{"id":"https://openalex.org/W7204966924","doi":"https://doi.org/10.64898/2026.08.26.747432","title":"Novel Dissymmetric Ionizable Lipid-Assembled Lipid Nanoparticles for Delivery of Ferroptosis-Related siRNA in Diabetic Treatment","display_name":"Novel Dissymmetric Ionizable Lipid-Assembled Lipid Nanoparticles for Delivery of Ferroptosis-Related siRNA in Diabetic Treatment","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204966924","doi":"https://doi.org/10.64898/2026.08.26.747432"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.747432","doi":"https://doi.org/10.64898/2026.08.26.747432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747432","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747432.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747432.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148843170","display_name":"Han Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhang","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405023","display_name":"Yuanyuan Liu","orcid":"https://orcid.org/0000-0001-6862-1928","observed_orcids":["https://orcid.org/0000-0001-6862-1928","https://orcid.org/0000-0003-2859-9927"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Liu","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153329148","display_name":"Fengyang He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyang He","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060747305","display_name":"Genping Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Genping Xue","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148910213","display_name":"Yi Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Kang","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148848544","display_name":"Zepu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zepu Zhang","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148899989","display_name":"Jixin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jixin Ma","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002297902","display_name":"Junhai Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhai Xiao","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018174095","display_name":"Qingbin Meng","orcid":"https://orcid.org/0000-0001-8915-9509","observed_orcids":["https://orcid.org/0000-0001-8915-9509"]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingbin Meng","raw_affiliation_strings":["Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Military Medical Sciences, NO. 27 Taiping Road, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]},{"raw_affiliation_string":"State Key Laboratory of National Security Specially Needed Medicines, NO. 100 Yongding Road, Beijing 100039, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018174095"],"corresponding_institution_ids":["https://openalex.org/I2802541053"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ionizable-lipids","display_name":"ionizable lipids","score":0.953000009059906},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.8889999985694885},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8840000033378601},{"id":"https://openalex.org/keywords/islet-function","display_name":"islet function","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucose-and-lipid-metabolism","display_name":"glycolipid metabolism","score":0.824999988079071},{"id":"https://openalex.org/keywords/sirna-therapeutics","display_name":"siRNA therapeutics","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.7986999750137329},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7633000016212463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6970000267028809},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5648000240325928},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5465999841690063},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5120999813079834},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5044000148773193},{"id":"https://openalex.org/C3018040386","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Lipid vesicle","level":4,"score":0.4860000014305115},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4546999931335449},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4000999927520752},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.3792000114917755},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.36579999327659607},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3634999990463257},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3540000021457672},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.35339999198913574},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3400999903678894},{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33399999141693115},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3319999873638153},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2685999870300293},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.25130000710487366},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.747432","doi":"https://doi.org/10.64898/2026.08.26.747432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747432","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747432.