{"id":"https://openalex.org/W7204950661","doi":"https://doi.org/10.64898/2026.08.26.747192","title":"Entorhinal grid coding as a functional link between tau accumulation and episodic memory in human aging","display_name":"Entorhinal grid coding as a functional link between tau accumulation and episodic memory in human aging","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204950661","doi":"https://doi.org/10.64898/2026.08.26.747192"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.747192","doi":"https://doi.org/10.64898/2026.08.26.747192","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747192","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747192.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747192.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016036348","display_name":"Vladislava Segen","orcid":"https://orcid.org/0000-0002-6677-723X","observed_orcids":["https://orcid.org/0000-0002-6677-723X"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210126587","display_name":"Center for Behavioral Brain Sciences","ror":"https://ror.org/03d1zwe41","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210126587","https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Vladislava Segen","raw_affiliation_strings":["Center for Behavioral Brain Sciences, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6677-723X","affiliations":[{"raw_affiliation_string":"Center for Behavioral Brain Sciences, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210126587"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138666693","display_name":"Tu\u011f\u00e7e Belge Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tu\u011f\u00e7e Belge Bernard","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148902886","display_name":"Gerard Callau Navarro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerard Callau Navarro","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023597563","display_name":"Philip Bahrd","orcid":"https://orcid.org/0000-0001-9989-7054","observed_orcids":["https://orcid.org/0000-0001-9989-7054"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philip Bahrd","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093579402","display_name":"Niklas Behrenbruch","orcid":"https://orcid.org/0009-0002-7947-9220","observed_orcids":["https://orcid.org/0009-0002-7947-9220"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niklas Behrenbruch","raw_affiliation_strings":["Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087257171","display_name":"Beate Schumann\u2010Werner","orcid":"https://orcid.org/0000-0002-3530-5766","observed_orcids":["https://orcid.org/0000-0002-3530-5766"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Beate Schumann-Werner","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050190772","display_name":"Svenja Schwarck","orcid":"https://orcid.org/0000-0003-2024-9236","observed_orcids":["https://orcid.org/0000-0003-2024-9236"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Svenja Schwarck","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038056370","display_name":"Berta Garcia\u2010Garcia","orcid":"https://orcid.org/0000-0002-8585-6507","observed_orcids":["https://orcid.org/0000-0002-8585-6507"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Berta Garcia-Garcia","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, Faculty of Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, Faculty of Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034480643","display_name":"Henryk Barthel","orcid":"https://orcid.org/0000-0002-9322-9167","observed_orcids":["https://orcid.org/0000-0002-9322-9167"]},"institutions":[{"id":"https://openalex.org/I4210092841","display_name":"St\u00e4dtisches Klinikum Dessau","ror":"https://ror.org/00gj8pr18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210092841"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henryk Barthel","raw_affiliation_strings":["Department of Nuclear Medicine, Municipal Hospital Dessau, Dessau-Ro\u00dflau, Germany","Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Municipal Hospital Dessau, Dessau-Ro\u00dflau, Germany","institution_ids":["https://openalex.org/I4210092841"]},{"raw_affiliation_string":"Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008894116","display_name":"Osama Sabri","orcid":"https://orcid.org/0000-0002-6425-3504","observed_orcids":["https://orcid.org/0000-0002-6425-3504"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Osama Sabri","raw_affiliation_strings":["Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086684261","display_name":"Michael Christoph Kreissl","orcid":"https://orcid.org/0000-0001-5905-6015","observed_orcids":["https://orcid.org/0000-0001-5905-6015"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael C. Kreissl","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, Faculty of Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, Faculty of Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000608836","display_name":"Emrah D\u00fczel","orcid":"https://orcid.org/0000-0002-0139-5388","observed_orcids":["https://orcid.org/0000-0002-0139-5388","https://orcid.org/0000-0002-0656-5286"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210126587","display_name":"Center for Behavioral Brain Sciences","ror":"https://ror.org/03d1zwe41","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210126587","https://openalex.org/I95793202"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Emrah D\u00fczel","raw_affiliation_strings":["Center for Behavioral Brain Sciences, Magdeburg, Germany","Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Behavioral Brain Sciences, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210126587"]},{"raw_affiliation_string":"Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121040418","display_name":"Anne Maass","orcid":"https://orcid.org/0000-0002-7889-795X","observed_orcids":["https://orcid.org/0000-0002-7889-795X","https://orcid.org/0000-0001-9802-5246"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210126587","display_name":"Center for Behavioral Brain Sciences","ror":"https://ror.org/03d1zwe41","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210126587","https://openalex.org/I95793202"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Maass","raw_affiliation_strings":["Center for Behavioral Brain Sciences, Magdeburg, Germany","Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Behavioral Brain Sciences, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210126587"]},{"raw_affiliation_string":"Faculty of Natural Sciences, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080300207","display_name":"Thomas Wolbers","orcid":"https://orcid.org/0000-0003-2943-8949","observed_orcids":["https://orcid.org/0000-0003-2943-8949"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210126587","display_name":"Center