{"id":"https://openalex.org/W7204937703","doi":"https://doi.org/10.64898/2026.08.27.26361552","title":"Molecular landscape and risk stratification in acute myeloid leukemia \u2013 insights from the real-world REFORM-AML cohort","display_name":"Molecular landscape and risk stratification in acute myeloid leukemia \u2013 insights from the real-world REFORM-AML cohort","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204937703","doi":"https://doi.org/10.64898/2026.08.27.26361552"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.26361552","doi":"https://doi.org/10.64898/2026.08.27.26361552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361552","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361552.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361552.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021403966","display_name":"Daniel Tuyet Kristensen","orcid":"https://orcid.org/0000-0002-6753-7051","observed_orcids":["https://orcid.org/0000-0002-6753-7051"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Daniel Tuyet Kristensen","raw_affiliation_strings":["Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus Denmark","Department of Hematology, Aarhus University Hospital, Aarhus, Denmark","Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6753-7051","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Hematology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007708616","display_name":"Rasmus Froberg Br\u00f8ndum","orcid":"https://orcid.org/0000-0001-5537-6767","observed_orcids":["https://orcid.org/0000-0001-5537-6767"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Rasmus Froberg Br\u00f8ndum","raw_affiliation_strings":["Center for Clinical Data Science, Department of Clinical Medicine, Aalborg University and Research, Education, and Innovation, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Data Science, Department of Clinical Medicine, Aalborg University and Research, Education, and Innovation, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261","https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057373226","display_name":"Michael Knudsen","orcid":"https://orcid.org/0000-0002-6294-2517","observed_orcids":["https://orcid.org/0000-0002-6294-2517"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Knudsen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028656444","display_name":"Lykke Grubach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lykke Grubach","raw_affiliation_strings":["Department of Pathology, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031310020","display_name":"Claus Werenberg Marcher","orcid":"https://orcid.org/0000-0002-6595-2075","observed_orcids":["https://orcid.org/0000-0002-6595-2075"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus Marcher","raw_affiliation_strings":["Department of Clinical Research, University of Southern Denmark, Odense, Denmark","Department of Hematology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Hematology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000706071","display_name":"Birgitte Preiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birgitte Preiss","raw_affiliation_strings":["Department of Pathology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148902512","display_name":"Maria Lyng Bibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maria Lyng Bibi","raw_affiliation_strings":["Department of Pathology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030595220","display_name":"Estrid Vilma Solyom H\u00f8gdall","orcid":"https://orcid.org/0000-0003-4689-5658","observed_orcids":["https://orcid.org/0000-0003-4689-5658"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Estrid H\u00f8gdall","raw_affiliation_strings":["Department of Pathology, Copenhagen University Hospital, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Copenhagen University Hospital, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087286512","display_name":"Tim Svenstrup Poulsen","orcid":"https://orcid.org/0000-0001-9781-0541","observed_orcids":["https://orcid.org/0000-0001-9781-0541"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tim Svenstrup Poulsen","raw_affiliation_strings":["Department of Pathology, Copenhagen University Hospital, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Copenhagen University Hospital, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069287220","display_name":"Vibe Skov","orcid":"https://orcid.org/0000-0003-0097-7826","observed_orcids":["https://orcid.org/0000-0003-0097-7826"]},"institutions":[{"id":"https://openalex.org/I2799546111","display_name":"Roskilde Sygehus","ror":"https://ror.org/00t2n7611","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799546111"]},{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Vibe Skov","raw_affiliation_strings":["Department of Hematology, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I2799546111","https://openalex.org/I4210087803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043864217","display_name":"Andreas Due \u00d8rskov","orcid":"https://orcid.org/0000-0001-9996-7155","observed_orcids":["https://orcid.org/0000-0001-9996-7155"]},"institutions":[{"id":"https://openalex.org/I2799546111","display_name":"Roskilde Sygehus","ror":"https://ror.org/00t2n7611","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799546111"]},{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Due \u00d8rskov","raw_affiliation_strings":["Department of