{"id":"https://openalex.org/W7204968596","doi":"https://doi.org/10.3390/cimb48090894","title":"Ferrostatin-1 Attenuates CLP-Induced Colonic Injury: Associations with Ferroptosis-Related Alterations, Oxidative Stress, Inflammation, and Treatment Timing","display_name":"Ferrostatin-1 Attenuates CLP-Induced Colonic Injury: Associations with Ferroptosis-Related Alterations, Oxidative Stress, Inflammation, and Treatment Timing","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204968596","doi":"https://doi.org/10.3390/cimb48090894","pmid":"https://pubmed.ncbi.nlm.nih.gov/42793250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13605974"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48090894","doi":"https://doi.org/10.3390/cimb48090894","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48090894","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48090894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070837783","display_name":"Mehmet Tolga Kafadar","orcid":"https://orcid.org/0000-0002-9178-7843","observed_orcids":["https://orcid.org/0000-0002-9178-7843"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Tolga Kafadar","raw_affiliation_strings":["Department of General Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063733789","display_name":"Eda Y\u0130LD\u0130ZHAN","orcid":"https://orcid.org/0000-0002-5648-6498","observed_orcids":["https://orcid.org/0000-0002-5648-6498"]},"institutions":[{"id":"https://openalex.org/I161597582","display_name":"Recep Tayyip Erdo\u011fan University","ror":"https://ror.org/0468j1635","country_code":"TR","type":"education","lineage":["https://openalex.org/I161597582"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Eda Y\u0131ld\u0131zhan","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, 53100 Rize, Turkey","institution_ids":["https://openalex.org/I161597582"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070837783"],"corresponding_institution_ids":["https://openalex.org/I123466251"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":1.9314,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78240168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"48","issue":"9","first_page":"894","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferrostatin-1","display_name":"ferrostatin-1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/fecal-peritonitis","display_name":"fecal peritonitis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colonic-injury","display_name":"colonic injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9309999942779541},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.824999988079071},{"id":"https://openalex.org/keywords/acsl4","display_name":"ACSL4","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8679999709129333},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ferroptosis-inhibitors","display_name":"ferroptosis inhibitors","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6014999747276306},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.5774999856948853},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5583999752998352},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5392000079154968},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5192000269889832},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49459999799728394},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.4828999936580658},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.3928999900817871},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3407000005245209},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31529998779296875},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C203663253","wikidata":"https://www.wikidata.org/wiki/Q18026456","display_name":"GPX1","level":5,"score":0.29350000619888306},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C2779458865","wikidata":"https://www.wikidata.org/wiki/Q18029451","display_name":"MSRA","level":4,"score":0.27810001373291016},{"id":"https://openalex.org/C2777507495","wikidata":"https://www.wikidata.org/wiki/Q185317","display_name":"Cecum","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2583000063896179},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2567000091075897}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cimb48090894","doi":"https://doi.org/10.3390/cimb48090894","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48090894","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13605974","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13605974/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13605974/pdf/cimb-48-00894.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"},{"id":"pmid:42793250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42793250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c84fce9b497b477cb6c80d942adf19b3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c84fce9b497b477cb6c80d942adf19b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 48, Iss 9, p 894 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb48090894","doi":"https://doi.org/10.3390/cimb48090894","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48090894","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204968596.pdf","grobid_xml":"https://content.openalex.org/works/W7204968596.