{"id":"https://openalex.org/W7204932801","doi":"https://doi.org/10.38079/igusabder.1939863","title":"Hypertension-Related Microstructural Changes in the Vitreous Humor Detected by Diffusion MRI","display_name":"Hypertension-Related Microstructural Changes in the Vitreous Humor Detected by Diffusion MRI","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204932801","doi":"https://doi.org/10.38079/igusabder.1939863"},"language":"en","primary_location":{"id":"doi:10.38079/igusabder.1939863","doi":"https://doi.org/10.38079/igusabder.1939863","is_oa":true,"landing_page_url":"https://doi.org/10.38079/igusabder.1939863","pdf_url":"https://dergipark.org.tr/en/download/article-file/5959202","source":{"id":"https://openalex.org/S4210199784","display_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","issn_l":"2536-4499","issn":["2536-4499"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/5959202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120069476","display_name":"Davut \u00dcnsal \u00c7apkan","orcid":"https://orcid.org/0009-0007-6937-8799","observed_orcids":["https://orcid.org/0009-0007-6937-8799"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Davut \u00dcnsal \u00c7apkan","raw_affiliation_strings":["Medical Point Hastanesi"],"raw_orcid":"https://orcid.org/0009-0007-6937-8799","affiliations":[{"raw_affiliation_string":"Medical Point Hastanesi","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5120069476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"30","first_page":"445","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.21410000324249268,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.996999979019165},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.7689999938011169},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.8169999718666077},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7450000047683716},{"id":"https://openalex.org/keywords/orbital-imaging","display_name":"orbital imaging","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7440000176429749},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.6775000095367432},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5874000191688538},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5733000040054321},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5249999761581421},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.5138000249862671},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4794999957084656},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.46230000257492065},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4077000021934509},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.40059998631477356},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.36250001192092896},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33889999985694885},{"id":"https://openalex.org/C69941244","wikidata":"https://www.wikidata.org/wiki/Q6045770","display_name":"Interclass correlation","level":4,"score":0.30239999294281006},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2619999945163727}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.38079/igusabder.1939863","doi":"https://doi.org/10.38079/igusabder.1939863","is_oa":true,"landing_page_url":"https://doi.org/10.38079/igusabder.1939863","pdf_url":"https://dergipark.org.tr/en/download/article-file/5959202","source":{"id":"https://openalex.org/S4210199784","display_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","issn_l":"2536-4499","issn":["2536-4499"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1939863","doi":null,"is_oa":true,"landing_page_url":"https://izlik.org/JA48ZJ47CG","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi No. 30","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.38079/igusabder.1939863","doi":"https://doi.org/10.38079/igusabder.1939863","is_oa":true,"landing_page_url":"https://doi.org/10.38079/igusabder.1939863","pdf_url":"https://dergipark.org.tr/en/download/article-file/5959202","source":{"id":"https://openalex.org/S4210199784","display_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","issn_l":"2536-4499","issn":["2536-4499"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318287","host_organization_name":"Association of Food Technology, Turkey","host_organization_lineage":["https://openalex.org/P4310318287"],"host_organization_lineage_names":["Association of Food Technology, Turkey"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0130stanbul Geli\u015fim \u00dcniversitesi Sa\u011fl\u0131k Bilimleri Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204932801.pdf","grobid_xml":"https://content.openalex.org/works/W7204932801.