{"id":"https://openalex.org/W7205017289","doi":"https://doi.org/10.1021/acs.analchem.6c04726","title":"A CATER Logic-Gated Nanodevice for Single Nucleotide Polymorphism Discrimination in Whole Blood","display_name":"A CATER Logic-Gated Nanodevice for Single Nucleotide Polymorphism Discrimination in Whole Blood","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7205017289","doi":"https://doi.org/10.1021/acs.analchem.6c04726","pmid":"https://pubmed.ncbi.nlm.nih.gov/42915241"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.6c04726","doi":"https://doi.org/10.1021/acs.analchem.6c04726","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c04726","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035120884","display_name":"Chongyu Xie","orcid":"https://orcid.org/0009-0005-8979-7849","observed_orcids":["https://orcid.org/0009-0005-8979-7849"]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongyu Xie","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":"https://orcid.org/0009-0005-8979-7849","affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014517797","display_name":"Jing Le","orcid":"https://orcid.org/0000-0002-1473-756X","observed_orcids":["https://orcid.org/0000-0002-1473-756X"]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Jing","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":"https://orcid.org/0000-0002-1473-756X","affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138919604","display_name":"Qianqian Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Li","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101901626","display_name":"Shaoguang Li","orcid":"https://orcid.org/0000-0001-6101-0358","observed_orcids":["https://orcid.org/0000-0001-6101-0358"]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaoguang Li","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148970384","display_name":"Hui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5149067360","display_name":"Fan Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3124059619","display_name":"China University of Geosciences","ror":"https://ror.org/04gcegc37","country_code":"CN","type":"education","lineage":["https://openalex.org/I3124059619"]},{"id":"https://openalex.org/I3125743391","display_name":"China University of Geosciences (Beijing)","ror":"https://ror.org/04q6c7p66","country_code":"CN","type":"education","lineage":["https://openalex.org/I3125743391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Xia","raw_affiliation_strings":["China University of Geosciences , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China University of Geosciences , , ,","institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101901626"],"corresponding_institution_ids":["https://openalex.org/I3124059619","https://openalex.org/I3125743391"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57259635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"36","first_page":"27203","last_page":"27214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism-detection","display_name":"single nucleotide polymorphism detection","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cationic-copolymers","display_name":"cationic copolymers","score":0.7170000076293945},{"id":"https://openalex.org/keywords/strand-displacement-reaction","display_name":"strand displacement reaction","score":0.6710000038146973},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7570000290870667},{"id":"https://openalex.org/keywords/electrochemical-dna-biosensor","display_name":"electrochemical DNA biosensor","score":0.718999981880188},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ferrocene","display_name":"ferrocene","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mismatch-discrimination","display_name":"mismatch discrimination","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2909374376","wikidata":"https://www.wikidata.org/wiki/Q2726733","display_name":"Nanodevice","level":2,"score":0.824400007724762},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.776199996471405},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5999000072479248},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5795000195503235},{"id":"https://openalex.org/C59701697","wikidata":"https://www.wikidata.org/wiki/Q6895959","display_name":"Molecular Inversion Probe","level":5,"score":0.4415999948978424},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4083999991416931},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.4059999883174896},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.34929999709129333},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.3377000093460083},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.31709998846054077},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.30219998955726624},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2897000014781952},{"id":"https://openalex.org/C137390916","wikidata":"https://www.wikidata.org/wiki/Q900923","display_name":"DNA\u2013DNA