Hematology, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I2799546111","https://openalex.org/I4210087803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087303275","display_name":"Kirsten Groenbaek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kirsten Gr\u00f8nb\u00e6k","raw_affiliation_strings":["Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark","Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen","Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013538977","display_name":"Jakob Werner Hansen","orcid":"https://orcid.org/0000-0002-7315-3775","observed_orcids":["https://orcid.org/0000-0002-7315-3775"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jakob Werner Hansen","raw_affiliation_strings":["Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047133712","display_name":"Claudia Sch\u00f6llkopf","orcid":"https://orcid.org/0000-0003-1465-506X","observed_orcids":["https://orcid.org/0000-0003-1465-506X"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claudia Sch\u00f6llkopf","raw_affiliation_strings":["Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056577241","display_name":"Jack B. Cowland","orcid":"https://orcid.org/0000-0002-7429-5388","observed_orcids":["https://orcid.org/0000-0002-7429-5388"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jack Bernard Cowland","raw_affiliation_strings":["Department of Clinical Genetics, Rigshospitalet, Copenhagen University hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, Rigshospitalet, Copenhagen University hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006055158","display_name":"Mette Klarskov Andersen","orcid":"https://orcid.org/0000-0003-2449-5565","observed_orcids":["https://orcid.org/0000-0003-2449-5565"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mette Klarskov","raw_affiliation_strings":["Department of Clinical Genetics, Rigshospitalet, Copenhagen University hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics, Rigshospitalet, Copenhagen University hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040796271","display_name":"Marianne Tang Severinsen","orcid":"https://orcid.org/0000-0003-0996-1812","observed_orcids":["https://orcid.org/0000-0003-0996-1812"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marianne Tang Severinsen","raw_affiliation_strings":["Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]},{"raw_affiliation_string":"Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067708890","display_name":"Christopher Vejgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christopher Vejgaard","raw_affiliation_strings":["Department of Hematology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075239871","display_name":"Ole H. Larsen","orcid":"https://orcid.org/0000-0001-5213-7349","observed_orcids":["https://orcid.org/0000-0001-5213-7349"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole Halfdan Larsen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026616543","display_name":"S\u00f8ren Vang","orcid":"https://orcid.org/0000-0002-1899-4205","observed_orcids":["https://orcid.org/0000-0002-1899-4205"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Vang","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680152","display_name":"Martin Boegsted","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Martin B\u00f8gsted","raw_affiliation_strings":["Center for Clinical Data Science, Department of Clinical Medicine, Aalborg University and Research, Education, and Innovation, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Data Science, Department of Clinical Medicine, Aalborg University and Research, Education, and Innovation, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261","https://openalex.org/I891191580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014772070","display_name":"Anne Stidsholt Roug","orcid":"https://orcid.org/0000-0003-2621-5432","observed_orcids":["https://orcid.org/0000-0003-2621-5432"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne Stidsholt Roug","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus Denmark","Department of Hematology, Aarhus University Hospital, Aarhus, Denmark","Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Hematology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5021403966"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2799976261","https://openalex.org/I2802335433","https://openalex.org/I891191580"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9399999976158142},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.5569999814033508},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6389999985694885},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.6060000061988831},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7559999823570251},{"id":"https://openalex.org/keywords/age-and-sex-differences","display_name":"age and sex differences","score":0.609000027179718},{"id":"https://openalex.org/keywords/intensive-therapy","display_name":"intensive treatment","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7827000021934509},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7749999761581421},{"id":"https://openalex.org/C164622146","wikidata":"https://www.wikidata.org/wiki/Q9035","display_name":"Danish","level":2,"score":0.6732000112533569},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5996000170707703},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5979999899864197},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5952000021934509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5848000049591064},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5091999769210815},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.45579999685287476},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.438400000333786},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4138999879360199},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C37381756","wikidata":"https://www.wikidata.org/wiki/Q20203288","display_name":"Representativeness