{"id":"https://openalex.org/W7204920675","doi":"https://doi.org/10.64898/2026.08.31.748372","title":"X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments","display_name":"X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204920675","doi":"https://doi.org/10.64898/2026.08.31.748372"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.31.748372","doi":"https://doi.org/10.64898/2026.08.31.748372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748372","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748372.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748372.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003999899","display_name":"Antonia Hauth","orcid":"https://orcid.org/0000-0002-6165-4468","observed_orcids":["https://orcid.org/0000-0002-6165-4468"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antonia Hauth","raw_affiliation_strings":["EMBL;"],"raw_orcid":"https://orcid.org/0000-0002-6165-4468","affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023935664","display_name":"Agnese Loda","orcid":"https://orcid.org/0000-0001-8109-128X","observed_orcids":["https://orcid.org/0000-0001-8109-128X"]},"institutions":[{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Agnese Loda","raw_affiliation_strings":["Institut Imagine;"],"raw_orcid":"https://orcid.org/0000-0001-8109-128X","affiliations":[{"raw_affiliation_string":"Institut Imagine;","institution_ids":["https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148869596","display_name":"Nikolai Bykov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nikolai Bykov","raw_affiliation_strings":["Centre for Genomic Regulation (CRG);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic Regulation (CRG);","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050660085","display_name":"Yuvia Alheli Perez-Rico","orcid":"https://orcid.org/0000-0001-8436-0748","observed_orcids":["https://orcid.org/0000-0001-8436-0748"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yuvia A. Perez-Rico","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071642617","display_name":"Isabell Rall","orcid":"https://orcid.org/0000-0001-5911-4609","observed_orcids":["https://orcid.org/0000-0001-5911-4609"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabelle Rall","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016487121","display_name":"Bahtiyar Kurtulmus","orcid":"https://orcid.org/0000-0001-5796-0887","observed_orcids":["https://orcid.org/0000-0001-5796-0887"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bahtiyar Kurtulmus","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062765335","display_name":"Christel Picard","orcid":"https://orcid.org/0000-0002-6135-596X","observed_orcids":["https://orcid.org/0000-0002-6135-596X"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christel Picard","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030078016","display_name":"Tim Pollex","orcid":"https://orcid.org/0000-0001-5669-3940","observed_orcids":["https://orcid.org/0000-0001-5669-3940"]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Pollex","raw_affiliation_strings":["EMBL;"],"raw_orcid":"https://orcid.org/0000-0001-5669-3940","affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047327833","display_name":"Nicolas Servant","orcid":"https://orcid.org/0000-0003-1678-7410","observed_orcids":["https://orcid.org/0000-0003-1678-7410"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Servant","raw_affiliation_strings":["Institut Curie;"],"raw_orcid":"https://orcid.org/0000-0003-1678-7410","affiliations":[{"raw_affiliation_string":"Institut Curie;","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037367297","display_name":"Laura Villacorta","orcid":"https://orcid.org/0000-0002-9509-8594","observed_orcids":["https://orcid.org/0000-0002-9509-8594"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210111092","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/01zjc6908","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210111092","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE","ES","FR"],"is_corresponding":false,"raw_author_name":"Laura Villacorta","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL);","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210111092","https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094013506","display_name":"L\u00e9na Clerquin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lena Clerquin","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140364528","display_name":"Caterina Simoncini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caterina Simoncini","raw_affiliation_strings":["EMBL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL;","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082758634","display_name":"Marc A. Mart\u0131\u0301-Renom","orcid":"https://orcid.org/0000-0002-0151-4279","observed_orcids":["https://orcid.org/0000-0002-0151-4279"]},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marc Marti-Renom","raw_affiliation_strings":["Centre for Genomic Regulation (CRG);"],"raw_orcid":"https://orcid.org/0000-0002-0151-4279","affiliations":[{"raw_affiliation_string":"Centre for Genomic Regulation (CRG);","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018287271","display_name":"\u00c9dith Heard","orcid":"https://orcid.org/0000-0001-8052-7117","observed_orcids":["https://orcid.org/0000-0001-8052-7117"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edith Heard","raw_affiliation_strings":["The Crick Institute"],"raw_orcid":"https://orcid.org/0000-0001-8052-7117","affiliations":[{"raw_affiliation_string":"The Crick Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018287271"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cohesin","display_name":"cohesin","score":0.972000002861023},{"id":"https://openalex.org/keywords/rad21","display_name":"RAD21","score":0.8849999904632568},{"id":"https://openalex.org/keywords/loop-extrusion","display_name":"loop