":[64],"center":[65],"B":[66],"cell,":[67],"long-lived":[69],"plasma":[70],"cell":[71],"responses.":[72],"Vaccination":[73],"with":[74],"PbE140":[75],"mRNA-LNP":[76,92],"resulted":[77],"in":[78,84,93,107],"reduced":[79,95],"parasitemia":[80],"improved":[82],"survival":[83],"pathogen-challenged":[85],"mice.":[86],"Importantly,":[87],"antibodies":[88],"elicited":[89],"by":[90,101,105],"PvE140":[91],"mice":[94],"invasion":[96],"human":[99],"reticulocytes":[100],"merozoites":[104],"56%\u201378%":[106],"ex":[108],"vivo":[109],"functional":[110],"assays.":[111],"These":[112],"findings":[113],"suggest":[114],"that":[115],"may":[117],"be":[118],"promising":[120],"candidate":[122],"for":[123],"next-generation":[124],"vivax.":[128]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-03T00:00:00"}
