{"id":"https://openalex.org/W7205089237","doi":null,"title":"New gamma carboline compounds usable in the treatment of neurodegenerative diseases","display_name":"New gamma carboline compounds usable in the treatment of neurodegenerative diseases","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W7205089237"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-05518846v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05518846v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Japan, Patent n\u00b0 : 6388456 ; IND15032-JP-PCT. 2018","raw_type":"info:eu-repo/semantics/patent"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010117098","display_name":"Patricia Melnyk","orcid":"https://orcid.org/0000-0002-9555-3446","observed_orcids":["https://orcid.org/0000-0002-9555-3446"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Melnyk, Patricia","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091590853","display_name":"Pascal Carato","orcid":"https://orcid.org/0000-0002-8893-5155","observed_orcids":["https://orcid.org/0000-0002-8893-5155"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carato, Pascal","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040583320","display_name":"St\u00e9phane Burlet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Burlet, St\u00e9phane","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nguyen, Thi, Hien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nguyen, Thi, Hien","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014873420","display_name":"Philippe Verwaerde","orcid":"https://orcid.org/0000-0002-0184-1990","observed_orcids":["https://orcid.org/0000-0002-0184-1990"]},"institutions":[{"id":"https://openalex.org/I4210100895","display_name":"Eurasant\u00e9","ror":"https://ror.org/0165tjs71","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210100895"]},{"id":"https://openalex.org/I4405265732","display_name":"Alzprotect (France)","ror":"https://ror.org/05kk7gg34","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405265732"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Verwaerde, Philippe","raw_affiliation_strings":["Alzprotect - Alzprotect : Therapeutic solutions for neurodegeneration (Parc Eurasant\u00e9 \u2013 Le Galenis \u2013 85 rue Nelson Mandela \u2013 59120 Loos \u2013 France - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzprotect - Alzprotect : Therapeutic solutions for neurodegeneration (Parc Eurasant\u00e9 \u2013 Le Galenis \u2013 85 rue Nelson Mandela \u2013 59120 Loos \u2013 France - France)","institution_ids":["https://openalex.org/I4210100895","https://openalex.org/I4405265732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046524146","display_name":"Nicolas Sergeant","orcid":"https://orcid.org/0000-0003-1448-124X","observed_orcids":["https://orcid.org/0000-0003-1448-124X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sergeant, Nicolas","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","Universit\u00e9 de Lille (EPE Universit\u00e9 de Lille. -- 42 rue Paul Duez, 59000 Lille - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]},{"raw_affiliation_string":"Universit\u00e9 de Lille (EPE Universit\u00e9 de Lille. -- 42 rue Paul Duez, 59000 Lille - France)","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148957143","display_name":"Cecilia Estrella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Estrella, Cecilia","raw_affiliation_strings":["U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1172 Inserm - Equipe Alzheimer and Tauopathies - LilNCog (France)","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-carbolines","display_name":"\u03b3-carbolines","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.6909999847412109},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4587000012397766},{"id":"https://openalex.org/C2780615836","wikidata":"https://www.wikidata.org/wiki/Q2471869","display_name":"USable","level":2,"score":0.45260000228881836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3587000072002411},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3562999963760376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34220001101493835},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3319000005722046},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32330000400543213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29350000619888306},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2892000079154968},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27709999680519104}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:hal-05518846v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05518846v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Japan, Patent n\u00b0 : 6388456 ; IND15032-JP-PCT. 2018","raw_type":"info:eu-repo/semantics/patent"},{"id":"pmh:oai:HAL:hal-05518857v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05518857v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"United States, Patent n\u00b0 : 9,714,245 ; IND15032-US-PCT. 2017","raw_type":"info:eu-repo/semantics/patent"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7205184930","https://openalex.org/W7205112517","https://openalex.org/W7205132672","https://openalex.org/W3176334651","https://openalex.org/W2048897274","https://openalex.org/W1181779553","https://openalex.org/W6983573096","https://openalex.org/W3099654534","https://openalex.org/W2518796992","https://openalex.org/W3112326197"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}