{"id":"https://openalex.org/W7205016379","doi":"https://doi.org/10.64898/2026.08.31.748312","title":"Single-Cell Profiling of Dynamic Epicardial Cell States During Myocardial Infarction","display_name":"Single-Cell Profiling of Dynamic Epicardial Cell States During Myocardial Infarction","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7205016379","doi":"https://doi.org/10.64898/2026.08.31.748312","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922454","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684445"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.31.748312","doi":"https://doi.org/10.64898/2026.08.31.748312","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748312.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159852197","display_name":"David Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wong","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126267367","display_name":"Jenny Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Cheng","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088751229","display_name":"Xia Yang","orcid":"https://orcid.org/0000-0002-3971-038X","observed_orcids":["https://orcid.org/0000-0002-3971-038X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Yang","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90029","Molecular Biology Institute, University of California, Los Angeles, CA, 90029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032978625","display_name":"Pearl J. Quijada","orcid":"https://orcid.org/0000-0003-2477-2374","observed_orcids":["https://orcid.org/0000-0003-2477-2374"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pearl Quijada","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","Eli and Edythe Broad Stem Research Center, University of California, Los Angeles, CA, 90029","Molecular Biology Institute, University of California, Los Angeles, CA, 90029"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli and Edythe Broad Stem Research Center, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, CA, 90029","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032978625"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epicardium","display_name":"epicardium","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/periostin","display_name":"periostin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.843999981880188},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.8140000104904175},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/semaphorins","display_name":"semaphorins","score":0.7689999938011169},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cardiac-repair","display_name":"cardiac repair","score":0.5669999718666077},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6215000152587891},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5856000185012817},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5471000075340271},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.49160000681877136},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4722000062465668},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4629000127315521},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45419999957084656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44830000400543213},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43880000710487366},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.43869999051094055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39890000224113464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3783000111579895},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37310001254081726},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3582000136375427},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.3497999906539917},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.33970001339912415},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.311599999666214},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.2955999970436096},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.2865000069141388},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.2565000057220459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25529998540878296},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.31.748312","doi":"https://doi.org/10.64898/2026.08.31.748312","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42922454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684445","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684445/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.08.31.748312","doi":"https://doi.org/10.64898/2026.08.31.748312","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748312","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748312.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2919808203","display_name":null,"funder_award_id":"T32HL069766","funder_id":"https://openalex.org/F4320338403","funder_display_name":"Common Fund"},{"id":"https://openalex.org/G3848310471","display_name":null,"funder_award_id":"R01HL172852","funder_id":"https://openalex.org/F4320338403","funder_display_name":"Common Fund"},{"id":"https://openalex.org/G408495707","display_name":"Restoring fetal angiogenic factors for the treatment of ischemic heart disease","funder_award_id":"19CDA34590003","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G7668677711","display_name":"Vascular Biology Training Grant","funder_award_id":"T32HL069766","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000868947","display_name":"Muscle Cell Biology, Pathophysiology, and Therapeutics","funder_award_id":"T32AR065972","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000879093","display_name":"Regulation of angiogenesis by cardiac fibroblasts","funder_award_id":"1r01hl172852-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332502","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337596","display_name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","ror":"https://ror.org/046rm7j60"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":"https://ror.org/001d55x84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7205016379.pdf","grobid_xml":"https://content.openalex.org/works/W7205016379.