{"id":"https://openalex.org/W7205364776","doi":null,"title":"ISA-VRD IMPROVES OUTCOMES IN HIGH-RISK (HR) NEWLY DIAGNOSED TRANSPLANT-INELIGIBLE MULTIPLE MYELOMA (NDMM TI) USING THE IMS/IMWG CONSENSUS HR DEFINITION: RESULTS FROM THE BENEFIT PHASE 3 TRIAL (IFM 2020-05)","display_name":"ISA-VRD IMPROVES OUTCOMES IN HIGH-RISK (HR) NEWLY DIAGNOSED TRANSPLANT-INELIGIBLE MULTIPLE MYELOMA (NDMM TI) USING THE IMS/IMWG CONSENSUS HR DEFINITION: RESULTS FROM THE BENEFIT PHASE 3 TRIAL (IFM 2020-05)","publication_year":2025,"publication_date":"2025-06-12","ids":{"openalex":"https://openalex.org/W7205364776"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-05559175v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05559175v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EHA congress 2025, Jun 2025, Milan, Italy. pp.PF727","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030565933","display_name":"Jill Corre","orcid":"https://orcid.org/0000-0003-1580-6106","observed_orcids":["https://orcid.org/0000-0003-1580-6106"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corre, Jill","raw_affiliation_strings":["IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047625349","display_name":"J\u00e9r\u00f4me Lambert","orcid":"https://orcid.org/0000-0001-7086-9295","observed_orcids":["https://orcid.org/0000-0001-7086-9295","https://orcid.org/0000-0001-9818-4431"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lambert, J\u00e9r\u00f4me","raw_affiliation_strings":["AP-HP - H\u00f4pital Saint-Louis [Paris] (1 Avenue Claude Vellefaux, 75010 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP - H\u00f4pital Saint-Louis [Paris] (1 Avenue Claude Vellefaux, 75010 Paris - France)","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064113917","display_name":"Arthur Bobin","orcid":"https://orcid.org/0000-0002-8416-391X","observed_orcids":["https://orcid.org/0000-0002-8416-391X"]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bobin, Arthur","raw_affiliation_strings":["CHU de Poitiers [La Mil\u00e9trie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (2 rue de la Mil\u00e9trie \u2013 86000 Poitiers \u2013 France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Poitiers [La Mil\u00e9trie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (2 rue de la Mil\u00e9trie \u2013 86000 Poitiers \u2013 France - France)","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036677725","display_name":"Salomon Manier","orcid":"https://orcid.org/0000-0001-7653-711X","observed_orcids":["https://orcid.org/0000-0001-7653-711X"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Manier, Salomon","raw_affiliation_strings":["CHRU Lille - Centre Hospitalier R\u00e9gional Universitaire [CHU Lille] (CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHRU Lille - Centre Hospitalier R\u00e9gional Universitaire [CHU Lille] (CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex - France)","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082698003","display_name":"Aurore Perrot","orcid":"https://orcid.org/0000-0003-0131-8689","observed_orcids":["https://orcid.org/0000-0003-0131-8689"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Perrot, Aurore","raw_affiliation_strings":["IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027311948","display_name":"Lionel Karlin","orcid":"https://orcid.org/0000-0002-1185-4488","observed_orcids":["https://orcid.org/0000-0002-1185-4488"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karlin, Lionel","raw_affiliation_strings":["CHLS - Centre Hospitalier Lyon Sud [CHU - HCL] (165 Chemin du Grand Revoyet69495 Pierre-B\u00e9nite - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHLS - Centre Hospitalier Lyon Sud [CHU - HCL] (165 Chemin du Grand Revoyet69495 Pierre-B\u00e9nite - France)","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008275706","display_name":"Nicolas Bigot","orcid":"https://orcid.org/0009-0005-4591-0205","observed_orcids":["https://orcid.org/0009-0005-4591-0205","https://orcid.org/0000-0002-4247-0217"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bigot, No\u00e9mie","raw_affiliation_strings":["AP-HP - Assistance publique - H\u00f4pitaux de Paris (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP - Assistance publique - H\u00f4pitaux de Paris (France)","institution_ids":["https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013996935","display_name":"Kamel