{"id":"https://openalex.org/W7205014598","doi":"https://doi.org/10.26434/chemrxiv.15000952/v2","title":"DeepHeal: An Interpretable Framework for Phenotype-Based Antineoplastic Drug Discovery Using Drug-Perturbation Proteomics","display_name":"DeepHeal: An Interpretable Framework for Phenotype-Based Antineoplastic Drug Discovery Using Drug-Perturbation Proteomics","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7205014598","doi":"https://doi.org/10.26434/chemrxiv.15000952/v2"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15000952/v2","doi":"https://doi.org/10.26434/chemrxiv.15000952/v2","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15000952/v2","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15000952/v2","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15000952/v2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050711583","display_name":"Disheng Feng","orcid":"https://orcid.org/0000-0003-4530-8634","observed_orcids":["https://orcid.org/0000-0003-4530-8634"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Disheng Feng","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129483787","display_name":"Jing Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liang","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148998812","display_name":"Kexin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kexin Zhang","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074421390","display_name":"Xu Cai","orcid":"https://orcid.org/0000-0002-1790-7915","observed_orcids":["https://orcid.org/0000-0002-1790-7915","https://orcid.org/0009-0005-9323-1020"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Cai","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110595680","display_name":"Yueying Yang","orcid":"https://orcid.org/0009-0000-3710-0951","observed_orcids":["https://orcid.org/0009-0000-3710-0951"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueying Yang","raw_affiliation_strings":["Shenyang Pharmaceutical University","Wuya College of Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120315138","display_name":"Meijing Wang","orcid":"https://orcid.org/0000-0003-4067-1127","observed_orcids":["https://orcid.org/0000-0003-4067-1127"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meijing Wang","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344257","display_name":"Hua Li","orcid":"https://orcid.org/0000-0003-1903-836X","observed_orcids":["https://orcid.org/0000-0003-1903-836X"]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy"],"raw_orcid":"https://orcid.org/0000-0003-1903-836X","affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121163316","display_name":"Lixia Chen","orcid":"https://orcid.org/0000-0003-2196-1428","observed_orcids":["https://orcid.org/0000-0003-2196-1428"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixia Chen","raw_affiliation_strings":["Fujian University of Traditional Chinese Medicine","Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","Shenyang Pharmaceutical University","Wuya College of Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I118783713"]},{"raw_affiliation_string":"Institute of Digital Materia Medica & Structural Pharmacology, College of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretable-representation-learning","display_name":"interpretable representation learning","score":0.8370000123977661},{"id":"https://openalex.org/keywords/supervised-contrastive-learning","display_name":"supervised contrastive learning","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8392000198364258},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.6980999708175659},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6884999871253967},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6396999955177307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6347000002861023},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6129000186920166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5375000238418579},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4659000039100647},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.45680001378059387},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4122999906539917},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3158000111579895},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.3125},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.288100004196167},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2847000062465668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28049999475479126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27160000801086426},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2630000114440918}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15000952/v2","doi":"https://doi.org/10.26434/chemrxiv.15000952/v2","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15000952/v2","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15000952/v2","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15000952/v2","doi":"https://doi.org/10.26434/chemrxiv.15000952/v2","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15000952/v2","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15000952/v2","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G321598939","display_name":null,"funder_award_id":"XJB2022008","funder_id":"https://openalex.org/F4320324830","funder_display_name":"Fujian