{"id":"https://openalex.org/W7204949361","doi":"https://doi.org/10.26434/chemrxiv.15008152/v1","title":"Understanding male urethral mechanics: from ex vivo testing to mathematical modelling and in situ assessment, a review.","display_name":"Understanding male urethral mechanics: from ex vivo testing to mathematical modelling and in situ assessment, a review.","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204949361","doi":"https://doi.org/10.26434/chemrxiv.15008152/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15008152/v1","doi":"https://doi.org/10.26434/chemrxiv.15008152/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008152/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008152/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008152/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092727956","display_name":"Isabelle Martinier","orcid":"https://orcid.org/0009-0006-1021-0935","observed_orcids":["https://orcid.org/0009-0006-1021-0935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Martinier","raw_affiliation_strings":["Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT"],"raw_orcid":"https://orcid.org/0009-0006-1021-0935","affiliations":[{"raw_affiliation_string":"Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148894475","display_name":"Jiaxin Qin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaxin Qin","raw_affiliation_strings":["Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086126270","display_name":"Laetitia M.O. de Kort","orcid":"https://orcid.org/0000-0002-9239-8356","observed_orcids":["https://orcid.org/0000-0002-9239-8356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laetitia de Kort","raw_affiliation_strings":["Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052714637","display_name":"Wouter van Dort","orcid":"https://orcid.org/0009-0007-8703-1529","observed_orcids":["https://orcid.org/0009-0007-8703-1529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wouter van Dort","raw_affiliation_strings":["Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019640312","display_name":"Jesper de Claville Christiansen","orcid":"https://orcid.org/0000-0001-5501-7019","observed_orcids":["https://orcid.org/0000-0001-5501-7019"]},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jesper de Claville Christiansen","raw_affiliation_strings":["Department of Materials and Production, Aalborg University, Fibigerstraede 16, Aalborg, Denmark, 9220"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Production, Aalborg University, Fibigerstraede 16, Aalborg, Denmark, 9220","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011976479","display_name":"Cristian Pablo Pennisi","orcid":"https://orcid.org/0000-0002-7716-1182","observed_orcids":["https://orcid.org/0000-0002-7716-1182"]},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Cristian Pablo Pennisi","raw_affiliation_strings":["Aalborg University","Faculty of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University","institution_ids":["https://openalex.org/I891191580"]},{"raw_affiliation_string":"Faculty of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015842439","display_name":"Petra de Graaf","orcid":"https://orcid.org/0000-0002-3183-8901","observed_orcids":["https://orcid.org/0000-0002-3183-8901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petra de Graaf","raw_affiliation_strings":["Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Regenerative Medicine Utrecht, Uppsalalaan 8, Utrecht, Netherlands, 3584 CT","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.13840000331401825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/male-urethra","display_name":"male urethra","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hypospadias","display_name":"hypospadias","score":0.875},{"id":"https://openalex.org/keywords/urethral-stricture","display_name":"urethral stricture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urethroplasty","display_name":"urethroplasty","score":0.7160000205039978},{"id":"https://openalex.org/keywords/autograft","display_name":"autograft","score":0.7369999885559082},{"id":"https://openalex.org/keywords/corpus-spongiosum","display_name":"corpus spongiosum","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anisotropic-viscoelasticity","display_name":"anisotropic viscoelasticity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tissue-compliance","display_name":"tissue compliance","score":0.6990000009536743},{"id":"https://openalex.org/keywords/urethral-pressure","display_name":"urethral pressure","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7696999907493591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5738999843597412},{"id":"https://openalex.org/C2777085111","wikidata":"https://www.wikidata.org/wiki/Q9386","display_name":"Urethra","level":2,"score":0.4636000096797943},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.38929998874664307},{"id":"https://openalex.org/C2778655861","wikidata":"https://www.wikidata.org/wiki/Q1585753","display_name":"Urethral stricture","level":3,"score":0.3792000114917755},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3734999895095825},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.365200012922287},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.30630001425743103},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C2779656439","wikidata":"https://www.wikidata.org/wiki/Q712529","display_name":"Artificial urinary sphincter","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C2994543053","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical testing","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2919999957084656},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C2778531004","wikidata":"https://www.wikidata.org/wiki/Q281490","display_name":"Urinary incontinence","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C116558999","wikidata":"https://www.wikidata.org/wiki/Q4131496","display_name":"Reconstructive