{"id":"https://openalex.org/W7206201359","doi":"https://doi.org/10.1093/sexmed/qfag075","title":"Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank","display_name":"Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank","publication_year":2026,"publication_date":"2026-07-23","ids":{"openalex":"https://openalex.org/W7206201359","doi":"https://doi.org/10.1093/sexmed/qfag075","pmid":"https://pubmed.ncbi.nlm.nih.gov/42689252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13537451"},"language":"en","primary_location":{"id":"doi:10.1093/sexmed/qfag075","doi":"https://doi.org/10.1093/sexmed/qfag075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfag075","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/sexmed/qfag075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087043684","display_name":"Kaixian Wang","orcid":"https://orcid.org/0009-0003-1919-2719","observed_orcids":["https://orcid.org/0009-0003-1919-2719"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai-Xian Wang","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine , Jinan 250355 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":"https://orcid.org/0009-0003-1919-2719","affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine , Jinan 250355 ,","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005857584","display_name":"Bao-Peng Liu","orcid":"https://orcid.org/0000-0003-1277-7397","observed_orcids":["https://orcid.org/0000-0003-1277-7397"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Peng Liu","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002055762","display_name":"Jianing Wang","orcid":"https://orcid.org/0000-0001-5752-9050","observed_orcids":["https://orcid.org/0000-0001-5752-9050","https://orcid.org/0009-0002-0115-491X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Ning Wang","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149231947","display_name":"Kai-Zheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai-Zheng Wang","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine , Jinan 250355 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine , Jinan 250355 ,","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149411248","display_name":"Yi-Zhan He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Zhan He","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128641054","display_name":"Meng-Yao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-Yao Yu","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126002412","display_name":"Zi\u2010Ming Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi-Ming Shao","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128663673","display_name":"Long Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Long Sun","raw_affiliation_strings":["Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Health Commission of China (NHC) Key Lab of Health Economics and Policy Research (Shandong University) , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Psychiatry and Psychology, Cheeloo College of Medicine, Shandong University , Jinan 250012 ,","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149413661","display_name":"Mei-Xia Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151294","display_name":"Shandong Women\u2019s University","ror":"https://ror.org/03rp8h078","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mei-Xia Xu","raw_affiliation_strings":["School of Marxism, Shandong Women\u2019s University , Jinan 250300 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Marxism, Shandong Women\u2019s University , Jinan 250300 ,","institution_ids":["https://openalex.org/I4210151294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5128663673","https://openalex.org/A5149413661"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210151294"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62220003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"6","first_page":"qfag075","last_page":"qfag075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10327","display_name":"Adolescent Sexual and Reproductive Health","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-at-sexual-debut","display_name":"age at first sexual intercourse","score":0.9890000224113464},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sexual-initiation","display_name":"sexual initiation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/frailty-index","display_name":"frailty index","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6230000257492065},{"id":"https://openalex.org/keywords/nonlinear-relationship","display_name":"nonlinear relationship","score":0.6949999928474426},{"id":"https://openalex.org/keywords/threshold-effects","display_name":"threshold effects","score":0.621999979019165},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8119999766349792},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.44699999690055847},{"id":"https://openalex.org/keywords/life-course-trajectories","display_name":"life course trajectories","score":0.746999979019165},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.8460000157356262},{"id":"https://openalex.org/keywords/uk-biobank","display_name":"UK Biobank","score":0.9990000128746033},{"id":"https://openalex.org/keywords/restricted-cubic-splines","display_name":"restricted cubic splines","score":0.3970000147819519},{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.44600000977516174},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7800999879837036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7781999707221985},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.7487000226974487},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6915000081062317},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6710000038146973},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.5960000157356262},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.5360000133514404},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4471000134944916},{"id":"https://openalex.org/C2780202899","wikidata":"https://www.wikidata.org/wiki/Q5873","display_name":"Sexual intercourse","level":3,"score":0.3675999939441681},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3650999963283539},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.36489999294281006},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C2909041561","wikidata":"https://www.wikidata.org/wiki/Q25099514","display_name":"Frailty Index","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C121752807","wikidata":"https://www.wikidata.org/wiki/Q1981388","display_name":"Reproductive health","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/sexmed/qfag075","doi":"https://doi.org/10.1093/sexmed/qfag075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfag075","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13537451","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13537451/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13537451/pdf/qfag075.