{"id":"https://openalex.org/W7204978349","doi":"https://doi.org/10.63932/3067-7106.1094","title":"Sedation minimization and early mobility to prevent intensive care unit delirium","display_name":"Sedation minimization and early mobility to prevent intensive care unit delirium","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7204978349","doi":"https://doi.org/10.63932/3067-7106.1094"},"language":"en","primary_location":{"id":"doi:10.63932/3067-7106.1094","doi":"https://doi.org/10.63932/3067-7106.1094","is_oa":true,"landing_page_url":"https://doi.org/10.63932/3067-7106.1094","pdf_url":"https://digitalshowcase.lynchburg.edu/cgi/viewcontent.cgi?article=1094&context=jms","source":{"id":"https://openalex.org/S5407048920","display_name":"Lynchburg Journal of Medical Science","issn_l":"3067-7106","issn":["3067-7106"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lynchburg Journal of Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://digitalshowcase.lynchburg.edu/cgi/viewcontent.cgi?article=1094&context=jms","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148837377","display_name":"Alana M Kugelard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21978226","display_name":"University of Lynchburg","ror":"https://ror.org/03grk0f38","country_code":"US","type":"education","lineage":["https://openalex.org/I21978226"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alana M Kugelard","raw_affiliation_strings":["University of Lynchburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lynchburg","institution_ids":["https://openalex.org/I21978226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5148837377"],"corresponding_institution_ids":["https://openalex.org/I21978226"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66579748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icu-delirium","display_name":"ICU delirium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/early-mobilization","display_name":"early mobilization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/abcdef-bundle","display_name":"ABCDEF bundle","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/spontaneous-awakening-trials","display_name":"spontaneous awakening trials","score":0.7139999866485596},{"id":"https://openalex.org/keywords/family-involvement","display_name":"family involvement","score":0.8619999885559082},{"id":"https://openalex.org/keywords/delirium-prevention","display_name":"delirium prevention","score":0.8029999732971191},{"id":"https://openalex.org/keywords/critical-illness","display_name":"critical illness","score":0.628000020980835},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.9355000257492065},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.8747000098228455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7875999808311462},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6425999999046326},{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.6148999929428101},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.597100019454956},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5019000172615051},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.38839998841285706},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.32839998602867126},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.32030001282691956},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2778584172","wikidata":"https://www.wikidata.org/wiki/Q7579051","display_name":"Spontaneous breathing trial","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.63932/3067-7106.1094","doi":"https://doi.org/10.63932/3067-7106.1094","is_oa":true,"landing_page_url":"https://doi.org/10.63932/3067-7106.1094","pdf_url":"https://digitalshowcase.lynchburg.edu/cgi/viewcontent.cgi?article=1094&context=jms","source":{"id":"https://openalex.org/S5407048920","display_name":"Lynchburg Journal of Medical Science","issn_l":"3067-7106","issn":["3067-7106"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lynchburg Journal of Medical Science","raw_type":"journal-article"},{"id":"pmh:oai:digitalshowcase.lynchburg.edu:jms-1094","doi":null,"is_oa":true,"landing_page_url":"https://digitalshowcase.lynchburg.edu/jms/vol2/iss3/2","pdf_url":"https://digitalshowcase.lynchburg.edu/context/jms/article/1094/viewcontent/1094_KUGELARD.pdf","source":{"id":"https://openalex.org/S4377196904","display_name":"Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I21978226","host_organization_name":"University of Lynchburg","host_organization_lineage":["https://openalex.org/I21978226"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lynchburg Journal of Medical