{"id":"https://openalex.org/W72055241","doi":null,"title":"A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.","display_name":"A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W72055241","mag":"72055241","pmid":"https://pubmed.ncbi.nlm.nih.gov/6619647"},"language":"en","primary_location":{"id":"pmid:6619647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6619647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111738488","display_name":"Kjell S. Sakar\u00edassen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K S Sakariassen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023922050","display_name":"P.A.M.M. Aarts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Aarts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660553","display_name":"Philip G. de Groot","orcid":"https://orcid.org/0009-0008-7680-8651","observed_orcids":["https://orcid.org/0009-0008-7680-8651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P G de Groot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089172952","display_name":"Wim P. M. Houdijk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Houdijk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112141811","display_name":"Jan J. Sixma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Sixma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6747,"has_fulltext":false,"cited_by_count":363,"citation_normalized_percentile":{"value":0.93081568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"4","first_page":"522","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfusion-chamber","display_name":"perfusion chamber","score":0.9100000262260437},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.878000020980835},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9419999718666077},{"id":"https://openalex.org/keywords/wall-shear-rate","display_name":"wall shear rate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/laminar-flow","display_name":"laminar flow","score":0.8199999928474426},{"id":"https://openalex.org/keywords/platelet-deposition","display_name":"platelet deposition","score":0.7279999852180481},{"id":"https://openalex.org/keywords/triton-x-100","display_name":"Triton X-100","score":0.8090000152587891},{"id":"https://openalex.org/keywords/collagen-fibers","display_name":"collagen fibers","score":0.6620000004768372},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.890999972820282},{"id":"https://openalex.org/keywords/indium-111-labeled-platelets","display_name":"indium-111 labeled platelets","score":0.7730000019073486},{"id":"https://openalex.org/keywords/laser-doppler-velocimetry","display_name":"laser Doppler anemometry","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7353034019470215},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7351342439651489},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5629732608795166},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5555145740509033},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5518338680267334},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.45618098974227905},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4416922926902771},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42414945363998413},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4108906388282776},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3353840112686157},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3252025842666626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30414217710494995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23589083552360535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20918869972229004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1761573851108551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15663683414459229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10150215029716492},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07423833012580872}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D010973","descriptor_name":"Platelet Adhesiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:6619647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6619647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:72055241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6619647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1495037852","https://openalex.org/W2079184391","https://openalex.org/W2561824243","https://openalex.org/W2783224704","https://openalex.org/W2077073832","https://openalex.org/W2362718365","https://openalex.org/W2360705987","https://openalex.org/W2396465336","https://openalex.org/W2052319375","https://openalex.org/W2945979514"],"abstract_inverted_index":{"A":[0,36,232],"flat":[1],"perfusion":[2,205],"chamber":[3,206],"was":[4,47,76,168],"developed":[5],"to":[6,71,95,127,165],"study":[7],"the":[8,50,106,133,160,173,189],"interaction":[9,220],"of":[10,102,116,121,136,159,178,218,234],"blood":[11,15,80,124],"platelets":[12,81,91,125],"in":[13,130],"flowing":[14],"with":[16,40,83,141,149,221],"cultured":[17],"human":[18],"vessel":[19],"wall":[20,99,235],"cells,":[21,123,223],"their":[22,224],"connective":[23,28,229],"tissue":[24,29,230],"matrix,":[25,226],"and":[26,64,105,188,210,215,227,238],"isolated":[27],"components":[30,46],"at":[31,59,98,112,244],"defined":[32],"shear":[33,68,100,236],"rate":[34,69],"conditions.":[35],"cover":[37,174],"slip":[38],"covered":[39],"endothelial":[41,96,107,122,137,222],"cells":[42,97,108,138,249],"or":[43,85,250],"extracellular":[44,128,161,225,251],"matrix":[45],"introduced":[48],"into":[49],"chamber.":[51],"Laser-Doppler":[52],"velocimetry":[53],"showed":[54,202],"a":[55,87,150,208],"symmetrical":[56,211],"flow":[57,60,212],"profile":[58],"rates":[61,101,237],"between":[62,132],"50":[63],"150":[65],"ml/min":[66],"(wall":[67],"300":[70],"1100":[72],"sec-1).":[73],"Platelet":[74,163,186],"deposition":[75],"estimated":[77],"by":[78,86,139,176,183],"using":[79],"labeled":[82],"indium-111":[84],"morphometric":[88],"method.":[89],"Blood":[90],"did":[92],"not":[93],"adhere":[94],"765":[103],"sec-1":[104],"remained":[109],"attached":[110],"for":[111,152],"least":[113],"10":[114],"min":[115],"perfusion.":[117],"In":[118],"preconfluent":[119],"cultures":[120],"adhered":[126],"material":[129],"areas":[131],"cells.":[134],"Removal":[135],"treatment":[140],"0.5%":[142],"Triton":[143],"X-100":[144],"induced":[145],"increased":[146],"platelet":[147,191,219],"adherence":[148,164,187],"preference":[151],"certain,":[153],"as":[154],"yet":[155],"unidentified,":[156],"fibrillar":[157],"structures":[158],"matrix.":[162],"equine":[166],"collagen":[167,180,198],"also":[169],"studied":[170],"after":[171],"coating":[172],"slips":[175],"spraying":[177],"small":[179],"droplets":[181],"followed":[182],"air":[184],"drying.":[185],"subsequent":[190],"aggregate":[192],"formation":[193],"occurred":[194],"predominantly":[195],"along":[196],"visible":[197],"fibers.":[199],"These":[200],"studies":[201],"that":[203],"this":[204],"has":[207],"laminar":[209],"allowing":[213],"qualitative":[214],"quantitative":[216],"investigation":[217],"pure":[228],"components.":[231],"variety":[233],"exposure":[239],"times":[240],"can":[241],"be":[242],"applied":[243],"controlled":[245],"conditions":[246],"without":[247],"removing":[248],"material.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