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sex Med","raw_type":"Text"},{"id":"pmid:42689252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42689252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/sexmed/qfag075","doi":"https://doi.org/10.1093/sexmed/qfag075","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfag075","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.645897626876831}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1486447921","display_name":null,"funder_award_id":"72574129","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5766255708","display_name":null,"funder_award_id":"91536","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G7642067595","display_name":null,"funder_award_id":"ZR2021QH310","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W2082704080","https://openalex.org/W2139518613","https://openalex.org/W2581245397","https://openalex.org/W2950392934","https://openalex.org/W2979434443","https://openalex.org/W2981752833","https://openalex.org/W3080182863","https://openalex.org/W3080994732","https://openalex.org/W3083327215","https://openalex.org/W3176120982","https://openalex.org/W3194731752","https://openalex.org/W3209956002","https://openalex.org/W4210860962","https://openalex.org/W4255815262","https://openalex.org/W4307283821","https://openalex.org/W4313837356","https://openalex.org/W4317727901","https://openalex.org/W4363646188","https://openalex.org/W4366483564","https://openalex.org/W4388229512","https://openalex.org/W4393259724","https://openalex.org/W4394953820","https://openalex.org/W4396611675","https://openalex.org/W4398206800","https://openalex.org/W4399380833","https://openalex.org/W4402275764","https://openalex.org/W4402939748","https://openalex.org/W4405276729","https://openalex.org/W4405494601","https://openalex.org/W4408037228","https://openalex.org/W4409148755","https://openalex.org/W4410769194","https://openalex.org/W4410974000","https://openalex.org/W4416445386"],"related_works":["https://openalex.org/W4390202203","https://openalex.org/W4393259724","https://openalex.org/W7135040922","https://openalex.org/W4407870241","https://openalex.org/W4319967860","https://openalex.org/W7162582001","https://openalex.org/W7134830942","https://openalex.org/W7084189064","https://openalex.org/W7167924533","https://openalex.org/W4386022906"],"abstract_inverted_index":{"Introduction:":[0],"Age":[1],"at":[2],"first":[3,183,228],"sexual":[4,11,338,347],"intercourse":[5],"(AFS)":[6],"is":[7],"an":[8,301,343],"indicator":[9],"of":[10,82,178,205,221,240,250,270,320],"initiation":[12],"and":[13,36,38,43,84,87,92,130,153,158,184,195,255,293,306,315,336],"may":[14,324],"reflect":[15],"broader":[16],"life-course":[17],"trajectories,":[18],"but":[19],"its":[20],"relationship":[21],"with":[22,61,105,117,167,174,267,286],"frailty":[23,37,79,107,154,168,222,241,295,328],"remains":[24],"unclear.":[25],"To":[26],"examine":[27],"genetic":[28,283],"evidence":[29,284,319],"for":[30,346],"a":[31,78,287],"potential":[32,288],"association":[33,289,303],"between":[34,90,151,290],"AFS":[35,62,67,91,102,152,160,264,292,323],"to":[39,115,128,138,327],"characterize":[40],"nonlinear,":[41],"threshold,":[42],"sex-specific":[44],"patterns":[45],"in":[46,120,155,169,181,223,226,242,253,258,331],"population-based":[47,298],"observational":[48,141],"analyses.":[49,172],"Methods:":[50],"=":[51,110,123,133,190,198,214,233],"109":[52],"449)":[53],"among":[54,304],"participants":[55,180,225],"aged":[56],"50":[57],"years":[58,69,162,252,257],"or":[59],"older":[60,307],"\u226515":[63],"years.":[64],"Participants":[65],"reporting":[66],"<15":[68,161],"were":[70,275],"analyzed":[71],"separately.":[72],"Frailty":[73],"status":[74],"was":[75,103,163,265],"defined":[76],"using":[77],"index":[80],"cutoff":[81],">0.21,":[83],"the":[85,170,175,182,227],"nonlinear":[86],"threshold":[88],"associations":[89,150,274],"frailty.":[93],"Results:":[94],"MR":[95,280],"analyses":[96,245,281,299],"showed":[97,147,300],"that":[98],"genetically":[99],"predicted":[100],"earlier":[101,291],"associated":[104,166,266],"higher":[106,203,238,294],"risk":[108,329],"(\u03b2":[109,122,132],"-0.30;":[111],"95%":[112,125,135,192,200,216,235],"CI,":[113,126,136,201,217,236],"-0.36":[114],"-0.25),":[116],"similar":[118],"estimates":[119],"males":[121],"-0.23;":[124],"-0.30":[127,137],"-0.16)":[129],"females":[131],"-0.22;":[134],"-0.13).":[139],"In":[140],"analyses,":[142],"restricted":[143],"cubic":[144],"spline":[145],"models":[146],"significant":[148],"L-shaped":[149,302],"both":[156],"NHANES":[157,254],"UKB.":[159,243,259],"not":[164,276,316],"significantly":[165],"overall":[171],"Compared":[173],"third":[176],"quintile":[177,229],"AFS,":[179],"second":[185],"quintiles":[186,210],"had":[187,211,230],"61%":[188],"(OR":[189,197,213,232],"1.61,":[191],"CI:":[193],"1.40-1.85)":[194],"19%":[196],"1.19,":[199],"1.05-1.41)":[202],"odds":[204,220,239,269],"frailty,":[206],"respectively,":[207],"whereas":[208],"fifth":[209],"23%":[212],"0.77,":[215],"0.64-0.91)":[218],"lower":[219,268],"NHANES;":[224],"34%":[231],"1.34,":[234],"1.18-1.52)":[237],"Threshold":[244],"identified":[246],"integer":[247],"cut":[248],"points":[249],"21":[251],"23":[256],"Below":[260],"these":[261],"thresholds,":[262],"later":[263,330],"frailty;":[271],"above":[272],"them,":[273],"statistically":[277],"significant.":[278],"Conclusion:":[279],"provided":[282],"consistent":[285],"risk,":[296],"while":[297],"middle-aged":[305],"adults.":[308],"These":[309],"findings":[310],"should":[311],"be":[312,325],"interpreted":[313],"cautiously":[314],"as":[317],"definitive":[318],"causality.":[321],"Earlier":[322],"relevant":[326],"life,":[332],"supporting":[333],"safe,":[334],"informed,":[335],"rights-based":[337],"development":[339],"rather":[340],"than":[341],"defining":[342],"optimal":[344],"age":[345],"debut.":[348]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-03T00:00:00"}