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1857174369","https://openalex.org/W2098735497","https://openalex.org/W2167538110","https://openalex.org/W2604709734","https://openalex.org/W2996163263","https://openalex.org/W3008943645","https://openalex.org/W3019083909","https://openalex.org/W3034330947","https://openalex.org/W3109260846","https://openalex.org/W3120318004","https://openalex.org/W3120495930","https://openalex.org/W3164590948","https://openalex.org/W3197333985","https://openalex.org/W4205645563","https://openalex.org/W4205787574","https://openalex.org/W4221098307","https://openalex.org/W4225001781","https://openalex.org/W4281484119","https://openalex.org/W4293434852","https://openalex.org/W4312124011","https://openalex.org/W4319656625","https://openalex.org/W4385142394","https://openalex.org/W4387392731","https://openalex.org/W4389178970","https://openalex.org/W4391752790","https://openalex.org/W4399871523","https://openalex.org/W4405294566","https://openalex.org/W4408738435","https://openalex.org/W4409830138"],"related_works":["https://openalex.org/W4221098307","https://openalex.org/W2460119535","https://openalex.org/W2347810291","https://openalex.org/W6929228911","https://openalex.org/W2036052883","https://openalex.org/W2381316579","https://openalex.org/W4390198321","https://openalex.org/W2908587733","https://openalex.org/W3038381031","https://openalex.org/W2782394803"],"abstract_inverted_index":{"Aim:":[0],"Hypertension":[1],"is":[2,16],"known":[3],"to":[4,73,78,117,193,301],"affect":[5],"several":[6],"target":[7],"organs":[8],"through":[9],"chronic":[10],"microvascular":[11],"injury.":[12],"Although":[13,265],"ocular":[14],"involvement":[15],"usually":[17],"assessed":[18],"by":[19,52],"retinal":[20],"or":[21],"choroidal":[22],"vascular":[23],"findings,":[24],"possible":[25],"changes":[26],"in":[27,48,150,155,262],"the":[28,49,74,201,206,303],"vitreous":[29,50,145,252,263,282],"humor":[30,51,88],"have":[31],"received":[32],"limited":[33],"attention.":[34],"This":[35,59],"study":[36,62],"investigated":[37],"whether":[38],"diffusion-weighted":[39],"magnetic":[40],"resonance":[41],"imaging":[42],"(DW-MRI)":[43],"could":[44],"detect":[45],"hypertension-related":[46],"alterations":[47],"measuring":[53],"apparent":[54],"diffusion":[55],"coefficient":[56],"(ADC)":[57],"values.Method:":[58],"retrospective":[60],"cross-sectional":[61],"included":[63],"100":[64,69],"patients":[65],"with":[66,122,140,152,163,177,213,230,248],"hypertension":[67,75,153,173,249],"and":[68,80,104,186,223,274,296],"controls":[70,156],"frequency":[71],"matched":[72],"group":[76],"according":[77],"age":[79],"sex":[81],"who":[82],"had":[83,250],"undergone":[84],"orbital":[85],"DW-MRI.":[86],"Vitreous":[87],"ADC":[89,94,106,146,180,199,232,241,253,267,283],"values":[90,107,254],"were":[91,108],"measured":[92],"on":[93],"maps":[95],"using":[96,130],"standardized":[97,195],"regions":[98],"of":[99,217,306],"interest":[100],"(ROI).":[101],"Right,":[102],"left,":[103],"mean":[105,123,179,231,240,266],"compared":[109],"between":[110,271],"groups.":[111],"Multivariable":[112],"linear":[113],"regression":[114],"was":[115,128,138,147,227,237],"used":[116],"determine":[118],"factors":[119],"independently":[120,175],"associated":[121,176],"ADC.":[124],"Within-sample":[125],"discriminative":[126],"performance":[127],"explored":[129],"receiver":[131],"operating":[132],"characteristic":[133],"(ROC)":[134],"analysis.":[135],"Intra-observer":[136,235],"reliability":[137],"evaluated":[139,207],"intraclass":[141],"correlation":[142],"coefficients.Results:":[143],"Mean":[144,198],"significantly":[148],"lower":[149,178,251],"participants":[151,273],"than":[154,255],"(2.18\u00b10.20":[157],"vs.":[158],"2.32\u00b10.18":[159],"\u00d710\u207b\u00b3":[160,219],"mm\u00b2/s;":[161],"p<0.001),":[162],"a":[164,214,285],"moderate-to-large":[165],"effect":[166],"size":[167],"(Cohen\u2019s":[168],"d=0.72).":[169],"In":[170],"multivariable":[171],"analysis,":[172],"remained":[174],"after":[181],"adjustment":[182],"for":[183,239],"age,":[184],"sex,":[185],"diabetes":[187],"mellitus":[188],"(B=\u22120.160,":[189],"95%":[190,210,244],"CI:":[191,211,245],"\u22120.210":[192],"\u22120.110;":[194],"\u03b2=\u22120.42;":[196],"p<0.001).":[197,234],"showed":[200,268],"highest":[202],"within-sample":[203,269],"discrimination":[204,270],"among":[205],"measures":[208],"(AUC=0.83,":[209],"0.77\u20130.89),":[212],"data-derived":[215],"cut-off":[216],"\u22642.25":[218],"mm\u00b2/s,":[220],"78.0%":[221],"sensitivity,":[222],"75.0%":[224],"specificity.":[225],"Age":[226],"inversely":[228],"correlated":[229],"(r=\u22120.34,":[233],"reproducibility":[236],"excellent":[238],"measurements":[242],"(ICC=0.96,":[243],"0.94\u20130.97).Conclusion:":[246],"Patients":[247],"controls,":[256,275],"which":[257],"may":[258],"reflect":[259],"subtle":[260],"differences":[261],"microstructure.":[264],"hypertensive":[272],"these":[276,307],"exploratory":[277],"findings":[278],"do":[279],"not":[280],"establish":[281],"as":[284],"clinical":[286,304],"diagnostic":[287],"test.":[288],"Prospective":[289],"multicenter":[290],"studies":[291],"incorporating":[292],"comprehensive":[293],"ophthalmological":[294],"assessments":[295],"external":[297],"validation":[298],"are":[299],"required":[300],"clarify":[302],"relevance":[305],"findings.":[308]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-09-02T00:00:00"}