{"id":"https://openalex.org/W7204999972","doi":"https://doi.org/10.1007/s12672-026-05804-5","title":"T cell receptor repertoire analysis reveals antigenic convergence and immunotherapeutic opportunities in prostate cancer","display_name":"T cell receptor repertoire analysis reveals antigenic convergence and immunotherapeutic opportunities in prostate cancer","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204999972","doi":"https://doi.org/10.1007/s12672-026-05804-5"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-026-05804-5","doi":"https://doi.org/10.1007/s12672-026-05804-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05804-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s12672-026-05804-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057686697","display_name":"Antonio Abatino","orcid":"https://orcid.org/0009-0005-8932-2501","observed_orcids":["https://orcid.org/0009-0005-8932-2501"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Abatino","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083124705","display_name":"Caterina Giordano","orcid":"https://orcid.org/0000-0001-8681-8230","observed_orcids":["https://orcid.org/0000-0001-8681-8230"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Giordano","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124322126","display_name":"Lisa Isdraele Romano","orcid":"https://orcid.org/0009-0009-1021-7311","observed_orcids":["https://orcid.org/0009-0009-1021-7311"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lisa Isdraele Romano","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044715881","display_name":"Giuseppe Fiume","orcid":"https://orcid.org/0000-0002-5414-6190","observed_orcids":["https://orcid.org/0000-0002-5414-6190"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Fiume","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014367632","display_name":"Maria Chiara Sarubbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Chiara Sarubbi","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002281040","display_name":"Donatella Malanga","orcid":"https://orcid.org/0000-0002-0491-7698","observed_orcids":["https://orcid.org/0000-0002-0491-7698"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Malanga","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","Interdepartmental Center of Services (CIS), Omics Sciences and Biobank, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Interdepartmental Center of Services (CIS), Omics Sciences and Biobank, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103721530","display_name":"Amodeo Antonio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Amodeo","raw_affiliation_strings":["Romolo Hospital, Crotone, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Romolo Hospital, Crotone, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066176296","display_name":"Stefano Alba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Alba","raw_affiliation_strings":["Romolo Hospital, Crotone, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Romolo Hospital, Crotone, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038625374","display_name":"Alberto Piana","orcid":"https://orcid.org/0000-0001-9247-7938","observed_orcids":["https://orcid.org/0000-0001-9247-7938"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Piana","raw_affiliation_strings":["Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051194589","display_name":"Cristian Fiori","orcid":"https://orcid.org/0000-0002-6345-1322","observed_orcids":["https://orcid.org/0000-0002-6345-1322"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristian Fiori","raw_affiliation_strings":["Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013771798","display_name":"Rocco Damiano","orcid":"https://orcid.org/0000-0001-6093-3644","observed_orcids":["https://orcid.org/0000-0001-6093-3644"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rocco Damiano","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070965901","display_name":"Francesco Cantiello","orcid":"https://orcid.org/0000-0001-9255-4358","observed_orcids":["https://orcid.org/0000-0001-9255-4358"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Cantiello","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076902141","display_name":"Fabio Crocerossa","orcid":"https://orcid.org/0000-0002-5114-2952","observed_orcids":["https://orcid.org/0000-0002-5114-2952"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Crocerossa","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007120604","display_name":"Giovanni Cuda","orcid":"https://orcid.org/0000-0001-6313-1866","observed_orcids":["https://orcid.org/0000-0001-6313-1866"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Cuda","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021887046","display_name":"Raffaella Gallo","orcid":"https://orcid.org/0000-0003-1234-5551","observed_orcids":["https://orcid.org/0000-0003-1234-5551"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Raffaella Gallo","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030231061","display_name":"Ilenia Aversa","orcid":"https://orcid.org/0000-0003-4721-6792","observed_orcids":["https://orcid.org/0000-0003-4721-6792"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilenia Aversa","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012337000","display_name":"Camillo Palmieri","orcid":"https://orcid.org/0000-0001-6707-4723","observed_orcids":["https://orcid.org/0000-0001-6707-4723"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camillo Palmieri","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, \u201cMagna Graecia\u201d University of Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021887046"],"corresponding_institution_ids":["https://openalex.org/I36443711"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66715042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.24169999361038208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/t-cell-receptor-beta-repertoire","display_name":"T cell receptor beta