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1976464405","https://openalex.org/W1977905350","https://openalex.org/W1979760309","https://openalex.org/W1997183854","https://openalex.org/W2002490399","https://openalex.org/W2023945291","https://openalex.org/W2024886564","https://openalex.org/W2051639904","https://openalex.org/W2059699981","https://openalex.org/W2074892323","https://openalex.org/W2133808995","https://openalex.org/W2549188196","https://openalex.org/W2729161724","https://openalex.org/W2762087180","https://openalex.org/W2804834775","https://openalex.org/W2808965517","https://openalex.org/W2911996561","https://openalex.org/W3108243840","https://openalex.org/W3108493784","https://openalex.org/W3123922203","https://openalex.org/W4213442676","https://openalex.org/W4233435953","https://openalex.org/W4285819579","https://openalex.org/W4294762989","https://openalex.org/W4387037392","https://openalex.org/W4390823737","https://openalex.org/W4392294768","https://openalex.org/W4399985132","https://openalex.org/W4400591731","https://openalex.org/W4403129160","https://openalex.org/W4405968901","https://openalex.org/W4406034749","https://openalex.org/W4410515898","https://openalex.org/W4413783960","https://openalex.org/W4414338325","https://openalex.org/W4414611840","https://openalex.org/W4415447436","https://openalex.org/W7164683401"],"related_works":["https://openalex.org/W7128453401","https://openalex.org/W4405204868","https://openalex.org/W4396956663","https://openalex.org/W7117488237","https://openalex.org/W4416685176","https://openalex.org/W4381890881","https://openalex.org/W4296613328","https://openalex.org/W7202265512","https://openalex.org/W4398788754","https://openalex.org/W4294992589"],"abstract_inverted_index":{"Fecal":[0],"peritonitis":[1],"induces":[2],"severe":[3],"oxidative":[4,32,101],"and":[5,8,24,37,62,77,82,90,102,108,111,154,157,197,204,219],"inflammatory":[6,78,103],"injury":[7,196],"may":[9],"involve":[10],"ferroptosis-related":[11,35,205],"mechanisms.":[12,234],"This":[13],"study":[14],"investigated":[15],"the":[16,134,144,162,174,209,230],"effects":[17],"of":[18,222,232],"Ferrostatin-1":[19],"(Fer-1)":[20],"on":[21,31],"cecal":[22],"ligation":[23],"puncture":[25],"(CLP)-induced":[26],"colonic":[27,80,195],"injury,":[28],"with":[29,200],"emphasis":[30],"stress,":[33],"inflammation,":[34],"alterations,":[36,104],"treatment":[38,128],"timing.":[39],"Thirty-five":[40],"male":[41],"Wistar":[42],"rats":[43],"were":[44,96,178],"randomly":[45],"assigned":[46],"to":[47,181,228],"five":[48],"groups:":[49],"Sham,":[50],"CLP,":[51],"CLP":[52,57,63,98],"+":[53,58,64],"dimethyl":[54],"sulfoxide":[55],"(DMSO),":[56],"Fer-1":[59,65,68,127,192],"(30":[60],"min),":[61],"(2":[66],"h).":[67],"(5":[69],"mg/kg,":[70],"intraperitoneally)":[71],"was":[72,198],"administered":[73],"after":[74],"CLP.":[75],"Biochemical":[76],"parameters,":[79],"histopathology,":[81],"acyl-CoA":[83],"synthetase":[84],"long-chain":[85],"family":[86],"member":[87],"4":[88,93],"(ACSL4)":[89],"glutathione":[91],"peroxidase":[92],"(GPX4)":[94],"immunoreactivity":[95,114],"evaluated.":[97],"induced":[99],"marked":[100],"increased":[105],"histopathological":[106],"damage":[107],"ACSL4":[109],"immunoreactivity,":[110],"decreased":[112],"GPX4":[113],"(all":[115],"overall":[116],"p":[117,124,167],"<":[118,168],"0.001,":[119],"except":[120],"total":[121],"antioxidant":[122],"status,":[123],"=":[125],"0.004).":[126],"generally":[129],"shifted":[130],"these":[131],"alterations":[132],"toward":[133],"sham":[135],"profile.":[136],"In":[137,184],"exploratory":[138],"comparisons":[139],"adjusted":[140],"for":[141],"multiple":[142],"testing,":[143],"2":[145],"h":[146],"group":[147,165],"showed":[148],"lower":[149],"malondialdehyde,":[150],"tumor":[151],"necrosis":[152],"factor-alpha,":[153],"interleukin-6":[155],"levels":[156],"higher":[158],"catalase":[159],"concentrations":[160],"than":[161],"30":[163],"min":[164],"(Holm-adjusted":[166],"0.05).":[169],"Group-adjusted":[170],"analyses":[171,186],"indicated":[172],"that":[173],"strong":[175],"pooled":[176],"correlations":[177],"largely":[179],"attributable":[180],"between-group":[182],"differences.":[183],"silico":[185],"provided":[187],"complementary":[188],"hypothesis-generating":[189],"molecular":[190],"context.":[191],"attenuated":[193],"CLP-induced":[194],"associated":[199],"favorable":[201],"oxidative\u2013inflammatory":[202],"changes":[203],"ACSL4/GPX4":[206],"alterations.":[207],"However,":[208],"timing":[210],"findings":[211],"do":[212],"not":[213],"establish":[214],"an":[215],"optimal":[216],"therapeutic":[217],"window,":[218],"direct":[220],"measures":[221],"ferroptotic":[223],"cell":[224],"death":[225],"are":[226],"required":[227],"clarify":[229],"contribution":[231],"ferroptosis-associated":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-02T00:00:00"}