{"id":"https://openalex.org/W7204990195","doi":"https://doi.org/10.21203/rs.3.rs-10710563/v1","title":"PEG-Related Complications and One-Year Survival in Patients with Neurological Disorders: A Retrospective Cohort Study","display_name":"PEG-Related Complications and One-Year Survival in Patients with Neurological Disorders: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7204990195","doi":"https://doi.org/10.21203/rs.3.rs-10710563/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10710563/v1","doi":"https://doi.org/10.21203/rs.3.rs-10710563/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10710563/v1","pdf_url":"https://www.researchsquare.com/article/rs-10710563/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10710563/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056553181","display_name":"G\u00fcven\u00e7 Diner","orcid":"https://orcid.org/0000-0002-7732-4092","observed_orcids":["https://orcid.org/0000-0002-7732-4092"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guvenc Diner","raw_affiliation_strings":["Mersin Sehir Research and Training Hospital"],"raw_orcid":"https://orcid.org/0000-0002-7732-4092","affiliations":[{"raw_affiliation_string":"Mersin Sehir Research and Training Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020709185","display_name":"G\u00fcven Erdo\u011frul","orcid":"https://orcid.org/0000-0002-9557-7675","observed_orcids":["https://orcid.org/0000-0002-9557-7675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guven Erdogrul","raw_affiliation_strings":["Mersin Sehir Research and Training Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin Sehir Research and Training Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005290567","display_name":"Boran Cihat Karaku\u015f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boran Karakus","raw_affiliation_strings":["Mersin Sehir Research and Training Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin Sehir Research and Training Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148983474","display_name":"Ayd\u0131n Karahan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayd\u0131n Karahan","raw_affiliation_strings":["Mersin Sehir Research and Training Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin Sehir Research and Training Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035800682","display_name":"Recep \u00c7a\u011flar","orcid":"https://orcid.org/0000-0003-0987-9202","observed_orcids":["https://orcid.org/0000-0003-0987-9202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Recep Caglar","raw_affiliation_strings":["Mersin Sehir Research and Training Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mersin Sehir Research and Training Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056553181"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/percutaneous-endoscopic-gastrostomy","display_name":"percutaneous endoscopic gastrostomy","score":1.0},{"id":"https://openalex.org/keywords/peg-complications","display_name":"PEG complications","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dysphagia","display_name":"dysphagia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/long-term-enteral-nutrition","display_name":"long-term enteral nutrition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/one-year-survival","display_name":"one-year survival","score":0.8109999895095825},{"id":"https://openalex.org/keywords/risk-factors-for-mortality","display_name":"mortality risk factors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tube-dislodgement","display_name":"tube dislodgement","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tube-obstruction","display_name":"tube obstruction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tube-migration","display_name":"tube migration","score":0.7319999933242798},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.7310000061988831},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520999789237976},{"id":"https://openalex.org/C2780075904","wikidata":"https://www.wikidata.org/wiki/Q2071310","display_name":"Percutaneous endoscopic gastrostomy","level":3,"score":0.8651000261306763},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7965999841690063},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6527000069618225},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5572999715805054},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5080000162124634},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C2777014482","wikidata":"https://www.wikidata.org/wiki/Q1495687","display_name":"Gastrostomy","level":2,"score":0.4862000048160553},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4846000075340271},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42829999327659607},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39629998803138733},{"id":"https://openalex.org/C3017742122","wikidata":"https://www.wikidata.org/wiki/Q1087035","display_name":"Gastrostomy