{"id":"https://openalex.org/W7204994922","doi":"https://doi.org/10.1002/jsfa.71032","title":"Noni fruit phenolic\u2010rich extract ameliorated non\u2010alcoholic fatty liver disease through regulating gut microbiota and bile acids profiling by targeting FXR \u2013 FGF15 signaling","display_name":"Noni fruit phenolic\u2010rich extract ameliorated non\u2010alcoholic fatty liver disease through regulating gut microbiota and bile acids profiling by targeting FXR \u2013 FGF15 signaling","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204994922","doi":"https://doi.org/10.1002/jsfa.71032","pmid":"https://pubmed.ncbi.nlm.nih.gov/42681837"},"language":"en","primary_location":{"id":"doi:10.1002/jsfa.71032","doi":"https://doi.org/10.1002/jsfa.71032","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.71032","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204994922"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115694991","display_name":"Huixian Wang","orcid":"https://orcid.org/0009-0006-8303-5824","observed_orcids":["https://orcid.org/0009-0006-8303-5824"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huixian Wang","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102681277","display_name":"Derui Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Derui Yang","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149028241","display_name":"Yi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Huang","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148946698","display_name":"Xinhui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhui Liu","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144046370","display_name":"Yunlan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunlan Liu","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101969271","display_name":"Zewei Ma","orcid":"https://orcid.org/0000-0002-2375-6041","observed_orcids":["https://orcid.org/0000-0002-2375-6041"]},"institutions":[{"id":"https://openalex.org/I4405260596","display_name":"Hainan Institute of Grain and Oil Science","ror":"https://ror.org/040f8z831","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405260596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zewei Ma","raw_affiliation_strings":["Hainan Institute of Grain and Oil Science  Qionghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan Institute of Grain and Oil Science  Qionghai China","institution_ids":["https://openalex.org/I4405260596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052970160","display_name":"Ruimin Wang","orcid":"https://orcid.org/0000-0001-7724-0289","observed_orcids":["https://orcid.org/0000-0001-7724-0289"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruimin Wang","raw_affiliation_strings":["School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China"],"raw_orcid":"https://orcid.org/0000-0001-7724-0289","affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Collaborative Innovation Center of One Health Hainan University  Haikou China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052970160"],"corresponding_institution_ids":["https://openalex.org/I20942203"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"107","issue":"1","first_page":"914","last_page":"926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13792","display_name":"Morinda citrifolia extract uses","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noni-fruit","display_name":"noni fruit","score":0.9599999785423279},{"id":"https://openalex.org/keywords/acacia-mearnsii","display_name":"Acacia mearnsii","score":0.7720000147819519},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fgf15","display_name":"FGF15","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.972000002861023},{"id":"https://openalex.org/keywords/cyp7a1","display_name":"CYP7A1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7990000247955322},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.930899977684021},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.8007000088691711},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.7809000015258789},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6949999928474426},{"id":"https://openalex.org/C89673097","wikidata":"https://www.wikidata.org/wiki/Q14907373","display_name":"Cholesterol 7 alpha-hydroxylase","level":3,"score":0.6927000284194946},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.5476999878883362},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.47850000858306885},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47429999709129333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46630001068115234},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45969998836517334},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45080000162124634},{"id":"https://openalex.org/C39321552","wikidata":"https://www.wikidata.org/wiki/Q18052005","display_name":"G protein-coupled bile acid receptor","level":3,"score":0.4187000095844269},{"id":"https://openalex.org/C2776514860","wikidata":"https://www.wikidata.org/wiki/Q3817359","display_name":"Hepatoprotection","level":4,"score":0.3982999920845032},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39649999141693115},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.3806000053882599},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.36149999499320984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34950000047683716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3310999870300293},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.3249000012874603},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.3174000084400177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3118000030517578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3077000081539154},{"id":"https://openalex.org/C10213722","wikidata":"https://www.wikidata.org/wiki/Q17912191","display_name":"CYP8B1","level":4,"score":0.304500013589859},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.2565000057220459},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2558000087738037}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000099150","descriptor_name":"Receptor, Farnesoid