Laribi","orcid":"https://orcid.org/0000-0002-4389-6164","observed_orcids":["https://orcid.org/0000-0002-4389-6164","https://orcid.org/0000-0001-5589-7570","https://orcid.org/0009-0004-8177-7870"]},"institutions":[{"id":"https://openalex.org/I4210125982","display_name":"Centre Hospitalier du Mans","ror":"https://ror.org/03bf2nz41","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210125982"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laribi, Kamel","raw_affiliation_strings":["Centre Hospitalier Le Mans (CH Le Mans) (Centre Hospitalier Le Mans194 av. Rubillard 72037 LE MANS CEDEX 9 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Le Mans (CH Le Mans) (Centre Hospitalier Le Mans194 av. Rubillard 72037 LE MANS CEDEX 9 - France)","institution_ids":["https://openalex.org/I4210125982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091463936","display_name":"Laurent Frenzel","orcid":"https://orcid.org/0000-0002-6085-2163","observed_orcids":["https://orcid.org/0000-0002-6085-2163"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frenzel, Laurent","raw_affiliation_strings":["AP-HP - H\u00f4pital Necker - Enfants Malades (149 Rue de S\u00e8vres 75015 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP - H\u00f4pital Necker - Enfants Malades (149 Rue de S\u00e8vres 75015 Paris - France)","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109100849","display_name":"Olivier Decaux","orcid":"https://orcid.org/0000-0003-2361-9669","observed_orcids":["https://orcid.org/0000-0003-2361-9669"]},"institutions":[{"id":"https://openalex.org/I4210155724","display_name":"Centre Hospitalier Universitaire de Rennes","ror":"https://ror.org/05qec5a53","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Decaux, Olivier","raw_affiliation_strings":["Service de M\u00e9decine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes] (CHU Rennes - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes] (CHU Rennes - France)","institution_ids":["https://openalex.org/I4210155724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016941619","display_name":"Bertrand Arnulf","orcid":"https://orcid.org/0000-0001-7719-3611","observed_orcids":["https://orcid.org/0000-0001-7719-3611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnulf, Bertrand","raw_affiliation_strings":["Service d'h\u00e9matologie biologique (75010 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'h\u00e9matologie biologique (75010 Paris - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002662805","display_name":"Karim Belhadj Merzoug","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belhadj Merzoug, Karim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003104663","display_name":"Ana\u00efs Schavgoulidze","orcid":"https://orcid.org/0000-0002-5526-4279","observed_orcids":["https://orcid.org/0000-0002-5526-4279"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Schavgoulidze, Ana\u00efs","raw_affiliation_strings":["IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IUCT Oncopole (Av. Ir\u00e8ne Joliot-Curie 31100 Toulouse - France)","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058940187","display_name":"Cyrille Touzeau","orcid":"https://orcid.org/0000-0003-0275-2575","observed_orcids":["https://orcid.org/0000-0003-0275-2575"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Touzeau, Cyrille","raw_affiliation_strings":["CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (1 Place Alexis-Ricordeau, 44000 Nantes - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (1 Place Alexis-Ricordeau, 44000 Nantes - France)","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020996390","display_name":"Mohamad Mohty","orcid":"https://orcid.org/0000-0002-7264-808X","observed_orcids":["https://orcid.org/0000-0002-7264-808X","https://orcid.org/0000-0001-8536-7781"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohty, Mohamad","raw_affiliation_strings":["AP-HP - H\u00f4pital Saint-Antoine (184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP - H\u00f4pital Saint-Antoine (184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12 - France)","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143602","display_name":"Philippe Moreau","orcid":"https://orcid.org/0000-0003-1780-8746","observed_orcids":["https://orcid.org/0000-0003-1780-8746"]},"institutions":[{"id":"https://openalex.org/I4210091049","display_name":"Institut des Mat\u00e9riaux Jean