{"id":"https://openalex.org/W7205007713","doi":"https://doi.org/10.64898/2026.08.28.747769","title":"Identification of a pan- orthoebolavirus -reactive antibody from an rVSV-EBOV vaccinated individual","display_name":"Identification of a pan- orthoebolavirus -reactive antibody from an rVSV-EBOV vaccinated individual","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7205007713","doi":"https://doi.org/10.64898/2026.08.28.747769"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747769","doi":"https://doi.org/10.64898/2026.08.28.747769","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747769","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.28.747769","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115493445","display_name":"Paulina Tarnow","orcid":"https://orcid.org/0000-0003-0011-2128","observed_orcids":["https://orcid.org/0000-0003-0011-2128"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paulina Tarnow","raw_affiliation_strings":["Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029082968","display_name":"Hadas Cohen\u2010Dvashi","orcid":"https://orcid.org/0000-0003-2101-6311","observed_orcids":["https://orcid.org/0000-0003-2101-6311"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hadas Cohen-Dvashi","raw_affiliation_strings":["Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009615378","display_name":"Cornelius Rohde","orcid":"https://orcid.org/0000-0002-4752-8326","observed_orcids":["https://orcid.org/0000-0002-4752-8326"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelius Rohde","raw_affiliation_strings":["German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009334726","display_name":"Verena Kr\u00e4hling","orcid":"https://orcid.org/0000-0001-8658-9626","observed_orcids":["https://orcid.org/0000-0001-8658-9626"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena Kr\u00e4hling","raw_affiliation_strings":["German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024497248","display_name":"Leon Ullrich","orcid":"https://orcid.org/0000-0002-4358-0717","observed_orcids":["https://orcid.org/0000-0002-4358-0717"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leon Ullrich","raw_affiliation_strings":["Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005043574","display_name":"Lutz Gieselmann","orcid":"https://orcid.org/0000-0003-3699-3318","observed_orcids":["https://orcid.org/0000-0003-3699-3318"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Gieselmann","raw_affiliation_strings":["Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149088275","display_name":"Hagar Zar Shuker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hagar Zar Shuker","raw_affiliation_strings":["Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147951991","display_name":"Shreeya Amatya","orcid":"https://orcid.org/0009-0003-0492-2942","observed_orcids":["https://orcid.org/0009-0003-0492-2942"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shreeya Amatya","raw_affiliation_strings":["Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036222002","display_name":"Anahita Fathi","orcid":"https://orcid.org/0000-0002-9351-9471","observed_orcids":["https://orcid.org/0000-0002-9351-9471"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anahita Fathi","raw_affiliation_strings":["Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","German Center for Infection Research, Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg, Germany","Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"German Center for Infection Research, Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037436749","display_name":"Alexandra Kupke","orcid":"https://orcid.org/0000-0001-8517-4779","observed_orcids":["https://orcid.org/0000-0001-8517-4779"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Kupke","raw_affiliation_strings":["German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037816815","display_name":"Christoph Kreer","orcid":"https://orcid.org/0000-0002-9140-9850","observed_orcids":["https://orcid.org/0000-0002-9140-9850"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Kreer","raw_affiliation_strings":["Laboratory for Immunodynamics and Molecular Evolution, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne; Cologne, Germany","Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Immunodynamics and Molecular Evolution, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144096297","display_name":"BSL4 Animal Facility Team","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BSL-4 Animal Facility Team","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067941504","display_name":"Manuel Koch","orcid":"https://orcid.org/0000-0002-2962-7814","observed_orcids":["https://orcid.org/0000-0002-2962-7814"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel Koch","raw_affiliation_strings":["Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044802324","display_name":"Marylyn M. Addo","orcid":"https://orcid.org/0000-0003-2836-9224","observed_orcids":["https://orcid.org/0000-0003-2836-9224"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marylyn M. Addo","raw_affiliation_strings":["Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","German Center for Infection Research, Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg, Germany","Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"German Center for Infection Research, Partner Site Hamburg-L\u00fcbeck-Borstel-Riems, Hamburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077285679","display_name":"Stephan Becker","orcid":"https://orcid.org/0000-0002-6621-9350","observed_orcids":["https://orcid.org/0000-0002-6621-9350"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Becker","raw_affiliation_strings":["German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research, Partner Site Gie\u00dfen-Marburg-Langen, Marburg, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institut f\u00fcr Virologie, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031748920","display_name":"Ron Diskin","orcid":"https://orcid.org/0000-0002-2837-5897","observed_orcids":["https://orcid.org/0000-0002-2837-5897"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ron Diskin","raw_affiliation_strings":["Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087929263","display_name":"Matthias Zehner","orcid":"https://orcid.org/0000-0001-5745-0836","observed_orcids":["https://orcid.org/0000-0001-5745-0836"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Matthias Zehner","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany","Department of Pediatrics, Weill Cornell Medicine, New York, NY, 10065, USA","German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany","Laboratory