X-Activated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002790","descriptor_name":"Cholesterol 7-alpha-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002790","descriptor_name":"Cholesterol 7-alpha-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031667","descriptor_name":"Dendrobium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jsfa.71032","doi":"https://doi.org/10.1002/jsfa.71032","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.71032","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},{"id":"pmid:42681837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42681837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the science of food and agriculture","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W2208262108","https://openalex.org/W2428595929","https://openalex.org/W2468692184","https://openalex.org/W2519008943","https://openalex.org/W2901124467","https://openalex.org/W2945998249","https://openalex.org/W2951582795","https://openalex.org/W2970026022","https://openalex.org/W3000749615","https://openalex.org/W3001680293","https://openalex.org/W3109895489","https://openalex.org/W3115725139","https://openalex.org/W3164973461","https://openalex.org/W3166722724","https://openalex.org/W3172197894","https://openalex.org/W3181456162","https://openalex.org/W3208813684","https://openalex.org/W4212930994","https://openalex.org/W4286252736","https://openalex.org/W4286512176","https://openalex.org/W4289130587","https://openalex.org/W4292242295","https://openalex.org/W4293462145","https://openalex.org/W4295196957","https://openalex.org/W4295922492","https://openalex.org/W4304144157","https://openalex.org/W4306152405","https://openalex.org/W4307813217","https://openalex.org/W4309563498","https://openalex.org/W4311468925","https://openalex.org/W4323036951","https://openalex.org/W4384131713","https://openalex.org/W4384933273","https://openalex.org/W4385341024","https://openalex.org/W4386282944","https://openalex.org/W4386455159","https://openalex.org/W4386835379","https://openalex.org/W4388977867","https://openalex.org/W4391309974","https://openalex.org/W4393002876","https://openalex.org/W4394693695","https://openalex.org/W4394989922","https://openalex.org/W4395445997","https://openalex.org/W4396574173","https://openalex.org/W4396621089","https://openalex.org/W4397030425","https://openalex.org/W4400239570","https://openalex.org/W4403284498","https://openalex.org/W4403300760","https://openalex.org/W4403365640","https://openalex.org/W4405439949","https://openalex.org/W4407823210","https://openalex.org/W4408846035","https://openalex.org/W4410008141","https://openalex.org/W4410101365","https://openalex.org/W4411708120","https://openalex.org/W4411848423","https://openalex.org/W7117541043","https://openalex.org/W7153601224"],"related_works":["https://openalex.org/W4286512176","https://openalex.org/W4411708120","https://openalex.org/W4295898031","https://openalex.org/W4406715544","https://openalex.org/W4407319370","https://openalex.org/W2920929185","https://openalex.org/W4388247477","https://openalex.org/W7167673829","https://openalex.org/W4406605370","https://openalex.org/W4408532042"],"abstract_inverted_index":{"BACKGROUND:":[0],"Non-alcoholic":[1],"fatty":[2],"liver":[3,12,113],"disease":[4,13],"(NAFLD)":[5],"is":[6,30,67],"the":[7,119,125,148,163,178,192],"leading":[8,129],"cause":[9],"of":[10,121,124,132,138,162,195,206],"chronic":[11],"globally,":[14],"covering":[15],"a":[16,53,198],"spectrum":[17],"from":[18],"simple":[19],"hepatic":[20,95,109,133],"steatosis":[21],"to":[22,70,130],"steatohepatitis.":[23],"With":[24],"limited":[25],"pharmacological":[26],"interventions":[27],"available,":[28],"there":[29],"growing":[31],"interest":[32],"in":[33,56,85,91],"natural":[34],"products":[35],"for":[36,201],"NAFLD":[37,71,175],"prevention":[38],"and":[39,61,64,88,94,103,111,135,140,151,185],"management.":[40],"The":[41],"farnesoid":[42],"X":[43],"receptor":[44],"(FXR)-fibroblast":[45],"growth":[46],"factor":[47],"15":[48],"(FGF15)":[49],"signaling":[50,127],"pathway":[51],"plays":[52],"pivotal":[54],"role":[55],"regulating":[57,181],"bile":[58,182],"acid":[59,183],"(BA)":[60],"lipid":[62,89,141],"metabolism,":[63,184],"its":[65,152],"dysregulation":[66],"closely":[68],"linked":[69],"progression.":[72],"RESULTS:":[73],"Noni":[74],"fruit":[75],"phenolic-rich":[76],"extract":[77],"(NFE)":[78],"treatment":[79],"ameliorated":[80],"high-fat":[81,172],"diet":[82,173],"(HFD)-induced":[83,174],"increases":[84],"body":[86],"weight":[87],"accumulation":[90],"both":[92],"serum":[93,100],"tissues,":[96],"accompanied":[97],"by":[98,176],"reduced":[99,112],"aspartate":[101],"aminotransferase":[102,105],"alanine":[104],"activities,":[106],"indicating":[107],"improved":[108],"function":[110],"injury.":[114],"Moreover,":[115],"NFE":[116,144,169,196],"intervention":[117,145,170,200],"modulated":[118],"expression":[120],"key":[122],"components":[123],"FXR-FGF15":[126,164,179],"pathway,":[128,180],"downregulation":[131],"CYP7A1":[134],"subsequent":[136],"modulation":[137],"BA":[139,157],"metabolism.":[142],"Notably,":[143],"can":[146],"modulate":[147],"gut":[149,187],"microbiota":[150],"metabolic":[153],"functions,":[154],"thereby":[155],"sustaining":[156],"homeostasis":[158],"through":[159],"feedback":[160],"regulation":[161],"pathway.":[165],"CONCLUSION:":[166],"In":[167],"summary,":[168],"alleviates":[171],"modulating":[177],"reshaping":[186],"microbiota.":[188],"These":[189],"results":[190],"support":[191],"potential":[193],"application":[194],"as":[197],"nutritional":[199],"NAFLD.":[202],"\u00a9":[203],"2026":[204],"Society":[205],"Chemical":[207],"Industry.":[208]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-02T00:00:00"}