repertoire","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5370000004768372},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cdr3-motifs","display_name":"CDR3 motifs","score":0.7350000143051147},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immunotherapy-targets","display_name":"immunotherapy targets","score":0.5950000286102295},{"id":"https://openalex.org/keywords/t-cell-clonality","display_name":"T cell clonality","score":0.6359999775886536},{"id":"https://openalex.org/keywords/ifn-gamma-response","display_name":"IFN-gamma response","score":0.574999988079071},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6866000294685364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6011000275611877},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.5758000016212463},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5076000094413757},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.4659999907016754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45980000495910645},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4350000023841858},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41990000009536743},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38609999418258667},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.3790999948978424},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37630000710487366},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.3725999891757965},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3310999870300293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3138999938964844},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2856000065803528},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.25929999351501465},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2551000118255615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12672-026-05804-5","doi":"https://doi.org/10.1007/s12672-026-05804-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05804-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s12672-026-05804-5","doi":"https://doi.org/10.1007/s12672-026-05804-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-026-05804-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6708653696","display_name":null,"funder_award_id":"FESR-FSE 2014-2020 \u201cSAGGIO PER IL DOSAGGIO DELLA PROTEINA PD-L1 IN CAMPIONI BIOLOGICI\u201d,","funder_id":"https://openalex.org/F4320326073","funder_display_name":"Regione Calabria"}],"funders":[{"id":"https://openalex.org/F4320326073","display_name":"Regione Calabria","ror":"https://ror.org/03swz0133"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0],"T-cell":[1,27,124,210],"receptor":[2,182],"\u03b2":[3],"(TCR\u03b2)":[4],"repertoire":[5],"reflects":[6],"antigen-driven":[7,152,240],"adaptive":[8],"immune":[9],"responses":[10],"and":[11,29,47,55,60,79,93,110,126,143,161,188,201,208,221,244,248,270],"provides":[12],"insight":[13],"into":[14],"tumor\u2013immune":[15],"interaction.":[16],"In":[17],"prostate":[18,275],"cancer":[19],"(PCa),":[20],"the":[21,30,232,265],"immunosuppressive":[22],"tumor":[23,46,77],"microenvironment":[24],"limits":[25],"effective":[26],"activation,":[28],"antigenic":[31,61],"drivers":[32],"shaping":[33],"intratumoral":[34,241],"TCR":[35,257],"repertoires":[36,50,74,139],"remains":[37],"poorly":[38],"defined.":[39],"This":[40],"study":[41],"aimed":[42],"to":[43,56,71,105],"characterize":[44],"matched":[45,76],"peripheral":[48,80],"TCR\u03b2":[49,73,138,242],"from":[51,75,86,178],"treatment-na\u00efve":[52,87],"PCa":[53,88,135],"patients":[54],"identify":[57,106,245],"shared":[58,107],"clonotypes":[59,174],"specificities":[62],"associated":[63,172],"with":[64,147,150,175,231,259],"disease":[65],"severity.":[66],"Next-generation":[67],"sequencing":[68,129,216],"was":[69,94,101,119],"used":[70],"profile":[72,224],"biopsies":[78],"blood":[81],"mononuclear":[82],"cells":[83,228],"(PBMCs)":[84],"obtained":[85],"patients.":[89,136],"Repertoires":[90],"clonality,":[91],"diversity,":[92],"assessed":[95],"using":[96,103,121],"established":[97],"metrics.":[98],"Antigenic":[99],"convergence":[100],"evaluated":[102],"GLIPH2":[104,170],"CDR3\u03b2":[108],"motifs":[109],"predicted":[111],"tumor-associated":[112],"antigen":[113,186,190,260],"(TAA)":[114],"recognition.":[115],"Preliminary":[116],"functional":[117],"validation":[118,193],"performed":[120],"IFN-\u03b3":[122,206],"ELISpot,":[123],"expansion,":[125],"single-cell":[127],"RNA":[128,215],"in":[130,212,225,274],"an":[131,218,238],"independent":[132],"cohort":[133],"of":[134,165,167,256,267],"Tumor-derived":[137],"displayed":[140],"reduced":[141],"richness":[142],"increased":[144],"clonality":[145],"compared":[146],"PBCMs,":[148],"consistent":[149],"local":[151],"expansion.":[153],"High-grade":[154],"tumors":[155],"demonstrated":[156,217],"greater":[157],"interpatient":[158],"clonotype":[159],"sharing":[160],"motif-level":[162],"convergence,":[163],"indicative":[164],"recognition":[166],"common":[168],"TAAs.":[169],"analysis":[171],"expanded":[173],"epitopes":[176,204],"derived":[177],"prostate-specific":[179,184,189],"G-protein":[180],"coupled":[181],"(PSGR),":[183],"membrane":[185],"(PSMA),":[187],"(PSA).":[191],"Functional":[192],"confirmed":[194],"that":[195],"peptide":[196,233],"pools":[197],"containing":[198],"PSGR-,":[199],"PSMA-,":[200],"Transglutaminase-4":[202],"(TGM4)-derived":[203],"induced":[205],"production":[207],"antigen-specific":[209],"proliferation":[211],"vitro.":[213],"Single-cell":[214],"enhanced":[219],"activation":[220],"cytotoxic":[222],"transcriptional":[223],"CD3\u207a":[226],"T":[227],"following":[229],"stimulation":[230],"pool.":[234],"These":[235],"findings":[236],"reveal":[237],"oligoclonal,":[239],"landscape":[243],"PSGR,":[246],"PSMA,":[247],"TGM4":[249],"as":[250],"immunogenic,":[251],"potentially":[252],"actionable":[253],"targets.":[254],"Integration":[255],"profiling":[258],"discovery":[261],"pipelines":[262],"may":[263],"support":[264],"development":[266],"TCR-based":[268],"biomarkers":[269],"precision":[271],"immunotherapeutic":[272],"strategies":[273],"cancer.":[276]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-09-02T00:00:00"}