{"id":"https://openalex.org/W7204992925","doi":"https://doi.org/10.1136/jnis-2026-esmint.64","title":"A71 Predictive value of fractional flow in symptomatic intracranial atherosclerotic stenosis","display_name":"A71 Predictive value of fractional flow in symptomatic intracranial atherosclerotic stenosis","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204992925","doi":"https://doi.org/10.1136/jnis-2026-esmint.64"},"language":"en","primary_location":{"id":"doi:10.1136/jnis-2026-esmint.64","doi":"https://doi.org/10.1136/jnis-2026-esmint.64","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnis-2026-esmint.64","pdf_url":null,"source":{"id":"https://openalex.org/S66405466","display_name":"Journal of NeuroInterventional Surgery","issn_l":"1759-8478","issn":["1759-8478","1759-8486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts","raw_type":"proceedings-article"},"parent_works":[],"lineage":["https://openalex.org/W7204992925"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130053971","display_name":"Ming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Wang","raw_affiliation_strings":["Zhejiang Hospital, Brain Center, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Hospital, Brain Center, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000923830","display_name":"Wanning Zheng","orcid":"https://orcid.org/0009-0006-7858-452X","observed_orcids":["https://orcid.org/0009-0006-7858-452X"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanning Zheng","raw_affiliation_strings":["Zhejiang Hospital, Brain Center, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Hospital, Brain Center, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070622110","display_name":"Rong Zou","orcid":"https://orcid.org/0000-0002-3840-9595","observed_orcids":["https://orcid.org/0000-0002-3840-9595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Zou","raw_affiliation_strings":["Arterylow Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arterylow Technology, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068241026","display_name":"Jianping Xiang","orcid":"https://orcid.org/0000-0002-3333-159X","observed_orcids":["https://orcid.org/0000-0002-3333-159X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianping Xiang","raw_affiliation_strings":["Arterylow Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arterylow Technology, Hangzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060766325","display_name":"Shu Wan","orcid":"https://orcid.org/0000-0002-0186-6274","observed_orcids":["https://orcid.org/0000-0002-0186-6274"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Wan","raw_affiliation_strings":["Zhejiang Hospital, Brain Center, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Hospital, Brain Center, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A40.1","last_page":"A40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracranial-atherosclerotic-stenosis","display_name":"intracranial atherosclerotic stenosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fractional-flow","display_name":"fractional flow","score":0.9020000100135803},{"id":"https://openalex.org/keywords/computational-fluid-dynamics","display_name":"computational fluid dynamics","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7379999756813049},{"id":"https://openalex.org/keywords/revascularization-decision-making","display_name":"revascularization decision-making","score":0.7239999771118164},{"id":"https://openalex.org/keywords/symptomatic-carotid-stenosis","display_name":"symptomatic carotid stenosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/digital-subtraction-angiography","display_name":"digital subtraction angiography","score":0.6809999942779541},{"id":"https://openalex.org/keywords/degree-of-stenosis","display_name":"stenosis severity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.4869999885559082},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7289000153541565},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.699999988079071},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6705999970436096},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5460000038146973},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.39340001344680786},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3887999951839447},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C2777987666","wikidata":"https://www.wikidata.org/wiki/Q1440572","display_name":"Fractional flow