{"id":"https://openalex.org/W7204993178","doi":"https://doi.org/10.1158/1535-7163.33414159","title":"Supplementary Figure S7 from A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma","display_name":"Supplementary Figure S7 from A Novel CDK12 Inhibitor Induces Homologous Recombination Deficiency to Enhance PARP Inhibitor Efficacy in Uterine Serous Carcinoma","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204993178","doi":"https://doi.org/10.1158/1535-7163.33414159"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.33414159","doi":"https://doi.org/10.1158/1535-7163.33414159","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414159","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7204993178"],"child_works_count":0,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.33414159","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111513142","display_name":"Shunsuke Kawahara","orcid":"https://orcid.org/0009-0000-1221-2236","observed_orcids":["https://orcid.org/0009-0000-1221-2236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Kawahara","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-1221-2236","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076072821","display_name":"Mana Taki","orcid":"https://orcid.org/0000-0002-1540-0985","observed_orcids":["https://orcid.org/0000-0002-1540-0985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mana Taki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1540-0985","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088883992","display_name":"Junzo Hamanishi","orcid":"https://orcid.org/0000-0002-7750-0623","observed_orcids":["https://orcid.org/0000-0002-7750-0623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junzo Hamanishi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7750-0623","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017799711","display_name":"Shunsuke Ebara","orcid":"https://orcid.org/0000-0001-6057-6173","observed_orcids":["https://orcid.org/0000-0001-6057-6173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Ebara","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6057-6173","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028817103","display_name":"Ryusuke Murakami","orcid":"https://orcid.org/0000-0001-5007-5674","observed_orcids":["https://orcid.org/0000-0001-5007-5674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryusuke Murakami","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5007-5674","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101931361","display_name":"Kohei Hamada","orcid":"https://orcid.org/0009-0003-0354-7722","observed_orcids":["https://orcid.org/0009-0003-0354-7722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kohei Hamada","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-0354-7722","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103068848","display_name":"Koichi Watanabe","orcid":"https://orcid.org/0009-0008-1483-0263","observed_orcids":["https://orcid.org/0009-0008-1483-0263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Watanabe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1483-0263","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149093616","display_name":"Yuko Hosoe","orcid":"https://orcid.org/0009-0003-0456-0961","observed_orcids":["https://orcid.org/0009-0003-0456-0961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Hosoe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-0456-0961","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077286593","display_name":"Yuka Mise","orcid":"https://orcid.org/0000-0001-7102-2555","observed_orcids":["https://orcid.org/0000-0001-7102-2555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuka Mise","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7102-2555","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080234022","display_name":"Shiro Takamatsu","orcid":"https://orcid.org/0000-0002-1569-6421","observed_orcids":["https://orcid.org/0000-0002-1569-6421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiro Takamatsu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1569-6421","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071870767","display_name":"Taito Miyamoto","orcid":"https://orcid.org/0000-0001-7453-1611","observed_orcids":["https://orcid.org/0000-0001-7453-1611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taito Miyamoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7453-1611","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038964984","display_name":"Rin Mizuno","orcid":"https://orcid.org/0009-0008-2028-2718","observed_orcids":["https://orcid.org/0009-0008-2028-2718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rin Mizuno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2028-2718","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005542590","display_name":"Koji Yamanoi","orcid":"https://orcid.org/0000-0002-1240-5422","observed_orcids":["https://orcid.org/0000-0002-1240-5422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Yamanoi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1240-5422","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006506867","display_name":"Ken D Yamaguchi","orcid":"https://orcid.org/0000-0002-7669-1405","observed_orcids":["https://orcid.org/0000-0002-7669-1405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Yamaguchi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7669-1405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149004921","display_name":"Hiroko Yamakawa","orcid":"https://orcid.org/0009-0003-5456-7643","observed_orcids":["https://orcid.org/0009-0003-5456-7643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroko Yamakawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-5456-7643","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049230435","display_name":"Nobuyuki Kakiuchi","orcid":"https://orcid.org/0000-0003-4893-5414","observed_orcids":["https://orcid.org/0000-0003-4893-5414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuyuki Kakiuchi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4893-5414","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023191265","display_name":"Tsukasa Baba","orcid":"https://orcid.org/0000-0003-0066-3747","observed_orcids":["https://orcid.org/0000-0003-0066-3747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsukasa Baba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0066-3747","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042588749","display_name":"Seishi Ogawa","orcid":"https://orcid.org/0000-0002-7778-5374","observed_orcids":["https://orcid.org/0000-0002-7778-5374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seishi Ogawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7778-5374","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055343516","display_name":"Daisuke Morishita","orcid":"https://orcid.org/0000-0002-8200-0391","observed_orcids":["https://orcid.org/0000-0002-8200-0391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Morishita","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8200-0391","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000202709","display_name":"Kosuke Yusa","orcid":"https://orcid.org/0000-0002-3442-021X","observed_orcids":["https://orcid.org/0000-0002-3442-021X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Yusa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3442-021X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051800836","display_name":"Masaki Mandai","orcid":"https://orcid.org/0000-0003-4428-8029","observed_orcids":["https://orcid.org/0000-0003-4428-8029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaki Mandai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4428-8029","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk12-inhibitors","display_name":"CDK12 inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9639999866485596},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.9580000042915344},{"id":"https://openalex.org/keywords/uterine-serous-carcinoma","display_name":"uterine serous carcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/weight-monitoring","display_name":"weight monitoring","score":0.8659999966621399},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.4880000054836273},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.7218000292778015},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6240000128746033},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.614300012588501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4805000126361847},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.38510000705718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36559998989105225},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.34060001373291016},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.32120001316070557},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28110000491142273},{"id":"https://openalex.org/C2776056115","wikidata":"https://www.wikidata.org/wiki/Q574834","display_name":"Angiogenesis inhibitor","level":3,"score":0.2605000138282776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.33414159","doi":"https://doi.org/10.1158/1535-7163.33414159","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414159","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.33414159","doi":"https://doi.org/10.1158/1535-7163.33414159","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.33414159","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403436939","https://openalex.org/W4413905591","https://openalex.org/W7213241418","https://openalex.org/W7164992437","https://openalex.org/W4417031930","https://openalex.org/W7135076096","https://openalex.org/W7205010952","https://openalex.org/W4403436732","https://openalex.org/W4403436765","https://openalex.org/W7106575161"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S7":[2],"shows":[3],"longitudinal":[4],"body":[5],"weight":[6,25],"monitoring":[7],"in":[8],"mice":[9],"bearing":[10],"ARK2":[11],"xenografts":[12],"treated":[13],"with":[14],"vehicle,":[15],"CTX-439,":[16],"olaparib,":[17],"or":[18],"their":[19],"combination,":[20],"demonstrating":[21],"no":[22],"significant":[23],"treatment-related":[24],"loss":[26],"during":[27],"the":[28],"dosing":[29],"period.":[30]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
