{"id":"https://openalex.org/W7204997484","doi":"https://doi.org/10.1158/1535-7163.33414978","title":"Supplementary Table 1 from MRTX1133 Suppresses ERK Signaling but Elicits Context-Dependent Antiproliferative Responses in KRAS (G12C) Cancer Cells","display_name":"Supplementary Table 1 from MRTX1133 Suppresses ERK Signaling but Elicits Context-Dependent Antiproliferative Responses in KRAS (G12C) Cancer Cells","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204997484","doi":"https://doi.org/10.1158/1535-7163.33414978"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.33414978","doi":"https://doi.org/10.1158/1535-7163.33414978","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414978","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.33414978","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063000558","display_name":"Abraham C. Sianoya","orcid":"https://orcid.org/0000-0002-5070-7843","observed_orcids":["https://orcid.org/0000-0002-5070-7843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abraham C. Sianoya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5070-7843","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149038319","display_name":"Yan Zuo","orcid":"https://orcid.org/0009-0008-2555-2756","observed_orcids":["https://orcid.org/0009-0008-2555-2756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Zuo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2555-2756","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061390911","display_name":"Cynthia V. Pagba","orcid":"https://orcid.org/0000-0002-3642-4361","observed_orcids":["https://orcid.org/0000-0002-3642-4361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia V. Pagba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3642-4361","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089666266","display_name":"Jacob L. Jakubec","orcid":"https://orcid.org/0009-0007-2017-8497","observed_orcids":["https://orcid.org/0009-0007-2017-8497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob L. Jakubec","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2017-8497","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041724011","display_name":"Stephanie A. Planque","orcid":"https://orcid.org/0009-0009-0057-3603","observed_orcids":["https://orcid.org/0009-0009-0057-3603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie A. Planque","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-0057-3603","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046674705","display_name":"Jeffrey A. Frost","orcid":"https://orcid.org/0000-0001-9722-1536","observed_orcids":["https://orcid.org/0000-0001-9722-1536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Frost","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9722-1536","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011332945","display_name":"Paul Mark B. Medina","orcid":"https://orcid.org/0000-0001-6116-1818","observed_orcids":["https://orcid.org/0000-0001-6116-1818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Mark B. Medina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6116-1818","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087588530","display_name":"Alemayehu Abebe Gorfe","orcid":"https://orcid.org/0000-0002-9328-4692","observed_orcids":["https://orcid.org/0000-0002-9328-4692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alemayehu A. Gorfe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9328-4692","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7627000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrtx1133","display_name":"MRTX1133","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.828000009059906},{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antiproliferative-response","display_name":"antiproliferative response","score":0.875}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5881999731063843},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5752000212669373},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.49380001425743103},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.48339998722076416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47940000891685486},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4472000002861023},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42980000376701355},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41780000925064087},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.38190001249313354},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32749998569488525},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C155985219","wikidata":"https://www.wikidata.org/wiki/Q409325","display_name":"Extracellular signal-regulated kinases","level":4,"score":0.28949999809265137},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2637999951839447},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.33414978","doi":"https://doi.org/10.1158/1535-7163.33414978","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414978","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.33414978","doi":"https://doi.org/10.1158/1535-7163.33414978","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414978","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7205003435","https://openalex.org/W7205016266","https://openalex.org/W7135403100","https://openalex.org/W4307034052","https://openalex.org/W7148984544","https://openalex.org/W7163016961","https://openalex.org/W4406336178","https://openalex.org/W7163050870","https://openalex.org/W7163003243","https://openalex.org/W4361940306"],"abstract_inverted_index":{"Research":[0],"Resource":[1],"Identifiers":[2],"(RRID)":[3],"for":[4],"resources":[5],"used":[6],"in":[7],"the":[8],"study.":[9]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}