University of Traditional Chinese Medicine"},{"id":"https://openalex.org/G4364662860","display_name":"\u836f\u7269\u5e72\u9884\u7ec6\u80de\u4ee3\u8c22\u7ec4\u5b66\u8868\u578b\u56fe\u8c31\u6784\u5efa\u4e0e\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u836f\u6548\u9884\u6d4b\u7814\u7a76","funder_award_id":"2025J01929","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G578994137","display_name":null,"funder_award_id":"X2024005","funder_id":"https://openalex.org/F4320324830","funder_display_name":"Fujian University of Traditional Chinese Medicine"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320324830","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7205014598.pdf","grobid_xml":"https://content.openalex.org/works/W7205014598.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1538419182","https://openalex.org/W2038252445","https://openalex.org/W2052214665","https://openalex.org/W2121604817","https://openalex.org/W2163922914","https://openalex.org/W2281427448","https://openalex.org/W2461427403","https://openalex.org/W2519691041","https://openalex.org/W2612467560","https://openalex.org/W2729684734","https://openalex.org/W2735897797","https://openalex.org/W2951029718","https://openalex.org/W2967369839","https://openalex.org/W2991106430","https://openalex.org/W2994796322","https://openalex.org/W3003119869","https://openalex.org/W3027038786","https://openalex.org/W3043124935","https://openalex.org/W3049002444","https://openalex.org/W3159454489","https://openalex.org/W3179083918","https://openalex.org/W4284882692","https://openalex.org/W4285404371","https://openalex.org/W4306403480","https://openalex.org/W4313453500","https://openalex.org/W4386306875","https://openalex.org/W4387743679","https://openalex.org/W4390734334","https://openalex.org/W4392951752","https://openalex.org/W4396696200","https://openalex.org/W4396769373","https://openalex.org/W4399766536","https://openalex.org/W4405459516","https://openalex.org/W4406818430"],"related_works":["https://openalex.org/W7136338824","https://openalex.org/W7138975099","https://openalex.org/W7220934931","https://openalex.org/W4366086369","https://openalex.org/W4388843362","https://openalex.org/W4400140760","https://openalex.org/W3096232714","https://openalex.org/W4295873438","https://openalex.org/W7165530048","https://openalex.org/W7172455664"],"abstract_inverted_index":{"Drug-perturbation":[0],"proteomics":[1],"provides":[2],"a":[3,83],"direct":[4],"molecular":[5],"readout":[6],"of":[7,128],"compound-induced":[8],"cellular":[9,163],"states,":[10],"but":[11],"its":[12,19],"high":[13],"dimensionality":[14],"and":[15,42,56,71,102,188,197],"limited":[16],"interpretability":[17],"hinder":[18],"use":[20],"for":[21,125,192],"mechanism-oriented":[22],"drug":[23],"discovery.":[24],"Here,":[25],"we":[26],"present":[27],"DeepHeal,":[28],"an":[29,49],"interpretable":[30,177],"consensus":[31,68,178],"representation":[32,179],"framework":[33,180],"that":[34,181],"transforms":[35,182],"drug-induced":[36],"proteomic":[37,80,158],"responses":[38],"into":[39,186],"biologically":[40],"readable":[41],"experimentally":[43],"actionable":[44],"antineoplastic":[45,90,152],"response":[46,117,153,190],"programs.":[47],"Using":[48],"HCT116":[50,132],"perturbation":[51,159],"atlas":[52],"comprising":[53],"875":[54],"compounds":[55,124,142],"9,960":[57],"protein":[58],"features,":[59],"DeepHeal":[60,119,148,169],"integrates":[61],"ensemble":[62],"variational":[63],"autoencoders,":[64],"supervised":[65],"contrastive":[66],"learning,":[67],"latent-variable":[69],"aggregation,":[70],"protein-level":[72],"attribution.":[73],"A":[74],"label-independent":[75],"Average":[76],"branch":[77,87],"captures":[78],"recurrent":[79],"variation,":[81],"whereas":[82],"complementary":[84],"label-aware":[85],"SupCon":[86],"concentrates":[88],"known":[89],"structure.":[91],"The":[92],"resulting":[93],"latent":[94],"programs":[95,191],"are":[96],"mapped":[97],"back":[98],"to":[99,171],"proteins,":[100],"pathways,":[101],"interaction":[103],"networks,":[104],"revealing":[105],"shared":[106],"cell-cycle,":[107],"DNA-replication,":[108],"stress-response,":[109],"metabolic,":[110],"proteostasis,":[111],"apoptosis-related":[112],"programs,":[113],"together":[114],"with":[115,134,143],"mechanism-dependent":[116],"heterogeneity.":[118],"prioritized":[120],"19":[121],"initially":[122],"unlabeled":[123],"experimental":[126,198],"follow-up,":[127],"which":[129],"seven":[130],"inhibited":[131],"cells":[133],"IC\u2085\u2080":[135],"values":[136],"below":[137],"10":[138],"\u03bcM,":[139],"including":[140],"two":[141],"nanomolar":[144],"activity.":[145],"Without":[146],"retraining,":[147],"representations":[149],"further":[150],"recovered":[151],"states":[154],"across":[155],"566":[156],"external":[157],"profiles":[160],"spanning":[161],"multiple":[162],"contexts.":[164],"Together,":[165],"these":[166],"findings":[167],"establish":[168],"as,":[170],"our":[172],"knowledge,":[173],"the":[174],"first":[175],"proteomics-first":[176],"large-scale":[183],"drug-perturbation":[184],"proteomes":[185],"protein-":[187],"pathway-resolved":[189],"cross-context":[193],"anticancer":[194],"candidate":[195],"prioritization":[196],"validation.":[199]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
