{"id":"https://openalex.org/W7205028183","doi":null,"title":"Mitochondria-enriched extracellular vesicles as mediators and biomarkers of endothelial stress induced by polycyclic aromatic hydrocarbon mixtures","display_name":"Mitochondria-enriched extracellular vesicles as mediators and biomarkers of endothelial stress induced by polycyclic aromatic hydrocarbon mixtures","publication_year":2026,"publication_date":"2026-03-22","ids":{"openalex":"https://openalex.org/W7205028183"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-05597478v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05597478v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.toxicology.org/events/am/am2026","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chauvin, Camille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chauvin, Camille","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107686390","display_name":"Joan Guillouzouic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillouzouic, Joan","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058816164","display_name":"Valentine Gen\u00eat","orcid":"https://orcid.org/0009-0004-6638-9941","observed_orcids":["https://orcid.org/0009-0004-6638-9941"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Genet, Valentine","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149006913","display_name":"Eug\u00e9nie Vidal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802759292","display_name":"Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique Thermique et Optique - Sciences et Technologies","ror":"https://ror.org/004fmxv66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802759292","https://openalex.org/I37553959","https://openalex.org/I4210095849","https://openalex.org/I4405256580","https://openalex.org/I53262699"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vidal, Eug\u00e9nie","raw_affiliation_strings":["FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)","institution_ids":["https://openalex.org/I2802759292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148951303","display_name":"Amessird Hicham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802759292","display_name":"Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique Thermique et Optique - Sciences et Technologies","ror":"https://ror.org/004fmxv66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802759292","https://openalex.org/I37553959","https://openalex.org/I4210095849","https://openalex.org/I4405256580","https://openalex.org/I53262699"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hicham, Amessird","raw_affiliation_strings":["FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)","institution_ids":["https://openalex.org/I2802759292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103180832","display_name":"Agn\u00e8s Burel","orcid":"https://orcid.org/0000-0003-2990-3345","observed_orcids":["https://orcid.org/0000-0003-2990-3345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burel, Agn\u00e8s","raw_affiliation_strings":["MRic-TEM (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRic-TEM (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000159315","display_name":"Nina Soler","orcid":"https://orcid.org/0000-0002-6060-5461","observed_orcids":["https://orcid.org/0000-0002-6060-5461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soler, Nina","raw_affiliation_strings":["MRic-TEM (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRic-TEM (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106934518","display_name":"Florian Barathon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Barathon, Florian","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054140824","display_name":"Odile Sergent","orcid":"https://orcid.org/0000-0002-9488-2141","observed_orcids":["https://orcid.org/0000-0002-9488-2141"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sergent, Odile","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]},{"raw_affiliation_string":"UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)","institution_ids":["https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056517514","display_name":"Normand Podechard","orcid":"https://orcid.org/0000-0002-2638-3180","observed_orcids":["https://orcid.org/0000-0002-2638-3180"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Podechard, Normand","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]},{"raw_affiliation_string":"UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)","institution_ids":["https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021242692","display_name":"Chlo\u00e9 Cloteau","orcid":"https://orcid.org/0000-0002-3527-0698","observed_orcids":["https://orcid.org/0000-0002-3527-0698"]},"institutions":[{"id":"https://openalex.org/I4400008889","display_name":"UMS