{"id":"https://openalex.org/W7204953563","doi":"https://doi.org/10.1245/s10434-026-20525-3","title":"The Times They Are A-Changin\u2019: Pancreatic Cancer Surgery in the RAS Inhibitor Era","display_name":"The Times They Are A-Changin\u2019: Pancreatic Cancer Surgery in the RAS Inhibitor Era","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204953563","doi":"https://doi.org/10.1245/s10434-026-20525-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/42681165"},"language":"en","primary_location":{"id":"doi:10.1245/s10434-026-20525-3","doi":"https://doi.org/10.1245/s10434-026-20525-3","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20525-3","pdf_url":"https://link.springer.com/content/pdf/10.1245/s10434-026-20525-3.pdf","source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1245/s10434-026-20525-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013005773","display_name":"Herv\u00e9 Tiriac","orcid":"https://orcid.org/0000-0001-5039-6750","observed_orcids":["https://orcid.org/0000-0001-5039-6750"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Tiriac","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, UC San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, UC San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089839809","display_name":"Andrew M. Lowy","orcid":"https://orcid.org/0000-0002-7106-0735","observed_orcids":["https://orcid.org/0000-0002-7106-0735"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew M. Lowy","raw_affiliation_strings":["Department of Surgery, Division of Surgical Oncology, UC San Diego, La Jolla, CA, USA. alowy@health.ucsd.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, UC San Diego, La Jolla, CA, USA. alowy@health.ucsd.edu","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089839809"],"corresponding_institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65855031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"12","first_page":"9947","last_page":"9949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pancreatic-cancer-surgery","display_name":"pancreatic cancer surgery","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ras-inhibitors","display_name":"RAS inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.4339999854564667},{"id":"https://openalex.org/keywords/oncogenic-ras-mutations","display_name":"oncogenic Ras mutations","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9347000122070312},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8266000151634216},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6351000070571899},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5810999870300293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5598000288009644},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3779999911785126},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C2992687050","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Cancer surgery","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C2778494859","wikidata":"https://www.wikidata.org/wiki/Q3361964","display_name":"Pancreatectomy","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.27950000762939453},{"id":"https://openalex.org/C2778975757","wikidata":"https://www.wikidata.org/wiki/Q1266423","display_name":"Pancreaticoduodenectomy","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1245/s10434-026-20525-3","doi":"https://doi.org/10.1245/s10434-026-20525-3","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20525-3","pdf_url":"https://link.springer.com/content/pdf/10.1245/s10434-026-20525-3.pdf","source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:42681165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42681165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of surgical oncology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1245/s10434-026-20525-3","doi":"https://doi.org/10.1245/s10434-026-20525-3","is_oa":true,"landing_page_url":"https://doi.org/10.1245/s10434-026-20525-3","pdf_url":"https://link.springer.com/content/pdf/10.1245/s10434-026-20525-3.pdf","source":{"id":"https://openalex.org/S177486402","display_name":"Annals of Surgical Oncology","issn_l":"1068-9265","issn":["1068-9265","1534-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4092785716056824,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204953563.pdf","grobid_xml":"https://content.openalex.org/works/W7204953563.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W4413315162","https://openalex.org/W7160408317","https://openalex.org/W7162952636","https://openalex.org/W7163317289"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2026-09-02T00:00:00"}