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1914848506","https://openalex.org/W1966202908","https://openalex.org/W1968038752","https://openalex.org/W1970972097","https://openalex.org/W1996689493","https://openalex.org/W2012416932","https://openalex.org/W2019720121","https://openalex.org/W2034163879","https://openalex.org/W2042090952","https://openalex.org/W2048097993","https://openalex.org/W2050882211","https://openalex.org/W2065931840","https://openalex.org/W2067591094","https://openalex.org/W2075282559","https://openalex.org/W2077226203","https://openalex.org/W2086523815","https://openalex.org/W2089414860","https://openalex.org/W2116091611","https://openalex.org/W2128832316","https://openalex.org/W2130620308","https://openalex.org/W2132562087","https://openalex.org/W2157671340","https://openalex.org/W2166323322","https://openalex.org/W2279233812","https://openalex.org/W2304356514","https://openalex.org/W2522665294","https://openalex.org/W2585988088","https://openalex.org/W2800350399","https://openalex.org/W2809940763","https://openalex.org/W2913246638","https://openalex.org/W2924188812","https://openalex.org/W2963544910","https://openalex.org/W2969697326","https://openalex.org/W3003280117","https://openalex.org/W3010618844","https://openalex.org/W3108202447","https://openalex.org/W3132661792","https://openalex.org/W3165135037","https://openalex.org/W3177497024","https://openalex.org/W3181267383","https://openalex.org/W4200347088","https://openalex.org/W4253496709","https://openalex.org/W4280603249","https://openalex.org/W4292336342","https://openalex.org/W4312192875","https://openalex.org/W4385142582","https://openalex.org/W4390942346","https://openalex.org/W4411550660","https://openalex.org/W4415930430"],"related_works":["https://openalex.org/W4415789702","https://openalex.org/W3177497024","https://openalex.org/W3174932781","https://openalex.org/W7084181310","https://openalex.org/W4403246149","https://openalex.org/W2016055688","https://openalex.org/W7098491340","https://openalex.org/W3108959956","https://openalex.org/W6999833796","https://openalex.org/W1992056163"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"The":[2],"epicardium":[3,184],"is":[4],"reactivated":[5],"after":[6,48,57,76,200,226],"myocardial":[7],"infarction":[8],"(MI);":[9],"however,":[10],"the":[11,140,183,265,289],"gene":[12,118,160,239],"expression":[13,75,105,141],"profiles":[14,106],"of":[15,110,128,158,174,182,270],"post-MI":[16],"adult":[17,46,291],"epicardial":[18,33,86,96,197,238],"subpopulations":[19],"remain":[20],"incompletely":[21],"defined.":[22],"Methods":[23],"Single-cell":[24],"RNA":[25],"sequencing":[26],"was":[27,65,125],"performed":[28,66],"on":[29,67],"lineage-traced":[30],"Wt1":[31,36,68,150,210],"+":[32,99,101,153,206,217,220],"cells":[34,97,272],"from":[35],"CreERT":[37],"2":[38],"/+":[39],";":[40,43],"R26":[41],"tdT/+":[42],"Pdgfra":[44],"nGFP/+":[45],"mice":[47],"sham":[49],"surgery":[50],"or":[51],"at":[52],"7":[53,121],"and":[54,92,114,133,170,176,189,213,218,228,259,284],"14":[55,137],"days":[56,122,138,225],"permanent":[58],"artery":[59],"ligation":[60],"to":[61,72,131,167,180,254],"induce":[62],"MI.":[63],"Immunostaining":[64,188],"-lineage-traced":[69],"cardiac":[70],"tissue":[71],"validate":[73],"spatial":[74],"ischemic":[77],"injury.":[78],"Results":[79],"Unbiased":[80],"clustering":[81],"identified":[82],"nine":[83],"transcriptionally":[84],"distinct":[85],"populations,":[87],"encompassing":[88],"mesothelial,":[89],"fibroblast/mesenchymal,":[90],"transitional,":[91],"proliferative":[93],"phenotypes.":[94],"Fibroblast-like":[95],"(Wt1":[98],"/Pdgfra":[100],")":[102],"showed":[103,155],"time-dependent":[104],"associated":[107],"with":[108],"upregulation":[109,157],"epithelial-to-mesenchymal":[111],"transition":[112],"(EMT)":[113],"extracellular":[115],"matrix":[116],"(ECM)":[117],"programs.":[119],"At":[120],"post-MI,":[123,139],"there":[124],"notable":[126],"enrichment":[127],"genes":[129],"related":[130,166],"chemokines":[132],"Wnt":[134],"components.":[135],"By":[136],"profile":[142],"shifted":[143],"toward":[144],"immune":[145],"regulation.":[146],"In":[147],"contrast,":[148],"a":[149,203,214,243],"high":[151],"/Msln":[152],"population":[154],"minimal":[156],"EMT":[159],"programs":[161,240],"but":[162],"enhanced":[163],"paracrine":[164],"signaling":[165,244,286],"wound":[168],"healing":[169],"semaphorins,":[171],"suggesting":[172],"reactivation":[173],"reparative":[175,282],"angiogenic":[177],"functions":[178],"akin":[179],"those":[181],"during":[185],"embryonic":[186],"development.":[187],"in":[190,241,288],"situ":[191],"hybridization":[192],"fluorescence":[193],"analyses":[194],"validated":[195],"laminar":[196],"cell":[198,246,252],"placement":[199],"MI,":[201],"comprising":[202],"surface":[204,247],"Msln":[205],"sheet,":[207],"an":[208,249],"overlapping":[209],"-lineage":[211],"band,":[212],"subadjacent":[215],"PDGFR\u03b1":[216],"Periostin":[219],"compartment":[221],"that":[222],"expands":[223],"7-14":[224],"MI":[227],"regresses":[229],"by":[230],"day":[231],"28":[232],"post-ischemia.":[233],"Conclusions":[234],"Our":[235],"data":[236],"define":[237],"which":[242],"epithelial":[245],"overlays":[248],"effector":[250],"mesenchymal":[251],"stroma":[253],"coordinate":[255],"angiogenesis,":[256],"leukocyte":[257],"recruitment,":[258],"ECM":[260],"remodeling.":[261],"This":[262],"study":[263],"presents":[264],"first":[266],"integrated":[267],"single-cell":[268],"atlas":[269],"epicardial-derived":[271],"across":[273],"multiple":[274],"post-ischemic":[275],"timepoints,":[276],"offering":[277],"new":[278],"insights":[279],"into":[280],"their":[281],"potential":[283],"dynamic":[285],"diversity":[287],"injured":[290],"heart.":[292]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}