Science","raw_type":"text"},{"id":"pmh:oai:digitalshowcase.lynchburg.edu:dmscjournal-3767","doi":null,"is_oa":false,"landing_page_url":"https://digitalshowcase.lynchburg.edu/cgi/viewcontent.cgi?article=3767&context=dmscjournal","pdf_url":null,"source":{"id":"https://openalex.org/S4377196904","display_name":"Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I21978226","host_organization_name":"University of Lynchburg","host_organization_lineage":["https://openalex.org/I21978226"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Lynchburg Doctoral Project Assignment Repository","raw_type":"text"}],"best_oa_location":{"id":"doi:10.63932/3067-7106.1094","doi":"https://doi.org/10.63932/3067-7106.1094","is_oa":true,"landing_page_url":"https://doi.org/10.63932/3067-7106.1094","pdf_url":"https://digitalshowcase.lynchburg.edu/cgi/viewcontent.cgi?article=1094&context=jms","source":{"id":"https://openalex.org/S5407048920","display_name":"Lynchburg Journal of Medical Science","issn_l":"3067-7106","issn":["3067-7106"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lynchburg Journal of Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204978349.pdf","grobid_xml":"https://content.openalex.org/works/W7204978349.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165391996","https://openalex.org/W7218734758","https://openalex.org/W4401397858","https://openalex.org/W7007835164","https://openalex.org/W2564697221","https://openalex.org/W4283359784","https://openalex.org/W2036180756","https://openalex.org/W2014040727","https://openalex.org/W4416387107","https://openalex.org/W6906347986"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,22,52,232],"this":[3],"paper":[4],"is":[5,34],"to":[6,117,229],"synthesize":[7],"current":[8],"evidence":[9],"on":[10,115,224],"sedation":[11,125,188],"minimization,":[12,189],"early":[13,190],"mobility,":[14,191],"and":[15,37,49,54,63,73,89,104,166,175,196,199,217,227],"multicomponent":[16],"care":[17,24],"bundles":[18,180],"for":[19],"the":[20,74,183,203],"prevention":[21],"intensive":[23],"unit":[25],"(ICU)":[26],"delirium":[27,33,118,130,145,177,192],"in":[28,137],"critically":[29],"ill":[30],"adults.":[31],"ICU":[32,48,237],"a":[35,60],"common":[36],"serious":[38],"complication":[39],"associated":[40,127,170],"with":[41,77,112,128,133,147,171],"increased":[42],"mortality,":[43],"prolonged":[44],"mechanical":[45],"ventilation,":[46],"extended":[47],"hospital":[50],"length":[51],"stay,":[53],"long-term":[55],"cognitive":[56],"impairment,":[57],"making":[58],"it":[59],"significant":[61],"safety":[62],"quality-of-care":[64],"concern.":[65],"A":[66],"literature":[67],"review":[68],"was":[69,126],"conducted":[70],"using":[71],"PubMed":[72],"Cochrane":[75],"Library,":[76],"search":[78],"terms":[79],"including":[80,161],"\u201cICU":[81],"delirium,\u201d":[82],"\u201csedation":[83],"minimization,\u201d":[84],"\u201clight":[85],"sedation,\u201d":[86],"\u201cearly":[87],"mobilization,\u201d":[88],"\u201cABCDEF":[90],"bundle.\u201d":[91],"Filters":[92],"included":[93],"adult":[94],"populations,":[95],"peer-reviewed":[96],"studies,":[97,103],"randomized":[98],"controlled":[99],"trials,":[100,198],"prospective":[101],"cohort":[102],"clinical":[105],"guidelines":[106],"published":[107],"from":[108],"2017":[109],"through":[110],"2026,":[111],"inclusion":[113],"based":[114],"relevance":[116],"prevention.":[119],"Studies":[120],"consistently":[121],"demonstrated":[122,202],"that":[123,212],"lighter":[124],"reduced":[129,176],"incidence":[131],"compared":[132],"deep":[134],"sedation,":[135],"particularly":[136],"mechanically":[138],"ventilated":[139],"individuals.":[140],"Pharmacologic":[141],"choice":[142],"also":[143],"influenced":[144],"outcomes,":[146,214],"dexmedetomidine":[148],"demonstrating":[149],"more":[150],"delirium-sparing":[151],"effects":[152],"than":[153],"agents":[154],"such":[155,181],"as":[156,182],"propofol.":[157],"Early":[158],"mobility":[159],"interventions":[160,234],"physical":[162],"therapy,":[163,165],"occupational":[164],"progressive":[167],"mobilization":[168],"were":[169],"improved":[172],"functional":[173],"recovery":[174],"incidence.":[178],"Structured":[179],"ABCDEF":[184],"framework,":[185],"which":[186],"integrate":[187],"monitoring,":[193],"spontaneous":[194],"awakening":[195],"breathing":[197],"family":[200],"engagement,":[201],"most":[204],"consistent":[205,230],"benefits.":[206],"These":[207],"findings":[208],"support":[209],"evidence-based":[210],"practices":[211],"improve":[213],"reduce":[215],"complications,":[216],"enhance":[218],"recovery.":[219],"Future":[220],"research":[221],"should":[222],"focus":[223],"implementation":[225],"strategies":[226],"barriers":[228],"adoption":[231],"these":[233],"across":[235],"all":[236],"settings.":[238]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-09-02T00:00:00"}