{"id":"https://openalex.org/W7205015015","doi":"https://doi.org/10.64898/2026.08.30.748149","title":"Integrated Transcriptomic and CRISPR Dependency Analysis Prioritizes a CDK1\u2013AURKB Mitotic Vulnerability Axis in Diffuse Intrinsic Pontine Glioma","display_name":"Integrated Transcriptomic and CRISPR Dependency Analysis Prioritizes a CDK1\u2013AURKB Mitotic Vulnerability Axis in Diffuse Intrinsic Pontine Glioma","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7205015015","doi":"https://doi.org/10.64898/2026.08.30.748149"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.30.748149","doi":"https://doi.org/10.64898/2026.08.30.748149","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.748149","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.748149.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.748149.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140506705","display_name":"Arnav Rajeev","orcid":"https://orcid.org/0009-0002-6912-5007","observed_orcids":["https://orcid.org/0009-0002-6912-5007"]},"institutions":[{"id":"https://openalex.org/I17784594","display_name":"Austin Community College","ror":"https://ror.org/044tz3m61","country_code":"US","type":"education","lineage":["https://openalex.org/I17784594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnav Rajeev","raw_affiliation_strings":["Austin Community College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austin Community College","institution_ids":["https://openalex.org/I17784594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148962451","display_name":"Soumith Veeragoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17784594","display_name":"Austin Community College","ror":"https://ror.org/044tz3m61","country_code":"US","type":"education","lineage":["https://openalex.org/I17784594"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soumith Veeragoni","raw_affiliation_strings":["Austin Community College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austin Community College","institution_ids":["https://openalex.org/I17784594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121360039","display_name":"Anish Sundar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17784594","display_name":"Austin Community College","ror":"https://ror.org/044tz3m61","country_code":"US","type":"education","lineage":["https://openalex.org/I17784594"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anish Sundar","raw_affiliation_strings":["Austin Community College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austin Community College","institution_ids":["https://openalex.org/I17784594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5121360039"],"corresponding_institution_ids":["https://openalex.org/I17784594"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":1.0},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aurora-b-kinase","display_name":"Aurora B kinase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cdc20","display_name":"CDC20","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cdca8","display_name":"CDCA8","score":0.9710000157356262},{"id":"https://openalex.org/keywords/brainstem-tumors","display_name":"brainstem tumors","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7333999872207642},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.580299973487854},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5683000087738037},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5182999968528748},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.5181999802589417},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41260001063346863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4059999883174896},{"id":"https://openalex.org/C2777075493","wikidata":"https://www.wikidata.org/wiki/Q1137072","display_name":"Hindbrain","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29660001397132874},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2962000072002411},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2759000062942505},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.30.748149","doi":"https://doi.org/10.64898/2026.08.30.748149","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.748149","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.748149.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.30.748149","doi":"https://doi.org/10.64898/2026.08.30.748149","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.748149","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.748149.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7205015015.pdf","grobid_xml":"https://content.openalex.org/works/W7205015015.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2003422441","https://openalex.org/W2051921450","https://openalex.org/W2053349906","https://openalex.org/W2100239923","https://openalex.org/W2145755261","https://openalex.org/W2510777522","https://openalex.org/W2888147573","https://openalex.org/W2889354357","https://openalex.org/W3127789712","https://openalex.org/W4200497629","https://openalex.org/W4311585488","https://openalex.org/W4316362846","https://openalex.org/W4378908509","https://openalex.org/W4387329303"],"related_works":["https://openalex.org/W2606835938","https://openalex.org/W2617421042","https://openalex.org/W4231073318","https://openalex.org/W3111333073","https://openalex.org/W3182331756","https://openalex.org/W2888147573","https://openalex.org/W4214711475","https://openalex.org/W2940500631","https://openalex.org/W7165796930","https://openalex.org/W4281733365"],"abstract_inverted_index":{"Abstract":[0],"Diffuse":[1],"intrinsic":[2],"pontine":[3],"glioma":[4,60],"(DIPG),":[5],"now":[6],"classified":[7],"within":[8],"diffuse":[9],"midline":[10],"glioma,":[11],"H3K27-altered,":[12],"remains":[13],"a":[14,64,80,127,156],"lethal":[15],"pediatric":[16],"brainstem":[17,58],"tumor":[18,151],"with":[19,56,108],"limited":[20],"therapeutic":[21],"options.":[22],"Here,":[23],"we":[24],"integrated":[25],"public":[26],"DIPG":[27,54,100,164],"transcriptomic":[28],"datasets,":[29],"protein\u2013protein":[30],"interaction":[31],"modeling,":[32],"functional":[33],"enrichment,":[34],"immune":[35,124],"deconvolution,":[36],"survival":[37],"analysis,":[38],"and":[39,74,91,144,165],"DepMap":[40,136],"CRISPR":[41,137],"dependency":[42],"data":[43,139],"to":[44],"nominate":[45],"candidate":[46,147],"mitotic":[47,82,129,161],"vulnerabilities.":[48],"Differential":[49],"expression":[50],"analysis":[51,78,96,119],"comparing":[52],"27":[53],"tumors":[55],"6":[57],"low-grade":[59],"comparator":[61],"samples":[62],"identified":[63],"proliferative":[65],"transcriptional":[66],"program":[67],"enriched":[68],"for":[69,159],"chromosome":[70],"segregation,":[71],"nuclear":[72],"division,":[73],"cell-cycle":[75],"pathways.":[76],"Network":[77],"prioritized":[79],"compact":[81],"hub":[83,130],"module":[84],"containing":[85],"CDK1,":[86,141],"AURKB,":[87,142],"TOP2A,":[88,143],"CDC20,":[89],"CDCA8,":[90],"related":[92],"G2/M":[93],"regulators.":[94],"CIBERSORT":[95],"of":[97],"an":[98,109],"independent":[99],"cohort":[101],"inferred":[102,123],"low":[103],"cytotoxic":[104],"T-cell":[105],"signal,":[106],"consistent":[107],"immune-cold":[110],"phenotype,":[111],"although":[112],"immune-cell":[113],"fractions":[114],"require":[115],"orthogonal":[116],"validation.":[117],"Survival":[118],"showed":[120],"that":[121],"neither":[122],"scores":[125],"nor":[126],"composite":[128],"score":[131],"significantly":[132],"stratified":[133],"overall":[134],"survival.":[135],"gene-effect":[138],"nominated":[140],"BIRC5":[145],"as":[146],"dependencies":[148],"across":[149],"brain":[150],"models.":[152,171],"These":[153],"findings":[154],"provide":[155],"computational":[157],"framework":[158],"prioritizing":[160],"vulnerabilities":[162],"in":[163,169],"support":[166],"experimental":[167],"validation":[168],"disease-relevant":[170]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
