{"id":"https://openalex.org/W7204997564","doi":"https://doi.org/10.1038/s41598-026-60341-z","title":"Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration","display_name":"Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204997564","doi":"https://doi.org/10.1038/s41598-026-60341-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42686804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13538558"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-60341-z","doi":"https://doi.org/10.1038/s41598-026-60341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-60341-z","pdf_url":"https://www.nature.com/articles/s41598-026-60341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-60341-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070817572","display_name":"Mohamed Samir Turkey","orcid":"https://orcid.org/0000-0002-1576-0841","observed_orcids":["https://orcid.org/0000-0002-1576-0841"]},"institutions":[{"id":"https://openalex.org/I4210165376","display_name":"October 6 University","ror":"https://ror.org/05y06tg49","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210165376"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed Samir Turkey","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Pharmacy, October 6 University, Giza, Egypt. Mohamed.Turky.pharm@o6u.edu.eg"],"raw_orcid":"https://orcid.org/0000-0002-1576-0841","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Pharmacy, October 6 University, Giza, Egypt. Mohamed.Turky.pharm@o6u.edu.eg","institution_ids":["https://openalex.org/I4210165376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072524647","display_name":"Jilan A. Nazeam","orcid":"https://orcid.org/0000-0003-1149-8222","observed_orcids":["https://orcid.org/0000-0003-1149-8222"]},"institutions":[{"id":"https://openalex.org/I4210165376","display_name":"October 6 University","ror":"https://ror.org/05y06tg49","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210165376"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Jilan A. Nazeam","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, Egypt","institution_ids":["https://openalex.org/I4210165376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108660814","display_name":"Farag F. Sherbiny","orcid":"https://orcid.org/0000-0003-0359-4345","observed_orcids":["https://orcid.org/0000-0003-0359-4345"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Farag F. Sherbiny","raw_affiliation_strings":["Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050244926","display_name":"Sulaiman Mohammed Alnasser","orcid":"https://orcid.org/0000-0001-8678-5029","observed_orcids":["https://orcid.org/0000-0001-8678-5029"]},"institutions":[{"id":"https://openalex.org/I156216236","display_name":"Qassim University","ror":"https://ror.org/01wsfe280","country_code":"SA","type":"education","lineage":["https://openalex.org/I156216236"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sulaiman M. Alnasser","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia","institution_ids":["https://openalex.org/I156216236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083945467","display_name":"Walied Abdo","orcid":"https://orcid.org/0000-0003-4635-8342","observed_orcids":["https://orcid.org/0000-0003-4635-8342"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Walied Abdo","raw_affiliation_strings":["Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036217477","display_name":"Tohada M. AL\u2010Noshokaty","orcid":"https://orcid.org/0000-0002-5449-7089","observed_orcids":["https://orcid.org/0000-0002-5449-7089"]},"institutions":[{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tohada M. AL-Noshokaty","raw_affiliation_strings":["Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083762816","display_name":"Shimaa Ali Abass","orcid":"https://orcid.org/0000-0002-0695-2251","observed_orcids":["https://orcid.org/0000-0002-0695-2251"]},"institutions":[{"id":"https://openalex.org/I130309236","display_name":"Kafrelsheikh University","ror":"https://ror.org/04a97mm30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130309236"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shimaa A. Abass","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Kafer El-Sheikh University, Kafr El-Sheikh, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Kafer El-Sheikh University, Kafr El-Sheikh, Egypt","institution_ids":["https://openalex.org/I130309236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070817572"],"corresponding_institution_ids":["https://openalex.org/I4210165376"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51938294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrastis-canadensis","display_name":"Hydrastis canadensis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/multidrug-resistant-pseudomonas-aeruginosa","display_name":"multidrug-resistant Pseudomonas aeruginosa","score":0.9679999947547913},{"id":"https://openalex.org/keywords/burn-wound-infection","display_name":"burn wound infection","score":0.9599999785423279},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lasr","display_name":"LasR","score":0.9160000085830688},{"id":"https://openalex.org/keywords/rhlr","display_name":"RhlR","score":0.9200000166893005},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.765999972820282},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6520000100135803},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/topical-administration","display_name":"topical administration","score":0.6150000095367432},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8176000118255615},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7439000010490417},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6632000207901001},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.6420999765396118},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5361999869346619},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5160999894142151},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.46129998564720154},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4235999882221222},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.3262999951839447},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31299999356269836},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.31130000948905945},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.2831999957561493},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2671999931335449},{"id":"https://openalex.org/C2781427627","wikidata":"https://www.wikidata.org/wiki/Q410503","display_name":"Pyocyanin","level":5,"score":0.2540000081062317}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014946","descriptor_name":"Wound