{"id":"https://openalex.org/W7204953120","doi":"https://doi.org/10.64898/2026.08.26.747232","title":"Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson\u2019s disease through RhoA inhibition","display_name":"Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson\u2019s disease through RhoA inhibition","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204953120","doi":"https://doi.org/10.64898/2026.08.26.747232"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.747232","doi":"https://doi.org/10.64898/2026.08.26.747232","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747232","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.747232.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.747232.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038238427","display_name":"Sissel Ida Schmidt","orcid":"https://orcid.org/0000-0003-4939-8155","observed_orcids":["https://orcid.org/0000-0003-4939-8155"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sissel Ida Schmidt","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0003-4939-8155","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035519174","display_name":"Justyna Okarmus","orcid":"https://orcid.org/0000-0001-8310-6553","observed_orcids":["https://orcid.org/0000-0001-8310-6553"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Justyna Okarmus","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0001-8310-6553","affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000535844","display_name":"Matias Ryding","orcid":"https://orcid.org/0000-0003-1151-7497","observed_orcids":["https://orcid.org/0000-0003-1151-7497"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Matias Ryding","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0003-1151-7497","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147581873","display_name":"Ida Keller Skousen","orcid":"https://orcid.org/0009-0005-0478-293X","observed_orcids":["https://orcid.org/0009-0005-0478-293X"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ida Keller Skousen","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":"https://orcid.org/0009-0005-0478-293X","affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148867908","display_name":"Nicolaj Frederik Broner Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicolaj Frederik Broner Jensen","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111317213","display_name":"Emil Birch Christensen","orcid":"https://orcid.org/0000-0002-0470-0210","observed_orcids":["https://orcid.org/0000-0002-0470-0210"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Emil Birch Christensen","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107864491","display_name":"Lucas Seidelin Winkelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lucas S. Winkelmann","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046296228","display_name":"Alice Dupont Juhl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Alice Dupont Juhl","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148919205","display_name":"Miamaja Klaebel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Miamaja Kl\u00e6bel","raw_affiliation_strings":["Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000520766","display_name":"Morten Blaabjerg","orcid":"https://orcid.org/0000-0001-6007-1861","observed_orcids":["https://orcid.org/0000-0001-6007-1861"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Blaabjerg","raw_affiliation_strings":["BRIDGE \u2013 Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, DK;","Department of Clinical Research, University of Southern Denmark, Odense, DK;","Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","Department of Neurology, Odense University Hospital, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0001-6007-1861","affiliations":[{"raw_affiliation_string":"BRIDGE \u2013 Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurology, Odense University Hospital, Odense, DK;","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090412968","display_name":"Kristine Freude","orcid":"https://orcid.org/0000-0001-9480-2386","observed_orcids":["https://orcid.org/0000-0001-9480-2386"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristine Freude","raw_affiliation_strings":["Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen, Copenhagen, DK"],"raw_orcid":"https://orcid.org/0000-0001-9480-2386","affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen, Copenhagen, DK","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090901298","display_name":"Daniel W\u00fcstner","orcid":"https://orcid.org/0000-0003-4995-9709","observed_orcids":["https://orcid.org/0000-0003-4995-9709"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Daniel W\u00fcstner","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0003-4995-9709","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028723665","display_name":"Richard