Rouxel","ror":"https://ror.org/00cqpd580","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210091049","https://openalex.org/I4210128300","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Moreau, Philippe","raw_affiliation_strings":["IMN - Institut des Mat\u00e9riaux de Nantes Jean Rouxel (Campus Sciences 2 Rue de la Houssini\u00e8re - BP 32229 44322 NANTES CEDEX 3 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMN - Institut des Mat\u00e9riaux de Nantes Jean Rouxel (Campus Sciences 2 Rue de la Houssini\u00e8re - BP 32229 44322 NANTES CEDEX 3 - France)","institution_ids":["https://openalex.org/I4210091049","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024315315","display_name":"Thierry T.F. Facon","orcid":"https://orcid.org/0000-0001-7705-8460","observed_orcids":["https://orcid.org/0000-0001-7705-8460"]},"institutions":[{"id":"https://openalex.org/I4210155195","display_name":"H\u00f4pital Claude Huriez","ror":"https://ror.org/05cpv3t46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210155195"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I2800365227","https://openalex.org/I4210159433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Facon, Thierry","raw_affiliation_strings":["H\u00f4pital Claude Huriez [Lille] (rue Michel Polonowski, 59000 Lille - France)","IMRB - Institut Mondor de Recherche Biom\u00e9dicale (8 rue du G\u00e9n\u00e9ral Sarrail 94010 Cr\u00e9teil - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Claude Huriez [Lille] (rue Michel Polonowski, 59000 Lille - France)","institution_ids":["https://openalex.org/I4210155195"]},{"raw_affiliation_string":"IMRB - Institut Mondor de Recherche Biom\u00e9dicale (8 rue du G\u00e9n\u00e9ral Sarrail 94010 Cr\u00e9teil - France)","institution_ids":["https://openalex.org/I4210159433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089853890","display_name":"Cyrille Hulin","orcid":"https://orcid.org/0000-0002-3749-5161","observed_orcids":["https://orcid.org/0000-0002-3749-5161"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hulin, Cyrille","raw_affiliation_strings":["CHRU Nancy - Centre Hospitalier R\u00e9gional Universitaire de Nancy (Si\u00e8ge social : 29 avenue du Mar\u00e9chal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXH\u00f4pital Central : 29 Avenue du Mar\u00e9chal de Lattre de Tassigny, 54035 NancyH\u00f4pitaux de Brabois / Enfants : Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-NancyMaternit\u00e9 r\u00e9gionale :10 Avenue Dr Heydenreich, 54000 Nancy - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHRU Nancy - Centre Hospitalier R\u00e9gional Universitaire de Nancy (Si\u00e8ge social : 29 avenue du Mar\u00e9chal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXH\u00f4pital Central : 29 Avenue du Mar\u00e9chal de Lattre de Tassigny, 54035 NancyH\u00f4pitaux de Brabois / Enfants : Rue du Morvan, 54500 Vand\u0153uvre-l\u00e8s-NancyMaternit\u00e9 r\u00e9gionale :10 Avenue Dr Heydenreich, 54000 Nancy - France)","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048560248","display_name":"Xavier P Leleu","orcid":"https://orcid.org/0000-0002-9822-4170","observed_orcids":["https://orcid.org/0000-0002-9822-4170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leleu, Xavier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.92211838,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"F727","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isatuximab","display_name":"isatuximab","score":0.8309999704360962},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.843999981880188},{"id":"https://openalex.org/keywords/transplant-ineligible-multiple-myeloma","display_name":"transplant-ineligible multiple myeloma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/newly-diagnosed-multiple-myeloma","display_name":"newly diagnosed multiple myeloma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-risk-disease","display_name":"high-risk disease","score":0.7390000224113464},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8187000155448914},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7174000144004822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5742999911308289},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5727999806404114},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3522000014781952},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29510000348091125},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-05559175v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05559175v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EHA