extrusion","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chromatin-compartmentalization","display_name":"chromatin compartmentalization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.8650000095367432},{"id":"https://openalex.org/keywords/h3k27-acetylation","display_name":"H3K27 acetylation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/h3k27-methylation","display_name":"H3K27 methylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/3d-genome-organization","display_name":"3D genome organization","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.9463000297546387},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.9114999771118164},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6087999939918518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6007000207901001},{"id":"https://openalex.org/C115821613","wikidata":"https://www.wikidata.org/wiki/Q21103063","display_name":"Cohesin","level":4,"score":0.5759000182151794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5227000117301941},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43619999289512634},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.4083000123500824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.39070001244544983},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.3817000091075897},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.36730000376701355},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35120001435279846},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3391000032424927},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3091999888420105},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.2849999964237213},{"id":"https://openalex.org/C212702","wikidata":"https://www.wikidata.org/wiki/Q178150","display_name":"Insulator (electricity)","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2581999897956848},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.2549000084400177},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.31.748372","doi":"https://doi.org/10.64898/2026.08.31.748372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748372","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748372.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.31.748372","doi":"https://doi.org/10.64898/2026.08.31.748372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.748372","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.748372.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4843829382","display_name":"Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation","funder_award_id":"838408","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4847574367","display_name":"Chromatin architecture and Design","funder_award_id":"813327","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5136962677","display_name":"Determination of transcription factor cooperativity driving expression from the inactive X chromosome","funder_award_id":"882771","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204920675.pdf","grobid_xml":"https://content.openalex.org/works/W7204920675.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4307965754"],"related_works":["https://openalex.org/W4372319053","https://openalex.org/W2021798161","https://openalex.org/W6977384778","https://openalex.org/W2092787490","https://openalex.org/W1971578865","https://openalex.org/W2977605818","https://openalex.org/W6939552556","https://openalex.org/W6942334431","https://openalex.org/W1937070725","https://openalex.org/W2047054611"],"abstract_inverted_index":{"X-chromosome":[0],"inactivation":[1],"involves":[2],"chromosome-wide":[3],"gene":[4,123],"silencing":[5,135],"accompanied":[6],"by":[7,58],"extensive":[8],"chromatin":[9,154,199],"changes,":[10],"as":[11,201],"well":[12],"the":[13,23,73,105,165,173,179,202],"loss":[14,114],"of":[15,22,75,85,115,134,138,152,167,175,190,205],"topologically":[16],"associating":[17],"domains.":[18,208],"Yet":[19],"discrete":[20],"regions":[21,148],"inactive":[24,106,180],"X":[25,41,107,181],"chromosome":[26],"retain":[27],"activity":[28,177],"within":[29],"localised":[30],"3D":[31,194],"domains,":[32],"which":[33],"contain":[34],"active":[35,153,184],"genes":[36,139],"that":[37,145],"variably":[38],"escape":[39,57,60,80,95,102,147],"from":[40],"inactivation.":[42],"The":[43],"transcription":[44],"factor":[45],"and":[46,77,87,159,192],"architectural":[47],"protein":[48],"CTCF":[49,76,86,98,191],"has":[50],"been":[51],"proposed":[52],"to":[53],"be":[54],"implicated":[55],"in":[56,79,89,132,140,156,161],"insulating":[59],"domains":[61],"or":[62,125,136],"sustaining":[63],"their":[64],"topology":[65],"via":[66],"cohesin-mediated":[67],"loop":[68,116],"extrusion.":[69],"Here,":[70],"we":[71,143],"test":[72],"role":[74],"cohesin":[78],"using":[81],"acute":[82],"degron-mediated":[83],"depletion":[84],"RAD21":[88],"neural":[90],"progenitor":[91],"cells":[92],"with":[93,101,113,164,172],"established":[94],"profiles.":[96],"Although":[97],"occupancy":[99],"correlates":[100],"status":[103],"on":[104,178],"chromosome,":[108],"its":[109],"removal":[110],"-":[111,118],"together":[112],"extrusion":[117],"does":[119,129],"not":[120],"disrupt":[121],"escapee":[122,185,207],"expression,":[124],"domain":[126],"organization,":[127],"nor":[128],"it":[130],"result":[131],"spreading":[133],"activation":[137],"cis.":[141],"Rather,":[142],"show":[144],"facultative":[146,206],"are":[149,187],"self-sustaining":[150],"compartments":[151,186],"enriched":[155],"H3K27":[157,162],"acetylation":[158],"depleted":[160],"methylation,":[163],"magnitude":[166],"compartment":[168],"strength":[169],"scaling":[170],"up":[171],"degree":[174],"transcriptional":[176],"chromosome.":[182],"These":[183],"propagated":[188],"independently":[189],"RAD21-dependent":[193],"architecture.":[195],"Our":[196],"findings":[197],"identify":[198],"compartmentalization":[200],"primary":[203],"feature":[204]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}