hybridization","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2662999927997589}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055664","descriptor_name":"Electrochemical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.6c04726","doi":"https://doi.org/10.1021/acs.analchem.6c04726","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.6c04726","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:42915241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42915241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6067982912063599,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1899531375","display_name":null,"funder_award_id":"22474130","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4585512698","display_name":null,"funder_award_id":"U24A20502","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7408231008","display_name":null,"funder_award_id":"2021YFA1200403","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7638340728","display_name":null,"funder_award_id":"2024ZD0531600","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G8288068835","display_name":null,"funder_award_id":"22274144","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1980301976","https://openalex.org/W1994284144","https://openalex.org/W2000160799","https://openalex.org/W2013259685","https://openalex.org/W2016613181","https://openalex.org/W2020984951","https://openalex.org/W2060913290","https://openalex.org/W2093730101","https://openalex.org/W2105944077","https://openalex.org/W2121308112","https://openalex.org/W2127230663","https://openalex.org/W2160763121","https://openalex.org/W2168625835","https://openalex.org/W2460117772","https://openalex.org/W2547045813","https://openalex.org/W2619415841","https://openalex.org/W2793903661","https://openalex.org/W2915027573","https://openalex.org/W2946855199","https://openalex.org/W2955133234","https://openalex.org/W2978275123","https://openalex.org/W3028639351","https://openalex.org/W3032974666","https://openalex.org/W3173568073","https://openalex.org/W3194373273","https://openalex.org/W4220745607","https://openalex.org/W4221105403","https://openalex.org/W4280615599","https://openalex.org/W4285387277","https://openalex.org/W4311738738","https://openalex.org/W4318069675","https://openalex.org/W4378966410","https://openalex.org/W4380791912","https://openalex.org/W4381469689","https://openalex.org/W4386092780","https://openalex.org/W4386707820","https://openalex.org/W4386851058","https://openalex.org/W4402333621","https://openalex.org/W4407356072","https://openalex.org/W4407386298","https://openalex.org/W4407837239","https://openalex.org/W4409247106","https://openalex.org/W4411504414","https://openalex.org/W4414782045"],"related_works":[],"abstract_inverted_index":{"Single":[0],"nucleotide":[1],"polymorphisms":[2],"(SNPs)":[3],"are":[4,38,58],"critical":[5],"genetic":[6],"markers":[7],"for":[8,149,178,195],"disease":[9],"diagnosis":[10],"and":[11,83,113,129,162,165],"personalized":[12],"medicine,":[13],"yet":[14],"their":[15],"precise":[16],"detection":[17,87],"remains":[18],"challenging.":[19],"Conventional":[20],"DNA":[21],"strand":[22,74],"displacement-based":[23],"SNP":[24,86,120,180,196],"assays":[25],"employ":[26],"either":[27],"toehold-mediated":[28],"or":[29,44,93],"toehold-free":[30,49,73],"strategies.":[31],"Toehold-mediated":[32],"strategies":[33,50],"exhibit":[34],"rapid":[35],"kinetics":[36,185],"but":[37,57],"limited":[39],"to":[40,103,144],"mutations":[41],"located":[42],"in":[43,54,169],"near":[45],"the":[46,135],"toehold,":[47],"whereas":[48],"provide":[51],"broad":[52],"flexibility":[53],"mutation":[55,151],"placement":[56],"hampered":[59],"by":[60,139,182],"slow":[61],"reaction":[62,76],"kinetics.":[63],"To":[64],"address":[65],"this,":[66],"we":[67],"develop":[68],"a":[69,100,108,140,175],"comb-type":[70],"cationic":[71,96],"copolymer-accelerated":[72],"displacement":[75],"(CATER)":[77],"platform":[78,154],"that":[79],"enables":[80,115,155],"rapid,":[81],"robust,":[82],"mismatch-sensitive":[84],"electrochemical":[85,188],"without":[88],"relying":[89],"on":[90],"toehold":[91],"regions":[92],"enzymes.":[94],"The":[95,153],"copolymer":[97],"acts":[98],"as":[99],"molecular":[101],"chaperone":[102],"accelerate":[104],"hybridization":[105],"kinetics,":[106],"while":[107],"dual-reporter":[109],"system":[110],"(methylene":[111],"blue":[112],"ferrocene)":[114],"ratiometric":[116,131],"signal":[117,127,189],"readout.":[118],"Importantly,":[119],"discrimination":[121,167],"is":[122],"quantitatively":[123],"achieved":[124],"through":[125],"kinetic":[126],"separation":[128],"nonoverlapping":[130],"threshold":[132],"intervals,":[133],"with":[134,186],"latter":[136],"further":[137],"processed":[138],"cascade":[141],"logic-gate":[142],"framework":[143],"generate":[145],"discrete":[146],"digital":[147],"outputs":[148],"unambiguous":[150],"discrimination.":[152],"accurate":[156],"determination":[157],"of":[158],"both":[159],"mismatch":[160],"positions":[161],"substitution":[163],"types":[164],"retains":[166],"capability":[168],"whole":[170],"blood.":[171],"This":[172],"work":[173],"establishes":[174],"generalizable":[176],"strategy":[177],"high-resolution":[179],"analysis":[181],"integrating":[183],"polymer-assisted":[184],"logic-gated":[187],"processing,":[190],"highlighting":[191],"its":[192],"translational":[193],"potential":[194],"genotyping.":[197]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2026-09-02T00:00:00"}