congress 2025, Jun 2025, Milan, Italy. pp.PF727","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7108439575","https://openalex.org/W4405038886","https://openalex.org/W4414302907","https://openalex.org/W4405044083","https://openalex.org/W4417013327","https://openalex.org/W4399480687","https://openalex.org/W7131814875","https://openalex.org/W4399280297","https://openalex.org/W4417012542","https://openalex.org/W4405042005"],"abstract_inverted_index":{"Background:Isa-VRd":[0],"has":[1,20],"become":[2],"a":[3,48,99],"new":[4,163,375],"standard":[5],"of":[6,102,343],"care":[7],"(SOC)":[8],"in":[9,31,34,47,89,134,138,144,209,216,230,299,310,351,358],"NDMM":[10,46,353,378],"TI":[11,43,379],"based":[12,61],"on":[13,62],"BENEFIT":[14,36,38,338],"and":[15,83,107,114,140,239,246,263,303],"IMROZ":[16],"studies.":[17],"The":[18],"IMS":[19,164],"recently":[21],"standardized":[22],"the":[23,28,35,63,112,125,129,151,162,168,210,217,231,260,271,282,300,311,326,337,344,374,386],"HR":[24,32,57,130,160,166,286,324,352,354],"definition.":[25],"We":[26],"investigated":[27],"Isa-VRd":[29,54,113,139,178,211,232,346,372],"regimen":[30,347],"patients":[33,44,110,137,143,149,207,380],"study.Methods:The":[37],"study":[39,339],"randomized":[40],"270":[41],"non-frail":[42],"with":[45,93,161,205],"1:1":[49],"ratio":[50,187],"to":[51,195,224,257,268,278,297,308,318,349,370,383],"receive":[52],"either":[53],"or":[55],"IsaRd.":[56],"status":[58,131],"was":[59,69,132,175,329],"defined":[60,70],"IMS/IMWG":[64,126],"consensus.":[65],"Sustained":[66],"MRD":[67,74,95,170,190,227,249,289,360,365],"negativity":[68,171,191,203,228,250,290,361],"as":[71,159,356,373],"3":[72],"consecutive":[73],"negative":[75],"assessments":[76],"(<10-5":[77],"by":[78],"NGS)":[79],"at":[80,173,237,240,243],"12,":[81],"18":[82,296],"24":[84,241],"months.":[85],"Data":[86],"are":[87],"presented":[88],"an":[90],"ITT":[91],"analysis":[92],"missing":[94],"values":[96],"considered":[97],"positive.Results:At":[98],"median":[100],"follow-up":[101],"33.4":[103],"months,":[104],"37":[105],"(27%)":[106,215],"50":[108],"(37%)":[109],"across":[111],"IsaRd":[115,350],"arms,":[116],"respectively,":[117],"had":[118],"ended":[119],"therapy,":[120],"mostly":[121],"for":[122,177,189,259,270,281,377],"disease":[123],"progression.Using":[124],"consensus":[127],"definition,":[128],"identified":[133],"42":[135],"(31%)":[136],"30":[141],"(22%)":[142],"Isa-Rd.":[145],"Overall,":[146],"49/247":[147],"(18%)":[148],"from":[150,336],"favorable/intermediate":[152],"IFM":[153],"LP":[154],"score":[155],"category":[156],"were":[157,199,234,252,292],"reclassified":[158],"criteria.Among":[165],"patients,":[167,287,325,355],"18-months":[169],"rate":[172],"10-5":[174,245],"higher":[176],"than":[179],"Isa-Rd,":[180],"50%":[181],"(n=21)":[182],"vs":[183,213],"27%":[184],"(n=8)":[185],"[odds":[186],"(OR)":[188],"2.75":[192],"(95%CI,":[193,222,276],"1":[194],"7.5)].":[196],"Similar":[197],"data":[198,321,368],"observed":[200,236],"using":[201],"10-6":[202,247],"threshold,":[204],"19":[206],"(45%)":[208],"arm":[212,219,233],"8":[214],"Isa-Rd":[218,272,312],"[OR":[220],"2.27":[221],"0,8":[223],"6.25)].":[225],"Higher":[226],"rates":[229,251,291],"also":[235],"12":[238],"months":[242],"both":[244,333],"thresholds.Sustained":[248],"34%":[253],"[n=46,":[254],"95%CI,":[255,266,295,306],"26":[256],"43]":[258],"Isa-VRD":[261,301],"group":[262,302,313],"16%":[264],"[n=22,":[265],"11":[267],"24]":[269],"group,":[273],"(OR=":[274,314],"2.73":[275],"1.52":[277],"4.88,":[279],"p=0.0007),":[280],"whole":[283],"cohort.":[284],"In":[285],"sustained":[288,364],"31%":[293],"[n=13,":[294],"47]":[298],"13%":[304],"[n=4,":[305],"4":[307],"31]":[309],"2.91,":[315],"95%CI:":[316],"0.84":[317],"10.6,":[319],"p=0.091).Survival":[320],"remain":[322],"immature.In":[323],"safety":[327],"profile":[328],"no":[330],"different":[331],"between":[332],"arms.Summary/Conclusion:The":[334],"results":[335],"demonstrated":[340],"meaningful":[341],"advantage":[342],"quadruplet-based":[345],"compared":[348],"reflected":[357],"improved":[359],"rates,":[362],"including":[363],"negativity.":[366],"These":[367],"continue":[369],"support":[371],"SOC":[376],"aged":[381],"65":[382],"79,":[384],"replacing":[385],"current":[387],"triplet-based":[388],"SOC.":[389]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-02T00:00:00"}