for Behavioral Brain Sciences","ror":"https://ror.org/03d1zwe41","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210126587","https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Wolbers","raw_affiliation_strings":["Center for Behavioral Brain Sciences, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2943-8949","affiliations":[{"raw_affiliation_string":"Center for Behavioral Brain Sciences, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210126587"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016036348"],"corresponding_institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210126587"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.8790000081062317},{"id":"https://openalex.org/keywords/grid-cells","display_name":"grid cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tau-accumulation","display_name":"tau accumulation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.9359999895095825},{"id":"https://openalex.org/keywords/normal-aging","display_name":"normal aging","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tau-pet","display_name":"tau PET","score":0.621999979019165},{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.8240000009536743},{"id":"https://openalex.org/keywords/memory-variability","display_name":"memory variability","score":0.5759999752044678},{"id":"https://openalex.org/keywords/bayesian-mediation-analysis","display_name":"Bayesian mediation analysis","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.9053000211715698},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6633999943733215},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5464000105857849},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.5386000275611877},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.516700029373169},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4745999872684479},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C24590219","wikidata":"https://www.wikidata.org/wiki/Q18601","display_name":"Long-term memory","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C90269970","wikidata":"https://www.wikidata.org/wiki/Q7302606","display_name":"Recognition memory","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.31929999589920044},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2565999925136566},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.2549999952316284},{"id":"https://openalex.org/C197914299","wikidata":"https://www.wikidata.org/wiki/Q18650","display_name":"Semantic memory","level":3,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.747192","doi":"https://doi.org/10.64898/2026.08.26.747192","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747192","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747192.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.747192","doi":"https://doi.org/10.64898/2026.08.26.747192","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747192","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.26.747192.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3097568876","display_name":null,"funder_award_id":"CRC 1436","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4006445760","display_name":null,"funder_award_id":"RTG2413","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8134286188","display_name":"GRK 2413: Die alternde Synapse  molekulare, zellul\u00e4re und verhaltensbiologische Mechanismen des kognitiven Leistungsabfalls","funder_award_id":"362321501","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G896486012","display_name":"SFB 1436: Neuronale Ressourcen der Kognition","funder_award_id":"425899996","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320309607","display_name":"Velux Stiftung","ror":"https://ror.org/00kgf1c95"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204950661.pdf","grobid_xml":"https://content.openalex.org/works/W7204950661.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1906155463","https://openalex.org/W7146955815","https://openalex.org/W7163537441","https://openalex.org/W7168705939"],"related_works":["https://openalex.org/W2775311168","https://openalex.org/W2001363649","https://openalex.org/W3112096142","https://openalex.org/W3111208361","https://openalex.org/W2765849014","https://openalex.org/W4233534743","https://openalex.org/W4238266248","https://openalex.org/W4312088353","https://openalex.org/W3134584945","https://openalex.org/W4312037148"],"abstract_inverted_index":{"Abstract":[0],"Episodic":[1],"memory":[2,32,42,107,158,183],"decline":[3],"is":[4,23,155],"a":[5,27,176],"common":[6],"feature":[7],"of":[8],"cognitively":[9,80],"normal":[10,81,186],"aging,":[11],"but":[12],"its":[13],"extent":[14],"varies":[15],"markedly":[16],"across":[17],"individuals.":[18],"Although":[19],"entorhinal":[20,50,90,100,114,135,162,171],"tau":[21,39,73,115,153,180],"pathology":[22],"thought":[24],"to":[25,30,41,84,125,157,182],"be":[26],"key":[28],"contributor":[29],"episodic":[31,59,96],"impairment,":[33],"the":[34,49,126],"neural":[35],"mechanisms":[36],"linking":[37,179],"early":[38],"accumulation":[40,181],"differences":[43],"remain":[44],"unclear.":[45],"Grid-cell":[46],"computations":[47],"in":[48,79,89,185],"cortex,":[51],"which":[52],"provide":[53,168],"scaffolds":[54],"for":[55],"organizing":[56],"experiences":[57],"into":[58],"memories,":[60],"offer":[61],"one":[62],"candidate":[63],"mechanism.":[64],"Here,":[65],"we":[66],"combined":[67],"virtual-reality":[68],"functional":[69,177],"MRI,":[70],"multivariate":[71],"analysis,":[72],"PET,":[74],"and":[75,109,130],"delayed":[76],"word-list":[77],"recall":[78],"older":[82],"adults":[83],"test":[85],"whether":[86],"tau-related":[87],"alterations":[88],"coding":[91],"are":[92],"associated":[93,104],"with":[94,105,111],"worse":[95],"memory.":[97],"Weaker":[98],"left":[99,113,161],"grid-cell-like":[101,119,163],"signal":[102,129],"was":[103,123,131],"poorer":[106],"performance,":[108],"individuals":[110],"higher":[112],"burden":[116,154],"showed":[117],"weaker":[118],"signal.":[120,164],"This":[121],"association":[122],"specific":[124],"canonical":[127],"six-fold":[128],"not":[132],"explained":[133],"by":[134],"volume,":[136],"mean":[137],"diffusivity,":[138],"or":[139],"intracortical":[140],"myelination.":[141],"A":[142],"cross-sectional":[143],"Bayesian":[144],"mediation":[145],"analysis":[146],"further":[147],"demonstrated":[148],"that":[149,170],"bilateral":[150],"medial":[151],"temporal":[152],"related":[156],"indirectly":[159],"through":[160],"Together,":[165],"these":[166],"findings":[167],"evidence":[169],"grid":[172],"codes":[173],"may":[174],"constitute":[175],"pathway":[178],"variability":[184],"aging.":[187]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-02T00:00:00"}