{"id":"https://openalex.org/W7204953215","doi":"https://doi.org/10.64898/2026.08.27.747468","title":"Sequential Molecular Interactions Shape A\u03b242 Aggregation, Propagation, and Toxicity","display_name":"Sequential Molecular Interactions Shape A\u03b242 Aggregation, Propagation, and Toxicity","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204953215","doi":"https://doi.org/10.64898/2026.08.27.747468"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.747468","doi":"https://doi.org/10.64898/2026.08.27.747468","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.27.747468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091898601","display_name":"Jofre Seira Curto","orcid":"https://orcid.org/0009-0001-1981-8238","observed_orcids":["https://orcid.org/0009-0001-1981-8238"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["ES","IT"],"is_corresponding":false,"raw_author_name":"Jofre Seira Curto","raw_affiliation_strings":["Instituto Italiano di Tecnologia, Genova, Italy","Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Italiano di Tecnologia, Genova, Italy","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117714557","display_name":"Genis Perez Collell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gen\u00eds P\u00e9rez Collell","raw_affiliation_strings":["Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107866343","display_name":"Manuel Ruiz","orcid":"https://orcid.org/0009-0007-8459-7949","observed_orcids":["https://orcid.org/0009-0007-8459-7949"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marina Romero Ruiz","raw_affiliation_strings":["Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":"https://orcid.org/0009-0007-8459-7949","affiliations":[{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056197299","display_name":"Sandra Villegas","orcid":"https://orcid.org/0000-0001-8644-4304","observed_orcids":["https://orcid.org/0000-0001-8644-4304"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra Villegas Hernandez","raw_affiliation_strings":["Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090247071","display_name":"M. Rosario Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-1750-7786","observed_orcids":["https://orcid.org/0000-0002-1750-7786"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Rosario Fernandez","raw_affiliation_strings":["Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1750-7786","affiliations":[{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057956968","display_name":"Natalia S\u00e1nchez de Groot","orcid":"https://orcid.org/0000-0002-0492-5532","observed_orcids":["https://orcid.org/0000-0002-0492-5532"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Natalia Sanchez de Groot","raw_affiliation_strings":["Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0492-5532","affiliations":[{"raw_affiliation_string":"Unitat de Bioqu\u00edmica. Departament de Bioqu\u00edmica i Biologia Molecular. Universitat Aut\u00f2noma de Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057956968"],"corresponding_institution_ids":["https://openalex.org/I123044942"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6380000114440918},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.6840000152587891},{"id":"https://openalex.org/keywords/amyloid-beta-toxicity","display_name":"amyloid-beta toxicity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6292999982833862},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.6122000217437744},{"id":"https://openalex.org/C4679612","wikidata":"https://www.wikidata.org/wiki/Q866298","display_name":"Aggregate (composite)","level":2,"score":0.5924999713897705},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5162000060081482},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49880000948905945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4708000123500824},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43549999594688416},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.41920000314712524},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4047999978065491},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.38510000705718994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3555000126361847},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C2778207910","wikidata":"https://www.wikidata.org/wiki/Q397610","display_name":"Agr\u00e9gation","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28600001335144043},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C203083617","wikidata":"https://www.wikidata.org/wiki/Q5433302","display_name":"Family