reserve","level":4,"score":0.2736999988555908},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2736000120639801}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jnis-2026-esmint.64","doi":"https://doi.org/10.1136/jnis-2026-esmint.64","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnis-2026-esmint.64","pdf_url":null,"source":{"id":"https://openalex.org/S66405466","display_name":"Journal of NeuroInterventional Surgery","issn_l":"1759-8478","issn":["1759-8478","1759-8486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Abstracts","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222120669","https://openalex.org/W4406018201","https://openalex.org/W7117896189","https://openalex.org/W4409049475","https://openalex.org/W4400892975","https://openalex.org/W2571148979","https://openalex.org/W7222080373","https://openalex.org/W4402693845","https://openalex.org/W4366982073","https://openalex.org/W4390546543"],"abstract_inverted_index":{"Background/Introduction":[0],"Intracranial":[1],"atherosclerotic":[2],"stenosis":[3,43,263],"(ICAS)":[4],"is":[5,23,49],"a":[6,24,165,286],"major":[7],"contributor":[8],"to":[9,60,164],"ischemic":[10],"stroke,":[11],"accounting":[12],"for":[13,32,289],"30%-50%":[14],"of":[15,26,29,40,64,76,86,106,123,129,169,190,262,280],"cases":[16],"in":[17,37,72,110,126,205,220,237,247,293],"Asian":[18],"populations.":[19],"At":[20],"present,":[21],"there":[22],"lack":[25],"definitive":[27],"indications":[28],"interventional":[30,215],"treatment":[31,39,112,172,245,273],"ICAS.":[33,77],"The":[34,103],"clinical":[35,270],"experience":[36],"the":[38,62,74,84,118,182,206,214,228],"coronary":[41],"artery":[42],"tells":[44],"us":[45],"that":[46],"functional":[47],"assessment":[48],"more":[50],"important":[51],"than":[52],"purely":[53],"morphological":[54],"assessment.":[55],"Numerous":[56],"studies":[57],"have":[58,90],"attempted":[59],"evaluate":[61,117],"feasibility":[63],"pressure-derived":[65],"parameters,":[66],"such":[67],"as":[68,285],"Fraction":[69],"Flow":[70],"(FF),":[71],"assessing":[73],"severity":[75],"To":[78,116],"avoid":[79],"procedural":[80],"complications":[81],"caused":[82],"by":[83],"use":[85],"pressure":[87],"guidewires,":[88],"we":[89],"developed":[91],"an":[92,156],"FF":[93,109,125,147,167,211,250,278],"detection":[94],"technology":[95],"based":[96,259],"on":[97,260],"computational":[98,158],"fluid":[99],"dynamic":[100],"(CFD)":[101],"analysis.":[102],"predictive":[104],"value":[105,122],"this":[107],"CFD-based":[108,124],"ICAS":[111,131,138,295],"remains":[113],"unclear.":[114],"Objective/Purpose":[115],"utility":[119],"and":[120,144,171,187,197],"prognostic":[121],"guiding":[127],"management":[128],"symptomatic":[130,137,294],"Methods/Case":[132],"Description":[133],"We":[134],"retrospectively":[135],"enrolled":[136],"patients":[139,202,209,248],"hospitalized":[140],"between":[141,244,272],"March":[142],"2019":[143],"May":[145],"2024.":[146],"values":[148],"were":[149,161,179,203,242],"derived":[150],"from":[151],"digital":[152],"subtraction":[153],"angiography":[154],"using":[155,181],"angiography-based":[157],"method.":[159],"Patients":[160],"stratified":[162],"according":[163],"pre-specified":[166],"threshold":[168,279],"0.76":[170,252,282],"modality":[173],"(interventional":[174],"vs.":[175],"conservative).":[176],"Clinical":[177],"outcomes":[178,271],"assessed":[180],"modified":[183],"Rankin":[184],"Scale":[185,193],"(mRS)":[186],"National":[188],"Institutes":[189],"Health":[191],"Stroke":[192],"(NIHSS)":[194],"at":[195,223],"discharge":[196],"12":[198,224],"months.":[199],"Results/Findings":[200],"132":[201],"included":[204],"study.":[207],"Among":[208],"with":[210,227,249],"\u2264":[212,281],"0.76,":[213],"group":[216,230],"showed":[217],"greater":[218],"improvement":[219,241],"mRS":[221,238],"scores":[222],"months":[225],"compared":[226],"conservative":[229],"(P":[231,253],"=":[232],"0.017).":[233],"No":[234],"significant":[235],"differences":[236],"or":[239],"NIHSS":[240],"observed":[243],"strategies":[246],">":[251,254],"0.05).":[255],"In":[256],"contrast,":[257],"stratification":[258],"degree":[261],"(DS%":[264],"\u2265":[265],"70%)":[266],"did":[267],"not":[268],"differentiate":[269],"groups.":[274],"Discussion/Conclusions/Learning":[275],"Points":[276],"An":[277],"may":[283],"serve":[284],"potential":[287],"criterion":[288],"making":[290],"revascularization":[291],"decisions":[292],"patients.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}