{"id":"https://openalex.org/W7204999910","doi":"https://doi.org/10.1038/s41413-026-00580-y","title":"Mechano-metabolic axis involves mitochondrial responses via BMP/Smad regulatory effect on cyclophilin D","display_name":"Mechano-metabolic axis involves mitochondrial responses via BMP/Smad regulatory effect on cyclophilin D","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204999910","doi":"https://doi.org/10.1038/s41413-026-00580-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42686692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13538553"},"language":"en","primary_location":{"id":"doi:10.1038/s41413-026-00580-y","doi":"https://doi.org/10.1038/s41413-026-00580-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-026-00580-y","pdf_url":"https://www.nature.com/articles/s41413-026-00580-y.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41413-026-00580-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004566405","display_name":"Rubens Sautchuk","orcid":"https://orcid.org/0000-0002-0302-7562","observed_orcids":["https://orcid.org/0000-0002-0302-7562"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rubens Sautchuk","raw_affiliation_strings":["Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-0302-7562","affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149008641","display_name":"Josaranie Nieves Santana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josaranie Nieves Santana","raw_affiliation_strings":["Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402081","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-9661-3914","observed_orcids":["https://orcid.org/0000-0002-9661-3914","https://orcid.org/0009-0006-3888-3533"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Yu","raw_affiliation_strings":["Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072046074","display_name":"Hani A. Awad","orcid":"https://orcid.org/0000-0003-2197-2610","observed_orcids":["https://orcid.org/0000-0003-2197-2610"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani Awad","raw_affiliation_strings":["Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA","Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-2197-2610","affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058183246","display_name":"Roman A. Eliseev","orcid":"https://orcid.org/0000-0002-6783-7388","observed_orcids":["https://orcid.org/0000-0002-6783-7388"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roman A. Eliseev","raw_affiliation_strings":["Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu","Department of Pathology, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu","Department of Pharmacology & Physiology, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu"],"raw_orcid":"https://orcid.org/0000-0002-6783-7388","affiliations":[{"raw_affiliation_string":"Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Pathology, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Pharmacology & Physiology, University of Rochester, Rochester, NY, USA. roman_eliseev@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058183246"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":3405,"currency":"USD","value_usd":3405},"apc_paid":{"value":3405,"currency":"USD","value_usd":3405},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56681514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophilin-d","display_name":"cyclophilin D","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bmp-smad-signaling","display_name":"BMP/Smad signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.8349999785423279},{"id":"https://openalex.org/keywords/osteoprogenitor-cells","display_name":"osteoprogenitor cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mechanical-unloading","display_name":"mechanical unloading","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tooth-extraction","display_name":"tooth extraction","score":0.7350000143051147},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7120000123977661},{"id":"https://openalex.org/keywords/spaceflight-bone-loss","display_name":"spaceflight bone loss","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.9092000126838684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8209999799728394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6328999996185303},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6103000044822693},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.5418999791145325},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40639999508857727},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C74897846","wikidata":"https://www.wikidata.org/wiki/Q6881870","display_name":"Mitochondrial membrane transport protein","level":4,"score":0.3621000051498413},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3483999967575073},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.34209999442100525},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.25360000133514404}],"mesh":[{"descriptor_ui":"D000081406","descriptor_name":"Peptidyl-Prolyl Isomerase F","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021983","descriptor_name":"Cyclophilins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41413-026-00580-y","doi":"https://doi.org/10.1038/s41413-026-00580-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-026-00580-y","pdf_url":"https://www.nature.com/articles/s41413-026-00580-y.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13538553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13538553/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13538553/pdf/41413_2026_Article_580.