tube","level":3,"score":0.3855000138282776},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.32760000228881836},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C2780813298","wikidata":"https://www.wikidata.org/wiki/Q2071287","display_name":"Percutaneous","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3041999936103821},{"id":"https://openalex.org/C2778045676","wikidata":"https://www.wikidata.org/wiki/Q1087035","display_name":"Feeding tube","level":2,"score":0.29330000281333923},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10710563/v1","doi":"https://doi.org/10.21203/rs.3.rs-10710563/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10710563/v1","pdf_url":"https://www.researchsquare.com/article/rs-10710563/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10710563/v1","doi":"https://doi.org/10.21203/rs.3.rs-10710563/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10710563/v1","pdf_url":"https://www.researchsquare.com/article/rs-10710563/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204990195.pdf","grobid_xml":"https://content.openalex.org/works/W7204990195.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W3133797281","https://openalex.org/W3151846021","https://openalex.org/W3182920513","https://openalex.org/W3198715926","https://openalex.org/W4367301076","https://openalex.org/W4380291920","https://openalex.org/W4381681580","https://openalex.org/W4386116834","https://openalex.org/W4400394729","https://openalex.org/W4403151294"],"related_works":["https://openalex.org/W4396952206","https://openalex.org/W4407780734","https://openalex.org/W7160077588","https://openalex.org/W2405088565","https://openalex.org/W2129753867","https://openalex.org/W2096480893","https://openalex.org/W2005205718","https://openalex.org/W2097855828","https://openalex.org/W4399020039","https://openalex.org/W2023504103"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Percutaneous":[2],"endoscopic":[3,268],"gastrostomy":[4],"(PEG)":[5],"is":[6],"widely":[7],"used":[8,91],"for":[9],"long-term":[10],"enteral":[11],"nutrition":[12],"in":[13,131,226,261],"patients":[14,133,190,194,263],"with":[15,60,161,184,195,243],"neurological":[16,61,231,262,272],"disorders":[17,62],"and":[18,24,33,44,71,77,107,124,152,178,205],"persistent":[19],"dysphagia.":[20],"However,":[21],"complication":[22],"rates":[23],"post-PEG":[25],"survival":[26,100,209],"vary":[27],"considerably":[28],"according":[29],"to":[30,92],"patient":[31],"characteristics":[32],"disease":[34],"burden.":[35],"This":[36,51],"study":[37,55],"evaluated":[38,115,247],"PEG-related":[39,80,128,165,223,270],"complications,":[40,244],"one-year":[41,125,207,220,254,274],"overall":[42,99,208],"survival,":[43],"baseline":[45,216,248],"predictors":[46,95],"of":[47,96,164,213,230],"these":[48],"outcomes.":[49],"Methods:":[50],"retrospective":[52],"single-center":[53],"cohort":[54],"included":[56],"276":[57],"consecutive":[58],"adults":[59],"who":[63],"underwent":[64],"PEG":[65],"placement":[66],"at":[67],"Mersin":[68],"City":[69],"Training":[70],"Research":[72],"Hospital":[73],"between":[74,117],"January":[75],"2017":[76],"December":[78],"2025.":[79],"complications":[81,129,138,166,224],"were":[82,139,180],"assessed":[83],"throughout":[84],"available":[85,187],"follow-up.":[86],"Multivariable":[87],"logistic":[88],"regression":[89],"was":[90,101,158,210,240],"identify":[93],"independent":[94],"complications.":[97,185],"One-year":[98],"estimated":[102,206],"using":[103],"the":[104,214,246],"Kaplan\u2013Meier":[105],"method,":[106],"a":[108],"prespecified":[109,215],"multivariable":[110],"Cox":[111],"proportional":[112],"hazards":[113],"model":[114],"associations":[116],"age,":[118],"sex,":[119],"C-reactive":[120,277],"protein":[121],"(CRP),":[122],"albumin,":[123],"mortality.":[126,221,255],"Results:":[127],"occurred":[130,201,225],"76":[132],"(27.5%).":[134],"The":[135],"most":[136],"frequent":[137],"PEG-site":[140,149],"discharge":[141],"(26.3%),":[142],"tube":[143,146,153],"dislodgement":[144],"(25.0%),":[145],"obstruction":[147],"(14.5%),":[148],"bleeding":[150],"(11.8%),":[151],"migration":[154],"(10.5%).":[155],"Increasing":[156],"age":[157],"independently":[159,182,218,241,252],"associated":[160,183,242],"lower":[162],"odds":[163],"(OR":[167],"per":[168],"10-year":[169],"increase,":[170],"0.758;":[171],"95%":[172],"CI,":[173],"0.634\u20130.908;":[174],"P=.003).":[175],"Sex,":[176],"CRP,":[177],"albumin":[179,279],"not":[181,251],"During":[186],"follow-up,":[188],"75":[189],"(27.2%)":[191],"died.":[192],"Among":[193],"evaluable":[196],"death":[197],"dates,":[198],"63":[199],"deaths":[200],"within":[202],"365":[203],"days,":[204],"76.4%.":[211],"None":[212],"variables":[217,249],"predicted":[219],"Conclusions:":[222],"more":[227],"than":[228],"one-quarter":[229],"patients,":[232],"while":[233],"approximately":[234],"three-quarters":[235],"survived":[236],"one":[237],"year.":[238],"Age":[239],"whereas":[245],"did":[250],"predict":[253],"Individualized":[256],"clinical":[257],"assessment":[258],"remains":[259],"essential":[260],"undergoing":[264],"PEG.":[265],"Keywords:":[266],"percutaneous":[267],"gastrostomy;":[269],"complications;":[271],"disorders;":[273],"survival;":[275],"mortality;":[276],"protein;":[278]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-02T00:00:00"}