{"id":"https://openalex.org/W7204992813","doi":"https://doi.org/10.1158/1541-7786.33414387","title":"Supplementary Table 4 from Variation at the R181 Residue of p53 Confers Loss of p53 DNA Binding Cooperativity with the Retention of Mitochondria-Associated Apoptosis","display_name":"Supplementary Table 4 from Variation at the R181 Residue of p53 Confers Loss of p53 DNA Binding Cooperativity with the Retention of Mitochondria-Associated Apoptosis","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204992813","doi":"https://doi.org/10.1158/1541-7786.33414387"},"language":null,"primary_location":{"id":"doi:10.1158/1541-7786.33414387","doi":"https://doi.org/10.1158/1541-7786.33414387","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.33414387","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.33414387","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081342204","display_name":"Renyta Moses","orcid":"https://orcid.org/0000-0003-4708-2958","observed_orcids":["https://orcid.org/0000-0003-4708-2958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renyta Moses","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4708-2958","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042308398","display_name":"Alexandra Indeglia","orcid":"https://orcid.org/0000-0001-9035-4969","observed_orcids":["https://orcid.org/0000-0001-9035-4969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Indeglia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9035-4969","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053279197","display_name":"Alison Schwartz","orcid":"https://orcid.org/0000-0003-3861-4203","observed_orcids":["https://orcid.org/0000-0003-3861-4203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison S. Levine","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3861-4203","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148976329","display_name":"Ryan Hausler","orcid":"https://orcid.org/0009-0005-4965-0017","observed_orcids":["https://orcid.org/0009-0005-4965-0017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan Hausler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-4965-0017","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139917590","display_name":"Gregory M. Kelly","orcid":"https://orcid.org/0009-0002-0474-2856","observed_orcids":["https://orcid.org/0009-0002-0474-2856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Kelly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0474-2856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005172064","display_name":"Sven A. Miller","orcid":"https://orcid.org/0000-0001-7295-5592","observed_orcids":["https://orcid.org/0000-0001-7295-5592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven A. Miller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7295-5592","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055705276","display_name":"Isabel Anez-Bruzual","orcid":"https://orcid.org/0000-0002-0762-6837","observed_orcids":["https://orcid.org/0000-0002-0762-6837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabel Anez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0762-6837","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149109984","display_name":"Melissa Heller","orcid":"https://orcid.org/0009-0007-4703-5314","observed_orcids":["https://orcid.org/0009-0007-4703-5314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Heller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4703-5314","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149019965","display_name":"Rosella Delgado","orcid":"https://orcid.org/0009-0003-6003-6232","observed_orcids":["https://orcid.org/0009-0003-6003-6232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosella Delgado","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6003-6232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149095359","display_name":"Caitlin Orr","orcid":"https://orcid.org/0009-0007-4447-2869","observed_orcids":["https://orcid.org/0009-0007-4447-2869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caitlin Orr","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4447-2869","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058251924","display_name":"Wendy K. Kohlmann","orcid":"https://orcid.org/0000-0002-9134-9640","observed_orcids":["https://orcid.org/0000-0002-9134-9640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendy Kohlmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9134-9640","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149069405","display_name":"Anne Naumer","orcid":"https://orcid.org/0009-0001-2956-1720","observed_orcids":["https://orcid.org/0009-0001-2956-1720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Naumer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-2956-1720","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021176951","display_name":"Jennie Vagher","orcid":"https://orcid.org/0009-0004-5818-6589","observed_orcids":["https://orcid.org/0009-0004-5818-6589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennie Vagher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-5818-6589","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007021385","display_name":"Sophie Hyman","orcid":"https://orcid.org/0000-0001-7456-0113","observed_orcids":["https://orcid.org/0000-0001-7456-0113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophie R. Cahill","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7456-0113","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019837009","display_name":"Luke Devon Maese","orcid":"https://orcid.org/0000-0002-8739-9100","observed_orcids":["https://orcid.org/0000-0002-8739-9100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke D. Maese","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8739-9100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087413939","display_name":"John Karanicolas","orcid":"https://orcid.org/0000-0003-0300-726X","observed_orcids":["https://orcid.org/0000-0003-0300-726X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Karanicolas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0300-726X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005206482","display_name":"Judy Ellen Garber","orcid":"https://orcid.org/0000-0001-9449-3982","observed_orcids":["https://orcid.org/0000-0001-9449-3982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judy E. Garber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9449-3982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088200304","display_name":"Maureen E. Murphy","orcid":"https://orcid.org/0000-0001-7644-7296","observed_orcids":["https://orcid.org/0000-0001-7644-7296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maureen E. Murphy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7644-7296","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061783891","display_name":"Kara N. Maxwell","orcid":"https://orcid.org/0000-0001-8192-4202","observed_orcids":["https://orcid.org/0000-0001-8192-4202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kara N. Maxwell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8192-4202","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.5830000042915344},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hypomorphic-variants","display_name":"hypomorphic variants","score":0.949999988079071},{"id":"https://openalex.org/keywords/history-of-cancer","display_name":"cancer history","score":0.722000002861023},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.875}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6697999835014343},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6327999830245972},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5648000240325928},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5291000008583069},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.49390000104904175},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.39649999141693115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37619999051094055},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35910001397132874},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.35600000619888306},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.3546999990940094},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3059000074863434},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2971000075340271},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.33414387","doi":"https://doi.org/10.1158/1541-7786.33414387","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.33414387","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.33414387","doi":"https://doi.org/10.1158/1541-7786.33414387","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.33414387","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Table":[0],"S4:":[1],"History":[2],"of":[3,7,11],"cancer":[4],"and":[5,14],"age":[6],"onset":[8],"in":[9,17],"carriers":[10],"R181,":[12],"DN/LOF,":[13],"hypomorphic":[15],"variants":[16],"the":[18],"patient":[19],"cohort.":[20]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-09-02T00:00:00"}