Wade\u2010Martins","orcid":"https://orcid.org/0000-0001-6691-580X","observed_orcids":["https://orcid.org/0000-0001-6691-580X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Wade-Martins","raw_affiliation_strings":["Kavli Institute of Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK;","Oxford Parkinson\u2019s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK;"],"raw_orcid":"https://orcid.org/0000-0001-6691-580X","affiliations":[{"raw_affiliation_string":"Kavli Institute of Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK;","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford Parkinson\u2019s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019170976","display_name":"Brent James Ryan","orcid":"https://orcid.org/0000-0002-6703-3718","observed_orcids":["https://orcid.org/0000-0002-6703-3718"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brent Ryan","raw_affiliation_strings":["Kavli Institute of Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK;","Oxford Parkinson\u2019s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK;"],"raw_orcid":"https://orcid.org/0000-0002-6703-3718","affiliations":[{"raw_affiliation_string":"Kavli Institute of Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK;","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Oxford Parkinson\u2019s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034946522","display_name":"Morten Meyer","orcid":"https://orcid.org/0000-0002-9571-1336","observed_orcids":["https://orcid.org/0000-0002-9571-1336"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Morten Meyer","raw_affiliation_strings":["BRIDGE \u2013 Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, DK;","Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","Department of Neurology, Odense University Hospital, Odense, DK;"],"raw_orcid":"https://orcid.org/0000-0002-9571-1336","affiliations":[{"raw_affiliation_string":"BRIDGE \u2013 Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, DK;","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Neurology, Odense University Hospital, Odense, DK;","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034946522"],"corresponding_institution_ids":["https://openalex.org/I177969490","https://openalex.org/I2801498763"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8949999809265137},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.7649999856948853},{"id":"https://openalex.org/keywords/rhoa-inhibition","display_name":"RhoA inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-isoprenylation","display_name":"isoprenylation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/familial-parkinson-s-disease","display_name":"familial Parkinson's disease","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.7850000262260437},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.6100000143051147},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.5809999704360962},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.972000002861023},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.6689000129699707},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.621399998664856},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5422999858856201},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5382999777793884},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.5289999842643738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48260000348091125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45910000801086426},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.45339998602867126},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4032000005245209},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3292999863624573},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C2777916540","wikidata":"https://www.wikidata.org/wiki/Q24767155","display_name":"Synuclein","level":5,"score":0.301800012588501},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C2781249495","wikidata":"https://www.wikidata.org/wiki/Q420685","display_name":"Rasagiline","level":4,"score":0.2849000096321106},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.2777999937534332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2754000127315521},{"id":"https://openalex.org/C2779473599","wikidata":"https://www.wikidata.org/wiki/Q17831671","display_name":"RhoC","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C23167141","wikidata":"https://www.wikidata.org/wiki/Q14912965","display_name":"Geranylgeranylation","level":4,"score":0.26409998536109924},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.2526000142097473},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.747232","doi":"https://doi.org/10.64898/2026.08.26.747232","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747232","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.747232.