heuristic","level":2,"score":0.3310999870300293},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3133000135421753},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.27.26361552","doi":"https://doi.org/10.64898/2026.08.27.26361552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361552","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361552.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.27.26361552","doi":"https://doi.org/10.64898/2026.08.27.26361552","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361552","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361552.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204937703.pdf","grobid_xml":"https://content.openalex.org/works/W7204937703.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1994791499","https://openalex.org/W2000445173","https://openalex.org/W2009720434","https://openalex.org/W2036897871","https://openalex.org/W2060587156","https://openalex.org/W2107027906","https://openalex.org/W2110065044","https://openalex.org/W2114586150","https://openalex.org/W2154397429","https://openalex.org/W2155943701","https://openalex.org/W2219591537","https://openalex.org/W2419140434","https://openalex.org/W2439189151","https://openalex.org/W2540667815","https://openalex.org/W2559537906","https://openalex.org/W2591153485","https://openalex.org/W2896480326","https://openalex.org/W2896872272","https://openalex.org/W3036919729","https://openalex.org/W3134703711","https://openalex.org/W3167688297","https://openalex.org/W3172203368","https://openalex.org/W3173024505","https://openalex.org/W4283271244","https://openalex.org/W4283716970","https://openalex.org/W4284884567","https://openalex.org/W4290648657","https://openalex.org/W4310153910","https://openalex.org/W4315487214","https://openalex.org/W4321598768","https://openalex.org/W4322757741","https://openalex.org/W4364380991","https://openalex.org/W4376279131","https://openalex.org/W4385230363","https://openalex.org/W4389089918","https://openalex.org/W4390781667","https://openalex.org/W4390848858","https://openalex.org/W4394666350","https://openalex.org/W4394760248","https://openalex.org/W4399271722","https://openalex.org/W4404096793","https://openalex.org/W4407946187"],"related_works":["https://openalex.org/W4386102413","https://openalex.org/W2891066325","https://openalex.org/W4310107679","https://openalex.org/W4387748470","https://openalex.org/W4283316744","https://openalex.org/W4404230709","https://openalex.org/W7093122195","https://openalex.org/W7133511617","https://openalex.org/W7162860092","https://openalex.org/W3013699398"],"abstract_inverted_index":{"ABSTRACT":[0],"Large":[1],"genomically":[2],"annotated":[3],"acute":[4],"myeloid":[5],"leukaemia":[6],"(AML)":[7],"datasets":[8],"exist,":[9],"but":[10,68],"population-based":[11],"contemporary":[12],"cohorts":[13],"remain":[14],"scarce.":[15],"Here":[16],"we":[17],"report":[18],"clinicopathological,":[19],"genomic,":[20],"and":[21,49,55,84,89,112,122,136,142,184,191,194],"outcome":[22],"data":[23,41],"from":[24],"Danish":[25,180],"AML":[26,29,163,181],"patients.":[27,75],"2,512":[28],"patients":[30,44,59,64,164],"were":[31,51,165],"identified":[32],"between":[33,53],"2015-2022,":[34],"of":[35,78,95,119,133,140,160,168,174],"whom":[36],"33.8%":[37],"had":[38,147],"available":[39],"NGS":[40,169],"(NGS+).":[42],"In":[43,58,99,157],"\u226470":[45],"years,":[46,61],"baseline":[47],"characteristics":[48],"outcomes":[50,159],"comparable":[52,148,166],"NGS+":[54,63,102],"NGS\u2212":[56],"groups.":[57],">70":[60],"more":[62],"received":[65],"intensive":[66],"treatment,":[67],"survival":[69],"was":[70],"similar":[71],"among":[72],"intensively":[73,100,161],"treated":[74,101,162],"The":[76,144],"distribution":[77],"mutations":[79],"varied":[80],"significantly":[81],"by":[82],"age":[83,88],"sex,":[85],"with":[86,115,138,188],"older":[87],"male":[90,185],"sex":[91,186],"exhibiting":[92],"higher":[93],"frequencies":[94],"adverse-risk":[96,189],"gene":[97],"mutations.":[98],"patients,":[103],"ELN2017":[104,193],"stratified":[105],"5-year":[106],"OS:":[107],"58.4%":[108],"(favorable),":[109],"43.4%":[110],"(intermediate),":[111],"28.2%":[113],"(adverse),":[114],"hazard":[116],"ratios":[117],"(HRs)":[118],"0.63":[120],"(favorable)":[121],"1.45":[123],"(adverse)":[124],"relative":[125],"to":[126],"intermediate.":[127],"ELN2022":[128,195],"yielded":[129],"corresponding":[130],"OS":[131,152],"rates":[132],"56.9%,":[134],"51.8%,":[135],"29.7%,":[137],"HRs":[139],"0.78":[141],"1.86.":[143],"two":[145],"models":[146],"predictive":[149],"performance":[150],"for":[151,178],"in":[153],"a":[154],"time-dependent":[155],"model.":[156],"conclusion,":[158],"irrespective":[167],"status,":[170],"underscoring":[171],"the":[172,175,179],"representativeness":[173],"REFORM-AML":[176],"database":[177],"population.":[182],"Age":[183],"correlated":[187],"mutations,":[190],"both":[192],"robustly":[196],"predicted":[197],"survival.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}