Infection","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014946","descriptor_name":"Wound Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-026-60341-z","doi":"https://doi.org/10.1038/s41598-026-60341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-60341-z","pdf_url":"https://www.nature.com/articles/s41598-026-60341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42686804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42686804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13538558","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13538558/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cccf51dd008742de95b05713123b4ae5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cccf51dd008742de95b05713123b4ae5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-60341-z","doi":"https://doi.org/10.1038/s41598-026-60341-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-60341-z","pdf_url":"https://www.nature.com/articles/s41598-026-60341-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321655","display_name":"Science and Technology Development Fund","ror":"https://ror.org/044vr6g03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204997564.pdf","grobid_xml":"https://content.openalex.org/works/W7204997564.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W18206448","https://openalex.org/W1543068333","https://openalex.org/W1964760806","https://openalex.org/W1978641850","https://openalex.org/W1994253192","https://openalex.org/W2017305946","https://openalex.org/W2023153930","https://openalex.org/W2027368837","https://openalex.org/W2054362555","https://openalex.org/W2062374558","https://openalex.org/W2081434748","https://openalex.org/W2086760146","https://openalex.org/W2094012923","https://openalex.org/W2099540110","https://openalex.org/W2105869534","https://openalex.org/W2122106315","https://openalex.org/W2129067221","https://openalex.org/W2134459918","https://openalex.org/W2134967712","https://openalex.org/W2152067625","https://openalex.org/W2163883372","https://openalex.org/W2165178639","https://openalex.org/W2461093102","https://openalex.org/W2606212754","https://openalex.org/W2800407297","https://openalex.org/W2915709393","https://openalex.org/W2969480054","https://openalex.org/W3004140701","https://openalex.org/W3007757377","https://openalex.org/W3069085940","https://openalex.org/W3096523997","https://openalex.org/W3131459325","https://openalex.org/W4210907925","https://openalex.org/W4211234775","https://openalex.org/W4224279218","https://openalex.org/W4281999972","https://openalex.org/W4283324706","https://openalex.org/W4310711907","https://openalex.org/W4321077879","https://openalex.org/W4321481959","https://openalex.org/W4324030562","https://openalex.org/W4366826824","https://openalex.org/W4389862589","https://openalex.org/W4390752095","https://openalex.org/W4391556214","https://openalex.org/W4392805943","https://openalex.org/W4398255840","https://openalex.org/W4402668912","https://openalex.org/W4406241047","https://openalex.org/W4410548971","https://openalex.org/W4411864256","https://openalex.org/W4412123225","https://openalex.org/W4414205221","https://openalex.org/W7140274608"],"related_works":["https://openalex.org/W4396945954","https://openalex.org/W7213278307","https://openalex.org/W4388680357","https://openalex.org/W6964872261","https://openalex.org/W3135634635","https://openalex.org/W7116657613","https://openalex.org/W2807968798","https://openalex.org/W4300870327","https://openalex.org/W4388942801","https://openalex.org/W7168297314"],"abstract_inverted_index":{"Multidrug-resistant":[0],"(MDR)":[1],"Pseudomonas":[2],"aeruginosa":[3],"is":[4],"a":[5,39,130,162],"prominent":[6],"pathogen":[7],"implicated":[8],"in":[9,49,51,54,69,144,164,172],"burn":[10,222],"wound":[11,148,210,223],"infections,":[12],"creating":[13],"substantial":[14],"therapeutic":[15,219],"obstacles":[16],"due":[17],"to":[18,85,161],"its":[19,213],"antibiotic":[20],"resistance":[21],"and":[22,35,53,67,80,93,95,115,118,123,138,153,166,174,187,208],"enhanced":[23,147],"virulence":[24,207],"mediated":[25],"by":[26,121,226],"quorum":[27],"sensing":[28],"(QS).":[29],"This":[30],"study":[31],"explored":[32],"the":[33,70,90,180,190],"anti-infective":[34],"wound-healing":[36],"properties":[37],"of":[38,133,182,192,197],"standardized":[40],"extract":[41],"from":[42],"Hydrastis":[43],"canadensis":[44],"(Goldenseal;":[45],"GS)":[46],"using":[47],"integrated":[48],"silico,":[50],"vitro,":[52,102],"vivo":[55],"approaches.":[56],"LC-ESI-MS/MS":[57],"profiling":[58],"identified":[59],"52":[60],"phytochemicals,":[61],"including":[62,185],"alkaloids,":[63],"flavonoids,":[64],"phenolic":[65],"acids,":[66],"glycosides,":[68],"extract.":[71],"Molecular":[72],"docking":[73],"against":[74],"QS":[75],"regulators":[76],"(LasR,":[77],"LasI,":[78],"RhlR,":[79],"RhlI)":[81],"revealed":[82],"preferential":[83],"binding":[84],"LasR,":[86],"with":[87],"naringenin-7-O-glucoside":[88],"showing":[89],"highest":[91],"affinity":[92],"chlorogenic":[94],"orotic":[96],"acids":[97],"exhibiting":[98],"selective":[99],"interactions.":[100],"In":[101,129],"GS":[103,140,204],"demonstrated":[104],"antibacterial":[105],"activity":[106],"(MIC":[107],"=":[108],"3.125":[109],"mg/mL),":[110],"significantly":[111],"inhibited":[112],"biofilm":[113],"formation,":[114],"reduced":[116],"lasR":[117],"rhlR":[119],"expression":[120],"95.3%":[122],"84.8%,":[124],"respectively":[125],"(p":[126],"<":[127],"0.001).":[128],"rat":[131],"model":[132],"second-degree":[134],"burns,":[135],"both":[136],"oral":[137,198],"topical":[139,193],"administration":[141],"was":[142],"evaluated":[143],"vivo,":[145],"revealing":[146],"contraction,":[149],"increased":[150],"collagen":[151],"deposition,":[152],"improved":[154],"histopathological":[155],"outcomes.":[156],"These":[157,200],"outcomes":[158],"were":[159],"linked":[160],"reduction":[163],"TNF-\u03b1":[165],"IL-1\u03b2":[167],"levels,":[168,176],"alongside":[169],"an":[170,217],"increase":[171],"VEGF":[173],"bFGF":[175],"as":[177,179,216],"well":[178],"upregulation":[181],"antimicrobial":[183],"peptides,":[184],"CAMP":[186],"RBD2.":[188],"Moreover,":[189],"efficacy":[191],"application":[194,215],"surpassed":[195],"that":[196,203],"administration.":[199],"findings":[201],"indicate":[202],"suppresses":[205],"QS-regulated":[206],"promotes":[209],"repair,":[211],"supporting":[212],"potential":[214],"adjunctive":[218],"approach":[220],"for":[221],"infections":[224],"caused":[225],"MDR":[227],"P.":[228],"aeruginosa.":[229]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-02T00:00:00"}