BioCore","ror":"https://ror.org/04r5nwv94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210096427","https://openalex.org/I4400008889","https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cloteau, Chlo\u00e9","raw_affiliation_strings":["BioCore [Nantes] (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioCore [Nantes] (France)","institution_ids":["https://openalex.org/I4400008889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036409697","display_name":"Josy\u2010Anne Froger","orcid":"https://orcid.org/0000-0003-3365-5284","observed_orcids":["https://orcid.org/0000-0003-3365-5284"]},"institutions":[{"id":"https://openalex.org/I4210144168","display_name":"Institut du Thorax","ror":"https://ror.org/049kkt456","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210144168","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Froger, Josy-Anne","raw_affiliation_strings":["ITX-lab - ITX-lab unit\u00e9 de recherche de l'institut du thorax UMR1087 UMR6291 (8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)","SCIAM - Service Commun d'Imagerie et d'Analyse Microscopique [SFR ICAT - UA] (Universit\u00e9 d'Angers | Institut de Biologie en Sant\u00e9 | Iris | CHU Rue Larrey 49933 ANGERS Cedex 09 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITX-lab - ITX-lab unit\u00e9 de recherche de l'institut du thorax UMR1087 UMR6291 (8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)","institution_ids":["https://openalex.org/I4210144168","https://openalex.org/I97188460"]},{"raw_affiliation_string":"SCIAM - Service Commun d'Imagerie et d'Analyse Microscopique [SFR ICAT - UA] (Universit\u00e9 d'Angers | Institut de Biologie en Sant\u00e9 | Iris | CHU Rue Larrey 49933 ANGERS Cedex 09 - France)","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024650279","display_name":"Soazig Le Lay","orcid":"https://orcid.org/0000-0003-2456-2422","observed_orcids":["https://orcid.org/0000-0003-2456-2422"]},"institutions":[{"id":"https://openalex.org/I4210144168","display_name":"Institut du Thorax","ror":"https://ror.org/049kkt456","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210144168","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Le Lay, Soazig","raw_affiliation_strings":["ITX-lab - ITX-lab unit\u00e9 de recherche de l'institut du thorax UMR1087 UMR6291 (8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITX-lab - ITX-lab unit\u00e9 de recherche de l'institut du thorax UMR1087 UMR6291 (8 quai Moncousu - BP 70721 - 44007 Nantes Cedex 1 - France)","institution_ids":["https://openalex.org/I4210144168","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048998029","display_name":"C\u00e9line \u00c9lie-Caille","orcid":"https://orcid.org/0000-0003-0154-2883","observed_orcids":["https://orcid.org/0000-0003-0154-2883"]},"institutions":[{"id":"https://openalex.org/I2802759292","display_name":"Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique Thermique et Optique - Sciences et Technologies","ror":"https://ror.org/004fmxv66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802759292","https://openalex.org/I37553959","https://openalex.org/I4210095849","https://openalex.org/I4405256580","https://openalex.org/I53262699"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elie-Caille, Celine","raw_affiliation_strings":["FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)","institution_ids":["https://openalex.org/I2802759292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021551940","display_name":"Benjamin Brunel","orcid":"https://orcid.org/0000-0003-2858-5074","observed_orcids":["https://orcid.org/0000-0003-2858-5074"]},"institutions":[{"id":"https://openalex.org/I2802759292","display_name":"Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique Thermique et Optique - Sciences et Technologies","ror":"https://ror.org/004fmxv66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802759292","https://openalex.org/I37553959","https://openalex.org/I4210095849","https://openalex.org/I4405256580","https://openalex.org/I53262699"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brunel, Benjamin","raw_affiliation_strings":["FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)","institution_ids":["https://openalex.org/I2802759292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105821860","display_name":"Wilfrid Boireau","orcid":"https://orcid.org/0000-0002-5667-8254","observed_orcids":["https://orcid.org/0000-0002-5667-8254"]},"institutions":[{"id":"https://openalex.org/I2802759292","display_name":"Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique Thermique et Optique - Sciences et