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.747432","doi":"https://doi.org/10.64898/2026.08.26.747432","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747432","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747432.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204966924.pdf","grobid_xml":"https://content.openalex.org/works/W7204966924.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W323406638","https://openalex.org/W1483024467","https://openalex.org/W1611419331","https://openalex.org/W1964146045","https://openalex.org/W1971942261","https://openalex.org/W1986789618","https://openalex.org/W1995770815","https://openalex.org/W1997183854","https://openalex.org/W2002490399","https://openalex.org/W2027774836","https://openalex.org/W2083249633","https://openalex.org/W2094399039","https://openalex.org/W2106885643","https://openalex.org/W2113972541","https://openalex.org/W2120535614","https://openalex.org/W2132741431","https://openalex.org/W2155239981","https://openalex.org/W2216422857","https://openalex.org/W2317018848","https://openalex.org/W2323505647","https://openalex.org/W2549188196","https://openalex.org/W2550324626","https://openalex.org/W2743305150","https://openalex.org/W2749918768","https://openalex.org/W2763984724","https://openalex.org/W2801179771","https://openalex.org/W2810909862","https://openalex.org/W2908499865","https://openalex.org/W2945507495","https://openalex.org/W2968060972","https://openalex.org/W2972869264","https://openalex.org/W2992823069","https://openalex.org/W3006492268","https://openalex.org/W3035225041","https://openalex.org/W3036363721","https://openalex.org/W3153698244","https://openalex.org/W3188940990","https://openalex.org/W3215674891","https://openalex.org/W4200599268","https://openalex.org/W4210282047","https://openalex.org/W4220826948","https://openalex.org/W4283803576","https://openalex.org/W4292702578","https://openalex.org/W4310706162","https://openalex.org/W4388965149","https://openalex.org/W4391968006","https://openalex.org/W4398250910","https://openalex.org/W4399290902","https://openalex.org/W4405755017","https://openalex.org/W4408315945","https://openalex.org/W7118173250","https://openalex.org/W7138938544","https://openalex.org/W7172021282"],"related_works":["https://openalex.org/W7222783046","https://openalex.org/W4399290902","https://openalex.org/W4409240190","https://openalex.org/W3003596414","https://openalex.org/W2113709410","https://openalex.org/W2048809853","https://openalex.org/W2536545287","https://openalex.org/W7167737054","https://openalex.org/W2474493778","https://openalex.org/W7171767393"],"abstract_inverted_index":{"Abstract":[0],"Small":[1],"interfering":[2],"RNA":[3],"(siRNA)":[4],"enables":[5],"precise":[6],"post-transcriptional":[7],"gene":[8,84],"silencing":[9,85],"for":[10,135,163],"refractory":[11],"diseases,":[12],"yet":[13],"its":[14],"clinical":[15,93],"translation":[16],"remains":[17],"limited":[18],"by":[19,29],"the":[20,30,92,136,146,164],"lack":[21],"of":[22,35,139,149,166],"safe":[23],"and":[24,41,51,61,69,87,99,116,123,159],"efficient":[25],"delivery":[26,157],"vectors.":[27],"Inspired":[28],"dissymmetric":[31,48],"alkyl":[32],"chain":[33],"architecture":[34],"natural":[36],"membrane":[37],"phospholipids,":[38],"we":[39,64],"designed":[40],"synthesized":[42],"34":[43],"novel":[44,140],"ionizable":[45,141],"lipids":[46],"with":[47,76],"hydrophobic":[49],"tails":[50],"formulated":[52],"them":[53],"into":[54],"lipid":[55,117],"nanoparticles":[56],"(LNPs).":[57],"Through":[58],"systematic":[59],"physicochemical":[60],"biological":[62],"assessments,":[63],"established":[65],"clear":[66],"structure-activity":[67],"relationships":[68],"identified":[70],"two":[71],"lead":[72,108],"LNPs":[73,109],"(O14-LNP,":[74],"H18a-LNP)":[75],"superior":[77],"endosomal":[78],"escape":[79],"capacity,":[80],"enhanced":[81],"in":[82],"vivo":[83],"potency,":[86],"favorable":[88],"biosafety":[89],"relative":[90],"to":[91],"benchmark":[94],"MC3-LNP.":[95],"In":[96],"both":[97],"streptozotocin-induced":[98],"spontaneous":[100],"db/db":[101],"type":[102],"2":[103],"diabetes":[104],"(T2D)":[105],"mouse":[106],"models,":[107],"delivering":[110],"ferroptosis-related":[111],"siRNAs":[112],"effectively":[113],"ameliorated":[114],"glucose":[115],"metabolic":[118],"disorders,":[119],"restored":[120],"islet":[121],"function,":[122],"alleviated":[124],"hepatic":[125],"steatosis.":[126],"This":[127],"study":[128],"not":[129],"only":[130],"lays":[131],"a":[132,155],"theoretical":[133],"foundation":[134],"rational":[137],"design":[138],"lipids,":[142],"but":[143],"also":[144],"validates":[145],"therapeutic":[147,161],"potential":[148],"siRNA":[150],"therapy":[151],"targeting":[152],"ferroptosis,":[153],"providing":[154],"versatile":[156],"platform":[158],"targeted":[160],"strategy":[162],"treatment":[165],"T2D.":[167]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
