{"id":"https://openalex.org/W7204920841","doi":"https://doi.org/10.64898/2026.08.25.746970","title":"Proteolytic Remodeling of Cargo Receptor Networks by RHBDL4 Tunes Secretory Pathway Flux","display_name":"Proteolytic Remodeling of Cargo Receptor Networks by RHBDL4 Tunes Secretory Pathway Flux","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204920841","doi":"https://doi.org/10.64898/2026.08.25.746970"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.746970","doi":"https://doi.org/10.64898/2026.08.25.746970","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746970","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.25.746970.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.25.746970.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067966979","display_name":"Susanne S Steigleder","orcid":"https://orcid.org/0009-0001-9322-5916","observed_orcids":["https://orcid.org/0009-0001-9322-5916"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne S. Steigleder","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148896383","display_name":"Clara Neumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clara Neumann","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009967495","display_name":"Marina Tauber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marina Tauber","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032066098","display_name":"Isabel Kr\u00e4mer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabel Kr\u00e4mer","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001166973","display_name":"Monika Pesch","orcid":"https://orcid.org/0000-0003-0884-1819","observed_orcids":["https://orcid.org/0000-0003-0884-1819"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Pesch","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059073921","display_name":"Julia Daniela Knopf","orcid":"https://orcid.org/0000-0002-5344-9771","observed_orcids":["https://orcid.org/0000-0002-5344-9771"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia D. Knopf","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061579676","display_name":"Julian N\u00fcchel","orcid":"https://orcid.org/0000-0002-8126-415X","observed_orcids":["https://orcid.org/0000-0002-8126-415X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian N\u00fcchel","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8126-415X","affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050289394","display_name":"Marius K. Lemberg","orcid":"https://orcid.org/0000-0002-0996-1268","observed_orcids":["https://orcid.org/0000-0002-0996-1268"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138270","display_name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases","ror":"https://ror.org/04c4bwh63","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210138270"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marius K. Lemberg","raw_affiliation_strings":["Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0996-1268","affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine, University of Cologne; Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270"]},{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050289394"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138270","https://openalex.org/I4210153755"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cargo-receptors","display_name":"cargo receptors","score":0.906000018119812},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.8349999785423279},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/intramembrane-proteolysis","display_name":"intramembrane proteolysis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/er-golgi-intermediate-compartment","display_name":"ER-Golgi intermediate compartment","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7846999764442444},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.7821999788284302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6758999824523926},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6646000146865845},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6243000030517578},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.5918999910354614},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.522599995136261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.445499986410141},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.43619999289512634},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3709000051021576},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C2909863526","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory Vesicle","level":4,"score":0.3057999908924103},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.2745000123977661},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.2736000120639801},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26019999384880066},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.746970","doi":"https://doi.org/10.64898/2026.08.25.746970","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746970","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.25.746970.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.25.746970","doi":"https://doi.org/10.64898/2026.08.25.746970","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746970","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.25.746970.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6656600998","display_name":"SFB 1036: Zellul\u00e4re Qualit\u00e4tskontrolle und Schadensbegrenzung","funder_award_id":"201348542","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204920841.pdf","grobid_xml":"https://content.openalex.org/works/W7204920841.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7112868670","https://openalex.org/W3003401886","https://openalex.org/W2414878614","https://openalex.org/W4290769491","https://openalex.org/W2100265094","https://openalex.org/W6944006944","https://openalex.org/W2105376178","https://openalex.org/W2093827098","https://openalex.org/W4285079381","https://openalex.org/W7023944276"],"abstract_inverted_index":{"Abstract":[0],"Cargo":[1],"receptors":[2,147],"are":[3],"central":[4],"organizers":[5],"of":[6,33,73,114,136,152,159],"the":[7,11,49,74,95,137],"secretory":[8,43,65,97,168],"pathway,":[9],"yet":[10],"mechanisms":[12],"controlling":[13],"their":[14],"abundance":[15],"remain":[16],"poorly":[17],"understood.":[18],"The":[19],"endoplasmic":[20],"reticulum":[21],"(ER)-resident":[22],"intramembrane":[23],"protease":[24],"RHBDL4":[25,56,84,88,100,119,153],"promotes":[26],"substrate":[27],"turnover":[28,62],"via":[29],"a":[30,149,164],"non-canonical":[31],"branch":[32],"ER-associated":[34],"degradation":[35],"and":[36,155],"has":[37],"recently":[38],"been":[39],"implicated":[40],"in":[41,131],"regulating":[42,167],"pathway":[44,66,169],"components.":[45],"We":[46],"previously":[47],"identified":[48],"p24":[50],"cargo":[51,60,79,91,139,146,160],"receptor":[52,61,80,92,140,161],"TMED7":[53],"as":[54,82,148,163],"an":[55],"substrate,":[57],"suggesting":[58],"that":[59,87,124],"contributes":[63],"to":[64],"regulation.":[67],"Here,":[68],"quantitative":[69],"proteomics":[70],"identify":[71,145],"members":[72],"ER-Golgi":[75],"intermediate":[76],"compartment":[77],"(ERGIC)":[78],"family":[81],"endogenous":[83],"substrates,":[85],"demonstrating":[86],"targets":[89],"multiple":[90,102],"families":[93],"within":[94],"early":[96],"pathway.":[98],"Accordingly,":[99],"modulates":[101],"ERGIC-dependent":[103],"transport":[104],"pathways.":[105],"In":[106],"addition,":[107],"unbiased":[108],"secretome":[109],"analysis":[110],"reveals":[111],"increased":[112],"secretion":[113],"lysosomal":[115,138],"precursor":[116],"proteins":[117],"upon":[118],"ablation.":[120],"Mechanistically,":[121],"we":[122],"show":[123],"this":[125],"phenotype":[126],"is":[127],"mediated,":[128],"at":[129],"least":[130],"part,":[132],"by":[133],"RHBDL4-dependent":[134],"cleavage":[135],"sortilin/SORT1.":[141],"Together,":[142],"these":[143],"findings":[144],"major":[150],"class":[151],"substrates":[154],"establish":[156],"proteolytic":[157],"remodeling":[158],"networks":[162],"mechanism":[165],"for":[166],"flux.":[170]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}