Technologies","ror":"https://ror.org/004fmxv66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802759292","https://openalex.org/I37553959","https://openalex.org/I4210095849","https://openalex.org/I4405256580","https://openalex.org/I53262699"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Boireau, Wilfrid","raw_affiliation_strings":["FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FEMTO-ST - Franche-Comt\u00e9 \u00c9lectronique M\u00e9canique, Thermique et Optique - Sciences et Technologies (UMR 6174) (32 avenue de l'Observatoire 25044 BESANCON CEDEX - France)","institution_ids":["https://openalex.org/I2802759292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004054550","display_name":"Lydie Sparfel","orcid":"https://orcid.org/0000-0002-4877-7017","observed_orcids":["https://orcid.org/0000-0002-4877-7017"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sparfel, Lydie","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]},{"raw_affiliation_string":"UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)","institution_ids":["https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031978455","display_name":"Eric Le Ferrec","orcid":"https://orcid.org/0000-0002-2015-2779","observed_orcids":["https://orcid.org/0000-0002-2015-2779"]},"institutions":[{"id":"https://openalex.org/I4210108239","display_name":"Institut de Recherche en Sant\u00e9, Environnement et Travail","ror":"https://ror.org/01p178v10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I165283593","https://openalex.org/I4210108239","https://openalex.org/I49451733","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Le Ferrec, E.","raw_affiliation_strings":["Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irset - Institut de recherche en sant\u00e9, environnement et travail (263 avenue G\u00e9n\u00e9ral Leclerc 35042 Rennes Cedex - France)","institution_ids":["https://openalex.org/I4210108239"]},{"raw_affiliation_string":"UR - Universit\u00e9 de Rennes (Campus de Beaulieu, 263 avenue G\u00e9n\u00e9ral Leclerc, CS 74205, 35042 RENNES CEDEX - France)","institution_ids":["https://openalex.org/I56067802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 210 (issue S1)","issue":"3635","first_page":"255","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9670000076293945},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9290000200271606},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.875},{"id":"https://openalex.org/keywords/pah-mixtures","display_name":"PAH mixtures","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8220000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ev-subpopulations","display_name":"EV subpopulations","score":0.75},{"id":"https://openalex.org/keywords/ev-biomarkers","display_name":"EV biomarkers","score":0.49799999594688416},{"id":"https://openalex.org/keywords/hmec-1-cells","display_name":"HMEC-1 cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.5770000219345093},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.8659999966621399},{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7821000218391418},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5475000143051147},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.5275999903678894},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.44359999895095825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41620001196861267},{"id":"https://openalex.org/C2777207669","wikidata":"https://www.wikidata.org/wiki/Q43648","display_name":"Hydrocarbon","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3321000039577484},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3019999861717224},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C2777720266","wikidata":"https://www.wikidata.org/wiki/Q19834818","display_name":"Aromatic hydrocarbon","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-05597478v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05597478v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.toxicology.org/events/am/am2026","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2973063088","https://openalex.org/W4409130235","https://openalex.org/W3048352626","https://openalex.org/W7155588013","https://openalex.org/W2964356230","https://openalex.org/W4402666445","https://openalex.org/W4417476574","https://openalex.org/W3162334408","https://openalex.org/W3153389509","https://openalex.org/W4200110239"],"abstract_inverted_index":{"Background":[0],"and":[1,29,57,80,98,110,118,173,205,243,265,288,306,349,357,382,408,417,443],"Purpose:":[2],"Chronic":[3],"exposure":[4,317,393,424,434],"to":[5,23,54,87,131,148,226,387,394],"polycyclic":[6],"aromatic":[7],"hydrocarbons":[8],"(PAHs),":[9],"persistent":[10],"environmental":[11,438,451],"pollutants":[12],"commonly":[13],"found":[14],"in":[15,230,303],"food,":[16],"is":[17],"associated":[18,436],"with":[19,181,245,250,326,406,437],"mitochondrial":[20,71,78,100,206,285,380,441],"dysfunction,":[21],"leading