{"id":"https://openalex.org/W7204960338","doi":"https://doi.org/10.1158/1078-0432.c.8686035","title":"Data from Phase I Trial of Intravenous VCN-01 Oncolytic Adenovirus and Durvalumab in Patients with Head and Neck Metastatic Squamous Cell Carcinoma Refractory to Immunotherapy","display_name":"Data from Phase I Trial of Intravenous VCN-01 Oncolytic Adenovirus and Durvalumab in Patients with Head and Neck Metastatic Squamous Cell Carcinoma Refractory to Immunotherapy","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204960338","doi":"https://doi.org/10.1158/1078-0432.c.8686035"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.8686035","doi":"https://doi.org/10.1158/1078-0432.c.8686035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8686035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.8686035","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089518617","display_name":"Maria Jov\u00e9","orcid":"https://orcid.org/0000-0003-1462-9021","observed_orcids":["https://orcid.org/0000-0003-1462-9021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jove","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1462-9021","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079422406","display_name":"Irene Bra\u00f1a","orcid":"https://orcid.org/0000-0002-1068-9601","observed_orcids":["https://orcid.org/0000-0002-1068-9601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Bra\u00f1a","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1068-9601","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054682698","display_name":"Marc Oliva","orcid":"https://orcid.org/0000-0001-5352-8130","observed_orcids":["https://orcid.org/0000-0001-5352-8130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Oliva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5352-8130","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013892733","display_name":"Alberto Hernando\u2010Calvo","orcid":"https://orcid.org/0000-0002-1692-1125","observed_orcids":["https://orcid.org/0000-0002-1692-1125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Hernando-Calvo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1692-1125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138197980","display_name":"Carlos Erasun","orcid":"https://orcid.org/0000-0002-6743-2903","observed_orcids":["https://orcid.org/0000-0002-6743-2903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Erasun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6743-2903","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046300715","display_name":"Ana Mato-Berciano","orcid":"https://orcid.org/0009-0005-0811-3581","observed_orcids":["https://orcid.org/0009-0005-0811-3581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mato-Berciano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0811-3581","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026232524","display_name":"Mar\u00eda Victoria Maliandi","orcid":"https://orcid.org/0000-0001-5447-2343","observed_orcids":["https://orcid.org/0000-0001-5447-2343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Victoria Maliandi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5447-2343","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022276874","display_name":"Silvia Torres-Manjon","orcid":"https://orcid.org/0009-0008-9378-1067","observed_orcids":["https://orcid.org/0009-0008-9378-1067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Torres-Manjon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-9378-1067","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067346260","display_name":"Luis Alfonso Rojas","orcid":"https://orcid.org/0000-0001-9218-4086","observed_orcids":["https://orcid.org/0000-0001-9218-4086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis A. Rojas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9218-4086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048270390","display_name":"Sheila Connelly","orcid":"https://orcid.org/0000-0003-0951-3593","observed_orcids":["https://orcid.org/0000-0003-0951-3593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheila Connelly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0951-3593","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023223057","display_name":"Miriam Baz\u00e1n\u2010Peregrino","orcid":"https://orcid.org/0000-0001-7367-8304","observed_orcids":["https://orcid.org/0000-0001-7367-8304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miriam Bazan-Peregrino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7367-8304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070513666","display_name":"Rafael Moreno","orcid":"https://orcid.org/0000-0001-9957-3105","observed_orcids":["https://orcid.org/0000-0001-9957-3105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Moreno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9957-3105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087380508","display_name":"Jaime Mart\u00ednez de Villarreal","orcid":"https://orcid.org/0000-0002-3003-7766","observed_orcids":["https://orcid.org/0000-0002-3003-7766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime Mart\u00ednez de Villarreal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3003-7766","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060086359","display_name":"Francisco X. Real","orcid":"https://orcid.org/0000-0001-9501-498X","observed_orcids":["https://orcid.org/0000-0001-9501-498X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco X. Real","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9501-498X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148899805","display_name":"Charles Le","orcid":"https://orcid.org/0009-0007-5110-1185","observed_orcids":["https://orcid.org/0009-0007-5110-1185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Le","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5110-1185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081259888","display_name":"Paolo Giovanni Nuciforo","orcid":"https://orcid.org/0000-0003-1380-0990","observed_orcids":["https://orcid.org/0000-0003-1380-0990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Nuciforo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1380-0990","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084444653","display_name":"Ram\u00f3n Alemany","orcid":"https://orcid.org/0000-0001-8660-550X","observed_orcids":["https://orcid.org/0000-0001-8660-550X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramon Alemany","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8660-550X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036172060","display_name":"Gabriel Capell\u00e1","orcid":"https://orcid.org/0000-0002-4669-7320","observed_orcids":["https://orcid.org/0000-0002-4669-7320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Capell\u00e0","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4669-7320","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148902686","display_name":"Carmen