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Res","raw_type":"Text"},{"id":"pmid:42686692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42686692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:da091872c0f8453a836b5a0a3604a795","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/da091872c0f8453a836b5a0a3604a795","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bone Research, Vol 14, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41413-026-00580-y","doi":"https://doi.org/10.1038/s41413-026-00580-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41413-026-00580-y","pdf_url":"https://www.nature.com/articles/s41413-026-00580-y.pdf","source":{"id":"https://openalex.org/S2764590364","display_name":"Bone Research","issn_l":"2095-4700","issn":["2095-4700","2095-6231"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","erih-plus","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3741530918","display_name":"Training Program in Oral Science","funder_award_id":"R90DE022529","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5320092752","display_name":"The role of mitochondrial dysfunction in the pathogenesis of osteoarthritis","funder_award_id":"R21AR070928","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5369377190","display_name":"Mitochondrial metabolism and bone formation","funder_award_id":"R01AR072601","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000876420","display_name":"Efferocytosis by Bone Marrow Stromal Cells and Bone Aging","funder_award_id":"R01AG076786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000885268","display_name":"Raman spectroscopic platform for transcutaneous monitoring of bone quality","funder_award_id":"R01AR070613","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000907411","display_name":"Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)","funder_award_id":"P30AR069655","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000917625","display_name":"Energy Metabolism in Osteoblasts and Bone Health","funder_award_id":"R01AG080188","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204999910.pdf","grobid_xml":"https://content.openalex.org/works/W7204999910.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W408663002","https://openalex.org/W1766726626","https://openalex.org/W1965270044","https://openalex.org/W1970326476","https://openalex.org/W1995990276","https://openalex.org/W2003035047","https://openalex.org/W2003366013","https://openalex.org/W2064918803","https://openalex.org/W2065324486","https://openalex.org/W2074552199","https://openalex.org/W2082973248","https://openalex.org/W2086675887","https://openalex.org/W2096378343","https://openalex.org/W2097793695","https://openalex.org/W2098586364","https://openalex.org/W2103378167","https://openalex.org/W2106207488","https://openalex.org/W2117389654","https://openalex.org/W2171104477","https://openalex.org/W2174726620","https://openalex.org/W2289876562","https://openalex.org/W2387637186","https://openalex.org/W2589563261","https://openalex.org/W2600079681","https://openalex.org/W2619027674","https://openalex.org/W2766666796","https://openalex.org/W2783721475","https://openalex.org/W2886661663","https://openalex.org/W2889380083","https://openalex.org/W3021204257","https://openalex.org/W3108506878","https://openalex.org/W3112643460","https://openalex.org/W3153190939","https://openalex.org/W3184121846","https://openalex.org/W4281737509","https://openalex.org/W4281975031","https://openalex.org/W4285766694","https://openalex.org/W4320485690","https://openalex.org/W4380871066","https://openalex.org/W4402609750"],"related_works":["https://openalex.org/W2923114823","https://openalex.org/W4281737509","https://openalex.org/W4402609750","https://openalex.org/W4320485690","https://openalex.org/W2802652858","https://openalex.org/W3021204257","https://openalex.org/W2018020008","https://openalex.org/W1601178202","https://openalex.org/W2974426831","https://openalex.org/W2588681757"],"abstract_inverted_index":{"Mechanical":[0],"stimulation":[1,13],"is":[2,37,63,220],"fundamental":[3],"for":[4,222],"anabolism":[5],"in":[6,112,123,144,147,161,173,189,206],"various":[7],"tissues,":[8],"including":[9],"bone.":[10,176],"Importantly,":[11],"mechanical":[12,69,227],"has":[14],"been":[15],"shown":[16],"to":[17,24,27,41,49,65,166,241,249],"induce":[18],"reprogramming":[19],"of":[20,90,98,131,154,158,171,179,212,226],"cell":[21,56],"metabolism,":[22],"likely":[23],"adjust":[25],"it":[26],"increased":[28],"anabolism.":[29],"The":[30,60],"signal":[31,44],"transduction":[32],"within":[33],"this":[34],"mechano-metabolic":[35,204],"axis":[36,205],"incompletely":[38],"understood.":[39],"Aiming":[40],"delineate":[42],"such":[43],"transduction,":[45],"we":[46,72,149,197],"exposed":[47],"osteoprogenitors":[48],"fluid":[50],"shear":[51],"stress":[52],"(FSS)":[53],"and":[54,58,71,105,119,138,169,214],"assessed":[55],"signaling":[57],"bioenergetics.":[59],"BMP/Smad":[61],"pathway":[62],"known":[64],"be":[66,237],"activated":[67,122],"by":[68,77,246],"stress,":[70],"indeed":[73,117],"detected":[74],"its":[75],"activation":[76],"FSS.":[78],"We":[79,109],"previously":[80],"reported":[81],"that":[82,111,202,233],"BMP":[83],"downregulates":[84],"cyclophilin":[85],"D":[86],"(CypD),":[87],"an":[88,238],"opener":[89],"the":[91,128,174,203,223],"mitochondrial":[92,101,139,216],"permeability":[93],"transition":[94],"pore":[95],"(MPTP).":[96],"Downregulation":[97],"CypD/MPTP":[99],"improves":[100],"inner":[102],"membrane":[103],"integrity":[104],"therefore":[106],"oxidative":[107],"function.":[108],"found":[110],"FSS-stimulated":[113],"cells,":[114],"CypD":[115,136,172,180,187,213,235],"was":[116,133],"downregulated":[118],"mitochondria":[120],"were":[121],"a":[124,151],"BMP-dependent":[125],"manner.":[126],"Meanwhile,":[127],"osteogenic":[129,207],"effect":[130,225],"FSS":[132],"dependent":[134],"on":[135],"downregulation":[137,211],"responses.":[140,217],"To":[141],"confirm":[142],"our":[143],"vitro":[145],"results":[146],"vivo,":[148],"optimized":[150],"novel":[152],"model":[153],"tooth":[155,254],"extraction-mediated":[156],"unloading":[157,164,247],"craniofacial":[159],"bones":[160],"mice.":[162],"Such":[163,218],"led":[165],"bone":[167,184,193,243],"loss":[168,244],"upregulation":[170],"affected":[175],"Osteoblast-specific":[177],"deletion":[178],"protected":[181],"against":[182],"unloading-mediated":[183],"loss,":[185],"while":[186],"re-expression":[188],"these":[190],"mice":[191],"restored":[192],"loss.":[194],"In":[195],"sum,":[196],"here":[198],"present":[199],"new":[200],"evidence":[201],"cells":[208],"involves":[209],"BMP/Smad-mediated":[210],"CypD-dependent":[215],"regulation":[219],"important":[221],"osteoanabolic":[224],"stimulation.":[228],"Our":[229],"data":[230],"also":[231],"suggest":[232],"targeting":[234],"can":[236],"effective":[239],"strategy":[240],"prevent":[242],"caused":[245],"due":[248],"immobility,":[250],"space":[251],"flight,":[252],"or":[253],"extraction.":[255]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-02T00:00:00"}