aggregation","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.27.747468","doi":"https://doi.org/10.64898/2026.08.27.747468","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.27.747468","doi":"https://doi.org/10.64898/2026.08.27.747468","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W96912361","https://openalex.org/W1528511554","https://openalex.org/W1968666821","https://openalex.org/W1973166472","https://openalex.org/W1980605491","https://openalex.org/W1980825524","https://openalex.org/W1984223653","https://openalex.org/W1995281235","https://openalex.org/W2030325989","https://openalex.org/W2049421402","https://openalex.org/W2058746325","https://openalex.org/W2068848980","https://openalex.org/W2073298789","https://openalex.org/W2077553363","https://openalex.org/W2098466396","https://openalex.org/W2104849621","https://openalex.org/W2109386523","https://openalex.org/W2121977115","https://openalex.org/W2130487415","https://openalex.org/W2139418286","https://openalex.org/W2142807222","https://openalex.org/W2157359173","https://openalex.org/W2165186407","https://openalex.org/W2189871153","https://openalex.org/W2249662344","https://openalex.org/W2320472363","https://openalex.org/W2487730443","https://openalex.org/W2563522749","https://openalex.org/W2614053601","https://openalex.org/W2734651019","https://openalex.org/W2761210275","https://openalex.org/W2771052591","https://openalex.org/W2904603472","https://openalex.org/W2909958034","https://openalex.org/W2952437732","https://openalex.org/W2969016969","https://openalex.org/W2973900732","https://openalex.org/W2978939437","https://openalex.org/W3011328885","https://openalex.org/W3013691599","https://openalex.org/W3037058757","https://openalex.org/W3039837585","https://openalex.org/W3042981350","https://openalex.org/W3110489045","https://openalex.org/W3142780846","https://openalex.org/W3161094838","https://openalex.org/W3214964819","https://openalex.org/W4205765478","https://openalex.org/W4210857662","https://openalex.org/W4214683393","https://openalex.org/W4220847586","https://openalex.org/W4280643104","https://openalex.org/W4283021994","https://openalex.org/W4311672498","https://openalex.org/W4313395925","https://openalex.org/W4323656754","https://openalex.org/W4376631181","https://openalex.org/W4386917580","https://openalex.org/W4387865699","https://openalex.org/W4388007097","https://openalex.org/W4388173903","https://openalex.org/W4390063994","https://openalex.org/W4396956486","https://openalex.org/W4401806028","https://openalex.org/W4406968803","https://openalex.org/W4407465790","https://openalex.org/W4410779315"],"related_works":["https://openalex.org/W4406787154","https://openalex.org/W2978136964","https://openalex.org/W4210988028","https://openalex.org/W2066881823","https://openalex.org/W4388365724","https://openalex.org/W4408242342","https://openalex.org/W2563522749","https://openalex.org/W7172536843","https://openalex.org/W2912558479","https://openalex.org/W7046841229"],"abstract_inverted_index":{"Abstract":[0],"Protein":[1],"aggregation":[2,48,77,80,147,154,174],"is":[3],"a":[4,56,156],"context-dependent":[5],"process":[6,158],"in":[7,31,46,107,124],"which":[8,125],"the":[9,14,17,72,98,129,141],"molecular":[10,40,113,142],"environment":[11],"can":[12,25],"influence":[13],"properties":[15,99,135],"of":[16,60,100,131],"resulting":[18,106],"assemblies.":[19],"In":[20],"biological":[21],"systems,":[22],"these":[23],"interactions":[24,93],"occur":[26],"sequentially,":[27],"as":[28,44,55,155],"aggregates":[29],"formed":[30],"one":[32],"cellular":[33],"or":[34],"tissue":[35],"context":[36],"may":[37,164],"encounter":[38],"different":[39],"partners":[41],"and":[42,63,86,103,114,136,159],"act":[43],"seeds":[45],"subsequent":[47,137],"events.":[49,148],"Here,":[50],"we":[51,89],"used":[52],"sequential":[53],"seeding":[54],"controlled":[57],"experimental":[58],"model":[59,123],"this":[61],"temporal":[62],"contextual":[64],"complexity":[65],"to":[66,166],"investigate":[67],"how":[68],"prion-like":[69],"sequences":[70,127],"from":[71],"gut":[73],"microbiome":[74],"modulate":[75],"amyloid-\u03b2":[76],"across":[78,172],"successive":[79,173],"cycles.":[81,175],"Combining":[82],"kinetic,":[83],"biophysical,":[84],"conformational,":[85],"toxicity":[87],"analyses,":[88],"show":[90],"that":[91,161,170],"early":[92],"with":[94,111],"exogenous":[95,126],"peptides":[96],"modify":[97],"first-generation":[101],"A\u03b240-":[102],"A\u03b242-derived":[104],"seeds,":[105],"propagated":[108],"A\u03b242":[109],"assemblies":[110],"distinct":[112],"functional":[115],"properties.":[116],"These":[117],"findings":[118],"support":[119],"an":[120],"Interaction":[121],"History":[122],"bias":[128],"emergence":[130],"aggregate":[132,168],"populations":[133],"whose":[134],"propagation":[138],"depend":[139],"on":[140],"contexts":[143],"experienced":[144],"during":[145],"earlier":[146],"Overall,":[149],"our":[150],"results":[151],"present":[152],"A\u03b2":[153],"history-dependent":[157],"suggest":[160],"single-step":[162],"assays":[163],"fail":[165],"capture":[167],"diversity":[169],"emerges":[171]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