surgery","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26409998536109924}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26434/chemrxiv.15008152/v1","doi":"https://doi.org/10.26434/chemrxiv.15008152/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008152/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008152/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pure.atira.dk:publications/2db44676-759d-4097-9ccb-d05a52bccb2f","doi":null,"is_oa":false,"landing_page_url":"https://vbn.aau.dk/da/publications/2db44676-759d-4097-9ccb-d05a52bccb2f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Martinier, I, Qin, J, de Kort, L, van Dort, W, Christiansen, J D C, Pennisi, C P & de Graaf, P 2026, Understanding male urethral mechanics: from ex vivo testing to mathematical modelling and in situ assessment, a review. https://doi.org/10.26434/chemrxiv.15008152/v1","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15008152/v1","doi":"https://doi.org/10.26434/chemrxiv.15008152/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008152/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008152/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204949361.pdf","grobid_xml":"https://content.openalex.org/works/W7204949361.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W325792335","https://openalex.org/W1500831274","https://openalex.org/W1502228150","https://openalex.org/W1516861728","https://openalex.org/W1975022940","https://openalex.org/W1975935170","https://openalex.org/W1976475162","https://openalex.org/W2002152924","https://openalex.org/W2008969125","https://openalex.org/W2022129782","https://openalex.org/W2025178154","https://openalex.org/W2048784971","https://openalex.org/W2055236594","https://openalex.org/W2069248608","https://openalex.org/W2079480052","https://openalex.org/W2081468387","https://openalex.org/W2095181161","https://openalex.org/W2109299623","https://openalex.org/W2149759192","https://openalex.org/W2166739553","https://openalex.org/W2223501223","https://openalex.org/W2290562180","https://openalex.org/W2306987624","https://openalex.org/W2321163949","https://openalex.org/W2425391697","https://openalex.org/W2464464054","https://openalex.org/W2483451257","https://openalex.org/W2556861736","https://openalex.org/W2584716400","https://openalex.org/W2765817363","https://openalex.org/W2791447457","https://openalex.org/W2792063525","https://openalex.org/W2801838398","https://openalex.org/W2886862695","https://openalex.org/W2903817466","https://openalex.org/W2905781802","https://openalex.org/W2913863236","https://openalex.org/W2952789948","https://openalex.org/W2952838303","https://openalex.org/W2953432407","https://openalex.org/W3042597581","https://openalex.org/W3121046601","https://openalex.org/W3133964859","https://openalex.org/W3155192054","https://openalex.org/W3167124105","https://openalex.org/W3193738488","https://openalex.org/W3194496458","https://openalex.org/W3208335870","https://openalex.org/W4241361208","https://openalex.org/W4293204797","https://openalex.org/W4307291695","https://openalex.org/W4313598166","https://openalex.org/W4323647754","https://openalex.org/W4382568017","https://openalex.org/W4386332394","https://openalex.org/W4390267948","https://openalex.org/W4390972303","https://openalex.org/W4391613892","https://openalex.org/W4400105615","https://openalex.org/W4402732800","https://openalex.org/W4404488790","https://openalex.org/W4404826439","https://openalex.org/W4409341468","https://openalex.org/W4409736267","https://openalex.org/W4411382302","https://openalex.org/W7168163854"],"related_works":["https://openalex.org/W7203913111","https://openalex.org/W2604508205","https://openalex.org/W2483451257","https://openalex.org/W7168163854","https://openalex.org/W7096531906","https://openalex.org/W2425391697","https://openalex.org/W3033439313","https://openalex.org/W4403595927","https://openalex.org/W2070145593","https://openalex.org/W2127296180"],"abstract_inverted_index":{"Male":[0],"urethral":[1,7,43,96,116,125,139],"disorders,":[2],"in":[3,48,65],"particular":[4],"hypospadias":[5],"and":[6,54,64,73,89,99,106],"stricture,":[8],"frequently":[9],"require":[10],"reconstructive":[11],"surgery.":[12],"However,":[13],"current":[14],"autologous":[15],"grafts":[16],"fail":[17],"to":[18,29],"replicate":[19],"the":[20,25,49,70,77,112,122],"supportive":[21],"bed":[22],"provided":[23],"by":[24],"corpus":[26],"spongiosum,":[27],"contributing":[28],"high":[30],"recurrence":[31],"rates.":[32],"Developing":[33],"functional,":[34],"off-the-shelf":[35],"tissue-engineered":[36],"replacements":[37],"requires":[38],"a":[39],"comprehensive":[40],"understanding":[41,123],"of":[42,76,114,124],"mechanics,":[44,126],"which":[45],"remains":[46],"fragmented":[47],"literature.":[50],"Here,":[51],"we":[52],"review":[53],"integrate":[55],"diverse":[56],"methodologies\u2014including":[57],"ex":[58],"vivo":[59],"mechanical":[60,104],"testing,":[61],"mathematical":[62],"modelling,":[63],"situ":[66],"clinical":[67],"assessments\u2014to":[68],"elucidate":[69],"complex,":[71],"anisotropic,":[72],"viscoelastic":[74],"properties":[75],"male":[78],"urethra.":[79],"This":[80],"multidimensional":[81],"approach":[82],"highlights":[83],"physiological":[84],"pressure":[85],"ranges,":[86],"tissue":[87],"compliance,":[88],"biomechanical":[90],"behaviour":[91],"under":[92],"dynamic":[93],"conditions,":[94],"stressing":[95],"mechanics'":[97],"location-":[98],"orientation-dependency.":[100],"We":[101],"provide":[102],"standardised":[103],"guidelines":[105],"modelling":[107],"frameworks":[108],"that":[109],"can":[110],"guide":[111],"design":[113],"biomimetic":[115],"grafts.":[117],"Ultimately,":[118],"this":[119],"work":[120],"advances":[121],"informing":[127],"regenerative":[128],"medicine":[129],"strategies":[130],"aimed":[131],"at":[132],"improving":[133],"long-term":[134],"outcomes":[135],"for":[136],"patients":[137],"with":[138],"disorders.":[140]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