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.747232","doi":"https://doi.org/10.64898/2026.08.26.747232","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747232","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.747232.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204953120.pdf","grobid_xml":"https://content.openalex.org/works/W7204953120.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4407229133"],"related_works":["https://openalex.org/W2068462701","https://openalex.org/W3138363060","https://openalex.org/W2051194668","https://openalex.org/W2181872998","https://openalex.org/W7128216688","https://openalex.org/W4381664024","https://openalex.org/W2044164680","https://openalex.org/W2211108236","https://openalex.org/W1577474909","https://openalex.org/W2801937771"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Statins":[2],"have":[3],"gained":[4],"increasing":[5],"interest":[6],"for":[7,30,37],"their":[8,17,31],"potential":[9],"therapeutic":[10,315],"effect":[11],"in":[12,60,134,140,152,181,252,275],"Parkinson\u2019s":[13],"disease":[14,264],"(PD).":[15],"Beyond":[16],"cholesterol-lowering":[18],"effect,":[19],"statins":[20],"decrease":[21],"synthesis":[22],"of":[23,43,63,78,132,199,212,216,220,245,278,295,321],"isoprenoids,":[24],"which":[25],"is":[26,35],"believed":[27],"to":[28],"account":[29],"pleiotropic":[32],"effects.":[33],"Isoprenylation":[34],"important":[36],"proper":[38],"membrane":[39],"localization":[40],"and":[41,65,96,120,125,151,167,172,183,189,231,234,248,266,298],"function":[42],"the":[44,61,71,76,130,195,319],"Rho":[45],"GTPases,":[46],"including":[47,161],"RhoA.":[48],"RhoA":[49,105,110,133,136,175,200,237,268,285,306,311,326],"signalling":[50,57,286],"has":[51],"emerged":[52],"as":[53,270,287,312],"a":[54,271,276,288,313],"possible":[55],"underlying":[56],"pathway":[58],"involved":[59],"pathogenesis":[62],"PD":[64,94,142,213,246,297],"other":[66],"neurodegenerative":[67],"diseases.":[68],"Methods":[69],"In":[70],"present":[72],"study,":[73],"we":[74,193],"investigated":[75],"effects":[77],"simvastatin":[79,301],"on":[80,104,325],"neurodegeneration-associated":[81],"phenotypes":[82,115,304],"using":[83,108,112],"human":[84],"induced":[85],"pluripotent":[86],"stem":[87],"cell-derived":[88],"dopaminergic":[89],"(DA)":[90],"neurons":[91],"from":[92],"both":[93],"patients":[95],"isogenic":[97],"PARK2":[98],"-/-":[99],"cell":[100,126,173],"lines.":[101],"The":[102],"dependence":[103],"was":[106,138,177,239,249],"confirmed":[107],"direct":[109],"inhibition":[111,176],"rhosin.":[113],"Assessed":[114],"included":[116],"structural":[117],"integrity,":[118],"mitochondrial":[119,166],"lysosomal":[121,168],"characteristics,":[122],"cytokine":[123,170],"secretion,":[124],"viability.":[127],"To":[128],"understand":[129],"relevance":[131],"PD,":[135],"activity":[137,201,238],"measured":[139],"32":[141,203],"patient":[143,257,322],"iPSC-derived":[144,204],"lines":[145,207,258],"with":[146,179,260],"different":[147],"familial":[148],"PD-related":[149],"mutations":[150],"healthy":[153,235,261],"controls.":[154,236],"Results":[155],"Simvastatin":[156],"rescued":[157],"multiple":[158,209,293],"PD-associated":[159,303],"phenotypes,":[160],"impaired":[162],"DA":[163,205],"neurite":[164],"outgrowth,":[165],"alterations,":[169],"release,":[171],"death.":[174],"associated":[178],"changes":[180],"mitophagy-":[182],"autophagy-related":[184],"markers,":[185],"suggesting":[186],"improved":[187],"autophagic":[188],"mitophagic":[190],"turnover.":[191],"Furthermore,":[192],"performed":[194],"first":[196],"systematic":[197],"screen":[198],"across":[202,241,292],"neuron":[206],"representing":[208],"genetic":[210,243,296],"forms":[211,244,294],"(PINK1":[214],"loss":[215,219],"function,":[217,221],"parkin":[218],"LRRK2":[222,224],"(G2019S),":[223],"(R1441C),":[225],"GBA":[226,228],"(L44P),":[227],"(N370S),":[229],"A53T,":[230],"SNCA":[232],"triplication)":[233],"perturbated":[240],"several":[242],"subtypes":[247],"significantly":[250],"increased":[251],"many,":[253],"although":[254],"not":[255],"all,":[256],"compared":[259],"controls,":[262],"highlighting":[263],"heterogeneity":[265],"supporting":[267],"dysregulation":[269],"shared":[272],"pathogenic":[273,290],"mechanism":[274,291],"subset":[277],"PD.":[279],"Conclusions":[280],"Our":[281],"findings":[282],"identify":[283],"aberrant":[284],"convergent":[289],"demonstrate":[299],"that":[300],"ameliorates":[302],"through":[305],"inhibition.":[307],"These":[308],"results":[309],"support":[310],"promising":[314],"target":[316],"while":[317],"emphasizing":[318],"importance":[320],"stratification":[323],"based":[324],"activity.":[327]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}
