{"id":"https://openalex.org/W7204942077","doi":"https://doi.org/10.1039/d6sc03808e","title":"Multivalent cations stabilize DNA duplexes beyond charge neutralization","display_name":"Multivalent cations stabilize DNA duplexes beyond charge neutralization","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204942077","doi":"https://doi.org/10.1039/d6sc03808e","pmid":"https://pubmed.ncbi.nlm.nih.gov/42713224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13552422"},"language":"en","primary_location":{"id":"doi:10.1039/d6sc03808e","doi":"https://doi.org/10.1039/d6sc03808e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6sc03808e","pdf_url":"https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC03808E/13730720/d6sc03808e.pdf","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC03808E/13730720/d6sc03808e.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026044720","display_name":"Yun-Long Chen","orcid":"https://orcid.org/0000-0002-6499-3641","observed_orcids":["https://orcid.org/0000-0002-6499-3641"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-Long Chen","raw_affiliation_strings":["Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113827616","display_name":"Chen-chen Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]},{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Chen Zheng","raw_affiliation_strings":["Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China","School of Physics and Optical Engineering, Zhejiang University of Technology, Hangzhou 310023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]},{"raw_affiliation_string":"School of Physics and Optical Engineering, Zhejiang University of Technology, Hangzhou 310023, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148862389","display_name":"Yan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031309301","display_name":"Zhi-Jie Tan","orcid":"https://orcid.org/0000-0002-7367-0182","observed_orcids":["https://orcid.org/0000-0002-7367-0182"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Jie Tan","raw_affiliation_strings":["Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121872005","display_name":"Xing-Hua Zhang","orcid":"https://orcid.org/0000-0002-9487-191X","observed_orcids":["https://orcid.org/0000-0002-9487-191X"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing-Hua Zhang","raw_affiliation_strings":["Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China"],"raw_orcid":"https://orcid.org/0000-0002-9487-191X","affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, School of Physics and Technology, Women and Children's Hospital, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031309301","https://openalex.org/A5121872005","https://openalex.org/A5148862389"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56508435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"41","first_page":"19978","last_page":"19986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivalent-cations","display_name":"multivalent cations","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-duplex-stability","display_name":"DNA duplex stability","score":0.8880000114440918},{"id":"https://openalex.org/keywords/charge-neutralization","display_name":"charge neutralization","score":0.777999997138977},{"id":"https://openalex.org/keywords/major-groove","display_name":"major groove","score":0.5820000171661377},{"id":"https://openalex.org/keywords/dna-thermodynamics","display_name":"DNA thermodynamics","score":0.7020000219345093},{"id":"https://openalex.org/keywords/ionic-environment","display_name":"ionic environment","score":0.7850000262260437},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7419999837875366},{"id":"https://openalex.org/keywords/protamine","display_name":"protamine","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.739300012588501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7221999764442444},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.7171000242233276},{"id":"https://openalex.org/C188082385","wikidata":"https://www.wikidata.org/wiki/Q73792","display_name":"Charge (physics)","level":2,"score":0.5031999945640564},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.44519999623298645},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3774000108242035},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.361299991607666},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33000001311302185},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6sc03808e","doi":"https://doi.org/10.1039/d6sc03808e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6sc03808e","pdf_url":"https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC03808E/13730720/d6sc03808e.pdf","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13552422","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13552422/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13552422/pdf/SC-OLF-D6SC03808E.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Sci","raw_type":"Text"},{"id":"pmid:42713224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42713224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6sc03808e","doi":"https://doi.org/10.1039/d6sc03808e","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6sc03808e","pdf_url":"https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC03808E/13730720/d6sc03808e.pdf","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3749309709","display_name":null,"funder_award_id":"No. 12374216","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4870161490","display_name":null,"funder_award_id":"2025AFA021","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G5529385052","display_name":null,"funder_award_id":"2024AFE008","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G6145075081","display_name":null,"funder_award_id":"12074294","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6663165729","display_name":null,"funder_award_id":"No. 12074294","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8231312614","display_name":null,"funder_award_id":"12374216","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204942077.pdf","grobid_xml":"https://content.openalex.org/works/W7204942077.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073485619","https://openalex.org/W1859298396","https://openalex.org/W4412554267","https://openalex.org/W2330054891","https://openalex.org/W2021265606","https://openalex.org/W7096218192","https://openalex.org/W2943393948","https://openalex.org/W2031842331","https://openalex.org/W2335447991","https://openalex.org/W3137404971"],"abstract_inverted_index":{"/bp":[0],"for":[1,15,54,68],"protamine,":[2],"which":[3,76],"is":[4],"a":[5,10,20,65],"small":[6],"arginine-rich":[7],"protein":[8],"with":[9],"highly":[11],"positive":[12],"charge":[13],"(\u224821":[14],"salmon":[16],"sperm),":[17],"corresponding":[18],"to":[19,49,78,86],"relative":[21],"increase":[22],"of":[23,40,82],"19.5%.":[24],"Consistently,":[25],"all-atom":[26],"molecular":[27],"dynamics":[28],"simulations":[29],"show":[30],"that":[31],"higher-valent":[32],"cations":[33],"preferentially":[34],"embed":[35],"in":[36,47,72],"the":[37,44,50,58],"minor":[38,45],"groove":[39],"DNA":[41,70],"and":[42,85,91],"clamp":[43],"groove,":[46],"contrast":[48],"major-groove":[51],"clamping":[52],"reported":[53],"RNA,":[55],"thereby":[56],"stabilizing":[57],"helix":[59],"more":[60],"efficiently.":[61],"These":[62],"findings":[63],"establish":[64],"single-molecule":[66],"framework":[67],"quantifying":[69],"thermodynamics":[71],"complex":[73],"ionic":[74,80],"environments,":[75],"contributes":[77],"understanding":[79],"control":[81],"genome":[83],"stability":[84],"designing":[87],"ion-tunable":[88],"DNA-based":[89],"nanostructures":[90],"delivery":[92],"systems.":[93]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-02T00:00:00"}
