{"id":"https://openalex.org/W7204993536","doi":"https://doi.org/10.1158/0008-5472.33414368","title":"Supplemental Figure S8 from Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells","display_name":"Supplemental Figure S8 from Thymosin Alpha-1 Restores Chemotherapy-Induced Antitumor Immunity by Chaperoning a MicroRNA Ligand of TLR7 in Dendritic Cells","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204993536","doi":"https://doi.org/10.1158/0008-5472.33414368"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.33414368","doi":"https://doi.org/10.1158/0008-5472.33414368","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33414368","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.33414368","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081712902","display_name":"Yiting Wei","orcid":"https://orcid.org/0000-0002-5505-9005","observed_orcids":["https://orcid.org/0000-0002-5505-9005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiting Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5505-9005","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148986467","display_name":"Jing Chen","orcid":"https://orcid.org/0009-0008-3298-9649","observed_orcids":["https://orcid.org/0009-0008-3298-9649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-3298-9649","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962340","display_name":"Yunpeng Zhang","orcid":"https://orcid.org/0000-0002-3653-5504","observed_orcids":["https://orcid.org/0000-0002-3653-5504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunpeng Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3653-5504","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149032993","display_name":"Yueming Liu","orcid":"https://orcid.org/0000-0001-7472-0287","observed_orcids":["https://orcid.org/0000-0001-7472-0287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueming Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7472-0287","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138633230","display_name":"Fengjiao Zhu","orcid":"https://orcid.org/0009-0007-1402-3704","observed_orcids":["https://orcid.org/0009-0007-1402-3704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fengjiao Zhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-1402-3704","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055659924","display_name":"Xuru Wang","orcid":"https://orcid.org/0000-0002-5325-3883","observed_orcids":["https://orcid.org/0000-0002-5325-3883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuru Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5325-3883","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148974976","display_name":"Xiaohe Zhou","orcid":"https://orcid.org/0000-0002-9040-2796","observed_orcids":["https://orcid.org/0000-0002-9040-2796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohe Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9040-2796","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149005080","display_name":"Chengdong Wu","orcid":"https://orcid.org/0000-0002-2126-6903","observed_orcids":["https://orcid.org/0000-0002-2126-6903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengdong Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2126-6903","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457812","display_name":"Wenqi Zhang","orcid":"https://orcid.org/0000-0003-4891-500X","observed_orcids":["https://orcid.org/0000-0003-4891-500X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenqi Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4891-500X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835468","display_name":"Jinpeng Chen","orcid":"https://orcid.org/0000-0002-8105-470X","observed_orcids":["https://orcid.org/0000-0002-8105-470X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinpeng Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8105-470X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138655046","display_name":"Yuchen Zhang","orcid":"https://orcid.org/0009-0001-0035-0380","observed_orcids":["https://orcid.org/0009-0001-0035-0380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuchen Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-0035-0380","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067816966","display_name":"Ning Pan","orcid":"https://orcid.org/0000-0001-8795-6926","observed_orcids":["https://orcid.org/0000-0001-8795-6926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Pan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8795-6926","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447187","display_name":"Kang Chen","orcid":"https://orcid.org/0000-0001-9892-3118","observed_orcids":["https://orcid.org/0000-0001-9892-3118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kang Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9892-3118","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051776059","display_name":"Shiya Zheng","orcid":"https://orcid.org/0000-0003-0249-4799","observed_orcids":["https://orcid.org/0000-0003-0249-4799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiya Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0249-4799","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036616564","display_name":"Chunguang Yan","orcid":"https://orcid.org/0000-0002-6077-9189","observed_orcids":["https://orcid.org/0000-0002-6077-9189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunguang Yan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6077-9189","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074313202","display_name":"Ling Liu","orcid":"https://orcid.org/0000-0001-6431-6352","observed_orcids":["https://orcid.org/0000-0001-6431-6352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6431-6352","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100331153","display_name":"Lixin Wang","orcid":"https://orcid.org/0000-0002-3480-4491","observed_orcids":["https://orcid.org/0000-0002-3480-4491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lixin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3480-4491","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymosin-alpha-1","display_name":"thymosin alpha 1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.6589999794960022},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7549999952316284},{"id":"https://openalex.org/keywords/chemotherapy-induced-immunosuppression","display_name":"chemotherapy-induced immunosuppression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cdc1","display_name":"cDC1","score":0.5950000286102295},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.31700000166893005},{"id":"https://openalex.org/keywords/cutaneous-dendritic-cells","display_name":"cutaneous dendritic cells","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.8093000054359436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7529000043869019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6335999965667725},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.58160001039505},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5343000292778015},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.517799973487854},{"id":"https://openalex.org/C2776451592","wikidata":"https://www.wikidata.org/wiki/Q424656","display_name":"Thymosin","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.42719998955726624},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.350600004196167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33899998664855957},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3188999891281128},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.28029999136924744},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2745000123977661},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2533000111579895},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25209999084472656},{"id":"https://openalex.org/C3020289777","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Vaccine adjuvant","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.33414368","doi":"https://doi.org/10.1158/0008-5472.33414368","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33414368","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.33414368","doi":"https://doi.org/10.1158/0008-5472.33414368","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33414368","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7164819712","https://openalex.org/W7204996355","https://openalex.org/W2072104741","https://openalex.org/W7117324424","https://openalex.org/W2100258681","https://openalex.org/W1908263826","https://openalex.org/W2757086211","https://openalex.org/W2059768985","https://openalex.org/W4388085900","https://openalex.org/W2193491173"],"abstract_inverted_index":{"T\u03b1-1":[0],"facilitates":[1],"migration":[2],"of":[3,9],"cutaneous":[4],"cDC1s":[5],"during":[6],"the":[7],"phagocytosis":[8],"ABs.":[10]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}