":[22],"oxidative":[24,378],"stress,":[25,379],"impaired":[26],"energy":[27],"metabolism,":[28],"activation":[30],"of":[31,41,63,96,124,150,152,158,164,216,219,241,259,272,309,321,355,392,414,419,422],"apoptotic":[32],"pathways.":[33],"Mitochondria":[34],"are":[35,51],"thus":[36,444],"emerging":[37],"as":[38,281,283],"key":[39],"targets":[40],"PAH":[42,91,234,295,316,423],"toxicity.":[43],"Endothelial":[44],"cells,":[45,105,368],"located":[46],"at":[47],"the":[48,61,94,121,238,246,251,257,315,365,389,395,420],"blood-tissue":[49],"interface,":[50],"also":[52],"sensitive":[53],"circulating":[55],"PAHs":[56,132,227],"respond":[58],"by":[59,102,171,175,210],"increasing":[60],"production":[62],"extracellular":[64],"vesicles":[65],"(EVs).":[66],"These":[67,336],"EVs":[68,97,125,168,220,242,322],"may":[69],"carry":[70],"components":[72],"(Mito-":[73],"EVs),":[74],"which":[75],"could":[76,431],"reflect":[77],"status":[79],"mediate":[81],"intercellular":[82],"communi-cation.":[83],"This":[84,178,400],"study":[85],"aimed":[86],"(i)":[88],"assess":[89],"how":[90],"mixtures":[92],"influence":[93,421],"release":[95,240],"their":[99,111,284],"cargo":[101],"human":[103,165,371],"endothelial":[104,128,140],"(ii)":[106],"characterize":[107,388],"EV":[108,261,267,344,359,397,415,433],"subpopulations":[109,360,416],"biochemical":[112,217],"signatures":[113],"using":[114,332,369],"an":[115],"integrated":[116,401],"workflow,":[117,402],"(iii)":[119],"investigate":[120],"biological":[122,353],"effects":[123,248],"derived":[126,221],"from":[127,222,323],"cells":[129,141,224],"exposed":[130,144,225],"on":[133,364],"immune":[134,366],"recipient":[135,367],"cells.":[136,375],"Methods:":[137],"Human":[138],"microvascular":[139],"(HMEC-1)":[142],"were":[143,169,385],"for":[145,342,449],"24":[146],"h":[147],"100nM":[149],"benzo[a]pyrene,":[151],"a":[153,159,182,333,446],"4-PAH":[154],"regulatory":[155],"mixture,":[156],"or":[157,229,278],"complex":[160],"18-PAH":[161,252],"mixture":[162],"representative":[163],"dietary":[166],"exposure.":[167,296,452],"isolated":[170],"ultracentrifugation":[172],"fractionated":[174],"density-gradient":[176,404],"centrifugation.":[177],"fractionation,":[179],"combined":[180],"multi-approach":[183],"characterization":[184,413],"pipeline":[185],"nanoparticle":[186],"tracking":[187],"analysis,":[188],"transmission":[189],"electron":[190],"microscopy,":[191],"flow":[192],"cytometry,":[193],"Western":[194],"blot,":[195],"Raman":[196,297],"spectroscopy,":[197],"Surface":[198],"Plasmon":[199],"Resonance":[200],"imaging":[201],"(SPRi),":[202],"lipidomics,":[203],"proteomics,":[204],"DNA":[207],"(mtDNA)":[208],"quantification":[209],"digital":[211],"PCR":[212],"-":[213,275,280],"allows":[214],"identification":[215],"fingerprints":[218,435],"HMEC-1":[223],"alone":[228],"mixture.":[231,253],"Results:":[232],"All":[233],"exposures":[235],"significantly":[236],"increased":[237],"total":[239],"Mito-EVs,":[244],"strongest":[247],"observed":[249],"Density-gradient":[254],"fractionation":[255,405],"revealed":[256,338],"presence":[258,271],"distinct":[260,339],"subpopulations,":[262],"including":[263,347,440],"Mito-EVs":[264,356],"mitochondria-depleted":[266,358],"fractions.":[268,398],"The":[269,319,352],"intravesicular":[270],"intact":[273],"mitochondria":[274],"either":[276],"polarized":[277],"depolarized":[279],"well":[282],"protein,":[286],"lipid,":[287],"mtDNA":[289],"content,":[290],"was":[291,329,361],"subsequently":[292],"evaluated":[293],"after":[294],"spectroscopy":[298],"analyses":[299],"high-":[300],"lighted":[301],"modifications":[302],"both":[304],"quantity":[305],"secondary":[307],"structure":[308],"vesicular":[310],"proteins,":[311],"allowing":[312],"discrimination":[313],"between":[314],"conditions.":[318,427],"interaction":[320],"crude-conditioned":[324],"media":[325],"multiple":[327],"ligands":[328],"then":[330],"monitored":[331],"SPRi":[334],"approach.":[335],"studies":[337],"response":[340],"patterns":[341],"potential":[343],"surface":[345],"markers,":[346],"CD36":[348],"ATP":[350],"synthase.":[351],"impact":[354],"further":[362],"investigated":[363],"primary":[370],"peripheral":[372],"blood":[373],"mononuclear":[374],"Cell":[376],"viability,":[377],"transfer,":[381],"bioenergetic":[383],"alterations":[384],"assessed":[386],"functional":[390],"consequences":[391],"different":[396],"Conclusions:":[399],"combining":[403],"multi-omics":[407],"biophysical":[409],"profiling,":[410],"enables":[411],"detailed":[412],"analysis":[418],"under":[425],"realistic":[426],"Overall,":[428],"this":[429],"approach":[430],"reveal":[432],"pollutants,":[439],"signatures,":[442],"offer":[445],"non-invasive":[447],"tool":[448],"monitoring":[450]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-02T00:00:00"}