for Infection and Immune Biology, Institute of Virology, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"Department of Pediatrics, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Laboratory for Infection and Immune Biology, Institute of Virology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086835391","display_name":"Florian Klein","orcid":"https://orcid.org/0000-0003-1376-1792","observed_orcids":["https://orcid.org/0000-0003-1376-1792","https://orcid.org/0000-0002-7082-0317"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Klein","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany","German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany","Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5086835391"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210115305","https://openalex.org/I4210153755"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/sudan-virus","display_name":"Sudan virus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bundibugyo-virus","display_name":"Bundibugyo virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cross-reactive-neutralizing-antibodies","display_name":"cross-reactive neutralizing antibodies","score":0.7519999742507935},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prophylactic-efficacy","display_name":"prophylaxis efficacy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7455000281333923},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7157999873161316},{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.6459000110626221},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6054999828338623},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5800999999046326},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5281999707221985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5192999839782715},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5080999732017517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4943999946117401},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4887999892234802},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4790000021457672},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39469999074935913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33090001344680786},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.29750001430511475},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.2621999979019165}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.747769","doi":"https://doi.org/10.64898/2026.08.28.747769","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747769","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747769","doi":"https://doi.org/10.64898/2026.08.28.747769","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747769","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W2011136801","https://openalex.org/W2022339063","https://openalex.org/W2029525307","https://openalex.org/W2038110764","https://openalex.org/W2062448305","https://openalex.org/W2081313987","https://openalex.org/W2124026197","https://openalex.org/W2128963410","https://openalex.org/W2142678478","https://openalex.org/W2147679296","https://openalex.org/W2180229411","https://openalex.org/W2266881505","https://openalex.org/W2276335432","https://openalex.org/W2288202420","https://openalex.org/W2344740792","https://openalex.org/W2572760626","https://openalex.org/W2587625522","https://openalex.org/W2616753020","https://openalex.org/W2787698206","https://openalex.org/W2806465206","https://openalex.org/W2809165801","https://openalex.org/W2935998528","https://openalex.org/W2971517551","https://openalex.org/W2978862345","https://openalex.org/W3002296182","https://openalex.org/W3006212265","https://openalex.org/W3020828664","https://openalex.org/W3034816694","https://openalex.org/W3119456195","https://openalex.org/W3158483423","https://openalex.org/W3165525344","https://openalex.org/W3184312244","https://openalex.org/W4200583593","https://openalex.org/W4220858119","https://openalex.org/W4307493844","https://openalex.org/W4323567118","https://openalex.org/W4362716855","https://openalex.org/W4387164156","https://openalex.org/W4389134948","https://openalex.org/W4392155415","https://openalex.org/W4393073994","https://openalex.org/W4407101507","https://openalex.org/W6949505400","https://openalex.org/W7172022868"],"related_works":["https://openalex.org/W4416451643","https://openalex.org/W7164544599","https://openalex.org/W2266881505","https://openalex.org/W2978862345","https://openalex.org/W7160505955","https://openalex.org/W7165873997","https://openalex.org/W7221656424","https://openalex.org/W3013411029","https://openalex.org/W4380152715","https://openalex.org/W7161585624"],"abstract_inverted_index":{"Abstract":[0],"Orthoebolaviruses":[1],"such":[2],"as":[3],"Ebola":[4],"virus":[5,8,12],"(EBOV),":[6],"Sudan":[7],"(SUDV)":[9],"and":[10,26,63,76,106,121],"Bundibugyo":[11],"(BDBV)":[13],"can":[14],"cause":[15],"severe":[16],"disease":[17],"with":[18,78,84,102,124],"high":[19],"case-fatality":[20],"rates.":[21],"While":[22],"licensed":[23],"EBOV":[24,31,75,118],"vaccines":[25],"therapeutic":[27,150],"antibodies":[28],"protect":[29],"against":[30,81],"infection,":[32],"no":[33],"single":[34,66],"monoclonal":[35],"antibody":[36,91,146],"currently":[37],"provides":[38],"broad":[39],"protection":[40,123],"across":[41],"multiple":[42],"orthoebolaviruses.":[43],"Here,":[44],"we":[45,69],"analyzed":[46],"the":[47,95,140],"humoral":[48],"immune":[49],"response":[50],"of":[51,142],"an":[52,117],"rVSV-EBOV":[53,137],"vaccinee":[54],"to":[55,94],"identify":[56],"pan-":[57,96],"orthoebolavirus":[58,97],"-neutralizing":[59],"antibodies.":[60,87],"Using":[61],"BDBV-":[62],"SUDV-glycoproteins":[64],"for":[65],"B":[67],"cell-sorting,":[68],"identified":[70],"B10,":[71],"which":[72],"neutralized":[73],"authentic":[74],"SUDV,":[77],"potent":[79],"activity":[80,126],"SUDV":[82,129],"compared":[83],"established":[85],"cross-reactive":[86],"Structural":[88],"analysis":[89],"mapped":[90],"B10":[92,111],"binding":[93],"conserved":[98],"GP2-stalk/HR2":[99],"region,":[100],"associated":[101],"asymmetric":[103],"trimer":[104],"destabilization":[105],"spike":[107],"opening.":[108],"In":[109],"vivo,":[110],"showed":[112],"significant":[113],"prophylactic":[114],"efficacy":[115],"in":[116,127],"mouse":[119,130],"model":[120],"partial":[122],"antiviral":[125],"a":[128,143],"model.":[131],"Together,":[132],"these":[133],"findings":[134],"demonstrate":[135],"that":[136,147],"vaccination":[138],"induced":[139],"development":[141],"broadly":[144],"orthoebolavirus-neutralizing":[145],"holds":[148],"exeptional":[149],"potential.":[151]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}