Blasco","orcid":"https://orcid.org/0009-0003-2565-9995","observed_orcids":["https://orcid.org/0009-0003-2565-9995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Blasco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-2565-9995","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035766272","display_name":"Manel Cascall\u00f3","orcid":"https://orcid.org/0009-0002-3260-600X","observed_orcids":["https://orcid.org/0009-0002-3260-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manel Cascall\u00f3","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3260-600X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037339388","display_name":"Ricard Mes\u00eda","orcid":"https://orcid.org/0000-0002-3785-3563","observed_orcids":["https://orcid.org/0000-0002-3785-3563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricard Mes\u00eda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3785-3563","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.9810000061988831},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6439999938011169},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hyaluronidase","display_name":"hyaluronidase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.4650000035762787},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.5580000281333923},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.9894000291824341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8123999834060669},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6635000109672546},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5942999720573425},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5857999920845032},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5795999765396118},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4706999957561493},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4611000120639801},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.4212999939918518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41600000858306885},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.39969998598098755},{"id":"https://openalex.org/C2778650287","wikidata":"https://www.wikidata.org/wiki/Q7838098","display_name":"Tremelimumab","level":5,"score":0.37929999828338623},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3790999948978424},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.364300012588501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3547999858856201},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3244999945163727},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3093999922275543},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.29789999127388},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C2911179620","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunopotentiator","level":3,"score":0.2915000021457672},{"id":"https://openalex.org/C2994491419","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous carcinoma","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.8686035","doi":"https://doi.org/10.1158/1078-0432.c.8686035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8686035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.8686035","doi":"https://doi.org/10.1158/1078-0432.c.8686035","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8686035","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163898817","https://openalex.org/W4295827782","https://openalex.org/W4387811131","https://openalex.org/W7204896621","https://openalex.org/W7204906029","https://openalex.org/W2994940568","https://openalex.org/W7204879641","https://openalex.org/W7204906281","https://openalex.org/W7204894420","https://openalex.org/W7204942154"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Zabilugene":[2],"almadenorepvec":[3],"(VCN-01)":[4],"is":[5],"a":[6],"hyaluronidase-expressing":[7],"oncolytic":[8],"adenovirus":[9],"that":[10],"increases":[11],"immune":[12,181],"checkpoint":[13],"antibody":[14],"tumor":[15,180,204,252],"uptake":[16],"in":[17,24,100,105,111,120,125,131,169,179,198,234],"mice.":[18],"VCN-01":[19,54,166,208,219,243,258],"was":[20,167,176,211,223,232],"evaluated":[21],"with":[22,26,139,190,246],"durvalumab":[23,69,77,90,210],"patients":[25,97,161,235],"recurrent/metastatic":[27],"head":[28],"and":[29,49,109,129,171,173,193,202,250,259],"neck":[30],"squamous":[31],"cell":[32,38,43],"carcinoma":[33],"(HNSCC)":[34],"refractory":[35],"to":[36],"anti\u2013programmed":[37],"death":[39,44],"protein":[40],"1":[41,46],"(PD-1)/programmed":[42],"ligand":[45],"(PD-L1).":[47],"Patients":[48,51],"Methods:":[50],"received":[52],"intravenous":[53],"[3.3E12":[55],"viral":[56],"particles":[57],"(vp),":[58],"low":[59],"dose":[60,66,222],"(LD)":[61],"or":[62,83],"1.0E13":[63,224],"vp,":[64],"high":[65],"(HD)]":[67],"plus":[68,209],"(1,500":[70],"mg/every":[71],"4":[72],"weeks)":[73],"concomitantly":[74],"(VCN-01":[75,85],"+":[76,89],"on":[78,86,91,226,238],"day":[79,87,92],"1;":[80,93],"arm":[81,94,101,106,112,121,126,132,140],"I)":[82],"sequentially":[84],"\u221214":[88],"II).":[95],"Six":[96],"were":[98,137,162,183],"enrolled":[99],"I":[102,122],"LD,":[103,108,123,128],"8":[104],"II":[107,113,127,133,141,221],"6":[110],"HD.":[114,134],"Results:":[115],"Two":[116],"dose-limiting":[117],"toxicities":[118],"occurred":[119],"one":[124],"none":[130],"Antitumor":[135],"responses":[136],"observed,":[138],"HD":[142],"displaying":[143],"the":[144,199,227],"longest":[145],"overall":[146],"survival":[147,231],"(OS)":[148],"of":[149,257],"17.3":[150],"months":[151],"(8.1\u2013not":[152],"estimable":[153],"[NE]),":[154],"although":[155],"not":[156],"statistically":[157],"significant.":[158],"Eleven":[159],"(61.1%)":[160],"alive":[163],">12":[164],"months.":[165],"detected":[168],"blood":[170],"tumors,":[172],"hyaluronidase":[174],"expression":[175,188],"confirmed.":[177],"Changes":[178],"markers":[182],"identified,":[184],"including":[185],"increased":[186,203,247],"PD-L1":[187],"correlating":[189],"OS.":[191],"Transcriptomic":[192],"radiomic":[194],"analyses":[195],"showed":[196],"changes":[197],"extracellular":[200],"matrix":[201],"perfusion.":[205],"Conclusions:":[206],"Sequential":[207,254],"better":[212],"tolerated":[213],"than":[214],"concomitant":[215],"treatment.":[216],"The":[217],"recommended":[218],"phase":[220],"vp":[225],"sequential":[228],"schedule.":[229],"Encouraging":[230],"observed":[233],"after":[236],"progressing":[237],"anti\u2013PD-(L)1":[239],"agents.":[240],"Data":[241],"support":[242],"replication":[244],"associated":[245],"PD-1,":[248],"PD-L1,":[249],"CD8":[251],"expression.":[253],"systemic":[255],"delivery":[256],"anti\u2013PD-L1":[260],"therapy":[261],"may":[262],"represent":[263],"an":[264],"improved":[265],"treatment":[266],"for":[267],"HNSCC.":[268]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-02T00:00:00"}